IndraLab
Statements
sparser
"Five more groups (n= 10) were light-cured in a natural tooth mold from two sites (labial and lingual) through a nanohybrid resin composite CAD-CAM restoration (Lava Ultimate A2 LT), for different irradiation times: 90 seconds per site, 40 seconds per site, 30 seconds per site, 20 seconds per site and 10 seconds per site."
sparser
"The HET-CAM test revealed that Soluplus and Pluronic F68 micelle dispersions behaved as the negative control (0.9% NaCl) without inducing bleeding, lysis or coagulation at the time of the study ( t H , t L , and t C > 301 s; IS = 0), which means that they can be considered non-irritants ( xref )."
CALM1 binds Multiple Myeloma and Dr. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"We found that stability estimates from the Cam-CAN data were unaffected by the length of raw recordings used for pre-processing and source imaging, as data lengths from 60 s to 150 s (tested in increments of 30 s) indicated no meaningful difference in stability from the full length (480 s) version in all frequencies except high-gamma ( xref )."
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."
GO affects CALM1
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77
CALM1 is modified
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39
4
CALM1 is phosphorylated.
|
14
4
CALM1 is glycosylated.
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14
sparser
"In addition, studies in our laboratories have been performed and are still in progress, mainly aimed to elucidate the expression and significance of the CAM glycosylation patterns, as well as to identify and characterize membrane molecular components implicated in the ion transport processes which occur in the chorionic epithelium [ xref – xref ]."
CALM1 is methylated.
|
8
sparser
"The recently completed genome of pineapple has and will continue to facilitate many areas of research in this species, and the present work focuses on the regulatory impact of DNA methylation on CAM pathway-related genes using temporal and spatial methylome and transcriptome analysis."
sparser
"The results showed CALM1 methylation to be significantly increased in cervical and endocervical cancer (CESC) and COAD compared with that in normal tissues, but significantly decreased in LIHC and PCPG ( xref ), showing an inverse trend compared with that of the expression pattern."
CALM1 is acetylated.
|
3
EP affects CALM1
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39
sparser
"This suggests that delirium screening can be performed efficiently by nurses and CNAs operating within their scope of practice, using for example the nurse two-step protocol with skip (UB-CAM), or the CNA UB-2 followed by nurse 3D-CAM with skip (not explicitly tested in our study)."
sparser
"The UB-2 can effectively rule out delirium in less than 40 seconds, with a 93% sensitivity in persons with and without dementia. xref , xref If the person correctly answers both items in the UB-2, the protocol is complete; if not, the 3D-CAM is administered as step two. xref , xref The 3D-CAM is a validated diagnostic interview for delirium that can be completed in three minutes. xref We refer to this two-step process as the UB-CAM. (See xref , xref , xref )"
sparser
"This study describes the barriers and facilitators related to the implementation of the Ultra-brief Confusion Assessment Method (UB-CAM), a rapid two-step delirium identification protocol (ultra-brief screen, followed by CAM in positives), field tested with hospitalized older adults (70+)."
sparser
"Herein, we propose a sandwich-type surface enhanced Raman scattering (SERS) immuno-nanosensor which is aimed for detecting and quantifying Carcinoembryonic antigen-related cell adhesion molecule 5 (CEA-CAM5), a protein involved in intercellular adhesion and signaling pathways that acts as a tumor marker in several types of cancer."
sparser
"These could not be explained by higher sensibility of the IL-33 KO mouse strain as the expression of the basic receptors described to be involved in the infectivity such as CEA-CAM [27] , TLR2 [22, 28] , and TLR3 [29] receptors were expressed at a comparable level in WT and IL-33 KO mice."
sparser
"In mammals, CEACAM families consist of a group of orthologous members (CEACAM16, CEACAM18, CEA-CAM19, CEACAM20) where counterparts can be clearly assigned in different species and a group of paralogous members which are most closely related to CEACAM1 within the same species [3] ."
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
CALM1 affects calcium(2+)
2
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18
CALM1 binds calcium(2+).
2
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9
Calcium(2+) binds CALM1. 10 / 19
2
|
9
reach
"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
CALM1 activates calcium(2+).
|
5
CALM1 inhibits calcium(2+).
|
4
sparser
"The monoclonal antibodies label a subset of CAM-cys modified peptide sequences and purified proteins (human von Willebrand Factor (gene:vWF), Jagged 1 (gene:JAG1), Laminin subunit alpha 2 (gene:LAMA2), Thrombospondin-2 (gene:TSP2), and Collagen IV (gene:COL4)) but do not recognize specific proteins such as Bovine serum albumin (gene:BSA) and human Thrombospondin-1 (gene:TSP1), Biglycan (gene:BGN) and Decorin (gene:DCN)."
sparser
"Of the antibodies identified by ELISA, we found by dot blotting that two rabbit IgG monoclonals (4E7 and 52H11) bound to the CAM-cys modified MYADML2 peptides but were incapable of binding to peptides lacking CAM-cys modifications (peptide sequences shown in xref ; blots shown in xref [probed with 4E7],1C [with 52H11], and 1D [with secondary antibody alone])."
