IndraLab

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"The downregulation of USP39 expression in HCC cells significantly inhibited tumor growth, by reducing the volume and weight of tumors (Fig. 8A–C)."

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"Conversely, USP39 knockdown inhibited proliferation in tumor size and weight of SK-hep-1 cells transfected with shTRIM26."

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"USP39 depletion led to reduced tumor mass and volume ( Fig. 3B ) ."

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"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells We next investigated the functional significance of the USP39-HMGA2 axis ."

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"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells ."

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"The results showed that USP39 knockdown led to an obvious reduction in tumor metastasis, while TRIM26 downregulation enhanced the tumor metastasis and reversed the reduction of shUSP39-related cell metastasis and the number of nodules in the lung (Fig. 8G, H)."

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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin β-catenin, a key molecular of Wnt/β-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."