IndraLab

Statements

CCNB1 binds USP39. 19 / 19
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"Our findings suggest that USP39-Cyclin B1 axis may function as the potential therapeutic target for the treatment of human glioma."
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"Co-immunoprecipitation and other assays were performed to detect the interacting of Cyclin B1 and USP39."
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"Next, we sought to detect an interaction of Cyclin B1 and USP39."
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"Additionally, the interaction between endogenous USP39 and Cyclin B1 in U87 cells was demonstrated by anti-Cyclin B1 immunoprecipitation (Fig. 2e)."
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"USP39 interacts with Cyclin B1 and stabilizes its expression by deubiquitinating Cyclin B1."
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"This study suggests that USP39-Cyclin B1 may represent a potential target in the treatment of glioma."
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"USP39 directly interacts with Cyclin B1."
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"The results further revealed that USP39 directly binds to Cyclin B1 (Fig. 2f)."
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"Next, we sought to detect an interaction of Cyclin B1 and USP39."
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"Anti-HA immunoprecipitated Flag-CycB1 and Flag-M2 immunoprecipitated HA-USP39, suggesting that USP39 and Cyclin B1 physically interact ( xref c and d)."
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"To test whether the Cyclin B1-USP39 interaction was direct, we performed GST-pull down assays using GST-USP39 and Flag-CycB1."
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"The results further revealed that USP39 directly binds to Cyclin B1 ( xref f)."
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"Collectively, these results indicate that USP39 directly interacts with Cyclin B1."
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"To understand the functional significance of the interaction between USP39 and Cyclin B1, we assessed whether USP39 deubiquitinated Cyclin B1 in cells."
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