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S110. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S280. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S172. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S53, S177, and S213 on S274. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S213 on S177. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S326, S180, S268, S274, S53, S177, and S213 on S221. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S274, S53, S177, and S213 on S268. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S221, S326, S180, S268, S274, S53, S177, and S213 on S175. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S171. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S174. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, S177, and S213 on S217. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S180, S268, S274, S53, and S177 on S213. 2 / 2
2
|
CALM1 dephosphorylates NFATC2 phosphorylated on S174, S276, S171, S56, S217, S280, S243, S110, S172, S175, S221, S326, S268, S274, S53, S177, and S213 on S180. 2 / 2
2
|
CALM1 affects B3LYP
|
25
sparser
"For Fe–Fe/Mo–Fe distances,
CAM-B3LYP gives worse deviations for both spin-coupled (and diamagnetic
complexes) than its parent B3LYP functional with MD = +0.061 Å
(MAD 0.067 Å) and the recent ωB97M-D3BJ functional (found
to be highly accurate for main group thermochemistry) xref , xref offers no improvement either, with MD of +0.067 Å (MAD = 0.067
Å)."
sparser
"The rate-determining
step can be either the bond rotation or the proton transfer, depending
on the rotating bond and the meso -substituents. xref , xref For this particular switch, several density functionals were benchmarked
against CCSD(T)/6-31G data, concluding that both CAM-B3LYP and M05-2X
provide the most reliable results. xref Besides
the Hückel–Möbius interconversion, we also considered
the switching from 28M to 28F with the associated
transition state ( 28TS 3 ), as
shown in."
Calcium(2+) affects CALM1
5
|
11
Calcium(2+) binds CALM1.
2
|
9
Calcium(2+) binds CALM1. 10 / 19
2
|
9
reach
"These marker proteins are listed in Table S-6 and include for instance calmodulin-1, MARCS, and the peptidyl-prolyl cis-trans isomerase FKBP9, which bind calcium; proteins with chaperone function (CH60, HSPB1, PRS4, and TCPA); components of the nuclear lamina (LMNA, LMNB1), as well as an interferon-induced GTP-binding protein (MX1); and vimentin, a class III intermediate filament."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
Calcium(2+) activates CALM1.
3
|
2
Calcium(2+) activates CALM1. 5 / 5
3
|
2
"Except for nfat5, nfatc1c4 are activated upon a rise in intracellular ca2+, which stimulates the serine/threonine phosphatase activity of calcineurin the ca2+-calcineurin signal is the most important signal for regulating nfat activation, but the signal that leads to ca2+ influx during neural tube differentiation is still unclear."
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
sparser
"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."
sparser
"Transmembrane protein P0 is an immunoglobulin-like cell adhesion molecule (Ig-CAM) and mediates the adhesion of the extracellular myelin surfaces. xref , xref , xref Periaxin is the second most abundant protein in PNS myelin and is a scaffolding protein. xref , xref , xref Periaxin is expressed before P0, MBP, or MAG and is suggested to play an important role during ensheathment and myelination in the PNS. xref In the CNS and PNS, MBP accounts for 8% of the myelin proteins and mediates the intracellular adhesion of cytoplasmic surfaces between individual layers of compact myelin. xref , xref , xref MBP is a highly heterogeneous protein as a result of alternative splicing and posttranslational modifications such as N-terminal acylation, GTP- and ADP-ribose binding sites, deamidation, methylated arginine, methionine sulfoxide, phosphorylation, and deimination of arginyl residues. xref , xref In the CNS of shiverer mutant mice, which do not express MBP, major dense lines are missing."
sparser
"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."
sparser
"Considering that quantification of the most abundant myelin proteins requires a high dynamic range ( xref ; xref ), we calculated the relative abundance of the 562 proteins identified in zebrafish myelin by MS E . According to this dataset, the most abundant zebrafish myelin proteins are myelin basic protein (MBPa), the Ig-CAM myelin protein zero (MPZa), the short-chain dehydrogenase 36K (also termed DHRS12), MPZb, and the complement inhibitor CD59, which respectively, constitute 7.6%, 7.3%, 6.3%, 4.7%, and 4.6% of the total myelin protein ( xref )."
sparser
"This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig‐CAM family such as ICAM and VCAM‐1, initiating the transendothelial migration and therefore the extravasation process. xref VCAM‐1 is therefore thought to play a key role in the process of malignant progression and its presence studied in terms of impact on cell migration. xref "
sparser
"For example, activity of the core AJ components E-cadherin (E-cad) and α-catenin (α-cat) has been linked to activation of the core Hippo kinase LATS1/2 and inhibition of YAP ( xref ; xref ; xref ), and in Drosophila the Ig-CAM protein Echinoid that localizes to AJs can promote Salvador/Hpo activity to inhibit Yki ( xref )."
