IndraLab

Statements

USP39 activates apoptotic process. 8 / 9
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"Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma."
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"The group of silencing USP39 increased the apoptotic cells (early apoptosis and late apoptosis) by 13-fold, as compared to the group of shCon (Additional file 1 : Figure S1A and B)."
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"Depletion of USP39 promotes apoptosis of U2OS cells."
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"Down-regulation of USP39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells [XREF_BIBR]."
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"Down-regulation of USP39 induced SMMC-7721 cells apoptosis."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
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"Second, we found that knocking down USP39 induces apoptosis of A549 and HCC827 cells, upregulates cleaved cas3, cleaved cas9 and DNA damage makers (53BP1 and gammaH2AX) [XREF_BIBR]."
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"Knocking-down of USP39 promotes the cell apoptosis and arrest of the cell cycle, whereas SP1 forcefully reversed these effects."
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