IndraLab

Statements

USP39 activates BRCA1. 2 / 2
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reach
"Although the aforementioned study showing the DUB activity of USP39 is controversial compared to that in previous studies (59,60), it is possible that USP39 modulates BRCA1-coupled HR in a PAR-independent fashion in various ways.Lastly, a recent study showed that the recruitment of 53BP1 to DNA lesions was not impaired after PARP inhibition (91)."
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reach
"However, we found that BRCA1 mRNA was significantly reduced by USP39 depletion."
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