sparser
"Transmembrane protein P0 is an immunoglobulin-like cell adhesion molecule (Ig-CAM) and mediates the adhesion of the extracellular myelin surfaces. xref , xref , xref Periaxin is the second most abundant protein in PNS myelin and is a scaffolding protein. xref , xref , xref Periaxin is expressed before P0, MBP, or MAG and is suggested to play an important role during ensheathment and myelination in the PNS. xref In the CNS and PNS, MBP accounts for 8% of the myelin proteins and mediates the intracellular adhesion of cytoplasmic surfaces between individual layers of compact myelin. xref , xref , xref MBP is a highly heterogeneous protein as a result of alternative splicing and posttranslational modifications such as N-terminal acylation, GTP- and ADP-ribose binding sites, deamidation, methylated arginine, methionine sulfoxide, phosphorylation, and deimination of arginyl residues. xref , xref In the CNS of shiverer mutant mice, which do not express MBP, major dense lines are missing."
sparser
"They contain a furin-like cleavable domain and transmembrane domains, i.e., C-terminal TM-1 and cytoplasmic tail. (f) Membrane-type MMPs, including MMP-17 and MMP-25, resemble archetypal MMPs and contain a C-terminal glycosylphosphatidylinositol (GPI) membrane anchor. (g) Other MMPs (MMP-23A and MMP-23B) also resemble archetypal MMPs, lack a hemopexin domain and contain N-terminal TM-II and cytoplasmic C-terminal immunoglobulin-like cell adhesion molecule (Ig-CAM) domains [ xref , xref ]."
sparser
"Considering that quantification of the most abundant myelin proteins requires a high dynamic range ( xref ; xref ), we calculated the relative abundance of the 562 proteins identified in zebrafish myelin by MS E . According to this dataset, the most abundant zebrafish myelin proteins are myelin basic protein (MBPa), the Ig-CAM myelin protein zero (MPZa), the short-chain dehydrogenase 36K (also termed DHRS12), MPZb, and the complement inhibitor CD59, which respectively, constitute 7.6%, 7.3%, 6.3%, 4.7%, and 4.6% of the total myelin protein ( xref )."
sparser
"This triggers the activation of integrins from the cancer cells allowing their firmer adhesion to members of the Ig‐CAM family such as ICAM and VCAM‐1, initiating the transendothelial migration and therefore the extravasation process. xref VCAM‐1 is therefore thought to play a key role in the process of malignant progression and its presence studied in terms of impact on cell migration. xref "
sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."
sparser
"The following oligonucleotide primers that detect murine CEA-CAM1 isoforms were used for detection: mouse CEACAM1, a common sense primer that detects both long and short isoform FP-5 0 -GCCATGCAGCCTCTA ACCCACC-3 0 ; and two antisense primers that detect specific isoforms, mouse CEACAM1-L BP-5 0 -CTGGAGGTTGAGGGTTTGTGCTC-3 0 and mouse CEA-CAM1-S BP-5 0 -TCAGAAGGAGCCAGACCCGCC-3 0 ."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"While N exon nucleotide sequences of CEACAM16, CEACAM18, CEA-CAM19 and CEACAM20 from different species cluster together, all other CEACAM N domain exon sequences of a given species are most closely related with the corresponding CEACAM1 sequence of that species, indicating that these genes were generated independently by multiple rounds of duplication of an ancestral CEA-CAM1 gene possibly followed by gene conversion events ( Figure 1A )."
sparser
"The following oligonucleotide primers that detect murine CEA-CAM1 isoforms were used for detection: mouse CEACAM1, a common sense primer that detects both long and short isoform FP-5 0 -GCCATGCAGCCTCTA ACCCACC-3 0 ; and two antisense primers that detect specific isoforms, mouse CEACAM1-L BP-5 0 -CTGGAGGTTGAGGGTTTGTGCTC-3 0 and mouse CEA-CAM1-S BP-5 0 -TCAGAAGGAGCCAGACCCGCC-3 0 ."
sparser
"These results suggest that in vitro binding of TCF4B and CaM or CaM1,2,3,4 can occur independently of Ca 2+ binding, but that in vivo CaM-dependent prevention of pyramidal cell aggregation by TCF4B gain of function requires Ca 2+ , because the Ca 2+ insensitive CaM1,2,3,4 was ineffective at rescuing cellular aggregation."
sparser
"These same resonances are exchange broadened in CaM bound to the CNGB1 CaM1 peptide (Bej and Ames xref ) and the α-subunit of the retinal cyclic nucleotide-gated channel (CNGA2) (Contessa et al. xref ), but are not exchange broadened in free CaM (Bej and Ames xref ; Kainosho et al. xref )."
sparser
"It was shown that GAD activity is induced by two different mechanisms: (i) in intact plant tissue and neutral pH GAD activity is stimulated in a Ca 2+ -dependent manner by binding of calmodulin to the CAM-binding site ( xref ); (ii) after wounding of plant cells the vacuolar content is released and the cytosol is acidified which leads to a Ca 2+ -independent activation of GADs ( xref )."
