IndraLab

Statements

FOXM1 binds USP39. 14 / 14
3 | 3 8
biogrid
No evidence text available
36119839
sparser
"Additionally, the deubiquitinating enzyme USP39 can also directly bind to FOXM1 and further deubiquitinate and stabilize FOXM1."
40003882
sparser
"In our work, USP39 interacted with FOXM1 and promoted the splicing of FOXM1 pre-mRNA."
37957720
biogrid
No evidence text available
36119839
biogrid
No evidence text available
36119839
reach
"Additionally, the deubiquitinating enzyme USP39 can also directly bind to FOXM1 and further deubiquitinate and stabilize FOXM1."
40003882
reach
"We also used RIP assay to confirm that FOXM1 bound with USP39 in human CSCC tissue (Additional file 1: Fig S2B)."
37957720
sparser
"The interaction between USP39 and FOXM1 was investigated using co-immunoprecipitation (co-IP) and in vitro deubiquitination analysis."
36119839
sparser
"It is worth noting that, as in HCC, USP39 interacts with FOXM1 in BC regulating ubiquitination and stabilizing FOXM1 through competitive bonding with the E3 ubiquitin ligase APC/Cdh1, which regulates BC cell proliferation ( xref )."
40990019
sparser
"In general, our research revealed the USP39-FOXM1 axis as a critical driver of breast cancer cell proliferation and provided a theoretical foundation for targeting the USP39-FOXM1 axis for pancreatic cancer treatment."
36119839
reach
"Results of RIP assay further verified this data and revealed the abundant enrichment of FOXM1 in the precipitates of anti-USP39, suggesting that FOXM1 bound with USP39 in CaSki and SiHa cells (Fig. 5F)."
37957720
sparser
"Results of RIP assay further verified this data and revealed the abundant enrichment of FOXM1 in the precipitates of anti-USP39, suggesting that FOXM1 bound with USP39 in CaSki and SiHa cells (Fig.  xref F)."
37957720
sparser
"Interestingly, USP39 is also subject to FOXM1 regulation Therefore, it was indicated that USP39 and FOXM1 constitute a negative feedback loop that co-regulates the proliferation of BC cells, thereby offering a novel approach to targeting the USP39-FOXM1 axis for the treatment of BC."
40990019
sparser
"We also used RIP assay to confirm that FOXM1 bound with USP39 in human CSCC tissue (Additional file xref : Fig S2B)."
37957720