IndraLab

Statements

USP39 deubiquitinates ZEB1. 6 / 6
1 | 5
reach
"In consideration of ZEB1 deubiquitination by USP39, we wondered if there were other protein participates in HCC development, which could be simultaneously regulated by USP39 and TRIM26."
36707504
reach
"Collectively, our findings suggest that the balanced deubiquitination and ubiquitination of ZEB1 by USP39 and TRIM26 represent a novel mechanism for the progression of HCC, and this discovery provides a promising strategy for targeting USP39 or TRIM26 in the treatment of HCC cases with aberrant ZEB1 expression levels."
33649471
reach
"USP39 promotes EMT and inhibits ZEB1 ubiquitination in HCC."
33649471
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"Mechanistically, TRIM26 ubiquitinates and targets ZEB1 for degradation, while USP39 deubiquitinates and stabilizes ZEB1 to promote hepatocellular carcinoma (HCC) [86]."
35454770
reach
"Other studies have shown that Ubiquitin-specific peptidase 39 (USP39) deubiquitinates and suppresses ZEB1 degradation, thus promoting the development of EMT and the onset of hepatocellular carcinoma."
37457025
ubibrowser
"Deubiquitinase <span class="match term0">USP39</span> and E3 ligase TRIM26 balance the level of <span class="match term1">ZEB1</span> ubiquitination and thereby determine the progression of hepatocellular carcinoma"
33649471