CALM1 affects apoptotic process
|
1
14
CALM1 affects angiogenesis
|
10
5
CALM1 activates angiogenesis.
|
8
CALM1 activates angiogenesis. 8 / 8
|
8
reach
"The CAM (Chick Chorioallantoic Membrane) model allows the assessment of the degree of angiogenesis, as well as the quality of the newly formed vessels, when intervening vascular endothelial growth factors (VEGF) or conversely, factors that inhibit the development of new blood vessels, such as antiangiogenic drugs."
CALM1 inhibits angiogenesis.
|
2
5
CALM1 affects cell adhesion
|
13
1
CALM1 activates cell adhesion.
|
12
CALM1 inhibits cell adhesion.
|
1
1
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
Myo1 affects CALM1
|
11
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
CALM1 affects Myo1
|
11
sparser
"If TORC2 does indeed phosphorylate Myo1, it would be important to know, first, whether TORC2 function is elevated in meiotic cells compared to mitotic cells and, second, what the effect of different growth conditions (vegetative, sexual, and nutrient limiting) is on the association of Myo1 with Cam1 vs. Cam2 as assessed via co-immunoprecipitations."
sparser
"Myo1 and Cam1 associated with the cell membrane in two distinct ways: we observed both (i) rapid, transient, binding of single Myo1 molecules to the cell membrane, characterized by low-intensity, single, stepwise, changes in intensity ( xref ), alongside (ii) longer endocytic events that were much brighter and took much longer ( xref )."
"Electrons flow from the C-terminal reductase domain of one NOS monomer to the N-terminal oxygenase domain of the other NOS monomer (Siddhanta et al., 1998). The primary mode of enzyme activation is the binding of calcium-bound calmodulin to the N-terminal CaM-binding domain. This facilitates a structure change and the flow of electrons from NADPH through the flavins to the oxygenase domain of the other eNOS monomer"
sparser
"Additionally, CR can act on the genes of the upstream pathway, such as IL1B and TNF, which are proinflammatory mediators [ xref , xref ], while ATR can act on downstream genes, such as CALM1 and NOS3, which are associated with learning and memory and anti-inflammatory processes."
"The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
5
2
|
2
CALM1 binds.
2
|
2
CALM1 is inactive.
3
|
"The in vitro phosphorylation of calmodulin by the insulin receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
"Phosphorylation of calmodulin by the epidermal-growth-factor-receptor tyrosine kinase. Phosphorylated calmodulin does not exhibit the characteristic ca2+ shift normally observed with calmodulin in electrophoretic gels, an observation that is consistent with this modification affecting the biological activity of the molecule."
CALM1 is active.
2
|
"Calmodulin is the best studied and prototypical example of the e-f-hand family of ca2+-sensing proteins. In the event of a transient rise in Ca2+, the Ca2+ ion is coordinated in each Ca2+-binding loop of Ca2+CaM by seven, primarily carboxylate, ligands. The binding of Ca2+ leads to substantial alterations in the interhelical angles within the EF hands in each domain and dramatically changes the two domains of CaM to produce more open conformations"
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
sparser
"The 3 calmodulin genes ( CALM1-3 ) were scored separately but discussed as a group because they all encode for an identical protein. xref CALM1 and CALM2 were first associated with LQTS by exome sequencing of 2 unrelated infants with QT prolongation where de novo variants were identified. xref Subsequent studies uncovered further genetic evidence for these genes, including CALM3. xref – xref Most recently, the International Calmodulinopthy Registry has published a series of 36 LQTS cases secondary to rare variants distributed among all 3 CALM genes. xref In all cases identified, no other family members were found to be phenotype-positive and were thus concordant with de novo variants, although not in all families was this proven by sequencing of both parents and confirmation of paternity."
Valproic acid affects CALM1
8
|
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects production
|
8
sparser
"For instance, both CAM and erythromycin (EM) inhibit the production of inflammatory cytokines, such as interleukin (IL)-6 and IL-8, inhibit the release of soluble intracellular adhesion molecule (ICAM)-1 from airway epithelial cells, and decrease airway neutrophil accumulation [ xref , xref ]."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
Hsa-miR-7-5p affects CALM1
7
|
Hsa-miR-557 affects CALM1
7
|
Hsa-miR-507 affects CALM1
7
|
Hsa-miR-450b-5p affects CALM1
7
|
Hsa-miR-3680-3p affects CALM1
7
|
Hsa-miR-1-3p affects CALM1
7
|
FveIF3g affects CALM1
|
7
sparser
"Unexpectedly, the mutant Fshr-CAM reversed the azoospermia and infertility of the LuRKO mice to a near-normal phenotype ( xref C,D), with normal development of the testes and accessory reproductive organs, and completion of spermatogenesis, despite delayed puberty and small litter sizes."
| PMC
DRG affects CALM1
|
7
Calcium binds CALM1.
