IndraLab

Statements

USP39 increases the amount of CTNNB1. 4 / 4
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"Detecting proteins separated from cytoplasmic and nuclear by western blotting showed that, knockdown of USP39 induced a reduction of nuclear β-catenin (Fig. 2F), whereas USP39 overexpression increased β-catenin level in the nucleus (Fig. 2G)."
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"In summary, our data reveal a novel mechanism in the progress of HCC that USP39 promotes the proliferation and migration of HCC through increasing beta-catenin level via both direct deubiquitination and reducing TRIM26 pre-mRNA maturation and splicing, which may provide a new idea and target for clinical treatment of HCC."
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"Furthermore, overexpression of USP39 increased β-catenin protein level, but co-overexpression of USP39 and TRIM26 counteracted the increase (Fig. 4B)."
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"In contrast, western blotting revealed that knockdown of USP39 led to a reduction of β-catenin (Fig. 2C), and overexpression of USP39 increased β-catenin protein level (Fig. 2D) in HCC cells."
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