IndraLab

Statements


3 | 5 3

sparser
"Intriguingly, USP39 can bind to TRIM26, suggesting that TRIM26 and USP39 governed the balance of ZEB1 expression levels and determined the fate of HCC cells on proliferation and metastasis [153] ."

reach
"More importantly, RNA immunoprecipitation showed that USP39 is bound to TRIM26 mRNA."

No evidence text available

No evidence text available

reach
"Intriguingly, USP39 can bind to TRIM26, suggesting that TRIM26 and USP39 governed the balance of ZEB1 expression levels and determined the fate of HCC cells on proliferation and metastasis [153] ."

No evidence text available

sparser
"USP39 and TRIM26 bind to each other directly and maintain the ubiquitin level of ZEB1, thus determining the proliferation and migration of HCC ( xref )."

sparser
"Additionally, USP39 directly interacts with the E3 ligase TRIM26, which is underexpressed in human HCC tissues, and can inhibit the proliferation and migration of HCC cells."

reach
"In addition, a direct interaction between USP39 and TRIM26 was identified by co-immunoprecipitation and immunofluorescence staining assays, respectively."

reach
"Co-immunoprecipitation assays showed a direct interaction between endogenous USP39 and TRIM26 in SK-hep-1 cells (Fig. 4A)."

reach
"To further confirm the interaction between USP39 and TRIM26, co-transfection with HA-USP39 and Myc-TRIM26 expressing plasmids were conducted in SK-hep-1 cell."