IndraLab

Statements

SP1 binds USP39. 11 / 11
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"Then, we used nude mice to establish a cancer xenograft model to demonstrate that the function of USP39-SP1 axis in tumor growth."
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"Miyamoto-Sato's study found that USP39 and SP1 protein may interact with each other in a dataset of protein-protein interactions (PPIs) network [14] ."
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"This provides an effective anti-tumor therapeutic strategy of HCC by an understanding of the USP39-SP1 protein axis."
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"Next, we extended our analysis by investigating whether endogenous USP39 and SP1 can interact with each other."
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"Together, these results suggest that USP39 directly interacts with SP1 protein."
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"Co-IP assay was used to test the binding of the full-length USP39 and SP1 (wildtype) and the deletion mutants in 293 T cells."
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"SP1 binds to C-terminal domain (amino acids 200–565) of USP39 (Supplementary Material Fig. 1 B)."
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No evidence text available
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"Interaction of USP39 and SP1 plays an important role in promoting cell proliferation, cell cycle, and tumor growth of HCC."
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No evidence text available
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No evidence text available
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