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USP39 deubiquitinates SP1. 3 / 3
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"In addition, USP39 participates in the deubiquitination of SP1 protein and promotes the proliferation of HCC cells in a SP1-dependent manner (26)."

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"Since USP39 is a de-ubiquitinating enzyme, we explored whether USP39 de-ubiquitinates and stabilizes SP1 protein."

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"For example, USP39 promotes the tumorigenesis of hepatocellular carcinoma by stabilizing and deubiquitinating SP1 ."