IndraLab
Statements
sparser
"The use of digital technology in dentistry has increased in recent years [ xref ], thanks to different computer-aided design and computer-aided manufacturing (CAD-CAM) systems being used to fabricate different types of prostheses [ xref ] and to intraoral scanners (IOSs) that allow us to obtain a full digital workflow from the impression to the delivery."
sparser
"Maxillary and mandibular edentulous models fabricated from cobalt-chromium alloy were scanned, and 2-mm-thick denture bases were designed and fabricated by using 4 fabrication techniques and materials: CAD-CAM milled (CCM), 3D printed (3DP), injection molded (IM), and compression molded (CM)."
sparser
"The 3Rs principle based on replacement, reduction,
and refinement was derived from this directive and set the focus on
the use of alternative methods. xref As early
as 1985, HET-CAM contributed to the 3Rs principle and is now acknowledged
as an alternative test option to the Draize test. xref It can be used to investigate the potential for irritation
and the biocompatibility of a formulation."
Multiple Myeloma binds Dr and CALM1. 4 / 4
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4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"To test our claim, we evaluate the degree of neural coordination using phase synchrony measures xref at different regimes of alpha frequency band in resting-state MEG recordings collected from participants aged 18–88 at the Cambridge Center for Ageing and Neuroscience (Cam-CAN) xref ."
sparser
"The spatial distribution of the CRON in the HCP and Cam-CAN samples is shown in xref A, B and C. As in the PRONIA study (Supplementary Fig. 2), the neurosignature comprised lower gray matter volume in cingulate, orbitofrontal, insular, temporal, parietal, and occipital brain regions, and higher cerebellar and prefrontal volumes."
sparser
"The distribution of decision scores in the Cam-CAN and HCP samples is shown in xref E. Even at uncorrected P-values, there was no association between decision scores and whole-brain gray matter volume in the young (r = 0.02, P = 0.82) and older Cam-CAN sub-sets (Pearson's r = 0.06, P = 0.28) and in the HCP sample (Pearson's r = −0.03, P = 0.27)."
sparser
"To test this hypothesis, the CHR-outcome-neurosignature derived from the PRONIA study, was used to build a binary classifier which was applied to sMRI data of participants from the Human Connectome Project (HCP) ( xref ) and the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN) ( xref )."
sparser
"MN1 (Meningioma-1) is frequently over-expressed in AML patients and is associated with a poor prognosis. xref – xref However, in patients with inv(16), highest MN1 expression has been reported with favorable prognosis to current therapeutics. xref MN1 functions as a transcriptional regulator that co-operates with the nuclear receptors for retinoic acid (RAR) and vitamin D, by acting as co-activator or co-repressor, depending on the interacting partners. xref – xref In addition, MN1 is frequently over-expressed and occasionally fused to TEL as part of the rare MN1-TEL translocation. xref Mn1 is known to be co-operating partner of several oncogenic fusion genes (NUP98–HOXD13, xref CALM–AF10, xref MLL–AF9 xref and MLL–ENL) xref and mutated RUNX1, xref and as a common target of insertional mutagenesis in a hematopoietic stem cell (HSC) gene therapy trial, xref thereby promoting leukemogenesis."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"In this issue of CCM, Fiest et at [ref] present results from a diagnostic accuracy study in which they test two family administered delirium screening tools, the Family Confusion Assessment Method (FAM-CAM) ( xref ), and the Sour Seven ( xref ) against the diagnosis of delirium according to the Diagnosis and Statistical Manual of Mental Disorders, Edition 5 (DSM-5)."
CALM1 affects B3LYP
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203
sparser
"All electronic structure calculations
were performed with the ORCA
software package (version 5.0.3). xref Each
set of calculations was conducted using five different density functionals:
the hybrid density functionals PBE0 xref , xref and B3LYP, xref , xref as well as the range-separated hybrid functionals LRC-ωPBEh, xref CAM-B3LYP, xref and
ωB97X. xref No optimization of the range-separation
parameter ω was done."
GO affects CALM1
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187
sparser
"We have released version 2 of a comprehensive set of integrated, reviewed annotations for human genes, which we call the “functionome.” We have also dramatically increased the number of GO-CAM models, with over 1500 models of metabolic and signaling pathways, primarily in human, mouse, budding and fission yeast, and fruit fly."
Isotocin-neurophysin IT 1 affects CALM1
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CALM1 is modified
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CALM1 is phosphorylated.
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21
sparser
"An involvement of mTORC2 in calcium regulation in muscle is also supported by the decrease in the phosphorylation of calmodulin 1 (CALM1) in Ric mKO muscle, since
calmodulins are calcium ion sensor proteins that transduce most of the calcium signalling to downstream protein kinases and phosphatases (Marcelo et al. 2016)."
CALM1 is acetylated.
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10
sparser
"This may be due to the lower affinity of Myo1 for unmodified Cam1, which would bring about dissociation of the two proteins at lower concentrations of cellular calcium, despite the pCa of the interaction being unaffected by Cam1 acetylation, and therefore failure to associate with the membrane."
sparser
"Using biochemical analysis of recombinant bacterially expressed amino‐terminally acetylated Cam1, we show this post‐translational modification impacts the helical structure and thermal stability of the Cam1 protein, enhancing its sensitivity to Ca 2+ and affinity for its major cellular binding partner, Myo1."
sparser
"It is worth noting that the proportion of native yeast Cam1 that is acetylated on its amino‐terminus within the yeast cell (40%) [ xref ], generating a subpopulation of CaM with distinct biophysical properties, coincides precisely with the proportion of discrete Cam1 foci (40%) that associates with Myo1 in the fission yeast cell [ xref ]."
CALM1 is methylated.
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9
sparser
"The results showed CALM1 methylation to be significantly increased in cervical and endocervical cancer (CESC) and COAD compared with that in normal tissues, but significantly decreased in LIHC and PCPG ( xref ), showing an inverse trend compared with that of the expression pattern."
sparser
"The recently completed genome of pineapple has and will continue to facilitate many areas of research in this species, and the present work focuses on the regulatory impact of DNA methylation on CAM pathway-related genes using temporal and spatial methylome and transcriptome analysis."
CALM1 is glycosylated.
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9
sparser
"In addition, studies in our laboratories have been performed and are still in progress, mainly aimed to elucidate the expression and significance of the CAM glycosylation patterns, as well as to identify and characterize membrane molecular components implicated in the ion transport processes which occur in the chorionic epithelium [ xref – xref ]."
sparser
"Further advances in production of metal coatings with finer granularity, together with improvements in imaging (tilting and angle of stereo images), may provide better definition of the topography associated with glycosylation and formation of multimeric CAM complexes. (J Histochem Cytochem 49:809-819, 2001)"
sparser
"It was shown that GAD activity is induced by two different mechanisms: (i) in intact plant tissue and neutral pH GAD activity is stimulated in a Ca 2+ -dependent manner by binding of calmodulin to the CAM-binding site ( xref ); (ii) after wounding of plant cells the vacuolar content is released and the cytosol is acidified which leads to a Ca 2+ -independent activation of GADs ( xref )."
reach
"These results suggest that CaM is produced by the CALM1 gene in the early-stage HDFs with an altered dermal composition, and that they are activated in the biological pathways associated with calcium ions.Since calcium signaling is presumably associated with the differentiation of fibroblasts in the elastin-variable hydrogel environments, we assessed the expression of S100A4 (also called fibroblast-specific protein 1, FSP1), which is a marker of differentiated fibroblasts as well as a calcium-binding protein."
sparser
"It was shown that GAD activity is induced by two different mechanisms: (i) in intact plant tissue and neutral pH GAD activity is stimulated in a Ca 2+ -dependent manner by binding of calmodulin to the CAM-binding site ( xref ); (ii) after wounding of plant cells the vacuolar content is released and the cytosol is acidified which leads to a Ca 2+ -independent activation of GADs ( xref )."
EP affects CALM1
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63
sparser
"For flow cytometric analysis of myCAF, iCAF, and apCAF populations, cells were stained for 30 min with anti‐mouse CD31‐FITC (102405, BioLegend), CD45‐APC/Cy7 (557659, BD), CD326 (Ep‐CAM)‐BV421 (118225, BioLegend), PDPN‐APC (127410, BioLegend), Ly6C‐PE (128008, BioLegend), and I‐A/I‐E (MHC‐II)‐PE/Cy7 (107630, BioLegend)."
NET affects CALM1
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61
sparser
"In the recent phase IV, prospective, open-label, exploratory study “Circulating Tumour Cells in Somatuline Autogel Treated NeuroEndocrine Tumors Patients” (CALM-NET) investigating the effect of the administration of 120 mg lanreotide AG every 28 days on CS symptoms, 70.6% of treated patients had an at least 50% reduction in diarrhea episodes and 77.1% in flushing episodes at follow-up [ xref ]."
sparser
"For example, dysregulation of Phgdh , Eno1 and Gapdh , three functionally linked glycolytic enzymes in module M3 suggests that lower levels of Blimp-1 are impacting on metabolic fitness and the acquisition of Ig-CAM adhesion molecules in M13 such as Icam1 , Bcam and Epcam argues for altered adhesive properties."
sparser
"Cells at the migratory pole of tumor masses upregulate genes associated with migration and epithelial-to-mesenchymal transition (EMT); vimentin ( VIM ), N-cadherin ( CDH2 ), epidermal growth factor receptor (EGFR) ( ERbB2 ) and downregulate genes associated with cellular adhesion (E-cadherin, Ig-CAM, selectins), in contrast to other cells in the mass which rather may be primed for proliferation and maintenance of the mass. xref , xref Another example reflects the selective pressure of hypoxia, wherein cells in the center of a larger tumor mass undergo programmed necrosis that together facilitate the upregulation of genes associated with angiogenesis; vascular endothelial growth factor ( VEGF) , angiopoietin-1 ( Ang-1 ), and angiopoietin-2 ( Ang-2 ). xref Within this changing environment, it cannot be forgotten that tumor cells are also undergoing immunoediting, with a changing profile that permits the induction of immune tolerance. xref , xref Moreover, while the immunogenicity of hormone-dependent breast cancers, may be regarded as low in comparison to the triple-negative breast cancers, xref that tumors are able to subvert immune cells to use secreted factors for tumor progression is of interest. xref Tumors can recruit a multitude of immune cells including myeloid-derived suppressor cells (MDSCs), which retain the capacity to differentiate into macrophages, granulocytes, and dendritic cells for example. xref Secreted factors from MDSCs including interleukin (IL)-6, transforming growth factor beta (TGF-β), and matrix metalloproteinase 9 are implicated in promoting tumor cell growth, invasion, and angiogenesis. xref , xref MDSCs also induce immune suppression by facilitating tolerance in cytotoxic T cells via nitration or nitrosylation of the T cell receptor or secreted nitric oxide, which prevents the natural killer (NK) cell-FcR mediated activity. xref , xref Cytotoxic function by T cells and NK cells are also controlled by T regulatory cells, which can be subverted by tumor cells to elicit pro-tumor responses. xref Tumor cells also use additional strategies to ensure evasion from cells of the innate and adaptive immune system; for example, downregulation of major histocompatibility complex (MHC) molecules, blockade of activating receptors or shedding of NK activating receptor ligands, inducing T cell anergy, and promoting macrophage differentiation into a pro-tumorigenic M2 phenotype. xref , xref , xref "
CR affects CALM1
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53
sparser
"Subsequently, Partial Least Squares (PLS) regression, Convolutional Neural Network (CNN), CNN combined with channel attention mechanism (CNN-CAM), CNN combined with spatial attention mechanism (CNN-SAM), and CNN combined with Convolutional Block Attention Mechanism (CNN-CBAM) models were developed and evaluated for their suitability and stability in predicting wood moisture content."
sparser
"Zhang et al. [ xref ] used 3D densely connected convolutional neural network (CAM-CNN) to extract brain MRI multilevel features for classification of Alzheimer's disease and mild cognitive impairment, densely connected difference at different unit levels; 3D dense unit introduces attention mechanism to generate attention maps and sum transformed MRI hierarchical data into more compact high-level; model has high classification prediction accuracy, and classification performance is at the highest level."
ESP32 affects CALM1
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43
sparser
"For an ESPlanktoscope using the ESP32-CAM module, which does not provide enough GPIO pins to control the motor directly, the motor driver must be controlled by a second ESP32 microcontroller board connected to the ESP32 camera module, as the ESP32 camera module does not offer enough GPIO pins to control the motor directly; in such a configuration, the ESP32 camera module sends a PWM signal to the second microcontroller in order to set the flow rate of the pump."
sparser
"Firmware binaries can be uploaded using either an over-the-air (OTA) mechanism or through the Web Serial-based web page, which provides a selection of customized firmware configurations (e.g. for the ESP32-CAM board, the Seeed Studio Xiao Sense board, Serial Camera, ESPectrophotometer)."
CALM1 affects calcium(2+)
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CALM1 binds calcium(2+).
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CALM1 binds calcium(2+). 10 / 26
4
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"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
"We report that HDAC4 and MITR contain calmodulin-binding domains that overlap with their MEF2-binding domains. Binding of calmodulin to HDAC4 leads to its dissociation from MEF2, relieving MEF2 from the transcriptional repression by HDAC4. Together, HDAC4, MITR, and Cabin1 constitute a family of calcium-sensitive transcriptional repressors of MEF2."
CALM1 activates calcium(2+).
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CALM1 activates calcium(2+). 8 / 8
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reach
"The facilitating effect of CaM1 was significantly enhanced (the K value was reduced from 0.61 to 0.28), but the inhibitory effect was significantly decreased (the K value was increased from 8 to 12) (Fig. 4q; Table S12), indicating that activation of CaM1 and L-VGCC by scoparone likely induced excessive activation of Ca signalling pathways by promoting CDF or blocking CDI of L-VGCC."
CALM1 inhibits calcium(2+).
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NP affects CALM1
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36
Calcium(2+) affects CALM1
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Calcium(2+) binds CALM1.
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CALM1 binds calcium(2+). 10 / 26
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"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
"We report that HDAC4 and MITR contain calmodulin-binding domains that overlap with their MEF2-binding domains. Binding of calmodulin to HDAC4 leads to its dissociation from MEF2, relieving MEF2 from the transcriptional repression by HDAC4. Together, HDAC4, MITR, and Cabin1 constitute a family of calcium-sensitive transcriptional repressors of MEF2."
Calcium(2+) activates CALM1.
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Calcium(2+) activates CALM1. 7 / 7
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"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+–CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the E–F hands in each domain and dramatically changes the two domains of CaM to produce more ‘open’ conformations"
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"A possible explanation is as follows: the percentage cumulative release of PVA-CAM is found to be a systematic and controlled release due to their less cytotoxic effects on blood cells, whereas the percentage cumulative release of uncapped-AgNPs is found to have a faster and sudden release profile due to the absence of a capping agent and their high toxicity to blood cells."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"To enhance the potential for antibodies to bind to reduced protein on immunoblots, a peptide corresponding to this sequence (CFDPKYGEPKRPPNCARGSCPWDSQL; accession # NP_001138585.2) was generated with a reduced N-terminal anchoring cysteine and two CAM-cys residues in place of the remaining native cysteines."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"Similarly on the 14 th day after excision wound injury, treatment with PVA-CAM showed an equal maximum regeneration of fibroblast and collagen and was significantly more effective and angiogenic compared with CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a moderate amount of collagen and fibroblast regeneration, with scant inflammation during their healing process."
sparser
"A possible explanation is as follows: the percentage cumulative release of PVA-CAM is found to be a systematic and controlled release due to their less cytotoxic effects on blood cells, whereas the percentage cumulative release of uncapped-AgNPs is found to have a faster and sudden release profile due to the absence of a capping agent and their high toxicity to blood cells."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"To enhance the potential for antibodies to bind to reduced protein on immunoblots, a peptide corresponding to this sequence (CFDPKYGEPKRPPNCARGSCPWDSQL; accession # NP_001138585.2) was generated with a reduced N-terminal anchoring cysteine and two CAM-cys residues in place of the remaining native cysteines."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
NCIT:C114489 affects CALM1
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NCIT:C114489 binds CALM1. 10 / 26
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sparser
"During the initial 100 s, the cumulative sorption
values were ∼62%, ∼77%, and ∼90% at the pressures
of 10, 20, and 30 bar, correspondingly, for CAM–LnA DES, whereas
the sorption magnitudes by CIT–LnA during the initial 100 s
of the experiment were ∼62%, ∼87%, and ∼92%,
respectively, at 10, 20, and 30 bar pressures."
sparser
"To assess the selectivity of the immunosensing platform and ensure that the change in the current is due to antigen binding and not the settling of proteins on the surface, a test of some compounds that may be in negative controls of real samples was conducted, including bovine serum albumin (BSA), carcinoembryonic antigen (CEA-CAM), prostate-specific antigen (PSA), 20S proteasome, ascorbic acid (AA), glucose, and dopamine."
sparser
"To assess the selectivity of the immunosensing platform and ensure that the change in the current is due to antigen binding and not the settling of proteins on the surface, a test of some compounds that may be in negative controls of real samples was conducted, including bovine serum albumin (BSA), carcinoembryonic antigen (CEA-CAM), prostate-specific antigen (PSA), 20S proteasome, ascorbic acid (AA), glucose, and dopamine."
