IndraLab

Statements

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"USP39 overexpression deprived miR-133a inhibitor mediated suppression of cell proliferation, suggesting that USP39 is involved in miR-133a-mediated biological role in gastric cancer cell HGC-27 (P < 0.0001) (XREF_FIG)."
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"In addition, it has been reported that overexpression of MGC-803 cells and knockdown of USP39 may inhibit MGC-803 cell proliferation and induce cell cycle arrest."
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"USP39 downregulation could inhibit RCC cell proliferation and progression, suggesting that USP39 may prove to be a potential target for inhibiting RCC."
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"Knockdown of USP39 significantly inhibited proliferation of TT cells in vitro."
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"Knockdown of USP39 suppressed the proliferation and cell cycle progression, and induced apoptosis, accompanied by the reduction of EGFR in both mRNA and protein levels in PC-3 and DU145 cells."
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"Downregulation of ubiquitin-specific peptidase 39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells."
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"Down-regulation of USP39 suppresses the proliferation and induces the apoptosis of human colorectal cancer cells [XREF_BIBR]."
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"Furthermore, knockdown of USP39 inhibited VSMC cell proliferation and the expression of cyclin D1 and cyclin-dependent kinase 4, as analyzed via cell counting, MTT assay and western blotting."
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"Downregulation of USP39 significantly reduces the proliferation and colony-forming ability of triple-negative breast cancer cells [65, 67]."
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"Subsequent studies will be required to verify whether the inhibition of STAT1 is responsible for the inhibition of gastric cancer cell proliferation by USP39 siRNA.The article also has some limitations, as the role of USP39 has not been validated in animal models."
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"Functionally, si‐USP39 suppressed the proliferation (Figure 4B,C), triggered the apoptosis (Figure 4D,E), and impaired the invasion (Figure 4F,G) in H1299 and A549 cells."
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"USP37 promotes S phase entry by activating CDK2 and regulates cell proliferation by stabilizing p27 ( Huang et al., 2011 ; Das et al., 2013 ), and USP39 inhibits malignant proliferation of several tum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We further observed that USP39 downregulation inhibits the cell proliferation and migration of A549 and HCC827 cells."
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"Knockdown of USP39 expression in U2OS cell significantly decreased cell proliferation, impaired colony formation ability."
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"In the present study, we observed that USP39 deletion could suppress NSCLC cell proliferation, invasion, and glutamine metabolism and induce cell apoptosis, while these effects were reversed after MRPL35 overexpression, indicating that the effects of MRPL35 on NSCLC might be associated with USP39‐induced deubiquitination."
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"Knockdown of USP39 significantly decreased cell proliferation and caused cell cycle arrest at G2/M phase."
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"The SUMOylation of spliceosome factors USP39 decreases the proliferation enhancing effect of USP39 on prostate cancer cells."
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"Down-regulation of USP39 inhibited cell proliferation and colony formation ability of SMMC-7721 cells."
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"USP39 was higher expressed in gastric cancer tissues than in paracancerous tissues, and USP39 downregulation could inhibit cell proliferation in gastric cancer cells ( Dong et al., 2018 )."
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"Overall, our data suggest that USP39 inactivation inhibits HCC cell proliferation, promotes cell apoptosis, and arrests cell cycle at the G0/G1 phase, at least in part, by downregulating SP1 protein.T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of USP39 remarkably inhibited the cell proliferation of osteosarcoma cells."
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"Wang et al. [21] also found that USP39 was highly expressed in breast cancer cells, and down-regulation of USP39 could significantly reduce the proliferation and colony formation of breast cancer cells."
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