IndraLab

Statements

USP39 activates double-strand break repair via nonhomologous end joining. 4 / 4
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"In parallel, we examined whether the ZF domain is important for USP39-mediated NHEJ repair or cell survival."
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"USP39 directly drives XRCC4/LIG4 dependent NHEJ repair."
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"Consistent with previous results, we observed that USP39 depletion reduced both HR and NHEJ repair (Figure 2F)."
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"In addition, we also found that reintroducing either WT USP39 or the RG/AA mutant rescued USP39 depletion-mediated HR failure, but the RG/AA mutant failed to rescue the NHEJ defect caused by USP39 ablation."
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