IndraLab

Statements

USP39 inhibits CDKN1A. 4 / 4
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"Its level is negatively correlated with that of USP39, and knockdown of USP39 prolongs the half-life of p21 and induces apoptosis in colon cancer cell lines[41]."
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"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
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"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."
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"USP39 down-regulates the p53/p21 signaling pathway and stabilizes CDK1 and cyclin B1 to promote the proliferation of ovarian cancer cells [34]."
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