2
|
"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
CALM1 affects FveIF3g
|
7
sparser
"Unexpectedly, the mutant Fshr-CAM reversed the azoospermia and infertility of the LuRKO mice to a near-normal phenotype ( xref C,D), with normal development of the testes and accessory reproductive organs, and completion of spermatogenesis, despite delayed puberty and small litter sizes."
| PMC
CALM1 affects DRG
|
7
Trichostatin A affects CALM1
|
6
Trichostatin A binds CALM1. 6 / 6
|
6
sparser
"A total of 50 patients who did not experience failure (17 CAM-TSA and 33 primary TSA) completed PRO measures at a mean follow-up of 4.8 years (range, 2.0-11.5 years), with no significant difference between the CAM-TSA (4.4 years [range, 2.1-10.5 years]) and primary TSA (5.0 years [range, 2.0-11.5 years]) groups ( P = ."
Monooxygenase activity affects CALM1
|
6
Monooxygenase activity binds CALM1. 6 / 6
|
6
sparser
"Meanwhile, through the construction and analysis of the network, we obtained important targets for LDD and the potential biological processes and signaling pathways for the treatment of osteoporosis (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix)."
sparser
"LDD may have a therapeutic effect on osteoporosis through regulating the targets (such as ALB, IGF1, SRC, and ESR1), biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) found in this research."
sparser
"Finally, animal experiments were conducted to verify the prediction results of systematic pharmacology. (1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"(1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"Cluster 1 is mainly involved in several signaling pathways in osteoporosis (such as MAPK, PI3K, and JAK-STAT signaling pathway) and positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, and neovascularization during bone remodeling."
Melittin affects CALM1
|
3
3
Hsa-miR-641 affects CALM1
6
|
Hsa-miR-6079 affects CALM1
6
|
Hsa-miR-6077 affects CALM1
6
|
Hsa-miR-490-5p affects CALM1
6
|
Hsa-miR-4802-3p affects CALM1
6
|
Hsa-miR-4650-5p affects CALM1
6
|
Hsa-miR-432-3p affects CALM1
6
|
Hsa-miR-3617-5p affects CALM1
6
|
Hsa-miR-3142 affects CALM1
6
|
Hsa-miR-1972 affects CALM1
6
|
Hsa-miR-1245b-5p affects CALM1
6
|
sparser
"We optimized engraftment conditions for primary MIBC tumors using the CAM-PDX model and tested concordance between cisplatin-based chemotherapy response of patients to matching PDX tumors using tumor growth coupled with immunohistochemistry markers of proliferation and apoptosis."
sparser
"Further, proteogenomic informed kinase inhibitor use on MIBC CAM-PDX models suggests a benefit from integration of rapid in vivo testing of novel therapeutics to inform more complex, pre-clinical mouse PDX experiments for more effective clinical trial design aimed at achieving optimal precision medicine for patients with limited treatment options."
TS affects CALM1
|
6
sparser
"In mean state sensitivity experiments with Sp‐CAM4, we have found that the seasonality of TISO in terms of the geographical location of occurrences and direction of propagation is primarily associated with the annual march of the maximum SST and low level zonal wind which tends to follow the SST."
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
Promethazine affects CALM1
6
|
Promethazine inhibits CALM1. 6 / 6
6
|
M109Q affects CALM1
|
6
sparser
"It indicates that ZAR1’s auto-phosphorylation is promoted by the binding of CaM1 or AGB1, but the binding is independent on the ZAR1 kinase activity, as CaM1 or AGB1 interacts with His-kinase K534>A . These data, together, strongly suggest that ZAR1, AGB1 and CaM1 form complex and the ZAR1 kinase activity is activated by the binding of CaM1 and/or AGB1."
CALM1 affects trichostatin A
|
6
Trichostatin A binds CALM1. 6 / 6
|
6
sparser
"A total of 50 patients who did not experience failure (17 CAM-TSA and 33 primary TSA) completed PRO measures at a mean follow-up of 4.8 years (range, 2.0-11.5 years), with no significant difference between the CAM-TSA (4.4 years [range, 2.1-10.5 years]) and primary TSA (5.0 years [range, 2.0-11.5 years]) groups ( P = ."
