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USP39 inhibits Neoplasms. 7 / 7
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"The downregulation of USP39 expression in HCC cells significantly inhibited tumor growth, by reducing the volume and weight of tumors (Fig. 8A–C)."
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"Gan et al. demonstrated that USP39 expression was overexpressed in osteosarcoma and that USP39 knockdown arrested osteosarcoma cells in G2/M phase, thereby inhibiting tumor growth and metastasis (104)."
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"We then examined whether the EC tumor suppression effect of the treatment with the histone lactylation inhibitor 2-DG could be reversed by increased USP39 levels."
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"USP37 promotes S phase entry by activating CDK2 and regulates cell proliferation by stabilizing p27 ( Huang et al., 2011 ; Das et al., 2013 ), and USP39 inhibits malignant proliferation of several tum[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Histone lactylation and USP39 promote EC development, and USP39 overexpression reverses the suppression of tumor growth by 2-DG in vivo."
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"These in vivo results are in accordance with our in vitro data, suggesting that USP39 functions as a tumor-promoting DUB and USP39 knockdown elicits suppressive effects on lung cancer growth by downregulating GLI1."
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"Knockdown of USP39 could inhibit the proliferation and induce apoptosis of SMMC-7721 cells, as well as the growth of xenograft tumors in nude mice."
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