IndraLab
Statements
USP39 binds PRPF4 bound to SART1, SNRNP200, PRPF6, LSM8, SNRPA, SNRPB, SNU13, SNRPE, SNRPF, SNRPG, LSM3, LSM6, SNRPD1, SNRPD2, SNRPD3, TXNL4A, EFTUD2, USP39, PRPF8, SNRNP27, PRPF31, SNRNP40, RBM42, DDX23, LSM7, LSM2, LSM5, and LSM4. 1 / 1
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"The major spliceosomal building blocks are the U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs). Each consists of a small nuclear RNA (snRNA) (or two, in the case of U4/U6), seven Sm proteins that form a ring (or seven Lsm proteins in the case of U6), and a variable number of snRNP-specific proteins (Fig. 1F) (Will and Lührmann 2011). Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction."