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USP39 deubiquitinates CTNNB1. 4 / 4
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"On account of the fact that β-catenin protein level was decreased with no change on mRNA level, and USP39 is a deubiquitinating enzyme, we hypothesized whether USP39 de-ubiquitinate and stabilize β-catenin."
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"Altogether, these data strongly supported that USP39 deubiquitinates β-catenin, and suppressed TRIM26 pre-mRNA maturation, further influenced its protein level and decreased its ubiquitination to β-catenin, which plays a key role in promoting HCC progression."
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"Furthermore, immunoprecipitation demonstrated that USP39 reduced the ubiquitination of β-catenin in SK-hep-1 cells (Fig. 3D)."
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"GST pull-down assay further demonstrated that USP39 could deubiquitylate β-catenin in vitro (Fig. 3E)."
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