IndraLab

Statements

USP39 inhibits TP53. 9 / 9
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"USP39 deficiency activates p53 pathway–induced apoptosis and metastasis in NSCLC [25]."
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"Moreover, depletion of USP39 blocked activation of Akt, mTOR, p53, and PARP signaling pathways."
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"USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53."
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"USP39 down-regulates the p53/p21 signaling pathway and stabilizes CDK1 and cyclin B1 to promote the proliferation of ovarian cancer cells [34]."
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"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."
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"Further studies demonstrated that depletion of USP39 results in an upregulation of p53 through prolonging its half-life and activating its transcriptional activation activity ."
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"Furthermore, USP39 knockdown increased the stability of the p53 protein by prolonging its half-life."
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"on A549 cells to confirm the key role of p53, the WB result demonstrated that exposure to PFT-alpha (30 or 40 mum/48 h) clearly inhibited the p53 pathway activation, which activated by USP39 knockdown in A549 cells."
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"Altogether, these results suggest that USP39 knockdown causes a significant accumulation of p53 via regulating both transcriptional levels and post-translational modifications of p53."
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