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CALM1 binds.
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sparser
"Five strains were sensitive to all four antibiotics (S1-S5), 6 strains were resistant to MTZ (MTZ1-MTZ6), 5 strains were resistant to LVFX (LVFX1-LVFX5), 5 strains were resistant to CAM (CAM1-CAM5), 3 strains exhibited dual drug resistance (DR1-DR3), and 6 strains were multidrug resistant (MDR1-MDR6)."
CALM1 phosphorylates itself.
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9
rlimsp
"Along with information from the crystal structure of Ca2+/CaM bound to CKII(290-314) (Meador, W. E., Means, A. R., and Quiocho, F. A. (1993) Science 262, 1718-1721), our results suggest a model in which CaM-dependent autophosphorylation of CaM-kinase induces a conformational change in the region of the CaM-binding domain which allows the formation of additional stabilizing interactions with CaM."
rlimsp
"Autophosphorylation of CaM-kinase II produces a form of the enzyme not requiring Ca(2+)/calmodulin for sustained activity. We report that autophosphorylated CaM-kinase II dephosphorylates itself in the presence of ADP (termed autodephosphorylation). The dephosphorylation was unaffected by phosphatase inhibitors and was nucleotide specific, occurring with ADP but not with AMP, GTP, or GDP. (32)P-ATP was produced when ADP was added to (32)P-labeled CaM-kinase II, indicating that the enzyme was undergoing dephosphorylation through a reversal of the autophosphorylation reaction. ATP addition also produced loss of (32)P from the autophosphorylated enzyme while maintaining the kinase in a phosphorylated state."
CALM1 is inactive.
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"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
reach
"Indeed, electrophysiological experiments confirmed these results, showing that scoparone did not promote CDF or block CDI in L-VGCC mutants (in which the combination of two key positions, Ile and Gln, in the IQ motif was replaced with Ala) because CaM1 binding to the IQ region of the Ca channel was impaired.Notably, it has been reported that CaM binds to the N-termini of Ca channels [36], which was confirmed in this study."
sparser
"Although CaM1 bound to a well-characterized IQ motif, mutations of the IQ motif that markedly weakened CaM1 binding blocked CDF and heightened CDI of Ca 2+ channels during a single depolarizing pulse, suggesting that CaM interactions with the IQ motif actively suppressed inactivation or promoted facilitation of Ca 2+ channels."
sparser
"Indeed, electrophysiological experiments confirmed these results, showing that scoparone did not promote CDF or block CDI in L-VGCC mutants (in which the combination of two key positions, Ile and Gln, in the IQ motif was replaced with Ala) because CaM1 binding to the IQ region of the Ca 2+ channel was impaired."
reach
"Indeed, electrophysiological experiments confirmed these results, showing that scoparone did not promote CDF or block CDI in L-VGCC mutants (in which the combination of two key positions, Ile and Gln, in the IQ motif was replaced with Ala) because CaM1 binding to the IQ region of the Ca channel was impaired.Notably, it has been reported that CaM binds to the N-termini of Ca channels [36], which was confirmed in this study."
sparser
"Although CaM1 bound to a well-characterized IQ motif, mutations of the IQ motif that markedly weakened CaM1 binding blocked CDF and heightened CDI of Ca 2+ channels during a single depolarizing pulse, suggesting that CaM interactions with the IQ motif actively suppressed inactivation or promoted facilitation of Ca 2+ channels."
sparser
"Indeed, electrophysiological experiments confirmed these results, showing that scoparone did not promote CDF or block CDI in L-VGCC mutants (in which the combination of two key positions, Ile and Gln, in the IQ motif was replaced with Ala) because CaM1 binding to the IQ region of the Ca 2+ channel was impaired."
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
sparser
"Of these, six LR interactions were highlighted by both analyses, including APOE-SORL1 , APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, CALM3-RYR2 ( xref ). xref illustrates that the LR pair APOE-SORL1 was downregulated in astrocytes-to-neurons and in microglia-to-neurons signaling."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
CALM1 affects apoptotic process
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sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
sparser
"Of these, six LR interactions were highlighted by both analyses, including APOE-SORL1 , APOE-LRP1, CALM1-CACNA1C, CALM1-RYR2, CALM3-CACNA1C, CALM3-RYR2 ( xref ). xref illustrates that the LR pair APOE-SORL1 was downregulated in astrocytes-to-neurons and in microglia-to-neurons signaling."
reach
"Additionally, the CaM1 assay showed that compared with the control treatment, treatment with the LC , LC , and LC doses of scoparone for 48 h markedly increased the specific activation of PDE by extracted CaM in vivo (by 3.67-, 2.79-, and 1.87-fold, respectively), further demonstrating that scoparone is an agonist of CaM1 (Fig. 4d)."
NAChRbeta2 affects CALM1
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CALM1 binds nAChRbeta2. 10 / 17
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sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
CALM1 affects nAChRbeta2
|
17
CALM1 binds nAChRbeta2. 10 / 17
|
17
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"These findings indicate that PVA-CAM have a predominant antibacterial activity and accelerate the healing potential of excision wound models in Wistar albino rats by enhancing angiogenesis in the wounded sections and are comparatively more efficient (among polymers) than uncapped-CAM, SBD-CAM or untreated wounds (the control)."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
sparser
"In C. neoformans , Cna1 is activated by Cam1 and plays an important role in growth at 37 °C. Under elevated temperatures, Cna1 targets a Crz1 ortholog; the Cna1-Crz1 pathway is required for expression of chitin synthase genes CHS5 and CHS6 , with a role in cell wall structure and fungal cell survival during infection [ xref ]."
PCL affects CALM1
|
16
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"Drug encapsulation
can either increase or decrease the mechanical
properties of electrospun PCL fibers. xref , xref It has been
shown that incorporation of the antibacterial drug linezolid into
PCL scaffolds improved their mechanical properties. xref It is known that drug–polymer interactions affect
the mechanical properties of electrospun polyester fibers, xref and as the solid-state analyses in our previous
study have revealed, different solvents may have affected the CAM–PCL
interactions at the molecular level differently. xref This may lead to different mechanical behavior of scaffolds."
sparser
"Previously developed and characterized
fibrous wound dressings were used, namely PCL-CAM and pristine PCL
(ES using a chloroform–methanol solvent system), xref and PCL-CIP and pristine PCL (ES using a formic
acid–acetic acid solvent system), slightly modified from Zupančič
et al. xref Different antibiotic-loaded dressings
enabled the comparison of the antibacterial efficacy of the dressings
with different drugs against dual-species wound infections (CAM vs
CIP) and the effect of fibers with different morphologies."
sparser
"PCL-CAM wound
dressing was tested only on S. aureus and E. coli biofilm due to the P. aeruginosa resistance to CAM. xref PCL-CIP dressing was tested on all three dual-species biofilm
combinations: S. aureus with E. coli , S. aureus with P. aeruginosa , and E. coli with P. aeruginosa ."
CALM1 affects cell adhesion
|
16
CALM1 affects PCL
|
16
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"Drug encapsulation
can either increase or decrease the mechanical
properties of electrospun PCL fibers. xref , xref It has been
shown that incorporation of the antibacterial drug linezolid into
PCL scaffolds improved their mechanical properties. xref It is known that drug–polymer interactions affect
the mechanical properties of electrospun polyester fibers, xref and as the solid-state analyses in our previous
study have revealed, different solvents may have affected the CAM–PCL
interactions at the molecular level differently. xref This may lead to different mechanical behavior of scaffolds."
sparser
"Previously developed and characterized
fibrous wound dressings were used, namely PCL-CAM and pristine PCL
(ES using a chloroform–methanol solvent system), xref and PCL-CIP and pristine PCL (ES using a formic
acid–acetic acid solvent system), slightly modified from Zupančič
et al. xref Different antibiotic-loaded dressings
enabled the comparison of the antibacterial efficacy of the dressings
with different drugs against dual-species wound infections (CAM vs
CIP) and the effect of fibers with different morphologies."
sparser
"PCL-CAM wound
dressing was tested only on S. aureus and E. coli biofilm due to the P. aeruginosa resistance to CAM. xref PCL-CIP dressing was tested on all three dual-species biofilm
combinations: S. aureus with E. coli , S. aureus with P. aeruginosa , and E. coli with P. aeruginosa ."
CALM1 affects AP180
|
16
reach
"(a) VEGF 0 (DMEM soaked implant), VEGF 30 (30 ng/implant), VEGF 100 (100 ng/implant) and VEGF 300 (300 ng / implant) induced CAM angiogenic response in absence of coronary endothelial cells (AcEC) and in presence of coronary endothelial cells (2 A 106 cells/ml, 0.5 A 104 cells and implant) of normal (+ ncEC) rats, diabetic rats 30 ds."
reach
"(a) VEGF 0 (DMEM soaked implant), VEGF 30 (30 ng/implant), VEGF 100 (100 ng/implant) and VEGF 300 (300 ng / implant) induced CAM angiogenic response in absence of coronary endothelial cells (AcEC), in presence of ischemia reperfusion injured coronary endothelial cells (2 A 106 cells/ml, 0.5 A 104 cells and implant) of diabetic 60 ds."
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
sparser
"CaM binding decreases the CNG channel-binding affinity for cGMP and causes decreased Ca 2+ influx. xref , xref Two CaM-binding sites are located in CNGB1 called CaM1 (residues 565–589) and CaM2 (residues 1120–1147) ( xref ). xref , xref , xref CaM1 is required for Ca 2+ -dependent modulation of the CNGA1/CNGB1 heteromeric channels. xref , xref The function of CaM2 is not known, but CaM2 is located adjacent to the CNBD where it could affect ligand binding. xref A recent cryoEM structure of the retinal CNG channel revealed that a helix within CNGB1 is bound to the C-terminal domain of CaM (residues 80–149, called the C-lobe). xref However, the cryoEM structure lacked sufficient resolution to distinguish whether the CaM C-lobe is bound to CaM1 or CaM2, and the CaM N-lobe (residues 1–80) was completely missing in the structure."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects angiogenesis
|
10
5
CALM1 activates angiogenesis.
|
8
CALM1 activates angiogenesis. 8 / 8
|
8
reach
"The CAM (Chick Chorioallantoic Membrane) model allows the assessment of the degree of angiogenesis, as well as the quality of the newly formed vessels, when intervening vascular endothelial growth factors (VEGF) or conversely, factors that inhibit the development of new blood vessels, such as antiangiogenic drugs."
CALM1 inhibits angiogenesis.
|
2
5
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
sparser
"CaM binding decreases the CNG channel-binding affinity for cGMP and causes decreased Ca 2+ influx. xref , xref Two CaM-binding sites are located in CNGB1 called CaM1 (residues 565–589) and CaM2 (residues 1120–1147) ( xref ). xref , xref , xref CaM1 is required for Ca 2+ -dependent modulation of the CNGA1/CNGB1 heteromeric channels. xref , xref The function of CaM2 is not known, but CaM2 is located adjacent to the CNBD where it could affect ligand binding. xref A recent cryoEM structure of the retinal CNG channel revealed that a helix within CNGB1 is bound to the C-terminal domain of CaM (residues 80–149, called the C-lobe). xref However, the cryoEM structure lacked sufficient resolution to distinguish whether the CaM C-lobe is bound to CaM1 or CaM2, and the CaM N-lobe (residues 1–80) was completely missing in the structure."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to barley and rice MLO proteins ( xref ; xref )."
sparser
"LC-MRM peaks were integrated, and relative peak areas for each transition (transition/sum of all transitions) as well as retention times were compared with HP-CAM signals for the same peptide. xref shows a representative example of a confirmed target LC-MRM for a mouse CYP 2C29 peptide, found via data-dependent MS/MS and confirmed by MRM analyses."
CM affects CALM1
|
14
sparser
"One possible problematic outcome of such dismissal is that patients, who already anticipate this negative response, may choose not to discuss their concurrent use of treatments with their HCP, and as such may assume the entire burden of managing the interactions of CM and CAM without any medical guidance, which puts them at a great health risk [ xref , xref ]."
sparser
"This binding is prohibited by mutation of two amino acid residues (L 18 R and W 21 R, corresponding to L 456 R and W 459 R in full-length MLO2) that are in analogous positions within the CAMBD to those that were previously identified as being essential for the binding of CAM to barley and rice MLO proteins ( xref ; xref )."
sparser
"LC-MRM peaks were integrated, and relative peak areas for each transition (transition/sum of all transitions) as well as retention times were compared with HP-CAM signals for the same peptide. xref shows a representative example of a confirmed target LC-MRM for a mouse CYP 2C29 peptide, found via data-dependent MS/MS and confirmed by MRM analyses."
CALM1 affects CM
|
14
sparser
"One possible problematic outcome of such dismissal is that patients, who already anticipate this negative response, may choose not to discuss their concurrent use of treatments with their HCP, and as such may assume the entire burden of managing the interactions of CM and CAM without any medical guidance, which puts them at a great health risk [ xref , xref ]."
Capsid protein affects CALM1
|
13
Capsid protein binds CALM1. 10 / 13
|
13
sparser
"All-atom models of intact, CAM-bound HBV Cp149 capsids were prepared based on crystal structures of pre-formed capsids complexed with AT130 (PDB 4G93, 4.2 Å), [ xref ] HAP1 (PDB 2G34, 5.0 Å), [ xref ] and HAP18 (PDB 5D7Y, 3.9 Å). [ xref ] The AT130- and HAP18-bound capsid models contain CAMs in all B and C sites and are referred to as saturated."
sparser
"Compared to a cryo-EM analysis of CAM-bound capsids that mostly revealed that CAM induced Cp tertiary and quaternary structural changes, the crystallography of CpY132A heximers revealed a more detailed interaction of the CAM molecule with amino acid residues of Cp at the HAP pocket due to an improved resolution [ xref , xref ]."
sparser
"Surgeons should consider obtaining global sagittal alignment radiographs in high-risk patients, particularly elderly individuals or those with evident postural abnormalities, as the CAM-SVA measurement provides valuable prognostic information that can inform patient counseling and surgical planning [ xref ]."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."
sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."
sparser
"Moreover, immunohistochemical (IHC) analysis showed negativity for epithelial markers, such as Cytokeratin AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1; therefore, further immunohistochemical markers were evaluated, and the conclusive diagnosis was based on a diffuse speckled nuclear positivity for NUT1 (clone C52B1)."
sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."
CALM1 affects capsid protein
|
13
Capsid protein binds CALM1. 10 / 13
|
13
sparser
"All-atom models of intact, CAM-bound HBV Cp149 capsids were prepared based on crystal structures of pre-formed capsids complexed with AT130 (PDB 4G93, 4.2 Å), [ xref ] HAP1 (PDB 2G34, 5.0 Å), [ xref ] and HAP18 (PDB 5D7Y, 3.9 Å). [ xref ] The AT130- and HAP18-bound capsid models contain CAMs in all B and C sites and are referred to as saturated."
sparser
"Compared to a cryo-EM analysis of CAM-bound capsids that mostly revealed that CAM induced Cp tertiary and quaternary structural changes, the crystallography of CpY132A heximers revealed a more detailed interaction of the CAM molecule with amino acid residues of Cp at the HAP pocket due to an improved resolution [ xref , xref ]."
sparser
"Surgeons should consider obtaining global sagittal alignment radiographs in high-risk patients, particularly elderly individuals or those with evident postural abnormalities, as the CAM-SVA measurement provides valuable prognostic information that can inform patient counseling and surgical planning [ xref ]."
sparser
"From an immunohistochemical point of view, EMPSGC is usually positive for Cytokeratin 7 (CK7), CK8, CK8/18, CKAE1/AE3, CK-CAM5.2, Epithelial Membrane Antigen (EMA), Gross Cystic Disease Fluid Protein-15 (GCDFP-15), WT1, Estrogen Receptor (ER), and Progesterone Receptor (PgR), but it is very important to underline the positivity for Synaptophysin (Syn) and/or Chromogranin A (CgA), Neuron-Specific Enolase (NSE), and CD56 [ xref , xref , xref ], which are markers of neuroendocrine differentiation."
sparser
"In terms of immunohistochemistry, MCC cells are positive for epithelial markers such as CK-CAM5.2, CKAE1-AE3, CK20, CK34BetaE12, BerEP4, and Epithelial membrane Antigen (EMA), PIEZO2 [ xref ], with some cases showing positivity for CK7 along with markers of neuroendocrine differentiation including chromogranin A (CgA), synaptophysin (Syn), and CD56 (NCAM1)."
sparser
"Moreover, immunohistochemical (IHC) analysis showed negativity for epithelial markers, such as Cytokeratin AE1/AE3, CK7, CK-CAM5.2, CK5/6, p40 and TTF1; therefore, further immunohistochemical markers were evaluated, and the conclusive diagnosis was based on a diffuse speckled nuclear positivity for NUT1 (clone C52B1)."
sparser
"Of all the reviewed immunohistochemical stains, cytokeratins (CK-PAN, CK-CAM, CK7) were the most represented: 39 of 60 cases (65%) had diffuse immunohistochemical staining to at least one of the cytokeratins, while the remaining 21 cases (35%) had focal or mild positivity for one of them."
"Phosphorylation of CaM at four sites by CK2 was found to follow a sequential order, with Ser81 as the first, Thr79 as the second, and Ser101 or Thr117 as the third. We found that in the complex between CaM and CaMKII, residue E115 of CaM is strongly interacting with K299 of the kinase through forming a salt-bridge (PDB entry 1WEL), it is quite likely that the phosphorylation induced structural change can disrupt this interaction and negatively affect the binding between the two proteins"
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"As holism is one of the main features that most of the practices defined (by Western) alternative or New Age share, I also refer to CAM-NAt as holistic practices.
Anthropology & Medicine
3
Several studies have found that middle-class women (Kligman 1998; Ross 2012; Woodhead 2007) are those who are most frequently drawn to CAM and NAt."
sparser
"Treatment was given on predetermined days, in which the prepared matrix scaffolds were used as substrates for impregnation of AgNPs. xref The process includes the exposure of various synthesized scaffolds ( i.e. , CAM alone, uncapped-CAM, capped = TSC-CAM, PVP-CAM and PVA-CAM, SBD-CAM) which were allowed to react on alternate days with the wound area in order to initiate the inflammatory phase followed by the other phases."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"Finally, PVA-AgNPs, PVP-AgNPs, TSC-AgNPs, uncapped-AgNPs and SBD-suspensions were incorporated into the formulated polymeric matrix to form PVA-AgNP impregnated CAM (PVA-CAM), PVP-AgNP impregnated CAM (PVP-CAM), TSC-AgNP impregnated CAM (TSC-CAM), uncapped-AgNP impregnated CAM (uncapped-CAM) and SBD-suspension impregnated CAM (SBD-CAM), respectively, and freeze dried for further analysis."
sparser
"Wound treatment with uncapped-CAM after the 9 th day of observation showed skin tissue with dense inflammation, an absence of fibroblast development and a very minimal amount of collagen regeneration, and was found to be comparatively less effective than CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM."
sparser
"Although the percentage wound contraction for PVP-CAM, TSC-CAM and SBD-CAM was quite a bit higher than for uncapped-CAM and the control group, wounds treated with PVA-CAM show the maximum significant wound contraction ( p ≤ 0.001) efficiency due to their biocompatibility with wound tissue."
sparser
"The combined CBAM ( xref ) dynamically learns both channel-wise and spatial attention distributions through the synergistic interaction of CAM and SAM, thereby improving feature extraction efficiency and network representational capacity, ultimately optimizing model performance ( xref , xref )."
sparser
"As holism is one of the main features that most of the practices defined (by Western) alternative or New Age share, I also refer to CAM-NAt as holistic practices.
Anthropology & Medicine
3
Several studies have found that middle-class women (Kligman 1998; Ross 2012; Woodhead 2007) are those who are most frequently drawn to CAM and NAt."
sparser
"Treatment was given on predetermined days, in which the prepared matrix scaffolds were used as substrates for impregnation of AgNPs. xref The process includes the exposure of various synthesized scaffolds ( i.e. , CAM alone, uncapped-CAM, capped = TSC-CAM, PVP-CAM and PVA-CAM, SBD-CAM) which were allowed to react on alternate days with the wound area in order to initiate the inflammatory phase followed by the other phases."
sparser
"At the same time, excision wounds treated with uncapped-CAM after the 14 th day showed the presence of a minimal amount of collagen with regeneration and incomplete tissue regeneration, compared with CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM, as shown in the xref , xref and xref ."
sparser
"From xref , it is proven that the percentage wound contraction for uncapped-CAM was significantly lower than the values for SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on all the respective (3 rd , 6 th , 9 th , 14 th and 20 th ) days, which may be due to the absence of surface coating or capping agents in the uncapped-CAM, which are responsible for nanoparticle stability and healing potential."
sparser
"Histopathological analyses of the excision wound models in the control group (without treatment), CAM alone, uncapped-CAM, SBD-CAM, TSC-CAM, PVP-CAM and PVA-CAM on the 9 th and 14 th day after the excision wound injury are depicted using H & E and MT staining in xref , xref and xref ."
sparser
"Histopathological studies on treatment with PVA-CAM in the excision wound model showed a maximum amount of fibroblast presence and collagen regeneration after the 9 th day of the healing process, which was found to be comparatively more effective than CAM alone, uncapped-CAM, PVP-CAM, TSC-CAM or SBD-CAM that showed a minimal amount of fibroblast and collagen regeneration, with the presence of dense inflammation."
sparser
"Finally, PVA-AgNPs, PVP-AgNPs, TSC-AgNPs, uncapped-AgNPs and SBD-suspensions were incorporated into the formulated polymeric matrix to form PVA-AgNP impregnated CAM (PVA-CAM), PVP-AgNP impregnated CAM (PVP-CAM), TSC-AgNP impregnated CAM (TSC-CAM), uncapped-AgNP impregnated CAM (uncapped-CAM) and SBD-suspension impregnated CAM (SBD-CAM), respectively, and freeze dried for further analysis."
sparser
"Wound treatment with uncapped-CAM after the 9 th day of observation showed skin tissue with dense inflammation, an absence of fibroblast development and a very minimal amount of collagen regeneration, and was found to be comparatively less effective than CAM alone, PVA-CAM, PVP-CAM, TSC-CAM or SBD-CAM."
sparser
"Although the percentage wound contraction for PVP-CAM, TSC-CAM and SBD-CAM was quite a bit higher than for uncapped-CAM and the control group, wounds treated with PVA-CAM show the maximum significant wound contraction ( p ≤ 0.001) efficiency due to their biocompatibility with wound tissue."
sparser
"The combined CBAM ( xref ) dynamically learns both channel-wise and spatial attention distributions through the synergistic interaction of CAM and SAM, thereby improving feature extraction efficiency and network representational capacity, ultimately optimizing model performance ( xref , xref )."
TM affects CALM1
|
10
sparser
"The data for CAM-Tm fall very close to those for the parent, but the
former define a slightly,
but distinctly,
biphasic curve (three inflection
points) that is below that of the parent in the range 40-50°C.
The data for carboxymethylated
tropomyosin (CM-Tm) are shown as open
circles in Fig. 2, along with spline curves for Tm (dotted) and CAM-Tm
(solid)."
sparser
"The World Health Organization (WHO) reported that between 70% and 90% of the populations of Canada, France, Germany, and Italy have used some form of TM or CAM and that 110 of the 193 WHO member states reported having some type of policy in place regarding regulation and/or registration of traditional medications in 2007 [ xref ]."
SP affects CALM1
|
10
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
CALM1 affects TM
|
10
sparser
"The data for CAM-Tm fall very close to those for the parent, but the
former define a slightly,
but distinctly,
biphasic curve (three inflection
points) that is below that of the parent in the range 40-50°C.
The data for carboxymethylated
tropomyosin (CM-Tm) are shown as open
circles in Fig. 2, along with spline curves for Tm (dotted) and CAM-Tm
(solid)."
sparser
"The World Health Organization (WHO) reported that between 70% and 90% of the populations of Canada, France, Germany, and Italy have used some form of TM or CAM and that 110 of the 193 WHO member states reported having some type of policy in place regarding regulation and/or registration of traditional medications in 2007 [ xref ]."
CALM1 affects SP
|
10
Myo1 affects CALM1
|
9
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"These ligands include PSGL-1, the hemopoietic stem cell marker CD34, glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) and mucosal addressin cell adhesion molecule 1 (MAd-CAM1), all of which contain a sulphated form of the sLe x tetrasaccharide. xref - xref However, there are other selectin ligands that occur naturally in humans which do not contain sLe x , the similar tetrasaccharide sLe a , nor structurally related carbohydrate moieties."
sparser
"The gene NCAN , a CNS-specific extracellular matrix protein whose expression has been linked to malignant behavior of neuroblastoma, xref and additional genes encoding cell surface proteins relevant for adhesion of neurons and leukocytes ( DSCAML1 , MAD-CAM1 ) also correlated significantly with OMAS neuroimmune symptoms."
sparser
"Throughout foetal development in mice, chemokines such as CXCL12 and -13, CCL19, -20 and -21, and adhesion molecules including vascular cell adhesion molecule 1 (VCAM-1), mucosal vascular addressing cell adhesion molecule 1 (MAD-CAM1) and intercellular adhesion molecule 1 (ICAM-1), altogether signal to promote the circulation of LTi cells and the migration of T- and B-lymphocytes into primordia resembling Peyer’s patches (Kunkel et al. xref ; Patel et al. xref )."
sparser
"Moreover, hypersialylation promotes tumor dissemination and metastasis by modulating the function of different integrins. xref For example, inhibiting sialylation in MM impairs interactions between tumor cells, VCAM1 and mucosal vascular addressin cell adhesion molecule 1 (MAD-CAM1) by altering the maturation of CD49d. xref Sialylation also participates in the generation of selectin ligands."
sparser
"The expression of some adhesion molecules on BM mononuclear cells was assessed by a panel
of MoAbs directed against: CD1 la, CDI lb, CDI lc, CD44, CD49d(VLA4), CD49e(VLA-5), LEC-CAM I.
P-170 expression
P-170 expression was evaluated by the MoAb C219 (Cis International, Centocor Diagnostics), which is an IgG2b antibody that recognizes a cytoplasmic antigen."
HR affects CALM1
|
9
sparser
"For examples, two particular CAMS, the Gradient Weighted CAM (Grad-CAM) and High Resolution CAM (HR-CAM) have been shown to provide insights into the process of AI decision-making for oral cancer and other cancer types, with improved diagnostic performance and positive user feedback ( xref – xref )."
sparser
"Specifically, Grad-CAM generates heatmaps by computing the gradients of the target class score with respect to the feature maps of the last convolutional layers in the CNN while HR-CAM aggregates feature maps from several layers to create a high-resolution localization map ( xref )."
sparser
"The N-terminal domain (aa 22–138) of CALM contains the ANTH domain, which specifically binds to lipids (PtdIns(4,5)P 2 ) in the plasma membrane. xref , xref , xref , xref The three-dimensional structure of the N-terminal 280 amino acids of CALM has been solved and consists of 10 α-helices, which aggregate to form a globular protein. xref The C-terminal half of CALM, on the other hand, has most likely a poorly ordered structure that contains multiple short protein interaction motifs, functioning like a flexible ‘fishing line'. xref This composition of CALM permits the establishment of interactions during clathrin-coated pit assembly. xref Interestingly, FHL2 binds to β-integrin, xref which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis. xref , xref Taken together, these data suggest a role for the CALM–FHL2 interaction in the complex interaction network in endocytosis."
DRG affects CALM1
|
9
CALM1 affects Myo1
|
9
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"These ligands include PSGL-1, the hemopoietic stem cell marker CD34, glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) and mucosal addressin cell adhesion molecule 1 (MAd-CAM1), all of which contain a sulphated form of the sLe x tetrasaccharide. xref - xref However, there are other selectin ligands that occur naturally in humans which do not contain sLe x , the similar tetrasaccharide sLe a , nor structurally related carbohydrate moieties."
sparser
"The gene NCAN , a CNS-specific extracellular matrix protein whose expression has been linked to malignant behavior of neuroblastoma, xref and additional genes encoding cell surface proteins relevant for adhesion of neurons and leukocytes ( DSCAML1 , MAD-CAM1 ) also correlated significantly with OMAS neuroimmune symptoms."
sparser
"Throughout foetal development in mice, chemokines such as CXCL12 and -13, CCL19, -20 and -21, and adhesion molecules including vascular cell adhesion molecule 1 (VCAM-1), mucosal vascular addressing cell adhesion molecule 1 (MAD-CAM1) and intercellular adhesion molecule 1 (ICAM-1), altogether signal to promote the circulation of LTi cells and the migration of T- and B-lymphocytes into primordia resembling Peyer’s patches (Kunkel et al. xref ; Patel et al. xref )."
sparser
"Moreover, hypersialylation promotes tumor dissemination and metastasis by modulating the function of different integrins. xref For example, inhibiting sialylation in MM impairs interactions between tumor cells, VCAM1 and mucosal vascular addressin cell adhesion molecule 1 (MAD-CAM1) by altering the maturation of CD49d. xref Sialylation also participates in the generation of selectin ligands."
sparser
"The expression of some adhesion molecules on BM mononuclear cells was assessed by a panel
of MoAbs directed against: CD1 la, CDI lb, CDI lc, CD44, CD49d(VLA4), CD49e(VLA-5), LEC-CAM I.
P-170 expression
P-170 expression was evaluated by the MoAb C219 (Cis International, Centocor Diagnostics), which is an IgG2b antibody that recognizes a cytoplasmic antigen."
CALM1 affects HR
|
9
sparser
"For examples, two particular CAMS, the Gradient Weighted CAM (Grad-CAM) and High Resolution CAM (HR-CAM) have been shown to provide insights into the process of AI decision-making for oral cancer and other cancer types, with improved diagnostic performance and positive user feedback ( xref – xref )."
sparser
"Specifically, Grad-CAM generates heatmaps by computing the gradients of the target class score with respect to the feature maps of the last convolutional layers in the CNN while HR-CAM aggregates feature maps from several layers to create a high-resolution localization map ( xref )."
sparser
"The N-terminal domain (aa 22–138) of CALM contains the ANTH domain, which specifically binds to lipids (PtdIns(4,5)P 2 ) in the plasma membrane. xref , xref , xref , xref The three-dimensional structure of the N-terminal 280 amino acids of CALM has been solved and consists of 10 α-helices, which aggregate to form a globular protein. xref The C-terminal half of CALM, on the other hand, has most likely a poorly ordered structure that contains multiple short protein interaction motifs, functioning like a flexible ‘fishing line'. xref This composition of CALM permits the establishment of interactions during clathrin-coated pit assembly. xref Interestingly, FHL2 binds to β-integrin, xref which together with clathrin, a major binding partner of CALM, has been shown to be involved in endocytosis. xref , xref Taken together, these data suggest a role for the CALM–FHL2 interaction in the complex interaction network in endocytosis."
CALM1 affects DRG
|
9
CALM1 affects APS
|
9
sparser
"Our sample shows a similar phenomenon, with a significant increase in TIR after 12 months of the implementation of an AID system, which is achieved at 3 months, regardless of the system used, with the exception of the Cam-APS system where TIR values decrease from the first 3 months to 1 year."
sparser
"Interestingly, despite the Cam-APS FX being the only licensed system to utilize ultra-rapid-acting insulin (URAI) analogs ( xref ), our analysis uncovered a lack of substantial glycemic improvement coupled with a higher frequency of adverse events when using URAI analogs with this system."
Valproic acid affects CALM1
8
|
sparser
"These values were significantly higher than those obtained from the zero-order model (0.5145 ± 0.014, 0.6242 ± 0.011, 0.5751 ± 0.024, and 0.4150 ± 0.10 for CAM gel, CAM-BE gel, CAM-ES gel, and CAM-SOL, respectively) and the Higuchi diffusion model (0.8081 ± 0.096, 0.8475 ± 0.017, 0.8203 ± 0.035, and 0.7240 ± 0.016, respectively)."
sparser
"According to xref , the results showed that after 36 h, the amount of CAM that penetrated the CAM-BE gel formulation was considerably (P<0.001) higher, at 154.37 ± 3.92 μg/cm 2 compared to 101.38 ± 2.79 μg/cm 2 , 136.02 ± 3.35 μg/cm 2 and 129.08 ± 5.10 μg/cm 2 obtained from CAM gel, CAM-ES gel and CAM-SOL."
sparser
"The higher deposition showed that CAM-BE gel accumulated for a longer period of time in the skin, serving as a reservoir and permitting CAM to function for an extended period of time at the nearby tissue of the skin’s deep layers in between treatments. xref , xref When compared to both CAM gel and CAM-SOL, the ethosomes’ ethanol, phospholipid, and edge activator considerably enhanced CAM penetration and epidermal deposition, according to earlier experimental findings."
sparser
"Related studies have shown that it is of quite interest to study the changes in lipid CH 2 in the stratum corneum, xref and the literature suggests that the position of the peaks in the spectra is due to the stretching vibrations of SC lipids, and the (-CH 2 ) asymmetric stretching vibration band of the treated skin in the PBS group appeared at 2926.31 cm −1 , which shifted to higher wave numbers after the CAM-SOL and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2927.56 cm −1 , 2929.49 cm −1 and 2940.60 cm −1 ), respectively."
sparser
"The Area 2850 peak’s decline indicated that the sample had an impact on the stratum corneum that included lipid extraction. xref Additionally, the peak’s shift to a higher wavenumber suggested that the stratum corneum’s intercellular lipid problem had increased and the CH 2 symmetric (2850 cm −1 ) vibration band of the treated skin in the CAM-SOL group appeared at 2854.27 cm −1 , which shifted to higher wave numbers after the PBS and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2853.31 cm −1 , 2852.34 cm −1 , and 2850.85 cm −1 ), respectively."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"Our investigations show no response to LFA-1/ICAM-1 alone, but that costimulation by LFA-1/CAM-1 interaction induces prolonged inositol phospholipid hydrolysis (up to 4 h), resulting in generation of both inositol(1,4,5)phosphate3 and inositol(1,3,4,5)phosphate4 and their derivatives."
sparser
"A = lack of M H C classI antigen expression by tumour cells permitting escape from cytolytic T-cells;
B=sheddingofI-CAM-1 into circulation may block T-cell receptors for this molecule and prevent tumour cell/cytolytic cell interactions; C=Tcells binding to classI antigen and D = stabilisation in association with I-CAM-1/LFA-1 interaction."
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
sparser
"These values were significantly higher than those obtained from the zero-order model (0.5145 ± 0.014, 0.6242 ± 0.011, 0.5751 ± 0.024, and 0.4150 ± 0.10 for CAM gel, CAM-BE gel, CAM-ES gel, and CAM-SOL, respectively) and the Higuchi diffusion model (0.8081 ± 0.096, 0.8475 ± 0.017, 0.8203 ± 0.035, and 0.7240 ± 0.016, respectively)."
sparser
"According to xref , the results showed that after 36 h, the amount of CAM that penetrated the CAM-BE gel formulation was considerably (P<0.001) higher, at 154.37 ± 3.92 μg/cm 2 compared to 101.38 ± 2.79 μg/cm 2 , 136.02 ± 3.35 μg/cm 2 and 129.08 ± 5.10 μg/cm 2 obtained from CAM gel, CAM-ES gel and CAM-SOL."
sparser
"The higher deposition showed that CAM-BE gel accumulated for a longer period of time in the skin, serving as a reservoir and permitting CAM to function for an extended period of time at the nearby tissue of the skin’s deep layers in between treatments. xref , xref When compared to both CAM gel and CAM-SOL, the ethosomes’ ethanol, phospholipid, and edge activator considerably enhanced CAM penetration and epidermal deposition, according to earlier experimental findings."
sparser
"Related studies have shown that it is of quite interest to study the changes in lipid CH 2 in the stratum corneum, xref and the literature suggests that the position of the peaks in the spectra is due to the stretching vibrations of SC lipids, and the (-CH 2 ) asymmetric stretching vibration band of the treated skin in the PBS group appeared at 2926.31 cm −1 , which shifted to higher wave numbers after the CAM-SOL and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2927.56 cm −1 , 2929.49 cm −1 and 2940.60 cm −1 ), respectively."
sparser
"The Area 2850 peak’s decline indicated that the sample had an impact on the stratum corneum that included lipid extraction. xref Additionally, the peak’s shift to a higher wavenumber suggested that the stratum corneum’s intercellular lipid problem had increased and the CH 2 symmetric (2850 cm −1 ) vibration band of the treated skin in the CAM-SOL group appeared at 2854.27 cm −1 , which shifted to higher wave numbers after the PBS and CAM-ES, and CAM-BE treatment shifted to higher wave numbers (2853.31 cm −1 , 2852.34 cm −1 , and 2850.85 cm −1 ), respectively."
CALM1 affects endocytosis
|
6
2
CALM1 activates endocytosis.
|
6
CALM1 activates endocytosis. 6 / 6
|
6
reach
"Recent studies by Muro et al. [35,37] revealed that to internalise anti-ICAM and anti-PECAM conjugates via constitutively non internalisable determinants ECs employ a novel, previously unknown internalisation pathway, which differs from clathrin- and caveoli mediated endocytosis and CAM mediated endocytosis."
reach
"The fact that this process takes place only in the case of multimeric ligands incubated with cells at 37degreesC, but not at 4degreesC, indicates that CAM mediated endocytosis is an active process, with close similarities to typical receptor mediated endocytosis (Muro et al., 2008)."
CALM1 inhibits endocytosis.
|
2
CALM1 inhibits endocytosis. 2 / 2
|
2
sparser
"Although the presence of this domain was required for CALM-AF10 to inhibit transferrin endocytosis in a transfected human cell line, internalization of growth factor receptors and their signaling was not affected in leukemia cells lines or in primary leukemia cells isolated from mice transplanted with cells transduced with CALM-AF10."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"We have demonstrated that a CRM1-AF10 fusion protein phenocopies CALM-AF10 in its ability to bind and activate Hoxa and Meis1 genes and to induce leukemia, supporting a model in which CRM1 enables the tethering of CALM-AF10 to Hoxa and Meis1 effector genes, thereby recruiting the AF10/DOT1L transcriptional complex and causing leukemia."
sparser
"Our investigations show no response to LFA-1/ICAM-1 alone, but that costimulation by LFA-1/CAM-1 interaction induces prolonged inositol phospholipid hydrolysis (up to 4 h), resulting in generation of both inositol(1,4,5)phosphate3 and inositol(1,3,4,5)phosphate4 and their derivatives."
sparser
"A = lack of M H C classI antigen expression by tumour cells permitting escape from cytolytic T-cells;
B=sheddingofI-CAM-1 into circulation may block T-cell receptors for this molecule and prevent tumour cell/cytolytic cell interactions; C=Tcells binding to classI antigen and D = stabilisation in association with I-CAM-1/LFA-1 interaction."
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
sparser
"Our pathway analyses highlighted biological functions—such as regulation of calcium ion transport, second messenger-mediated signaling, and maintenance of location, which encompass four dysregulated LR pairs, including CALM1-RYR2, CALM3-RYR2, CALM1-CACNA1C, CALM3-CACNA1C ( xref , Additional file 6: Table S5)."
sparser
"Our pathway analyses highlighted GO BPs—such as regulation of calcium ion transport, second messenger-mediated signaling, and maintenance of location, which encompass four dysregulated LR pairs, including CALM1-RYR2, CALM3-RYR2, CALM1-CACNA1C, and CALM3-CACNA1C (Fig. xref , Additional file xref : Table S6)."
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
sparser
"Inhibitory Killer Cell Immunoglobulin-Like Receptors KIR2DL1 and KIR2DL2/3 are reduced in both BP- and CAM-dNK cells at term compared to first trimester dNK. xref , xref At baseline, dNK and PB-NK express cytolytic molecules (PFN, GZMB, GNLY); however, PB-NK have higher PFN and GZMB and first trimester dNK (but not term dNK) have higher GNLY and 9kD GNLY. xref Unstimulated, first trimester dNK, but not PB-NK, secrete proangiogenic cytokines and growth factors (IL-6, VEGF, PLGF). xref , xref These data are supportive of a role for dNK in vascular remodeling in early gestation."
sparser
"Although certain activation receptors ( CD69 , NKp80 , NKp44 ) are expressed at the RNA level in CAM-dNK, but not in BP-dNK, functional and protein expression differences have not yet been identified. xref , xref - xref dNK function and functional receptor expression are distinct between first trimester and term (including between BP and CAM)- however, the basis for this functional change remains unclear."
sparser
"However, term dNK from the two compartments do show gene expression differences. xref scRNA-seq analyses have pointed to a relative increase in dNK in CAM, but not BP, in placentas of patients with preterm labor. xref Further, labor-associated differential interactions were identified for BP-dNK and CAM-dNK. xref We reanalyzed the Pique-Regi, 2019 scRNA-seq dataset and identified similar differences between BP- and CAM-dNK. xref Notably, we found that ~50% of the dNK in CAM are dNK2, similar to first trimester, while the dNK2 population is reduced (to 23%) in BP."
sparser
"Term BP- and CAM-dNK have higher activation responses than first trimester dNK. xref When first trimester dNK is sub-stratified by subtype, dNK3 has the highest effector response, followed by dNK2, and then dNK1. xref In agreement with the literature, we found markers associated with decreased effector function (CD9, KIR2DL1 and CD39) to be higher in first trimester dNK, while activating receptors (CD18, CD103, and CD69) was increased at term, in both BP and CAM ( xref - xref )."
sparser
"Our pathway analyses highlighted biological functions—such as regulation of calcium ion transport, second messenger-mediated signaling, and maintenance of location, which encompass four dysregulated LR pairs, including CALM1-RYR2, CALM3-RYR2, CALM1-CACNA1C, CALM3-CACNA1C ( xref , Additional file 6: Table S5)."
sparser
"Our pathway analyses highlighted GO BPs—such as regulation of calcium ion transport, second messenger-mediated signaling, and maintenance of location, which encompass four dysregulated LR pairs, including CALM1-RYR2, CALM3-RYR2, CALM1-CACNA1C, and CALM3-CACNA1C (Fig. xref , Additional file xref : Table S6)."
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
sparser
"Inhibitory Killer Cell Immunoglobulin-Like Receptors KIR2DL1 and KIR2DL2/3 are reduced in both BP- and CAM-dNK cells at term compared to first trimester dNK. xref , xref At baseline, dNK and PB-NK express cytolytic molecules (PFN, GZMB, GNLY); however, PB-NK have higher PFN and GZMB and first trimester dNK (but not term dNK) have higher GNLY and 9kD GNLY. xref Unstimulated, first trimester dNK, but not PB-NK, secrete proangiogenic cytokines and growth factors (IL-6, VEGF, PLGF). xref , xref These data are supportive of a role for dNK in vascular remodeling in early gestation."
sparser
"Although certain activation receptors ( CD69 , NKp80 , NKp44 ) are expressed at the RNA level in CAM-dNK, but not in BP-dNK, functional and protein expression differences have not yet been identified. xref , xref - xref dNK function and functional receptor expression are distinct between first trimester and term (including between BP and CAM)- however, the basis for this functional change remains unclear."
sparser
"However, term dNK from the two compartments do show gene expression differences. xref scRNA-seq analyses have pointed to a relative increase in dNK in CAM, but not BP, in placentas of patients with preterm labor. xref Further, labor-associated differential interactions were identified for BP-dNK and CAM-dNK. xref We reanalyzed the Pique-Regi, 2019 scRNA-seq dataset and identified similar differences between BP- and CAM-dNK. xref Notably, we found that ~50% of the dNK in CAM are dNK2, similar to first trimester, while the dNK2 population is reduced (to 23%) in BP."
sparser
"Term BP- and CAM-dNK have higher activation responses than first trimester dNK. xref When first trimester dNK is sub-stratified by subtype, dNK3 has the highest effector response, followed by dNK2, and then dNK1. xref In agreement with the literature, we found markers associated with decreased effector function (CD9, KIR2DL1 and CD39) to be higher in first trimester dNK, while activating receptors (CD18, CD103, and CD69) was increased at term, in both BP and CAM ( xref - xref )."
Hsa-miR-7-5p affects CALM1
7
|
Hsa-miR-450b-5p affects CALM1
7
|
Hsa-miR-3680-3p affects CALM1
7
|
Hsa-miR-1-3p affects CALM1
7
|
sparser
"These PAMPS networks, incorporating different crosslinkers, serve as the first network in the DN hydrogel, with the second network identically consisting of polyacrylamide (PAAm) crosslinked with N , N ′-methylenebis(acrylamide) (MBA) ( xref ). xref The resultant DN gels are denoted as DN-Cy, DN-Pin, and DN-Cam, respectively."
sparser
"As shown in xref and S7, xref when the gels, loaded with ferrous ions and xylenol orange (XO), were stretched to a strain of 6 and then unloaded in air, DN-Cam exhibited a noticeable colour change in the necked region, while DN-Cy and DN-Pin showed much weaker changes (see the ESI xref for a video clip)."
sparser
"Quantitative UV spectroscopic analysis revealed that DN-Cam generated approximately 130 μM mechanoradicals, over four times the amount produced by DN gels crosslinked with pinanediol and cis -cyclohexanediol, each of which generated only approximately 30 μM. Moreover, we investigated whether these mechanoradicals could trigger the polymerisation of monomers and crosslinkers, thereby endowing the gel with mechanoresponsive self-strengthening properties ( xref )."
TS affects CALM1
|
7
sparser
"To better understand the interaction between CALM and PtdIns(4,5)P 2 -enriched membranes, we employed quartz crystal microbalance with dissipation monitoring (QCM-D), which is a highly sensitive analytical technique used to detect real-time changes in both mass and viscoelastic properties of solid-supported lipid bilayers."
"The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
sparser
"Based on two nationally representative Chinese ageing cohorts (i.e. CLHLS, CHARLS), a ten-state Markov model (IMPACT-CAM), including prevalence, transition probability and mortality rate of dementia and its associated cardiovaiscualr diseases and disability, was constructed to predict dementia prevalence in people aged above 60 years by 2050, with different assumptions on the furture trends of dementia incidence and mortality rates."
| PMC
FveIF3g affects CALM1
|
7
sparser
"Unexpectedly, the mutant Fshr-CAM reversed the azoospermia and infertility of the LuRKO mice to a near-normal phenotype ( xref C,D), with normal development of the testes and accessory reproductive organs, and completion of spermatogenesis, despite delayed puberty and small litter sizes."
| PMC
sparser
"These PAMPS networks, incorporating different crosslinkers, serve as the first network in the DN hydrogel, with the second network identically consisting of polyacrylamide (PAAm) crosslinked with N , N ′-methylenebis(acrylamide) (MBA) ( xref ). xref The resultant DN gels are denoted as DN-Cy, DN-Pin, and DN-Cam, respectively."
sparser
"As shown in xref and S7, xref when the gels, loaded with ferrous ions and xylenol orange (XO), were stretched to a strain of 6 and then unloaded in air, DN-Cam exhibited a noticeable colour change in the necked region, while DN-Cy and DN-Pin showed much weaker changes (see the ESI xref for a video clip)."
sparser
"Quantitative UV spectroscopic analysis revealed that DN-Cam generated approximately 130 μM mechanoradicals, over four times the amount produced by DN gels crosslinked with pinanediol and cis -cyclohexanediol, each of which generated only approximately 30 μM. Moreover, we investigated whether these mechanoradicals could trigger the polymerisation of monomers and crosslinkers, thereby endowing the gel with mechanoresponsive self-strengthening properties ( xref )."
CALM1 affects TS
|
7
sparser
"To better understand the interaction between CALM and PtdIns(4,5)P 2 -enriched membranes, we employed quartz crystal microbalance with dissipation monitoring (QCM-D), which is a highly sensitive analytical technique used to detect real-time changes in both mass and viscoelastic properties of solid-supported lipid bilayers."
sparser
"Based on two nationally representative Chinese ageing cohorts (i.e. CLHLS, CHARLS), a ten-state Markov model (IMPACT-CAM), including prevalence, transition probability and mortality rate of dementia and its associated cardiovaiscualr diseases and disability, was constructed to predict dementia prevalence in people aged above 60 years by 2050, with different assumptions on the furture trends of dementia incidence and mortality rates."
| PMC
CALM1 affects FveIF3g
|
7
sparser
"Unexpectedly, the mutant Fshr-CAM reversed the azoospermia and infertility of the LuRKO mice to a near-normal phenotype ( xref C,D), with normal development of the testes and accessory reproductive organs, and completion of spermatogenesis, despite delayed puberty and small litter sizes."
| PMC
Trifluoperazine affects CALM1
1
3
|
2
Trichostatin A affects CALM1
|
6
Trichostatin A binds CALM1. 6 / 6
|
6
sparser
"A total of 50 patients who did not experience failure (17 CAM-TSA and 33 primary TSA) completed PRO measures at a mean follow-up of 4.8 years (range, 2.0-11.5 years), with no significant difference between the CAM-TSA (4.4 years [range, 2.1-10.5 years]) and primary TSA (5.0 years [range, 2.0-11.5 years]) groups ( P = ."
sparser
"The Diploma of Advanced Studies in Cardiac Arrhythmia Management III (DAS‐CAM III) participants initiated and conducted a survey to assess how physicians use digital devices in patients with possible AF and to identify the impact of data derived from ECG‐ and PPG‐based digital devices on clinical decision‐making."
Promethazine affects CALM1
6
|
Promethazine inhibits CALM1. 6 / 6
6
|
Loperamide affects CALM1
6
|
Loperamide inhibits CALM1. 6 / 6
6
|
Hsa-mir-3142 affects CALM1
6
|
Hsa-miR-6079 affects CALM1
6
|
Hsa-miR-6077 affects CALM1
6
|
Hsa-miR-490-5p affects CALM1
6
|
Hsa-miR-4802-3p affects CALM1
6
|
Hsa-miR-4650-5p affects CALM1
6
|
Hsa-miR-432-3p affects CALM1
6
|
Hsa-miR-3617-5p affects CALM1
6
|
Hsa-miR-1245b-5p affects CALM1
6
|
sparser
"Various strategies are used to optimize the allocation of Distributed Energy Resources (DERs), including simulation software tools like HOMER, DER-CAM, and NEPLAN xref – xref , deterministic method-ologies that involve numerical and iterative techniques xref , xref , and heuristic or metaheuristic optimization algorithms such as CS, GOA, and PSO xref , xref , xref ."
sparser
"Distributed energy resources (DER), combining technologies like CHP, WT, PV, and power-to-gas (P2G) systems have been modeled using tools such as DER-CAM and HOMER xref but many studies highlight the need for more advanced models that account for uncertainty and component interaction in dynamic environments. have been used to explore optimal design and economic efficiency; an integrated approach that combines renewable and non-renewable resources through EH modeling remains largely unexplored."
sparser
"Closing stomata in the leaves limits the activities of PEPCase (an enzyme that catalyzes the carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate in the C4 and CAM pathways of photosynthesis) and RuBPCase (an enzyme that catalyzes the fixation of carbon dioxide to ribulose-1,5-bisphosphate (RuBP) in the Calvin cycle) [ xref ]."
SD affects CALM1
|
6
Ru affects CALM1
|
6
sparser
"In this study, we have successfully prepared a cheap and efficient catalyst with uniform ruthenium nanoparticles through highly dispersed nanorod Ru–CAM precursors by a simple stirring-calcination method, which could make the Ru species highly-dispersed and avoid the bulk agglomeration in the following calcination process."
sparser
"As illustrated in xref , Ru/CNO are synthesized via a facile stirring-calcination method in which RuCl 3 ·3H 2 O from its aqueous solution coordinates with melamine through amino groups with high efficiency at first, subsequently self-assembling with cyanuric acid through hydrogen bonds to form the metal–CAM complex (Ru–CAM) precipitation with high dispersity of ruthenium."
sparser
"The exceptional HER activity could be attributed to the Ru–CAM formed through hydrogen-bond-driven self-assembly between melamine and cyanuric acid, which has a larger specific surface area and a great number of single-sites for the coordination of Ru with N and O, resulting in ruthenium precursors for subsequent annealing to be uniform ruthenium nanoparticles."
sparser
"In the second session, the posterior pole vessel characteristics of the normal ocular fundus and of vascular abnormalities characteristic of eyes with ROP (pre-plus and plus) were defined, using resources from the international classification of ROP,11 a teaching mirror and images obtained using a Ret-Cam digital camera."
PCL/PEO affects CALM1
|
6
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
PC affects CALM1
|
6
M109Q affects CALM1
|
6
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
sparser
"It indicates that ZAR1’s auto-phosphorylation is promoted by the binding of CaM1 or AGB1, but the binding is independent on the ZAR1 kinase activity, as CaM1 or AGB1 interacts with His-kinase K534>A . These data, together, strongly suggest that ZAR1, AGB1 and CaM1 form complex and the ZAR1 kinase activity is activated by the binding of CaM1 and/or AGB1."
sparser
"These results indicate that activation of FGFR in neurons by the NCAM F3 module 2 and the FG loop peptide induces neuritogenesis, and that this effect (as predicted) can be inhibited by ATP; they thus corroborate
Discussion
We here describe the structure of the NCAM F3 module 2, present the first direct evidence of an interaction between a CAM molecule and FGFR, and demonstrate a regulatory role of ATP in the NCAM-FGFR interaction."
CALM1 affects trichostatin A
|
6
Trichostatin A binds CALM1. 6 / 6
|
6
sparser
"A total of 50 patients who did not experience failure (17 CAM-TSA and 33 primary TSA) completed PRO measures at a mean follow-up of 4.8 years (range, 2.0-11.5 years), with no significant difference between the CAM-TSA (4.4 years [range, 2.1-10.5 years]) and primary TSA (5.0 years [range, 2.0-11.5 years]) groups ( P = ."
sparser
"The Diploma of Advanced Studies in Cardiac Arrhythmia Management III (DAS‐CAM III) participants initiated and conducted a survey to assess how physicians use digital devices in patients with possible AF and to identify the impact of data derived from ECG‐ and PPG‐based digital devices on clinical decision‐making."
sparser
"Various strategies are used to optimize the allocation of Distributed Energy Resources (DERs), including simulation software tools like HOMER, DER-CAM, and NEPLAN xref – xref , deterministic method-ologies that involve numerical and iterative techniques xref , xref , and heuristic or metaheuristic optimization algorithms such as CS, GOA, and PSO xref , xref , xref ."
sparser
"Distributed energy resources (DER), combining technologies like CHP, WT, PV, and power-to-gas (P2G) systems have been modeled using tools such as DER-CAM and HOMER xref but many studies highlight the need for more advanced models that account for uncertainty and component interaction in dynamic environments. have been used to explore optimal design and economic efficiency; an integrated approach that combines renewable and non-renewable resources through EH modeling remains largely unexplored."
sparser
"Closing stomata in the leaves limits the activities of PEPCase (an enzyme that catalyzes the carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate in the C4 and CAM pathways of photosynthesis) and RuBPCase (an enzyme that catalyzes the fixation of carbon dioxide to ribulose-1,5-bisphosphate (RuBP) in the Calvin cycle) [ xref ]."
CALM1 affects SD
|
6
CALM1 affects Ru
|
6
sparser
"In this study, we have successfully prepared a cheap and efficient catalyst with uniform ruthenium nanoparticles through highly dispersed nanorod Ru–CAM precursors by a simple stirring-calcination method, which could make the Ru species highly-dispersed and avoid the bulk agglomeration in the following calcination process."
sparser
"As illustrated in xref , Ru/CNO are synthesized via a facile stirring-calcination method in which RuCl 3 ·3H 2 O from its aqueous solution coordinates with melamine through amino groups with high efficiency at first, subsequently self-assembling with cyanuric acid through hydrogen bonds to form the metal–CAM complex (Ru–CAM) precipitation with high dispersity of ruthenium."
sparser
"The exceptional HER activity could be attributed to the Ru–CAM formed through hydrogen-bond-driven self-assembly between melamine and cyanuric acid, which has a larger specific surface area and a great number of single-sites for the coordination of Ru with N and O, resulting in ruthenium precursors for subsequent annealing to be uniform ruthenium nanoparticles."
sparser
"In the second session, the posterior pole vessel characteristics of the normal ocular fundus and of vascular abnormalities characteristic of eyes with ROP (pre-plus and plus) were defined, using resources from the international classification of ROP,11 a teaching mirror and images obtained using a Ret-Cam digital camera."
CALM1 affects PCL/PEO
|
6
sparser
"As shown before for the CAM-PCL/PEO
dressing, 90% of the drug is released in the first 60 min, but for
the CAM-PCL dressing, the amount of drug released is only 40% after
24 h and up to 50% after 48 h. xref Therefore,
the available drug concentration after 24 h of treatment is different,
being higher when using the CAM-PCL/PEO dressing."
sparser
"As previously shown, the drug
release kinetics into 10 mL 1 × PBS differ between the two wound
dressings, although no differences in the disk diffusion assay (release
into the gel) were seen. xref Interestingly,
previously reported biofilm assays revealed that the CAM-PCL dressing
was more effective compared with the CAM-PCL/PEO dressing on E. coli CFT073, most likely due to the different
release kinetics. xref In the current assay,
both formulations with the same drug load exhibited a similar antibiofilm
effect, as a 6-log difference was observed in bacterial numbers for E. coli and S. epidermidis ( xref A,C)."
CALM1 affects PC
|
6
CALM1 affects M109Q
|
6
reach
"These results indicated that SUMOylation of Kv7.2 and Kv7.3 specifically regulates their binding with CaM1.To verify the role of SUMOylation of Kv7.2 and Kv7.3 in their binding with CaM1, these plasmids were transfected with SUMO2, and the co-IP results showed that SUMO2 significantly enhanced the binding of both Kv7.2 and Kv7.3 with CaM1 (Fig. 4F)."
sparser
"It indicates that ZAR1’s auto-phosphorylation is promoted by the binding of CaM1 or AGB1, but the binding is independent on the ZAR1 kinase activity, as CaM1 or AGB1 interacts with His-kinase K534>A . These data, together, strongly suggest that ZAR1, AGB1 and CaM1 form complex and the ZAR1 kinase activity is activated by the binding of CaM1 and/or AGB1."
sparser
"These results indicate that activation of FGFR in neurons by the NCAM F3 module 2 and the FG loop peptide induces neuritogenesis, and that this effect (as predicted) can be inhibited by ATP; they thus corroborate
Discussion
We here describe the structure of the NCAM F3 module 2, present the first direct evidence of an interaction between a CAM molecule and FGFR, and demonstrate a regulatory role of ATP in the NCAM-FGFR interaction."
reach
"On the other hand, LPSinduced IL-8 production by human monocytes is suppressed by CAM through NF- B and AP-1.19 Although it can not be denied that CAM affects activation of AP-1, those findings suggest that the transcriptional factors responsible for the expression of IL-8 vary with the stimulants and the cells chosen for the experiment.CONCLUSION The present study demonstrates that expression ofboth IL-8 protein and mRNA in adenoidal fibroblasts is induced by HIE and IL-1 ."
CALM1 affects B3LYP/6-31G
|
6
sparser
"Density functional calculations were executed, and the geometries of losartan anion ( 1 ) were optimized at the DFT [ xref ] level of theory (Becke three-term correlation functional; the Lee, Yang and Parr exchange functional B3LYP, or long range corrected version of the B3LYP functional, or the Perdew, Burke and Ernzerhof functional PBE1PBE) or applying the Mőller–Plesset second order perturbation theory MP2 using the Gaussian 09 D.01 program [ xref ], namely the (1) B3LYP/6-31G(d,p) [ xref ], (2) CAM-B3LYP/6-31G(d,p) [ xref ], (3) B3LYP/6-311+G(d,p) [ xref , xref ], (4) PBE1PBE/6-31G(d,p) [ xref , xref ] and (5) MP2/6-31G(d,p) [ xref ] approach in the gaseous phase and applying the conductor-like polarizable continuum model (CPCM, water as a solvent) [ xref , xref , xref ]."
sparser
"NMR shielding for proton (H ref ) was calculated for TMS (tetramethylsilane) at the (1) B3LYP/6-31G(d,p), (2) CAM-B3LYP/6-31G(d,p), (3) B3LYP/6-311+G(d,p), (4) PBE1PBE/6-31G(d,p) and (5) MP2/6-31G(d,p) level of theory (gaseous phase and CPCM solvation model and water as solvent) at 293 K. It is noteworthy that the difference between dielectric constant values of water and DMSO are not significant (ε = 78.3 and 46.8, respectively [ xref ])."
sparser
"This paper focuses on the worldview hypotheses and research design approaches from nonlinear dynamical complex systems (NDS) science that can inform future studies of whole systems of complementary and alternative medicine (WS-CAM), e.g., Ayurveda, traditional Chinese medicine, and homeopathy."
B3LYP/6-31G affects CALM1
|
6
sparser
"Density functional calculations were executed, and the geometries of losartan anion ( 1 ) were optimized at the DFT [ xref ] level of theory (Becke three-term correlation functional; the Lee, Yang and Parr exchange functional B3LYP, or long range corrected version of the B3LYP functional, or the Perdew, Burke and Ernzerhof functional PBE1PBE) or applying the Mőller–Plesset second order perturbation theory MP2 using the Gaussian 09 D.01 program [ xref ], namely the (1) B3LYP/6-31G(d,p) [ xref ], (2) CAM-B3LYP/6-31G(d,p) [ xref ], (3) B3LYP/6-311+G(d,p) [ xref , xref ], (4) PBE1PBE/6-31G(d,p) [ xref , xref ] and (5) MP2/6-31G(d,p) [ xref ] approach in the gaseous phase and applying the conductor-like polarizable continuum model (CPCM, water as a solvent) [ xref , xref , xref ]."
sparser
"NMR shielding for proton (H ref ) was calculated for TMS (tetramethylsilane) at the (1) B3LYP/6-31G(d,p), (2) CAM-B3LYP/6-31G(d,p), (3) B3LYP/6-311+G(d,p), (4) PBE1PBE/6-31G(d,p) and (5) MP2/6-31G(d,p) level of theory (gaseous phase and CPCM solvation model and water as solvent) at 293 K. It is noteworthy that the difference between dielectric constant values of water and DMSO are not significant (ε = 78.3 and 46.8, respectively [ xref ])."
sparser
"This paper focuses on the worldview hypotheses and research design approaches from nonlinear dynamical complex systems (NDS) science that can inform future studies of whole systems of complementary and alternative medicine (WS-CAM), e.g., Ayurveda, traditional Chinese medicine, and homeopathy."
Monooxygenase activity affects CALM1
|
5
Monooxygenase activity binds CALM1. 5 / 5
|
5
sparser
"(1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"LDD may have a therapeutic effect on osteoporosis through regulating the targets (such as ALB, IGF1, SRC, and ESR1), biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) found in this research."
sparser
"Cluster 1 is mainly involved in several signaling pathways in osteoporosis (such as MAPK, PI3K, and JAK-STAT signaling pathway) and positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, and neovascularization during bone remodeling."
sparser
"Meanwhile, through the construction and analysis of the network, we obtained important targets for LDD and the potential biological processes and signaling pathways for the treatment of osteoporosis (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix)."
Mastoparan affects CALM1
|
2
3
Hsa-mir-1193 affects CALM1
5
|
Hsa-let-7c-3p affects CALM1
5
|
Fluphenazine affects CALM1
5
|
Calcium(0) affects CALM1
5
|
sparser
"CD designation Alternate names Expression pattern
Function
Significance
Clinical use (B-cell malignancies only)
CD5
CD10 CD11c CD19 CD20 CD22 CD23 CD79b
Leu-1, Ly-1, T1, Tp67
CALLA
α-subunit of αxβ2, p150,95
B4
B1, Leu-16, Bp35
HD39, BL-CAM, Lyb8
FcεRII, B6, Leu-20, BLAST-2
Igβ, B29
T cells, B1 subset of B cells
Enterocytes, renal tubules, glomeruli, granulocytes, T cell and B cell precursors
Monocytes, macrophages, NK cells, neutrophils, B cells and T cells
All B cells
A majority of B cells
A majority of B cells, basophils
B cells, platelets, macrophages, eosinophils, and follicular DCs1 Intracellular and
variable surface expression on B cells
Regulation of immune tolerance
Zinc metallo-peptidase specific for cleavage of 1-3 N-terminal amino acids
Cellular adhesion to fibrinogen
Amplification of BcR2 signals in complex w/CD21 and CD80
Signal transduction – growth or death signals, Ca2+ channel
Cell-cell adhesion, attenuation of BcR signals
Low affinity IgE receptor
Signaling component of the BcR
Increased propensity for malignant transformation, production of auto antigens
First antigen marker used in the diagnosis of malignant disease (ALL)
Characteristically overexpressed on hairy cells
T101 mAb against CLL (39,40)
J5 mAb against ALL (41)
none
B cell specific surface CBL-CD19 mAb
antigen
against B-NHL
(33,34)
Target of 1st FDA
IDEC-C2B8 mAb
approved mAb,
against B-NHL
rituximab (IDEC-C2B8) (20,23,30,32)
B cell specific surface Radiolabeled hLL2
antigen
against B-NHL (42)
Characteristically expressed on CLL cells
none
B cell specific surface none antigen
Quantitative Flow Cytometry of B-Cell Neoplasms 97
Table 2: Antibody-fluorochrome panels used for clinical flow cytometry between the years 1997 and 2003."
sparser
"The children were eligible for minor surgery, and the adults were
Early Decline in the Precursor B-cell Pool
TABLE 1 The set of monoclonal antibodies used for the selected quadruple immunostainings to separate precursor B-cell subsets in normal bone marrow
Combination
CD
Clone
Fluorochromes
Manufacturer
1
CD10
HI10A
FITC
BD Biosciences
CD20
L27
PE
BD Biosciences
CD19
J4.119
PECy5
Immunotec
CD45
2DI
APC
BD Biosciences
2
CD34
8G12
FITC
BD Biosciences
CD22
BL-CAM
PE
BD Biosciences
CD19
J4.119
PECy5
Immunotec
CD45
2DI
APC
BD Biosciences
33
Downloaded by [University of Wisconsin - Madison] at 11:32 13 January 2018
voluntary health care workers."
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
Subcutaneous Fat affects CALM1
|
5
Subcutaneous Fat binds CALM1. 5 / 5
|
5
sparser
"In an international adaptation, xref used the EVM and cultural sensitivity model (CSM; xref ) to adapt language, content, concepts, metaphors, and context dimensions of the Keeping it Real (KiR) school-based intervention in Mexico. xref implemented the xref model of cultural adaptations. xref reported using the Cultural Accommodation Model for Substance Abuse Treatment (CAM-SAT; xref )."
sparser
"Specifically, regarding substance abuse treatment, the Cultural Accommodation Model for Substance Abuse Treatment (CAM-SAT) ( xref ) was developed as a framework for guiding the development and testing of culturally accommodated versions of (face-to-face) treatment content and delivery to increase cultural relevance for Latino adolescents."
ResNet18 affects CALM1
|
5
Psn affects CALM1
|
5
PreIQ affects CALM1
|
5
|
5
Phenoxybenzamine affects CALM1
5
|
Mel affects CALM1
|
5
sparser
"The diagnosis was made based on the increased serum levels of β‐HCG and confirmed by the pathological report after D&C. Therefore, measurement of the serum values of β‐HCG can be beneficial in the diagnosis of both the primary and gestational presentations and secondary/metastatic conditions; β‐HCG can help determine the possibility of a germ cell or GTD origin of the tumor or rule out the differentiation of an epithelial tumor. xref Furthermore, immunohistochemical analysis has revealed the presence of antibodies, such as Mel‐CAM, HLA‐G, MUC‐4, and β‐catenin in the specimens, which suggests the possible mechanisms of the development of choriocarcinoma. xref Consistent with this notion, in our patient, an immunohistochemistry study revealed positive CK, Sall 4, high ki‐67 (>90%), and negative p63."
sparser
"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."
reach
"These relative protein levels, binding affinities and low Ca concentrations favor Cam1 binding to Myo1, over Cam2 at both IQ sites (Figure 8B), consistent with in vivo observations.Although Ca levels are low during vegetative growth, sporadic prolonged calcium bursts occur upon pheromone release during mating (Carbó et al., 2017; Iida et al., 1990), and levels elevate significantly (~10 fold) during the subsequent meiosis and sporulation (Suizu et al., 1995)."
KIF1Bbeta affects CALM1
|
5
sparser
"By incorporating genetic algorithms and particle swarm optimization, alongside temporal convolutional networks and domain-adversarial learning, the model achieved 94.2 percent classification accuracy and demonstrated strong generalization across diverse datasets, while SHAP-CAM enhanced interpretability for clinical decision-making."
sparser
"Our results demonstrated that (1) the five-dimensional classifiers (image quality, retinopathy, maculopathy gradability, maculopathy and photocoagulation) achieved high accuracy in each classification; (2) a three-level referable DR decision (image, eye and patient level) could be automatically generated by the DL platform; and (3) visualisation by the SHAP-CAM heatmaps provided the explainability for the referable lesion prediction from the platform."
sparser
"Further analysis revealed little change in MeCP2 distribution upon Fl-H1.0 expression: Principal component analysis revealed no clear separation between wild-type and Cam-tTA:Fl-H1.0 mice ( xref ); Spearman correlation coefficients of MeCP2 enrichment between wild-type and Cam-tTA:Fl-H1.0 mice was 0.93 at the binning size of 10 kb ( xref )."
sparser
"The global simulations all appear aggregated to some extent, but there is diversity in the spatial structure of convection; some simulations have one or two hemisphere‐scale aggregated regions (e.g., NICAM and CAM5), some have quasi‐regularly spaced aggregated clusters (e.g., UKMO‐GA7.1, ECHAM, ICON‐GCM, and IPSL‐CM6), some have convection organized along irregular lines (e.g., CNRM‐CM6‐1), and others seem only partially aggregated, with only a few dry, clear patches amidst more uniform convection (e.g., CAM6‐GCM, GEOS‐GCM, and MPAS)."
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
EA affects CALM1
|
5
sparser
"For a deep analysis of CAM interaction with Cp at the dimer–dimer interface and the optimal prediction of Cp mutations that confer resistance to CAMs, we analyzed CAM interaction with Cp in the context of capsids or CpY132A hexamer from the structures deposited in the database in detail."
sparser
"In the Y132A mutant, each of the three dimer-dimer interfaces in the hexamer accommodates one CAM (Fig. xref ), while in the Cp150 capsid, only one CAM binds per dimer in the B and C subunits (Fig. xref ); how this relates to CAM binding to wild-type Cp remains to be determined, because as the aberrant, irregular assemblies observed upon addition of CAM-A to wild-type Cp149 and alike have not been investigated by any direct structural approaches."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
CALM1 affects production
|
5
sparser
"For instance, both CAM and erythromycin (EM) inhibit the production of inflammatory cytokines, such as interleukin (IL)-6 and IL-8, inhibit the release of soluble intracellular adhesion molecule (ICAM)-1 from airway epithelial cells, and decrease airway neutrophil accumulation [ xref , xref ]."
CALM1 affects monooxygenase activity
|
5
Monooxygenase activity binds CALM1. 5 / 5
|
5
sparser
"(1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"LDD may have a therapeutic effect on osteoporosis through regulating the targets (such as ALB, IGF1, SRC, and ESR1), biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) found in this research."
sparser
"Cluster 1 is mainly involved in several signaling pathways in osteoporosis (such as MAPK, PI3K, and JAK-STAT signaling pathway) and positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, and neovascularization during bone remodeling."
sparser
"Meanwhile, through the construction and analysis of the network, we obtained important targets for LDD and the potential biological processes and signaling pathways for the treatment of osteoporosis (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix)."
CALM1 affects mastoparan
|
2
3
CALM1 affects formation
|
5
sparser
"CD designation Alternate names Expression pattern
Function
Significance
Clinical use (B-cell malignancies only)
CD5
CD10 CD11c CD19 CD20 CD22 CD23 CD79b
Leu-1, Ly-1, T1, Tp67
CALLA
α-subunit of αxβ2, p150,95
B4
B1, Leu-16, Bp35
HD39, BL-CAM, Lyb8
FcεRII, B6, Leu-20, BLAST-2
Igβ, B29
T cells, B1 subset of B cells
Enterocytes, renal tubules, glomeruli, granulocytes, T cell and B cell precursors
Monocytes, macrophages, NK cells, neutrophils, B cells and T cells
All B cells
A majority of B cells
A majority of B cells, basophils
B cells, platelets, macrophages, eosinophils, and follicular DCs1 Intracellular and
variable surface expression on B cells
Regulation of immune tolerance
Zinc metallo-peptidase specific for cleavage of 1-3 N-terminal amino acids
Cellular adhesion to fibrinogen
Amplification of BcR2 signals in complex w/CD21 and CD80
Signal transduction – growth or death signals, Ca2+ channel
Cell-cell adhesion, attenuation of BcR signals
Low affinity IgE receptor
Signaling component of the BcR
Increased propensity for malignant transformation, production of auto antigens
First antigen marker used in the diagnosis of malignant disease (ALL)
Characteristically overexpressed on hairy cells
T101 mAb against CLL (39,40)
J5 mAb against ALL (41)
none
B cell specific surface CBL-CD19 mAb
antigen
against B-NHL
(33,34)
Target of 1st FDA
IDEC-C2B8 mAb
approved mAb,
against B-NHL
rituximab (IDEC-C2B8) (20,23,30,32)
B cell specific surface Radiolabeled hLL2
antigen
against B-NHL (42)
Characteristically expressed on CLL cells
none
B cell specific surface none antigen
Quantitative Flow Cytometry of B-Cell Neoplasms 97
Table 2: Antibody-fluorochrome panels used for clinical flow cytometry between the years 1997 and 2003."
sparser
"The children were eligible for minor surgery, and the adults were
Early Decline in the Precursor B-cell Pool
TABLE 1 The set of monoclonal antibodies used for the selected quadruple immunostainings to separate precursor B-cell subsets in normal bone marrow
Combination
CD
Clone
Fluorochromes
Manufacturer
1
CD10
HI10A
FITC
BD Biosciences
CD20
L27
PE
BD Biosciences
CD19
J4.119
PECy5
Immunotec
CD45
2DI
APC
BD Biosciences
2
CD34
8G12
FITC
BD Biosciences
CD22
BL-CAM
PE
BD Biosciences
CD19
J4.119
PECy5
Immunotec
CD45
2DI
APC
BD Biosciences
33
Downloaded by [University of Wisconsin - Madison] at 11:32 13 January 2018
voluntary health care workers."
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
CALM1 affects Subcutaneous Fat
|
5
Subcutaneous Fat binds CALM1. 5 / 5
|
5
sparser
"In an international adaptation, xref used the EVM and cultural sensitivity model (CSM; xref ) to adapt language, content, concepts, metaphors, and context dimensions of the Keeping it Real (KiR) school-based intervention in Mexico. xref implemented the xref model of cultural adaptations. xref reported using the Cultural Accommodation Model for Substance Abuse Treatment (CAM-SAT; xref )."
sparser
"Specifically, regarding substance abuse treatment, the Cultural Accommodation Model for Substance Abuse Treatment (CAM-SAT) ( xref ) was developed as a framework for guiding the development and testing of culturally accommodated versions of (face-to-face) treatment content and delivery to increase cultural relevance for Latino adolescents."
CALM1 affects ResNet18
|
5
CALM1 affects Psn
|
5
CALM1 affects PreIQ
|
5
|
5
CALM1 affects Mel
|
5
sparser
"The diagnosis was made based on the increased serum levels of β‐HCG and confirmed by the pathological report after D&C. Therefore, measurement of the serum values of β‐HCG can be beneficial in the diagnosis of both the primary and gestational presentations and secondary/metastatic conditions; β‐HCG can help determine the possibility of a germ cell or GTD origin of the tumor or rule out the differentiation of an epithelial tumor. xref Furthermore, immunohistochemical analysis has revealed the presence of antibodies, such as Mel‐CAM, HLA‐G, MUC‐4, and β‐catenin in the specimens, which suggests the possible mechanisms of the development of choriocarcinoma. xref Consistent with this notion, in our patient, an immunohistochemistry study revealed positive CK, Sall 4, high ki‐67 (>90%), and negative p63."
sparser
"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."
reach
"These relative protein levels, binding affinities and low Ca concentrations favor Cam1 binding to Myo1, over Cam2 at both IQ sites (Figure 8B), consistent with in vivo observations.Although Ca levels are low during vegetative growth, sporadic prolonged calcium bursts occur upon pheromone release during mating (Carbó et al., 2017; Iida et al., 1990), and levels elevate significantly (~10 fold) during the subsequent meiosis and sporulation (Suizu et al., 1995)."
CALM1 affects KIF1Bbeta
|
5
sparser
"By incorporating genetic algorithms and particle swarm optimization, alongside temporal convolutional networks and domain-adversarial learning, the model achieved 94.2 percent classification accuracy and demonstrated strong generalization across diverse datasets, while SHAP-CAM enhanced interpretability for clinical decision-making."
sparser
"Our results demonstrated that (1) the five-dimensional classifiers (image quality, retinopathy, maculopathy gradability, maculopathy and photocoagulation) achieved high accuracy in each classification; (2) a three-level referable DR decision (image, eye and patient level) could be automatically generated by the DL platform; and (3) visualisation by the SHAP-CAM heatmaps provided the explainability for the referable lesion prediction from the platform."
sparser
"Further analysis revealed little change in MeCP2 distribution upon Fl-H1.0 expression: Principal component analysis revealed no clear separation between wild-type and Cam-tTA:Fl-H1.0 mice ( xref ); Spearman correlation coefficients of MeCP2 enrichment between wild-type and Cam-tTA:Fl-H1.0 mice was 0.93 at the binning size of 10 kb ( xref )."
sparser
"The global simulations all appear aggregated to some extent, but there is diversity in the spatial structure of convection; some simulations have one or two hemisphere‐scale aggregated regions (e.g., NICAM and CAM5), some have quasi‐regularly spaced aggregated clusters (e.g., UKMO‐GA7.1, ECHAM, ICON‐GCM, and IPSL‐CM6), some have convection organized along irregular lines (e.g., CNRM‐CM6‐1), and others seem only partially aggregated, with only a few dry, clear patches amidst more uniform convection (e.g., CAM6‐GCM, GEOS‐GCM, and MPAS)."
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
sparser
"For a deep analysis of CAM interaction with Cp at the dimer–dimer interface and the optimal prediction of Cp mutations that confer resistance to CAMs, we analyzed CAM interaction with Cp in the context of capsids or CpY132A hexamer from the structures deposited in the database in detail."
sparser
"In the Y132A mutant, each of the three dimer-dimer interfaces in the hexamer accommodates one CAM (Fig. xref ), while in the Cp150 capsid, only one CAM binds per dimer in the B and C subunits (Fig. xref ); how this relates to CAM binding to wild-type Cp remains to be determined, because as the aberrant, irregular assemblies observed upon addition of CAM-A to wild-type Cp149 and alike have not been investigated by any direct structural approaches."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
Phosphatidylcholine affects CALM1
|
4
Perphenazine affects CALM1
4
|
Hydroxyproline affects CALM1
|
4
Hsa-miR-106a-3p affects CALM1
4
|
Extracellular matrix affects CALM1
|
4
Cinchocaine affects CALM1
4
|
Bis(2-ethylhexyl) phthalate affects CALM1
4
|
WRKY53 affects CALM1
|
4
sparser
"To determine whether these conserved amino acids play key roles in the interaction between CAM1 and WRKY53, we mutated these amino acids to R. Only the simultaneous mutation of all four amino acids significantly affected the binding of CAM1 and WRKY53 ( xref e), which suggested that 57 V, 67 S, 68 L and 69 L form a fixed structure that combines with CAM1."
Venom factor affects CALM1
|
4
CALM1 binds Venom factor. 4 / 4
|
4
sparser
"This suggests that the initial recovery kinetics (up to 80%) distinguishes the reference foam clearly from the modified ones, whereas the final stage of shape recovery (from 80% to 95%) occurs with greater variability even within the bio-based group – particularly between VF-CAR (99.9 s) and VF-CAM (78.3 s)."
Sar affects CALM1
|
4
RBP45 affects CALM1
|
4
sparser
"However, the amount of GFP‐siRNAs in the patches receiving pCAMBIA1300‐35S‐GFP and pCAM‐RBP45 was significantly higher than that in the patches receiving pCAMBIA1300‐35S‐GFP and the empty vector, indicating that NtRBP45 facilitated siRNA accumulation and thus enhanced a sense transgene‐induced PTGS locally."
sparser
"After the immunoprecipitation (or immunodepletion) of CD235a, CD41a, and CD45 vesicles, the MEL-CAM antibody (CD146, expressed on the surface of SK-MEL-28 cells) still recognized the 64% of input EVs (light green vs light grey bars) positive to the epithelial marker, in contrast to the AL-CAM (CD166) antibody which resulted as an experimental negative control ( xref b)."
sparser
"On the other hand, in ETT, MEL-CAM and hPL are expressed only in individual cells while inhibin is diffusely positive in tumor cells; lastly, GC presents several staining patterns based on different types of neoplastic cells (syncytiotrophoblasts, cytotrophoblasts and intermediate trophoblasts), but the diagnostic key is the high mitotic index (Ki-67 > 90%) with a diffuse positivity for hCG xref ( xref )."
