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USP39 deubiquitinates E protein. 3 / 3
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"Furthermore, USP39 silencing had no effect on the replication of SARS-CoV-2 in the RNF5 KO cells compared with that in the wild-type cells ( Fig. 8 B–D), suggesting that USP39 specifically reverses po[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we report that USP39 facilitates viral replication by deubiquitinating SARS-CoV-2 E protein and preventing it degradation from the E3 ligase RNF5.Thirteen percent of DUBs have been predicted to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results suggest that USP39 decreases the ubiquitination of the E protein and enhances its stability.We next examined the co-localization of USP39 or USP14 with the E protein and RNF5."
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