IndraLab

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USP39 inhibits cell cycle. 16 / 16
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"Our loss-of-function experiments demonstrated that knockdown of the expression of USP39 repressed the proliferation of leukemia cells, induced cell cycle arrest, and cell apoptosis."
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"However, treated with PFT-alpha reduced the up-regulation of p21 and BAX induced by USP39 knockdown, but had no effect on the down-regulation of cell cycle related proteins (CDK1 and CyclinB1 and CDK2 and CyclinA2) induced by USP39 knockdown."
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"These results indicate that knockdown of USP39 induced G2/M phase cell cycle arrest via suppression of the CDK1 and Cyclin B1 complex."
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"To evaluate the role of cell cycle-regulatory molecules in knockdown of USP39 induced G2/M cell cycle arrest, we examined the effect of USP39 knockdown on cell cycle-regulatory molecules, including p21, CDK1 and cyclin A2."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
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"This indicates that USP39 shRNA could strongly block (p < 0.01) the cell cycle progression of TT cells."
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"Silencing of USP39 induced cell apoptosis and cell cycle arrest at G2/M phase."
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"In addition, flow cytometry analysis in the present study identified that the knockdown of USP39 induced cell cycle arrest in the G 2 / M phases, which may have induced the inhibition of proliferation."
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"In melanoma, knockdown USP39 inhibited cell growth and induced cell cycle arrest and apoptosis."
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"A further analysis indicated suppression of USP39 arrested cell cycle progression at G2/M phase via p21 dependent way."
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"Similarly, we observed that USP39 knockdown induced cell cycle arrest at G2/M phase in Jurkat cells (XREF_FIG C, D)."
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"Flow cytometric analysis showed that USP39 knockdown induced cell cycle arrest at G2/M phase and enhanced cell apoptosis in 95D cells."
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"We showed that USP39 knockdown induced the cell cycle arrest at G2/M phase in two lines of leukemia cells."
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"Indeed, knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma [XREF_BIBR]."
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"USP39 silencing via lentivirus mediated short hairpin RNA (shRNA) significantly suppressed melanoma cell proliferation, induced G0/G1 cell cycle phase arrest, and increased apoptosis in vitro."
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"Mechanism study showed that USP39 knockdown induced the arrest of cell cycle and apoptosis of leukemia cells."
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