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USP39 deubiquitinates ETS2. 6 / 6
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"USP39 deubiquitinates ETS2 without affecting its protein stability."
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"USP39 Deubiquitinates ETS2 but Does Not Affect Its Protein Stability."
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"Since ETS2 is targeted for proteasomal degradation through ubiquitination via the E3 ubiquitin ligase COP1 [8,14,15], we investigated whether USP39 deubiquitinates ETS2 and regulates its protein stability."
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"As depicted in Figure 4A, USP39 noticeably deubiquitinates the polyubiquitin chains of ETS2."
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"USP39 deubiquitinated both the mono- and polyubiquitination of endogenously ubiquitinated ETS2.Although ETS2 was deubiquitinated by USP39, the protein stability of ETS2 did not show substantial changes over the 30 h period in this study (Figure 4C,D)."
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"Subsequently, we found that USP39 deubiquitinates ETS2 and suppresses its transcriptional activity."
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