IndraLab
Statements
reach
"The zinc finger E-box binding homology cassette (ZEB1) is a key inducer of epithelial–mesenchymal transition (EMT), promoting cancer cell metastasis; USP39 inhibits the degradation of ZEB1 and promotes the development of EMT through deubiquitylation, further accelerating the invasion and metastasis of HCC cells [38]."
reach
"Collectively, we believe that USP39 reduces the degradation of ZEB1 protein through direct deubiquitination, which promotes EMT progression and the development of HCC.Ubiquitination and deubiquitination are two contrasting posttranslational processes that involve in the conjugation and removing of ubiquitin from targeted proteins, respectively."