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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP39 inhibits CDKN1A. 2 / 2

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"Meanwhile, we found that USP39 knockdown also activates the p53 pathway, upregulation of p53, p-p53 (S15), p21 and BAX in HCC827 cells."

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"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...