IndraLab

Statements

USP39 binds HDACs. 3 / 3
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reach
"These data suggest that H2A-H2B could enhance the interaction between Sad1 and HDACs, including Sir2 and Clr3.To further support the role of Sad1 in recruiting HDACs, we used ChIP-qPCR assay to examine how Sad1 affects the enrichment of Sir2 in telomere regions."
38773107
reach
"These results collectively suggest that the Sad1-H2AB interaction cooperatively enhances the interaction between Sad1 and HDACs, which facilitates the recruitment of HDACs to heterochromatin to ensure the correct epigenetic status required for heterochromatin silencing."
38773107
reach
"Mechanistically, H2A-H2B enhances the interaction between Sad1 and HDACs, including Clr3 and Sir2, to maintain epigenetic identity of heterochromatin."
38773107