IndraLab

Statements

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"USP39 promotes proliferation and invasion in vitro and tumor growth in vivo."
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"USP39 increases proliferation and invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice."
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"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro and tumor growth in vivo."
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
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"USP39 promotes proliferation / invasion in vitro and tumor growth in vivo ."
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"Third , we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [ 31 ] ."
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"As shown in XREF_FIG A-F, USP39 knockdown reduced the cell migration and invasion of both USP39KD cells in comparison to the control cells (* p < 0.05, ** p < 0.01, **** p < 0.0001)."
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"USP39 promoted the invasion of glioma cells in vivo and reduced the overall survival of the mice."
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"Knockdown of USP39 in U251 and U87 cell lines significantly inhibited their migration and invasion in vitro ."
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"Overexpression of USP39 significantly increased the invasion ability and cell survival curve ( p < 0.05)."
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"Moreover, USP39 knockdown significantly inhibited migration and invasion of A549 and HCC827 cells, also via activation of the p53 pathway, and downregulation of MMP2 and MMP9."
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"Third, we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [XREF_BIBR]."
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"USP39 promotes proliferation / invasion and epithelial-mesenchymal transition ( EMT ) of ovarian cancer cells ."
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"In addition, a transwell invasion assay revealed that forced expression of USP39 significantly enhanced the invasion capacity whereas knockdown of USP39 decreased the invasion potential of ovarian cancer cells."
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