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USP39 activates Neoplasms. 23 / 23
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"Specifically, USP39 promotes breast cancer cell proliferation and tumor growth by deubiquitinating and stabilizing the transcription factor FOXM1 [31]."
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"Here, we prove that USP39 promotes HCC cell proliferation and migration by directly deubiquitin beta-catenin, a key molecular of Wnt/beta-catenin signaling pathway whose abnormal expression or activation results in several tumors, following its co-localization with USP39."
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"Consistently, tumor weights from USP39 downregulation group were drastically decreased, while USP39 complementation led to increased tumor mass significantly (Fig. 7B, C)."
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"In addition, overexpression of USP39 accelerated the tumor growth and reversed the 2-DG-caused tumor inhibition (Fig. 6A–C)."
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"Importantly, silencing of USP39 significantly suppressed tumor growth in vitro and in vivo study [9,10] ."
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"Mainly, in the first group, we have genes with a suggested novel anti-cancer role in the testis (Fetub, Hoxd10, Slc45a3, Ube2l6), with increased expression levels inhibiting cancer cell development, supported by the protective role of Mt3; while the Usp39 gene, with elevated expression levels (the most of all the observed changes), should lead to some tumor-like changes within the testis tissue."
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"In human liver cancer cells, USP39 promoted tumor proliferation in a spliceosome-dependent manner."
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"Mechanically, histone lactylation stimulated USP39 expression to promote tumor progression."
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"To delve into the contribution of GLI1 in the tumor-promoting effects of USP39, we generated A549 and H1299 cell lines with stable GLI1 knockdown in conjunction with USP39 overexpression (Fig. 6C), and then performed MTT, colony formation, and transwell assays to examine the influence on cell growth and migration."
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"Therefore, our study reveals the LLPS characteristics of USP39 and its nucleolar association, thus providing a novel perspective to investigate the tumor-promoting functions of USP39."
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"The downregulation of USP39 expression in HCC cells significantly inhibited tumor growth, by reducing the volume and weight of tumors (Fig. 8A–C)."
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"Knockout of USP39 can inhibit tumor genesis, induce cell apoptosis, and inhibit lung adenocarcinoma cell metastasis [13]."
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"Conversely, USP39 knockdown inhibited proliferation in tumor size and weight of SK-hep-1 cells transfected with shTRIM26."
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"USP39 depletion led to reduced tumor mass and volume ( Fig. 3B ) ."
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"The results showed that USP39 knockdown led to an obvious reduction in tumor metastasis, while TRIM26 downregulation enhanced the tumor metastasis and reversed the reduction of shUSP39-related cell metastasis and the number of nodules in the lung (Fig. 8G, H)."
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"For example, in multiple lung cancer cell lines, downregulation of USP39 confers cancer cells resistance to chemo- and radiotherapy and, conversely, silencing of USP39 in the case of pancreatic cancer induces apoptosis and suppresses tumor growth [111, 112]."
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"Functional enrichment analysis indicated that USP39 potentially promotes tumor progression through multiple oncogenic signaling cascades."
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"In human liver cancer cells , USP39 promoted tumor proliferation in a spliceosome-dependent manner ."
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"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells We next investigated the functional significance of the USP39-HMGA2 axis ."
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"USP39 promotes tumor progression by increasing HMGA2 levels in ovarian cancer cells ."
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"We found that USP39 could upregulate Cyclin B1 protein stability to promote G2/M cell cycle transition and glioma cell proliferation, as well as tumor growth in vivo."
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"Several studies demonstrated the tumor-promoting role of USP39 in liver cancer."
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"H&E (Hematoxylin-eosin) staining analyses and the measured tumor area showed that USP39 promoted the growth of U87 tumor in vivo (Fig. 5g and h)."
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