IndraLab

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USP39 activates apoptotic process. 16 / 17
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"Previous studies have reported that USP39 silencing inhibits colon cancer cell growth and metastasis, and induces apoptosis by regulating the Wnt/β-catenin signaling pathway [31]."
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"Second, we found that knocking down USP39 induces apoptosis of A549 and HCC827 cells, upregulates cleaved cas3, cleaved cas9 and DNA damage makers (53BP1 and gammaH2AX) [XREF_BIBR]."
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"However, co-expressing Cyclin B1 failed to rescue the accelerated apoptosis of glioma cells induced by the downregulation of USP39 in glioma cells, suggesting the Cyclin B1 only affect the cell proliferation by regulating the cell cycle (data not shown)."
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"Furthermore, previous studies have shown that USP39 as an important regulator of the susceptibility to drug-induced apoptosis."
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"Moreover, we transfected Flag‐MRPL35 and si‐NC or si‐USP39 into 293 T cells and found that USP39 silencing enhanced MRPL35 ubiquitination (Figure 3H).3.4 USP39 Knockdown Suppresses NSCLC Cell Proliferation, Invasion, and Glutamine Metabolism and Induces Cell Apoptosis by MRPL35."
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"Depletion of USP39 promotes apoptosis of U2OS cells."
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"Downregulation of ubiquitin-specific peptidase 39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells."
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"Cai et al. [52] reported that USP39 promotes PC cell apoptosis by regulating the AKT signaling pathway."
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"Down-regulation of USP39 induced SMMC-7721 cells apoptosis."
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"The group of silencing USP39 increased the apoptotic cells (early apoptosis and late apoptosis) by 13-fold, as compared to the group of shCon (Additional file 1 : Figure S1A and B)."
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"In the present study, we observed that USP39 deletion could suppress NSCLC cell proliferation, invasion, and glutamine metabolism and induce cell apoptosis, while these effects were reversed after MRPL35 overexpression, indicating that the effects of MRPL35 on NSCLC might be associated with USP39‐induced deubiquitination."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
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"USP39 knockdown inhibits cell growth and enhances cell apoptosis."
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"Down-regulation of USP39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells [XREF_BIBR]."
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"Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma."
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"Complementary pathway activity analysis using the GSCA database demonstrated that USP39 predominantly activated the cell cycle (47% activation vs. 0% inhibition), DNA damage response (34% activation vs. 0% inhibition), and apoptosis (25% activation vs. 3% inhibition) pathways, while inhibiting RAS/MAPK signaling (0% activation vs. 34% inhibition) (Fig. 2B)."
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