IndraLab

Statements

USP39 activates VEGFA. 3 / 3
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"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
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"In renal cancer cells (RCCs), USP39 promotes malignant progression by regulating the anti-angiogenic variant of vascular endothelial growth factor A (VEGF-A), VEGF-A b, in addition to the RNA splicing-related proteins SRSF1 and SRPK1 [90]."
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"This potentially originating from the iUSP domain cannot bind ubiquitin either, and the ZnF of USP39 could interact with the splicing independent on ubiquitin [64], which provides the opportunity for SRSF1 binding to USP39 , though further exploration is required to confirm the conclusion.Firstly, one remaining limitation is how USP39 drives the changes in VEGF-A , which needs further research to elucidate the specific mechanisms."
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