CALM1 affects monooxygenase activity
|
6
Monooxygenase activity binds CALM1. 6 / 6
|
6
sparser
"Meanwhile, through the construction and analysis of the network, we obtained important targets for LDD and the potential biological processes and signaling pathways for the treatment of osteoporosis (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix)."
sparser
"LDD may have a therapeutic effect on osteoporosis through regulating the targets (such as ALB, IGF1, SRC, and ESR1), biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) found in this research."
sparser
"Finally, animal experiments were conducted to verify the prediction results of systematic pharmacology. (1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"(1) LDD-osteoporosis PPI network shows the potential compounds, potential targets (such as ALB, IGF1, SRC, and ESR1), clusters, biological processes (such as positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, and endothelial cell proliferation), and signaling and Reactome pathways (such as JAK-STAT signaling pathway, osteoclast differentiation, and degradation of the extracellular matrix) of LDD intervention in osteoporosis. (2) Human transcriptomics data and protein arrays data validated the findings of the LDD-osteoporosis PPI network. (3) The animal experiments showed that LDD can improve bone mineral density (BMD), increase serum estradiol (E2) and alkaline phosphatase (ALP) levels, and upregulate Wnt3a and β -catenin mRNA expression ( P < 0.05). (4) Molecular docking results showed that alisol A, dioscin, loganin, oleanolic acid, pachymic acid, and ursolic acid may stably bind to JAK2, ESR1, and CTNNB1."
sparser
"Cluster 1 is mainly involved in several signaling pathways in osteoporosis (such as MAPK, PI3K, and JAK-STAT signaling pathway) and positive regulation of calmodulin 1-monooxygenase activity, estrogen metabolism, endothelial cell proliferation, and neovascularization during bone remodeling."
CALM1 affects melittin
|
3
3
CALM1 affects formation
|
6
sparser
"We optimized engraftment conditions for primary MIBC tumors using the CAM-PDX model and tested concordance between cisplatin-based chemotherapy response of patients to matching PDX tumors using tumor growth coupled with immunohistochemistry markers of proliferation and apoptosis."
sparser
"Further, proteogenomic informed kinase inhibitor use on MIBC CAM-PDX models suggests a benefit from integration of rapid in vivo testing of novel therapeutics to inform more complex, pre-clinical mouse PDX experiments for more effective clinical trial design aimed at achieving optimal precision medicine for patients with limited treatment options."
CALM1 affects TS
|
6
sparser
"In mean state sensitivity experiments with Sp‐CAM4, we have found that the seasonality of TISO in terms of the geographical location of occurrences and direction of propagation is primarily associated with the annual march of the maximum SST and low level zonal wind which tends to follow the SST."
sparser
"CALM1 encodes a regulatory protein of RYR2 and is responsible for inhibiting Ca 2+ release from RYR2 in the sarcoplasmic reticulum to maintain a normal contraction‐relaxation cycle. xref Oxidative stress impairs binding of CALM1 to RYR2 , causing aberrant Ca 2+ release, resulting in cardiac hypertrophy and HF in murine and canine models. xref , xref Our results suggest that estradiol treatment led to tighter control of cardiac Ca 2+ physiology and improved diastolic relaxation."
CALM1 binds NH.
|
4
sparser
"The dissociation and rate constants for the branch of the pathway starting with NH 2 -CAM binding are more difficult to determine directly because of the lack of a spectral change upon NH 2 -CAM binding, the similarity of the rate constants for P formation and decay, and the inability to limit the reaction to a few steps."
CALM1 affects M109Q
|
6
sparser
"It indicates that ZAR1’s auto-phosphorylation is promoted by the binding of CaM1 or AGB1, but the binding is independent on the ZAR1 kinase activity, as CaM1 or AGB1 interacts with His-kinase K534>A . These data, together, strongly suggest that ZAR1, AGB1 and CaM1 form complex and the ZAR1 kinase activity is activated by the binding of CaM1 and/or AGB1."
sparser
"This paper focuses on the worldview hypotheses and research design approaches from nonlinear dynamical complex systems (NDS) science that can inform future studies of whole systems of complementary and alternative medicine (WS-CAM), e.g., Ayurveda, traditional Chinese medicine, and homeopathy."
