IndraLab

Statements

USP39 activates cell cycle. 17 / 17
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"First, we observed that depletion of USP39 contributes to abnormal cell cycle distribution by inducing cell cycle arrest at G2/M."
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"Taken together, these results suggest that knockdown of USP39 could inhibit TT cell proliferation by inducing G2/M phase cell cycle arrest."
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"In addition, it has been reported that overexpression of MGC-803 cells and knockdown of USP39 may inhibit MGC-803 cell proliferation and induce cell cycle arrest."
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"Taken together, our findings implicate that USP39 promotes the development of human leukemia by regulating cell cycle, survival, and proliferation of the cells."
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"Furthermore, suppression of USP39 arrested cell cycle progression at G 2 / M phase in SMMC-7721cells."
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"Knockdown of endogenous USP39 expression could suppress the oncogenic properties of osteosarcoma cells and induce cell cycle arrest at G2/M phase, promote apoptosis through PARP cleavage."
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"The mechanism by which USP39 knockdown arrested cell cycle might also affect the expression of negative and positive regulators of the cell cycle."
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"Complementary pathway activity analysis using the GSCA database demonstrated that USP39 predominantly activated the cell cycle (47% activation vs. 0% inhibition), DNA damage response (34% activation vs. 0% inhibition), and apoptosis (25% activation vs. 3% inhibition) pathways, while inhibiting RAS/MAPK signaling (0% activation vs. 34% inhibition) (Fig. 2B)."
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"Collectively, our data suggest that knocking down USP39 induces cell cycle arrest at S phase and G2/M phase, and results in apoptosis, and that the mechanism of apoptosis induced by USP39 knockdown may be related to DNA damage."
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"In addition, this study found that USP39 knockdown could inhibit cell cycle progression through an increase in the proportion of cells in the G2/M phase and a decrease in the proportion of cells in the G0/G and S phases."
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"Meanwhile, knockdown of USP39 could arrest cell cycle at G2/M via cyclin dependent pathway and promoted apoptosis through PARP cleavage [XREF_BIBR - XREF_BIBR]."
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"For example, USP39 promotes cell cycle, and proliferation, resulting in the development of leukemia [6] ."
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"This observation indicated that the cell cycle was blocked at the G2/M phase by USP39 knockdown in HL-60 cells (XREF_FIG A, B)."
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"USP39 knockdown inhibits cell cycle progression."
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"Knockdown of USP39 significantly decreased cell proliferation and caused cell cycle arrest at G2/M phase."
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"Knockdown of USP39 induced cell cycle arrest and its effect on cell cycle-regulatory molecules."
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"Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma."
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