IndraLab

Statements

USP39 binds ETS2. 15 / 15
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sparser
"Strategies that promote the interaction between USP39 and ETS2 may offer new avenues for precise therapeutic interventions."
37892157
sparser
"Additionally, USP39 can interact with ETS2 via its N-terminal region, thereby regulating the transcriptional activity of ETS2 ( xref )."
40672756
sparser
"USP39 interacts with ETS2 through their respective amino-terminal regions, and the zinc finger and PNT domains are not required for this binding."
37892157
sparser
"ETS2 Interacts with USP39 through the Respective Amino-Terminal Regions."
37892157
sparser
"To identify the domains responsible for the interaction between ETS2 and USP39, we created several deletion mutants of ETS2:ΔETS (ETS domain-deleted, aa 1–362), PNT-only (Pointed domain-containing, aa 1–170), ΔPNT (Pointed domain-deleted, aa 1–84 & 171–469) and 171–362 (containing aa 171–362) ( xref A)."
37892157
reach
"Based on the mutual binding affinity between USP39 and the substrate protein ETS2, as well as its influence on the transcriptional activity of ETS2, we selected USP39 as the candidate DUB for ETS2 and proceeded with further characterization."
37892157
sparser
"The results demonstrated that USP39 could bind to ETS2 and all its mutants except 171–362."
37892157
sparser
"These findings confirm that USP39 binds to the unspecified amino-terminal region of ETS2, and they indicate that the PNT domain is not required for their interaction."
37892157
reach
"To identify the domains responsible for the interaction between ETS2 and USP39, we created several deletion mutants of ETS2:ΔETS (ETS domain-deleted, aa 1–362), PNT-only (Pointed domain-containing, aa 1–170), ΔPNT (Pointed domain-deleted, aa 1–84 & 171–469) and 171–362 (containing aa 171–362) (Figure 3A)."
37892157
sparser
"We then examined the interaction between ETS2 and USP39 and USP39 mutants."
37892157
sparser
"The results demonstrate that ETS2 bound to USP39 and all its mutants."
37892157
reach
"The results demonstrated that USP39 could bind to ETS2 and all its mutants except 171–362."
37892157
reach
"We then examined the interaction between ETS2 and USP39 and USP39 mutants."
37892157
reach
"The results demonstrate that ETS2 bound to USP39 and all its mutants."
37892157
reach
"Strategies that promote the interaction between USP39 and ETS2 may offer new avenues for precise therapeutic interventions."
37892157