PR affects CALM1
|
4
sparser
"Forty-eight substrates ( n = 12/material) in the design of a mandibular first molar were fabricated using CAM (CAM-TD, Thermeo, pro3dure medical GmbH, Iserlohn, Germany; CAM-CL, CLEARsplint, Astron Dental Corporation, Lake Zurich, USA) and 3DP (3DP-GI, GR22 flex, pro3dure medical GmbH; 3DP-KY, KeySplint soft, Keystone Industries, Gibbstown, USA)."
sparser
"A post hoc power analysis (R Version 4.1.1 Patched (RStudio 2021.09.2 Build 382), RStudio, Boston, USA) comparing two-body wear values of CAM-TD and 3DP-GI showed that a sample size of 12 specimens per group, an observed effect of − 0.37 mm and a pooled SD of 0.32 mm yielded a statistical power of p = 0.8 (80%)."
NH affects CALM1
|
4
sparser
"The dissociation and rate constants for the branch of the pathway starting with NH 2 -CAM binding are more difficult to determine directly because of the lack of a spectral change upon NH 2 -CAM binding, the similarity of the rate constants for P formation and decay, and the inability to limit the reaction to a few steps."
Multiple Myeloma affects Dr
|
4
Multiple Myeloma binds Dr and CALM1. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"The soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) along with C-reactive protein (CRP) levels are vascular inflammatory markers for endothelial dysfunction associated with increased risk of diabetes and coronary heart disease xref , xref ."
sparser
"Total body dual-energy x-ray absorptiometry, abdominal computed tomography scans, hyperinsulinemic-euglycemic clamps, adipose tissue biopsies (n=28), and blood for Homeostasis model assessment-insulin resistance, and soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA)."
IR affects CALM1
|
4
sparser
"Other resistance mechanisms include overexpression of complement inhibitory protein as CD55 and CD59; bone marrow stromal cells (BMSC)-mediated suppression of ADCC by upregulating protein survivin in MM cells (cell adhesion-mediated immune resistance, CAM-IR); Fc-gamma-receptor polymorphisms, affecting ADCC and ADCP; reduction of NK cells, the most important mediators of daratumumab-mediated ADCC; production of neutralizing antibodies. xref Several studies are evaluating strategies that may overcome resistance to CD38 mAbs, such as adding pembrolizumab, a humanized PD-1 mAb, to daratumumab xref or combining daratumumab with azacitidine. xref Moreover, recent data support the possibility of treating patients refractory to daratumumab with isatuximab, due to MM cells “re-sensitization” after withdrawal daratumumab. xref However, the multicenter retrospective MAMMOTH study xref demonstrated that patients who become refractory to CD38 and those “penta-refractory” (refractory to CD38 mAb, two PIs and two IMiDs) had median OS of 8.6 and 5.6 months, respectively, so this poor outcome requires development and introduction in clinical practice of innovative therapeutic options."
"Inhibition of voltage-gated calcium channels by Gem requires GTP and calmodulin binding, but not phosphorylation of serine 261 or 289. Calmodulin binding in the C-terminal extension of Gem is required for maximal inhibition of HVA Ca2+ channels by ectopically expressed Gem, as determined by measurement of electrical activity in primary neurons and by Ca2+-evoked secretion in PC12 cells."
"Inhibition of voltage-gated calcium channels by Gem requires GTP and calmodulin binding, but not phosphorylation of serine 261 or 289. Calmodulin binding in the C-terminal extension of Gem is required for maximal inhibition of HVA Ca2+ channels by ectopically expressed Gem, as determined by measurement of electrical activity in primary neurons and by Ca2+-evoked secretion in PC12 cells."
reach
"Furthermore, malignant epithelial cells may accelerate the proliferation of CD4 Tregs and CD8 Tex through CALM1/FAS binding, and then activate the downstream nuclear factor kB (NF‐kB) transcript factors, such as NFKBIA, NFKB2 and REL, regulating downstream CCND2, CDK6 and TRAF1 expression (Figure S5)."
Dr affects Multiple Myeloma
|
4
Multiple Myeloma binds Dr and CALM1. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
CDs affects CALM1
|
4
sparser
"CAM-CDs also can reduce oxidative stress markers (MDA), increase PGE2 and mucin secretion (MUC5AC), and it simultaneously exerts slight inhibition of hydrogen potassium ATPase and pepsin activity to protect gastric mucosa, as well as increases the microbial diversity and regulates species composition of gut microbiota in rats with gastric ulcer."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects signal transduction
|
4
CALM1 activates signal transduction. 4 / 4
|
4
reach
"In some cases (e.g. CD44, N-cadherin) this CAM proteolysis additionally initiates an intracellular signalling pathway by the subsequent release of intracellular protein fragments, which participate in signal transduction.Many CAMs such as cadherins, selectins or members of the immunoglobulin superfamily are released as soluble forms in vitro and in vivo."
CALM1 affects protein synthesis
|
4
CALM1 affects phosphatidylcholine
|
4
CALM1 affects hydroxyproline
|
4
CALM1 affects extracellular matrix
|
4
CALM1 affects carbon monoxide
|
4
CALM1 affects activation
|
4
CALM1 affects WRKY53
|
4
sparser
"To determine whether these conserved amino acids play key roles in the interaction between CAM1 and WRKY53, we mutated these amino acids to R. Only the simultaneous mutation of all four amino acids significantly affected the binding of CAM1 and WRKY53 ( xref e), which suggested that 57 V, 67 S, 68 L and 69 L form a fixed structure that combines with CAM1."
CALM1 affects Venom factor
|
4
CALM1 binds Venom factor. 4 / 4
|
4
sparser
"This suggests that the initial recovery kinetics (up to 80%) distinguishes the reference foam clearly from the modified ones, whereas the final stage of shape recovery (from 80% to 95%) occurs with greater variability even within the bio-based group – particularly between VF-CAR (99.9 s) and VF-CAM (78.3 s)."
CALM1 affects Sar
|
4
CALM1 affects RBP45
|
4
sparser
"However, the amount of GFP‐siRNAs in the patches receiving pCAMBIA1300‐35S‐GFP and pCAM‐RBP45 was significantly higher than that in the patches receiving pCAMBIA1300‐35S‐GFP and the empty vector, indicating that NtRBP45 facilitated siRNA accumulation and thus enhanced a sense transgene‐induced PTGS locally."
sparser
"After the immunoprecipitation (or immunodepletion) of CD235a, CD41a, and CD45 vesicles, the MEL-CAM antibody (CD146, expressed on the surface of SK-MEL-28 cells) still recognized the 64% of input EVs (light green vs light grey bars) positive to the epithelial marker, in contrast to the AL-CAM (CD166) antibody which resulted as an experimental negative control ( xref b)."
sparser
"On the other hand, in ETT, MEL-CAM and hPL are expressed only in individual cells while inhibin is diffusely positive in tumor cells; lastly, GC presents several staining patterns based on different types of neoplastic cells (syncytiotrophoblasts, cytotrophoblasts and intermediate trophoblasts), but the diagnostic key is the high mitotic index (Ki-67 > 90%) with a diffuse positivity for hCG xref ( xref )."
CALM1 affects PR
|
4
sparser
"Forty-eight substrates ( n = 12/material) in the design of a mandibular first molar were fabricated using CAM (CAM-TD, Thermeo, pro3dure medical GmbH, Iserlohn, Germany; CAM-CL, CLEARsplint, Astron Dental Corporation, Lake Zurich, USA) and 3DP (3DP-GI, GR22 flex, pro3dure medical GmbH; 3DP-KY, KeySplint soft, Keystone Industries, Gibbstown, USA)."
sparser
"A post hoc power analysis (R Version 4.1.1 Patched (RStudio 2021.09.2 Build 382), RStudio, Boston, USA) comparing two-body wear values of CAM-TD and 3DP-GI showed that a sample size of 12 specimens per group, an observed effect of − 0.37 mm and a pooled SD of 0.32 mm yielded a statistical power of p = 0.8 (80%)."
CALM1 affects NH
|
4
sparser
"The dissociation and rate constants for the branch of the pathway starting with NH 2 -CAM binding are more difficult to determine directly because of the lack of a spectral change upon NH 2 -CAM binding, the similarity of the rate constants for P formation and decay, and the inability to limit the reaction to a few steps."
CALM1 affects Multiple Myeloma
|
4
Multiple Myeloma binds Dr and CALM1. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
CALM1 affects LQT14
|
4
sparser
"The soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) along with C-reactive protein (CRP) levels are vascular inflammatory markers for endothelial dysfunction associated with increased risk of diabetes and coronary heart disease xref , xref ."
sparser
"Total body dual-energy x-ray absorptiometry, abdominal computed tomography scans, hyperinsulinemic-euglycemic clamps, adipose tissue biopsies (n=28), and blood for Homeostasis model assessment-insulin resistance, and soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA)."
CALM1 affects IR
|
4
sparser
"Other resistance mechanisms include overexpression of complement inhibitory protein as CD55 and CD59; bone marrow stromal cells (BMSC)-mediated suppression of ADCC by upregulating protein survivin in MM cells (cell adhesion-mediated immune resistance, CAM-IR); Fc-gamma-receptor polymorphisms, affecting ADCC and ADCP; reduction of NK cells, the most important mediators of daratumumab-mediated ADCC; production of neutralizing antibodies. xref Several studies are evaluating strategies that may overcome resistance to CD38 mAbs, such as adding pembrolizumab, a humanized PD-1 mAb, to daratumumab xref or combining daratumumab with azacitidine. xref Moreover, recent data support the possibility of treating patients refractory to daratumumab with isatuximab, due to MM cells “re-sensitization” after withdrawal daratumumab. xref However, the multicenter retrospective MAMMOTH study xref demonstrated that patients who become refractory to CD38 and those “penta-refractory” (refractory to CD38 mAb, two PIs and two IMiDs) had median OS of 8.6 and 5.6 months, respectively, so this poor outcome requires development and introduction in clinical practice of innovative therapeutic options."
"Inhibition of voltage-gated calcium channels by Gem requires GTP and calmodulin binding, but not phosphorylation of serine 261 or 289. Calmodulin binding in the C-terminal extension of Gem is required for maximal inhibition of HVA Ca2+ channels by ectopically expressed Gem, as determined by measurement of electrical activity in primary neurons and by Ca2+-evoked secretion in PC12 cells."
"Inhibition of voltage-gated calcium channels by Gem requires GTP and calmodulin binding, but not phosphorylation of serine 261 or 289. Calmodulin binding in the C-terminal extension of Gem is required for maximal inhibition of HVA Ca2+ channels by ectopically expressed Gem, as determined by measurement of electrical activity in primary neurons and by Ca2+-evoked secretion in PC12 cells."
reach
"Furthermore, malignant epithelial cells may accelerate the proliferation of CD4 Tregs and CD8 Tex through CALM1/FAS binding, and then activate the downstream nuclear factor kB (NF‐kB) transcript factors, such as NFKBIA, NFKB2 and REL, regulating downstream CCND2, CDK6 and TRAF1 expression (Figure S5)."
CALM1 affects Dr, and Multiple Myeloma
|
4
Multiple Myeloma binds Dr and CALM1. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
CALM1 affects CDs
|
4
sparser
"CAM-CDs also can reduce oxidative stress markers (MDA), increase PGE2 and mucin secretion (MUC5AC), and it simultaneously exerts slight inhibition of hydrogen potassium ATPase and pepsin activity to protect gastric mucosa, as well as increases the microbial diversity and regulates species composition of gut microbiota in rats with gastric ulcer."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"If HPs were to routinely conduct a checklist-type exercise similar to the modified MIS-CAM tool, participants may find it easier to identify and report their risk-taking behaviours that they may otherwise feel uncomfortable discussing, either due to associated stigma or because they are unsure whether it qualifies as a ‘valid’ risk-taking behaviour."
sparser
"Our classification system (section ‘Suggested classification system for risk-taking behaviours’) presents a unified list of risk-taking behaviours based on empirical evidence which includes, extends and updates those behaviours currently documented in available risk-taking behaviour measures (a synthesised list is provided in). xref The evidence from both the risk-taking questionnaire and the narrative interviews (sections ‘The risk-taking questionnaire (modified MIS-CAM)’ and ‘Corpus analysis and qualitative evidence for key interview themes’) suggests that HPs generally demonstrate knowledge of the types of risk-taking that people living with bipolar engage in, although specific behaviours such as taking recreational drugs and attempting suicide may be overrepresented and other behaviours such as breaking social boundaries, excessive eating and extreme sports may be underrepresented."
sparser
"Amino acid divergence between the FCHO1 and structurally related FCHO2 (53% identity) and Sgip1 (49% identity) μHDs is paralleled by differences in partner protein selectivity; FCHO2 and Sgip1 contact a subset of FCHO1 partners ( xref , xref , xref ) including EPS15 ( xref E), but only the FCHO1 μHD binds to HRB and CALM in our assays."
Air Pollutants affects CALM1
4
|
sparser
"If HPs were to routinely conduct a checklist-type exercise similar to the modified MIS-CAM tool, participants may find it easier to identify and report their risk-taking behaviours that they may otherwise feel uncomfortable discussing, either due to associated stigma or because they are unsure whether it qualifies as a ‘valid’ risk-taking behaviour."
sparser
"Our classification system (section ‘Suggested classification system for risk-taking behaviours’) presents a unified list of risk-taking behaviours based on empirical evidence which includes, extends and updates those behaviours currently documented in available risk-taking behaviour measures (a synthesised list is provided in). xref The evidence from both the risk-taking questionnaire and the narrative interviews (sections ‘The risk-taking questionnaire (modified MIS-CAM)’ and ‘Corpus analysis and qualitative evidence for key interview themes’) suggests that HPs generally demonstrate knowledge of the types of risk-taking that people living with bipolar engage in, although specific behaviours such as taking recreational drugs and attempting suicide may be overrepresented and other behaviours such as breaking social boundaries, excessive eating and extreme sports may be underrepresented."
sparser
"Amino acid divergence between the FCHO1 and structurally related FCHO2 (53% identity) and Sgip1 (49% identity) μHDs is paralleled by differences in partner protein selectivity; FCHO2 and Sgip1 contact a subset of FCHO1 partners ( xref , xref , xref ) including EPS15 ( xref E), but only the FCHO1 μHD binds to HRB and CALM in our assays."
Tetrachloromethane affects CALM1
3
|
Sodium arsenite affects CALM1
3
|
Nitrendipine affects CALM1
|
3
MiR-26b affects CALM1
|
3
reach
"MiR-26b targeted CALM1 and affected the expression of CaM at the post-transcriptional level, which likely contributed to the progression of ACI brain injury.KEYWORDS : Acute cerebral infarction, calmodulin, NIHSS, miRNA-26bIntroductionStroke is a leading cause of death and long-term disability worldwide."
