IndraLab

Statements

USP39 activates angiogenesis. 5 / 5
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"USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A 165b alternative splicing via regulating SRSF1 and SRPK1."
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"USP39 level was higher in hypoxia-induced hRMECs, functionally, USP39 silencing reversed hypoxia-induced migration, invasion and angiogenesis in hRMECs."
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"USP39 stabilized SIRT2 expression by deubiquitination and promoted hypoxia-induced metastatic and angiogenic behaviors of RMECs in vitro, as well as retinal angiogenesis in vivo."
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"These findings indicated that knockdown or overexpression of USP39 could either inhibit or promote angiogenesis of endothelial cells."
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"To explore the potential mechanism of USP39-mediated angiogenesis and malignant proliferation, affinity purification–mass spectrometry (AP-MS) was used to explore the interactions between USP39 and the potential target protein."
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