IndraLab

Statements

NAT10 binds USP39. 10 / 10
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sparser
"Moreover, the GST pulldown assay showed that G‐749 treatment reduces the in vitro binding of USP39 to NAT10 protein (Figure  xref ; Figure xref , Supporting Information)."
40729677
sparser
"The interaction between NAT10 and USP39 was further confirmed by Co-IP (Fig. xref and Fig. xref )."
40593466
sparser
"First, the specific mechanism underlying the LPS-mediated enhancement of USP39 and NAT10 interactions remains unclear."
40593466
reach
"This Khib modification, in turn, promoted the interaction between NAT10 and the deubiquitinase USP39, thereby enhancing NAT10 protein stability and upregulating NAT10."
38065232
sparser
"Our previous studies have shown that the deubiquitin ligase Ubiquitin‐specific Peptidase 39 (USP39) directly interacts with NAT10 in a molecule‐specific manner to enhance the stability of NAT10. [ xref ] The results from co‐immunoprecipitation demonstrated a strong interaction between exogenous expression of NAT10 and USP39, whereas the interaction was weakened by G‐749 (Figure  xref )."
40729677
sparser
"This Khib modification, in turn, promoted the interaction between NAT10 and the deubiquitinase USP39, thereby enhancing NAT10 protein stability and upregulating NAT10."
38065232
sparser
"This modification enhances the interaction between NAT10 and USP39, leading to improved stability of the NAT10 protein [ xref ]."
41316475
sparser
"As a medium for NAT10 to interact with the deubiquitinase USP39, LINC00623 can bind to NAT10 and recruit USP39, thereby improving NAT10 stability by blocking its ubiquitination and degradation."
39817252
sparser
"Further pharmacological research indicated that G‐749 significantly weakened the interaction between NAT10 and the deubiquitinating ligase USP39, leading to the degradation of NAT10 in a proteasome‐dependent manner."
40729677
sparser
"LPS stabilizes NAT10 by promoting NAT10-USP39 interaction and reducing proteasomal degradation."
40593466