Hsa-mir-4729 affects CALM1
3
|
Hsa-mir-4696 affects CALM1
3
|
Hsa-mir-4530 affects CALM1
3
|
Hsa-mir-4439 affects CALM1
3
|
Hsa-mir-4311 affects CALM1
3
|
Hsa-mir-4295 affects CALM1
3
|
Hsa-mir-4280 affects CALM1
3
|
Hsa-mir-3666 affects CALM1
3
|
Hsa-mir-3163 affects CALM1
3
|
Hsa-mir-3123 affects CALM1
3
|
Hsa-miR-7851-3p affects CALM1
3
|
Hsa-miR-653-5p affects CALM1
3
|
Hsa-miR-619-3p affects CALM1
3
|
Hsa-miR-5590-3p affects CALM1
3
|
Hsa-miR-5580-3p affects CALM1
3
|
Hsa-miR-548c-3p affects CALM1
3
|
Hsa-miR-4671-3p affects CALM1
3
|
Hsa-miR-454-3p affects CALM1
3
|
Hsa-miR-3613-3p affects CALM1
3
|
Hsa-miR-3136-5p affects CALM1
3
|
Hsa-miR-301b-3p affects CALM1
3
|
Hsa-miR-301a-3p affects CALM1
3
|
Hsa-miR-19b-2-5p affects CALM1
3
|
Hsa-miR-19b-1-5p affects CALM1
3
|
Hsa-miR-19a-5p affects CALM1
3
|
Hsa-miR-1911-5p affects CALM1
3
|
Hsa-miR-142-5p affects CALM1
3
|
Hsa-miR-130b-3p affects CALM1
3
|
Hsa-miR-130a-3p affects CALM1
3
|
Hsa-miR-129-5p affects CALM1
3
|
Flunarizine affects CALM1
3
|
Chlorpromazine affects CALM1
2
|
1
Calcium atom affects CALM1
1
|
2
Calcium atom activates CALM1. 3 / 3
1
|
2
reach
"(%) (n = 161) Vitamins HerbsGarlic Echinacea Chamomile Licorice Ginko biloba Astragalus Milk thistle Valerian St John 's wort Kava kava Homeopathic remedies Other CAM products Calcium Fish oil Digestive enzymes Glucosamine Lactobacillus acidophilus Magnesium Omega-3 fatty acid Coenzyme Q10 Zinc Iron supplement Other +139 (86.3) 66 (41.0) 66 (41.0) 61 (37.9) 33 (20.5) 25 (15.5) 24 (14.9) 19 (11.8) 19 (11.8) 14 (8.7) 8 (5.0) 5 (3.1) 51 (31.7) 52 (32.3) 7 (4.3) 6 (3.7) 5 (3.1) 4 (2.5) 4 (2.5) 3 (1.9) 3 (1.9) 2 (1.2) 2 (1.2) 2 (1.2) 15 (9.3) * CAM = complementary and alternative medicine."
sparser
"Pairwise mean F st values revealed a clear differentiation between the Amazonian and Atlantic populations ( F st(WAM-ATL) = 0.16 ± 0.07; F st(CAM-ATL) = 0.15 ± 0.06; Supplementary Table xref ), which was higher compared to the differentiation within the two Amazonian populations ( F st(WAM-CAM) = 0.06 ± 0.02) (Supplementary Table xref )."
Albumin affects CALM1
|
3
Su affects CALM1
|
3
sparser
"By optimizing conditions to draw scatter plot maps, we further assessed the activity and food intake parameters using 2201 activity/rest scatter plots and 2160 food intake scatter plots at 1-hour intervals over 21 hours (ZT0: light on, ZT12: light off, plots deposited in the Cam-Su GRC database,) ( xref and xref Files)."
S12h affects CALM1
|
3
sparser
"The recently developed S12h and M06−2X bring the deviation from CC−cf down to ca. 2 kcal·mol −1 , while excellent results (deviation <0.5 kcal·mol −1 ) are obtained with four functionals: B2PLYP (48.53 kcal·mol −1 ), M06−L (49.45 kcal·mol −1 ), B97−3 (48.46 kcal·mol −1 ) and CAM−S12h (48.41 kcal·mol −1 )."
RACE affects CALM1
|
3
Positron-Emission Tomography affects CALM1
|
3
NPs affects CALM1
|
3
sparser
"Featured technologies include photosensitizer-based nanoplatforms (CAM-NPs) constructed with human serum albumin, composed of chlorin e6, axitinib, and dextro-1-methyl tryptophan that secrete significant immunogenic cell death biomarkers and reverse hypoxic situations [ xref – xref ]."
sparser
"For another, a rational design of photosensitizer-based nanoplatform (CAM-NPs) was constructed with the help of human serum albumin (HSA), composed of chlorin e6 (Ce6, a photosensitizer), axitinib (AXT, a tyrosine kinase inhibitor) and dextro-1-methyl tryptophan (1MT, an IDO inhibitor)."
3
|
MAM4 affects CALM1
|
3
"To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A binding to DCVs and increases vesicle motility. We show that Ca2+/CaM-dependent modulation on KIF1A allows for binding to vesicular cargo. Our results indicate that at low calcium concentrations, the tail domain of KIF1A does not bind to vesicular cargo, whereas at high calcium concentrations, CaM binds KIF1A, allowing for subsequent DCV motility."
Heart Defects, Congenital affects CALM1
|
3
GT affects CALM1
|
3
sparser
"Regarding the pharmacokinetic interaction between CAM and TAC, CAM is known to suppress TAC metabolism by inhibiting cytochrome P450 3A4, increasing TAC blood concentrations, and reducing expensive TAC dosage.[ xref xref ] However, repeated drug monitoring of TAC is required to prevent adverse reactions."
FP affects CALM1
|
3
EC affects CALM1
|
3
sparser
"The majority of included studies examined “X” biomarkers, which were divided into the following subcategories: inflammation xref – xref , xref , xref – xref , xref – xref , xref ( N = 76), vascular xref – xref , xref ( N = 6), synucleinopathy xref , xref ( N = 2), frontotemporal dementia (FTD) ( N = 1), endothelial cell-cell adhesion molecule (EC-CAM) ( N = 1), neuronal function ( N = 22), and sleep ( N = 4). (Details about X biomarkers are listed in xref – xref .)"
Deacetoxyvinzolidine affects CALM1
3
|
Clathrin affects AP180
|
3
sparser
"Thus, the authors should prepare a completely new version of the model figure that summarizes their own findings on the effects of TORC2-dependent myosin-1 phosphorylation (and Ca 2+ ) on Cam1 and Cam2 binding, on lever arm length, and on the function of myosin-1 during vegetative growth and meiosis."
CALM1 affects translation
|
3
CALM1 inhibits translation. 3 / 3
|
3
sparser
"CAM was discovered through its isolation from Streptomyces venezuelae and Streptomyces phleochromogenes var. chloromyceticus in 1947. xref Notably, CAM is one of the few natural products discovered to date that contains both a nitrophenyl ring and a halogen functional group. xref CAM inhibits translation by binding at the peptidyltransferase center of the 50S subunit of the bacterial ribosome in a position that overlaps with the aminoacyl moiety of the A-site tRNA. xref , xref An X-ray crystal structure of CAM bound to the 50S subunit of the bacterial ribosome revealed that its primary and secondary alcohols as well as the carbonyl of its dichloroacetamide functionality form hydrogen bonds with nucleotides of the 23S rRNA ( xref ). xref , xref "
CALM1 affects nitric oxide
|
3
CALM1 affects nitrendipine
|
3
CALM1 affects membrane depolarization
|
3
CALM1 affects glucocerebrosidase
|
3
CALM1 affects function
|
3
CALM1 affects cell differentiation
|
3
sparser
"Pairwise mean F st values revealed a clear differentiation between the Amazonian and Atlantic populations ( F st(WAM-ATL) = 0.16 ± 0.07; F st(CAM-ATL) = 0.15 ± 0.06; Supplementary Table xref ), which was higher compared to the differentiation within the two Amazonian populations ( F st(WAM-CAM) = 0.06 ± 0.02) (Supplementary Table xref )."
CALM1 affects activity
|
3
CALM1 affects Su
|
3
sparser
"By optimizing conditions to draw scatter plot maps, we further assessed the activity and food intake parameters using 2201 activity/rest scatter plots and 2160 food intake scatter plots at 1-hour intervals over 21 hours (ZT0: light on, ZT12: light off, plots deposited in the Cam-Su GRC database,) ( xref and xref Files)."
CALM1 affects S12h
|
3
sparser
"The recently developed S12h and M06−2X bring the deviation from CC−cf down to ca. 2 kcal·mol −1 , while excellent results (deviation <0.5 kcal·mol −1 ) are obtained with four functionals: B2PLYP (48.53 kcal·mol −1 ), M06−L (49.45 kcal·mol −1 ), B97−3 (48.46 kcal·mol −1 ) and CAM−S12h (48.41 kcal·mol −1 )."
CALM1 affects RACE
|
3
CALM1 affects Positron-Emission Tomography
|
3
CALM1 affects NPs
|
3
sparser
"Featured technologies include photosensitizer-based nanoplatforms (CAM-NPs) constructed with human serum albumin, composed of chlorin e6, axitinib, and dextro-1-methyl tryptophan that secrete significant immunogenic cell death biomarkers and reverse hypoxic situations [ xref – xref ]."
sparser
"For another, a rational design of photosensitizer-based nanoplatform (CAM-NPs) was constructed with the help of human serum albumin (HSA), composed of chlorin e6 (Ce6, a photosensitizer), axitinib (AXT, a tyrosine kinase inhibitor) and dextro-1-methyl tryptophan (1MT, an IDO inhibitor)."
CALM1 affects MAM4
|
3
"To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulated, we identified the KIF1A interactome and focused on three binding partners, the calcium binding protein calmodulin (CaM) and two synaptic scaffolding proteins: liprin-α and TANC2. We showed that calcium, acting via CaM, enhances KIF1A binding to DCVs and increases vesicle motility. We show that Ca2+/CaM-dependent modulation on KIF1A allows for binding to vesicular cargo. Our results indicate that at low calcium concentrations, the tail domain of KIF1A does not bind to vesicular cargo, whereas at high calcium concentrations, CaM binds KIF1A, allowing for subsequent DCV motility."
CALM1 affects Heart Defects, Congenital
|
3
CALM1 affects GT
|
3
sparser
"Regarding the pharmacokinetic interaction between CAM and TAC, CAM is known to suppress TAC metabolism by inhibiting cytochrome P450 3A4, increasing TAC blood concentrations, and reducing expensive TAC dosage.[ xref xref ] However, repeated drug monitoring of TAC is required to prevent adverse reactions."
CALM1 affects FP
|
3
CALM1 affects EC
|
3
sparser
"The majority of included studies examined “X” biomarkers, which were divided into the following subcategories: inflammation xref – xref , xref , xref – xref , xref – xref , xref ( N = 76), vascular xref – xref , xref ( N = 6), synucleinopathy xref , xref ( N = 2), frontotemporal dementia (FTD) ( N = 1), endothelial cell-cell adhesion molecule (EC-CAM) ( N = 1), neuronal function ( N = 22), and sleep ( N = 4). (Details about X biomarkers are listed in xref – xref .)"
CALM1 affects DNA-templated transcription
|
2
1
sparser
"Thus, the authors should prepare a completely new version of the model figure that summarizes their own findings on the effects of TORC2-dependent myosin-1 phosphorylation (and Ca 2+ ) on Cam1 and Cam2 binding, on lever arm length, and on the function of myosin-1 during vegetative growth and meiosis."
CALM1 affects B3LYP/D3
|
3
CALM1 affects Alzheimer Disease
|
3
CALM1 affects Adaptor_protein_II
|
1
2
B3LYP/D3 affects CALM1
|
3
Alzheimer Disease affects CALM1
|
3
Adaptor_protein_II affects CALM1
|
1
2
AP180 affects Clathrin
|
3
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects CALM1
|
1
2
Melittin affects mastoparan
|
2
Hsa-mir-4644 affects CALM1
2
|
Hsa-mir-4306 affects CALM1
2
|
Hsa-miR-6862-5p affects CALM1
2
|
Hsa-miR-6765-5p affects CALM1
2
|
Hsa-miR-655-3p affects CALM1
2
|
Hsa-miR-6088 affects CALM1
2
|
Hsa-miR-495-5p affects CALM1
2
|
Hsa-miR-423-5p affects CALM1
2
|
Hsa-miR-3184-5p affects CALM1
2
|
Hsa-miR-302c-5p affects CALM1
2
|
Hsa-miR-196b-5p affects CALM1
2
|
Hsa-miR-196a-5p affects CALM1
2
|
Hsa-miR-1227-3p affects CALM1
2
|
Radiation, Ionizing affects CALM1
|
2
Radiation, Ionizing binds CALM1. 2 / 2
|
2
sparser
"Further, BMSCs and vascular ECs from MM patients and healthy individuals significantly inhibit the T cell-mediated MM cell lysis in a cell–cell contact dependent manner and without substantial T cell suppression, suggesting the induction of a cell adhesion-mediated immune resistance (CAM-IR) against cytotoxic T cell lymphocytes."
NR affects CALM1
|
2
sparser
"Sciatic nerve injury elicits multiple cellular events, such as the removal of debris, axon sprouting and guidance, and formation of synapses with muscle to ensure rapid synapse reinnervation and muscle recovery. xref During the repair process, the axon pathfinding and synapse formation require distinct cell to cell or cell to matrix interaction mediated through cell adhesion molecules (CAMs), Ig superfamily of cell adhesion molecules (IgCAMs), Cadherins, and Integrins. xref As a result, these CAMs play important roles in a variety of nerve regeneration processes. xref IgCAMs, such as N‐CAM, Nr‐CAM and L1, have been implicated in the control of NMJ function through synaptic structure maintenance, vesicle release and recycling, and neurotrophin signalling regulation. xref , xref Cdon has been shown to function in a complex with N‐cadherin or other IgCAMs to mediate cell adhesion‐mediated signalling in promotion of myoblast differentiation. xref , xref Thus, it can be speculated that Cdon and other IgCAMs and Cadherins cooperate to modulate the specific cell‐to cell interaction required for nerve regrowth, synapse formation, and remyelination."
sparser
"This aligns with known roles of SEMA6D in regulating axon pathfinding and target selection in retinal ganglion cell axons through interactions with Plexin‐A1 and Nr‐CAM complexes. [ xref , xref ] These findings suggest conserved mechanisms may govern both visual and auditory circuit formation, warranting further investigation into SEMA6D‐mediated signaling in cochlear development."
CB affects CALM1
|
2
CALM1 affects metabolic process
|
2
CALM1 affects mastoparan, and melittin
|
2
CALM1 affects cell growth
|
2
CALM1 affects calcium atom
|
2
CALM1 activates calcium atom. 2 / 2
|
2
reach
"(%) (n = 161) Vitamins HerbsGarlic Echinacea Chamomile Licorice Ginko biloba Astragalus Milk thistle Valerian St John 's wort Kava kava Homeopathic remedies Other CAM products Calcium Fish oil Digestive enzymes Glucosamine Lactobacillus acidophilus Magnesium Omega-3 fatty acid Coenzyme Q10 Zinc Iron supplement Other +139 (86.3) 66 (41.0) 66 (41.0) 61 (37.9) 33 (20.5) 25 (15.5) 24 (14.9) 19 (11.8) 19 (11.8) 14 (8.7) 8 (5.0) 5 (3.1) 51 (31.7) 52 (32.3) 7 (4.3) 6 (3.7) 5 (3.1) 4 (2.5) 4 (2.5) 3 (1.9) 3 (1.9) 2 (1.2) 2 (1.2) 2 (1.2) 15 (9.3) * CAM = complementary and alternative medicine."
CALM1 affects Radiation, Ionizing
|
2
Radiation, Ionizing binds CALM1. 2 / 2
|
2
sparser
"Further, BMSCs and vascular ECs from MM patients and healthy individuals significantly inhibit the T cell-mediated MM cell lysis in a cell–cell contact dependent manner and without substantial T cell suppression, suggesting the induction of a cell adhesion-mediated immune resistance (CAM-IR) against cytotoxic T cell lymphocytes."
CALM1 affects NR
|
2
sparser
"Sciatic nerve injury elicits multiple cellular events, such as the removal of debris, axon sprouting and guidance, and formation of synapses with muscle to ensure rapid synapse reinnervation and muscle recovery. xref During the repair process, the axon pathfinding and synapse formation require distinct cell to cell or cell to matrix interaction mediated through cell adhesion molecules (CAMs), Ig superfamily of cell adhesion molecules (IgCAMs), Cadherins, and Integrins. xref As a result, these CAMs play important roles in a variety of nerve regeneration processes. xref IgCAMs, such as N‐CAM, Nr‐CAM and L1, have been implicated in the control of NMJ function through synaptic structure maintenance, vesicle release and recycling, and neurotrophin signalling regulation. xref , xref Cdon has been shown to function in a complex with N‐cadherin or other IgCAMs to mediate cell adhesion‐mediated signalling in promotion of myoblast differentiation. xref , xref Thus, it can be speculated that Cdon and other IgCAMs and Cadherins cooperate to modulate the specific cell‐to cell interaction required for nerve regrowth, synapse formation, and remyelination."
sparser
"This aligns with known roles of SEMA6D in regulating axon pathfinding and target selection in retinal ganglion cell axons through interactions with Plexin‐A1 and Nr‐CAM complexes. [ xref , xref ] These findings suggest conserved mechanisms may govern both visual and auditory circuit formation, warranting further investigation into SEMA6D‐mediated signaling in cochlear development."
CALM1 affects CB
|
2