IndraLab

Statements

USP39 binds TP53. 6 / 6
1 | 2 3
sparser
"USP39 indirectly regulates MDM2 or directly binds to p53, affecting its stability and transcriptional activity, and inhibiting tumor suppressive function [ xref ]."
40358671
reach
"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions : (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53?"
33255748
sparser
"Given the importance of the p53 pathway in the tumor promotor function of USP39, further investigations should address these key questions: (1) How does USP39 regulate p53 and what is the interaction between USP39 and p53? (2) is the oncogenic function of USP39 solely dependent on the p53 pathway, or is another signaling pathway involved?"
33255748
biogrid
No evidence text available
19615732
reach
"In osteosarcoma cells under ER stress, P53 directly binds to the promoter of miR-1281, and down-regulates USP39 in osteosarcoma cells through the p5-Mir-1281-USP39 axis, an ERS response pathway, to inhibit and promote cell apoptosis [111]."
36551309
sparser
"ERS-induced miR-1281, whose promoter binds to p53 and targets USP39, facilitating the apoptosis of osteosarcoma cells xref ."
40216868