IndraLab

Statements

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"We reported similar results in our previous study, in which knockdown of USP39 suppressed the glioma cell migration and invasion in vitro and inhibited glioma growth and invasion in vivo [12]."
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"USP39 level was higher in hypoxia-induced hRMECs, functionally, USP39 silencing reversed hypoxia-induced migration, invasion and angiogenesis in hRMECs."
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"Studies have shown that USP39 knockout inhibits the migration and invasion of colon cancer cells."
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"USP39 increases proliferation and invasion of ovarian cancer cells and promotes growth of xenograft tumors in mice."
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"Mechanistically, USP39 stabilized MRPL35 expression by deubiquitination and then promoted NSCLC cell proliferation, invasion, and glutamine metabolism."
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"In summary, USP39 significantly promotes the proliferation of HCC cells and enhances their capacity for invasion and metastasis through mechanisms that include the regulation of the Wnt/β-catenin signaling pathway, metabolic reprogramming, and EMT."
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"USP39 promotes proliferation and invasion in vitro and tumor growth in vivo."
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"Moreover, we transfected Flag‐MRPL35 and si‐NC or si‐USP39 into 293 T cells and found that USP39 silencing enhanced MRPL35 ubiquitination (Figure 3H).3.4 USP39 Knockdown Suppresses NSCLC Cell Proliferation, Invasion, and Glutamine Metabolism and Induces Cell Apoptosis by MRPL35."
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"In addition, a transwell invasion assay revealed that forced expression of USP39 significantly enhanced the invasion capacity whereas knockdown of USP39 decreased the invasion potential of ovarian cancer cells."
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"In glioma, USP39 acts as a splicing factor by altering the 3ʹ splice site to increase the expression of high mobility group protein A2 (HMGA2) and promotes the maturation of migratory invasion-associated proteins and TAZ mRNA, a key protein in the ADAM9 and Hippo signaling pathways."
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"In addition, overexpression of HMGA2 rescued the inhibition of proliferation, invasion and xenograft growth induced by silencing USP39."
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"Moreover, USP39 knockdown significantly inhibited migration and invasion of A549 and HCC827 cells, also via activation of the p53 pathway, and downregulation of MMP2 and MMP9."
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"Overexpression of USP39 significantly increased the invasion ability and cell survival curve (p < 0.05)."
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"As shown in XREF_FIG A-F, USP39 knockdown reduced the cell migration and invasion of both USP39KD cells in comparison to the control cells (* p < 0.05, ** p < 0.01, **** p < 0.0001)."
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"Third, we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [XREF_BIBR]."
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"USP39 promotes proliferation / invasion and epithelial-mesenchymal transition ( EMT ) of ovarian cancer cells ."
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"Knockdown of USP39 in U251 and U87 cell lines significantly inhibited their migration and invasion in vitro ."
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"Subsequent functional experiments revealed that USP39 promoted the proliferation and invasion of ovarian cancer cells in vitro and tumor growth in vivo."
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"USP39 promotes proliferation / invasion in vitro and tumor growth in vivo ."
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"USP39 overexpression promotes while its knockdown attenuates the growth, colony formation, migration, and invasion of gastric cancer cells."
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"On the other, USP39 promotes the proliferation and invasion of HCC cells by inhibiting splicing of TRIM26, thus affecting the ubiquitin of β-catenin induced by TRIM26."
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"Third , we demonstrated that USP39 knockdown inhibits cell migration and invasion by upregulating p53 and the downstream proteins MMP2 and MMP9 [ 31 ] ."
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"In the present study, we observed that USP39 deletion could suppress NSCLC cell proliferation, invasion, and glutamine metabolism and induce cell apoptosis, while these effects were reversed after MRPL35 overexpression, indicating that the effects of MRPL35 on NSCLC might be associated with USP39‐induced deubiquitination."
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"USP39 promoted the invasion of glioma cells in vivo and reduced the overall survival of the mice."
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