IndraLab

Statements

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"Specific inhibition of USP39 by these siRNAs led to a significant reduction in USP39 expression, accompanied by a substantial induction of cell death and a marked decrease in cellular metabolism in both OPM2 and KMM1 cells after 96 h (Fig.  xref A-B)."
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"Furthermore, inhibition of USP39 by siRNA resulted in a diminished clonogenic capacity in both cell lines, with the proteasome inhibitor BTZ serving as a positive control for inhibition of clonogenic potential (Fig.  xref C-D)."
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"Conversely, inhibition of USP39 by siRNA accelerated the degradation of ZEB1 induced by CHX (Fig.  xref D and Fig. S6B)."
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"Inhibition of USP39 by siRNA has downregulated FOXM1 and in turn led to tumor volume reduction in xenograft model of HCC ( xref )."
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