IndraLab

Statements

USP39 is acetylated. 8 / 8
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"After treatment with histone deacetylase (HDAC) inhibitor TSA or SIRT inhibitor NAM, USP39 acetylation level exhibited a significant elevation."
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"Then acetylation level of USP39 was also examined under the transfection of sh-SIRT7 in CaSki cells, and the results demonstrated that USP39 acetylation levels were significantly elevated by sh-SIRT7 (Fig.  xref D)."
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"Further analysis revealed that USP39 acetylation was inhibited by wild type SIRT7, and the mutant SIRT7 without USP39 acetylation activity (SIRT7 H187Y) was demonstrated to suppress USP39 deacetylation (Fig.  xref E)."
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"Conversely, the lysine deacetylase sirtuin 7 (SIRT7) removes the acetylation of USP39, promoting its stability and consequently accelerating the proliferation and tumorigenesis of HCC cells both in vitro and in vivo xref ."
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"Acetylated USP39 can be degraded by E3 ubiquitin ligase (VHL)-mediated proteasome ( xref )."
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"Previously, it was reported that USP39 could be acetylated by histone acetyltransferase MYST1, and the acetylated USP39 was subsequently degraded by E3 ubiquitin ligase VHL-mediated proteasomal degradation."
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"In HCC, SIRT7-mediated deacetylation impedes MYST1-facilitated acetylation of USP39, which is a prerequisite for its E3 ligase-induced degradation [ xref ] and accelerates the tumorigenesis of HCC."
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"Therefore, we assessed if USP39 acetylation was affected by SIRT7 in cervical cancer cells."
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