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
sparser
"This paper focuses on the worldview hypotheses and research design approaches from nonlinear dynamical complex systems (NDS) science that can inform future studies of whole systems of complementary and alternative medicine (WS-CAM), e.g., Ayurveda, traditional Chinese medicine, and homeopathy."
sparser
"An AR based system for enhancing spatial awareness and comprehension problems for engineering graphics education was designed (Chen et al 2011) . (Yan et al 2011) worked on an prototype for integrating Building Information Modeling (BIM) (providing geometric and alphanumeric information), and gaming to improve architectural visualization. (Pena 2014 ) researched a graphical application for tablet computers that supports 2D computer graphics and interaction for two-fold use: a teaching lab module and stand-alone instructional tool. (Shirazi and Behzadan 2015b) designed and assessed the effectiveness of a collaborative context-aware mobile augmented reality tool (CAM-ART) for the civil engineering curriculum. (Turkan et al 2017) designed and developed an AR application and run it in a pilot study at a junior level structural analysis class to assess the pedagogical impact and the design concepts employed by the AR tool."
| DOI
Mastoparan affects CALM1
|
2
3
Hsa-miR-1193 affects CALM1
5
|
Hsa-let-7c-3p affects CALM1
5
|
Extracellular matrix affects CALM1
|
5
Psn affects CALM1
|
5
Phenoxybenzamine affects CALM1
5
|
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
Loperamide affects CALM1
5
|
KIF1Bbeta affects CALM1
|
5
sparser
"The soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) along with C-reactive protein (CRP) levels are vascular inflammatory markers for endothelial dysfunction associated with increased risk of diabetes and coronary heart disease xref , xref ."
sparser
"Total body dual-energy x-ray absorptiometry, abdominal computed tomography scans, hyperinsulinemic-euglycemic clamps, adipose tissue biopsies (n=28), and blood for Homeostasis model assessment-insulin resistance, and soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA)."
sparser
"Further analysis revealed little change in MeCP2 distribution upon Fl-H1.0 expression: Principal component analysis revealed no clear separation between wild-type and Cam-tTA:Fl-H1.0 mice ( xref ); Spearman correlation coefficients of MeCP2 enrichment between wild-type and Cam-tTA:Fl-H1.0 mice was 0.93 at the binning size of 10 kb ( xref )."
sparser
"The global simulations all appear aggregated to some extent, but there is diversity in the spatial structure of convection; some simulations have one or two hemisphere‐scale aggregated regions (e.g., NICAM and CAM5), some have quasi‐regularly spaced aggregated clusters (e.g., UKMO‐GA7.1, ECHAM, ICON‐GCM, and IPSL‐CM6), some have convection organized along irregular lines (e.g., CNRM‐CM6‐1), and others seem only partially aggregated, with only a few dry, clear patches amidst more uniform convection (e.g., CAM6‐GCM, GEOS‐GCM, and MPAS)."
Fluphenazine affects CALM1
5
|
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
CALM1 affects translation
|
2
3
CALM1 inhibits translation.
|
3
CALM1 inhibits translation. 3 / 3
|
3
sparser
"CAM was discovered through its isolation from Streptomyces venezuelae and Streptomyces phleochromogenes var. chloromyceticus in 1947. xref Notably, CAM is one of the few natural products discovered to date that contains both a nitrophenyl ring and a halogen functional group. xref CAM inhibits translation by binding at the peptidyltransferase center of the 50S subunit of the bacterial ribosome in a position that overlaps with the aminoacyl moiety of the A-site tRNA. xref , xref An X-ray crystal structure of CAM bound to the 50S subunit of the bacterial ribosome revealed that its primary and secondary alcohols as well as the carbonyl of its dichloroacetamide functionality form hydrogen bonds with nucleotides of the 23S rRNA ( xref ). xref , xref "
CALM1 activates translation.
|
2
CALM1 affects mastoparan
|
2
3
CALM1 affects extracellular matrix
|
5
CALM1 affects activity
|
5
CALM1 affects Psn
|
5
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
CALM1 affects KIF1Bbeta
|
5
sparser
"The soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1) along with C-reactive protein (CRP) levels are vascular inflammatory markers for endothelial dysfunction associated with increased risk of diabetes and coronary heart disease xref , xref ."
sparser
"Total body dual-energy x-ray absorptiometry, abdominal computed tomography scans, hyperinsulinemic-euglycemic clamps, adipose tissue biopsies (n=28), and blood for Homeostasis model assessment-insulin resistance, and soluble forms of intracellular adhesion molecule (sICAM-1) and vascular CAM-1 (sVCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA)."
sparser
"Further analysis revealed little change in MeCP2 distribution upon Fl-H1.0 expression: Principal component analysis revealed no clear separation between wild-type and Cam-tTA:Fl-H1.0 mice ( xref ); Spearman correlation coefficients of MeCP2 enrichment between wild-type and Cam-tTA:Fl-H1.0 mice was 0.93 at the binning size of 10 kb ( xref )."
sparser
"The global simulations all appear aggregated to some extent, but there is diversity in the spatial structure of convection; some simulations have one or two hemisphere‐scale aggregated regions (e.g., NICAM and CAM5), some have quasi‐regularly spaced aggregated clusters (e.g., UKMO‐GA7.1, ECHAM, ICON‐GCM, and IPSL‐CM6), some have convection organized along irregular lines (e.g., CNRM‐CM6‐1), and others seem only partially aggregated, with only a few dry, clear patches amidst more uniform convection (e.g., CAM6‐GCM, GEOS‐GCM, and MPAS)."
