IndraLab

Statements

USP39 activates Interferon. 3 / 3
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"Intriguingly, USP39 promotes IFN-mediated antiviral responses by decreasing K6-linked but not canonical K48-linked polyubiquitination of STAT1 for degradation (118), eventhough K6-linked ubiquitin chains are often related to DNA damage instead of protein degradation (142)."
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"Mechanistically, USP39 does not affect the production of type I IFN but significantly promotes JAK and STAT downstream of type I signaling by enhancing IFN stimulated response elements promoter activity and expression of IFN stimulated genes."
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"Unlike USP2A, the deubiquitinating enzymes BRCC36, USP13, and USP39 positively regulate IFN activities by attenuating the polyubiquitination level of STAT1, and this process is independent of IFN treatment, which suggests divergent functional roles of these DUBs under differential contexts.Additionally, ATXN3 does not affect IFN-I production during viral infection but positively regulates IFNAR1-mediated downstream signaling by targeting HDAC3 (108)."
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