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USP39 deubiquitinates CHEK2. 2 / 3

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"Mechanistically, USP39 deubiquitinates and stabilizes CHK2, which in turn enhances CHK2 stability."

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"Additionally, USP39 deubiquitinates and stabilizes CHK2 in lung cancer, and the knockdown of USP39 compromises G2/M checkpoint, thereby conferring decreased apoptosis and resistance to chemotherapy and radiotherapy [114]."

36694209

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USP39 deubiquitinates CHEK2. 2 / 3

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