sparser
"Materials and Methods : A total of 58 skeletally mature Wistar rats were randomly assigned to various ACL injury groups: controlled abnormal movement-mid-portion (CAM-MP), controlled abnormal movement-femoral side (CAM-FS), ACL transection-mid-portion (ACLT-MP), or ACL transection-femoral side (ACLT-FS) injury groups."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
Hsa-miR-1276 affects CALM1
4
|
Hsa-miR-106a-3p affects CALM1
4
|
Radiation, Ionizing affects CALM1
|
4
RBP45 affects CALM1
|
4
sparser
"However, the amount of GFP‐siRNAs in the patches receiving pCAMBIA1300‐35S‐GFP and pCAM‐RBP45 was significantly higher than that in the patches receiving pCAMBIA1300‐35S‐GFP and the empty vector, indicating that NtRBP45 facilitated siRNA accumulation and thus enhanced a sense transgene‐induced PTGS locally."
Perphenazine affects CALM1
4
|
PR affects CALM1
|
4
sparser
"A post hoc power analysis (R Version 4.1.1 Patched (RStudio 2021.09.2 Build 382), RStudio, Boston, USA) comparing two-body wear values of CAM-TD and 3DP-GI showed that a sample size of 12 specimens per group, an observed effect of − 0.37 mm and a pooled SD of 0.32 mm yielded a statistical power of p = 0.8 (80%)."
sparser
"Forty-eight substrates ( n = 12/material) in the design of a mandibular first molar were fabricated using CAM (CAM-TD, Thermeo, pro3dure medical GmbH, Iserlohn, Germany; CAM-CL, CLEARsplint, Astron Dental Corporation, Lake Zurich, USA) and 3DP (3DP-GI, GR22 flex, pro3dure medical GmbH; 3DP-KY, KeySplint soft, Keystone Industries, Gibbstown, USA)."
NH affects CALM1
|
4
sparser
"The dissociation and rate constants for the branch of the pathway starting with NH 2 -CAM binding are more difficult to determine directly because of the lack of a spectral change upon NH 2 -CAM binding, the similarity of the rate constants for P formation and decay, and the inability to limit the reaction to a few steps."
Multiple Myeloma affects Dr
|
4
CALM1 binds Multiple Myeloma and Dr. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
reach
"These relative protein levels, binding affinities and low Ca concentrations favor Cam1 binding to Myo1, over Cam2 at both IQ sites (Figure 8B), consistent with in vivo observations.Although Ca levels are low during vegetative growth, sporadic prolonged calcium bursts occur upon pheromone release during mating (Carbó et al., 2017; Iida et al., 1990), and levels elevate significantly (~10 fold) during the subsequent meiosis and sporulation (Suizu et al., 1995)."
Dr affects Multiple Myeloma
|
4
CALM1 binds Multiple Myeloma and Dr. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
Cinchocaine affects CALM1
4
|
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects protein synthesis
|
4
CALM1 affects carbon monoxide
|
4
CALM1 affects Radiation, Ionizing
|
4
CALM1 affects RBP45
|
4
sparser
"However, the amount of GFP‐siRNAs in the patches receiving pCAMBIA1300‐35S‐GFP and pCAM‐RBP45 was significantly higher than that in the patches receiving pCAMBIA1300‐35S‐GFP and the empty vector, indicating that NtRBP45 facilitated siRNA accumulation and thus enhanced a sense transgene‐induced PTGS locally."
CALM1 affects PR
|
4
sparser
"A post hoc power analysis (R Version 4.1.1 Patched (RStudio 2021.09.2 Build 382), RStudio, Boston, USA) comparing two-body wear values of CAM-TD and 3DP-GI showed that a sample size of 12 specimens per group, an observed effect of − 0.37 mm and a pooled SD of 0.32 mm yielded a statistical power of p = 0.8 (80%)."
sparser
"Forty-eight substrates ( n = 12/material) in the design of a mandibular first molar were fabricated using CAM (CAM-TD, Thermeo, pro3dure medical GmbH, Iserlohn, Germany; CAM-CL, CLEARsplint, Astron Dental Corporation, Lake Zurich, USA) and 3DP (3DP-GI, GR22 flex, pro3dure medical GmbH; 3DP-KY, KeySplint soft, Keystone Industries, Gibbstown, USA)."
CALM1 affects Multiple Myeloma
|
4
CALM1 binds Multiple Myeloma and Dr. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
reach
"These relative protein levels, binding affinities and low Ca concentrations favor Cam1 binding to Myo1, over Cam2 at both IQ sites (Figure 8B), consistent with in vivo observations.Although Ca levels are low during vegetative growth, sporadic prolonged calcium bursts occur upon pheromone release during mating (Carbó et al., 2017; Iida et al., 1990), and levels elevate significantly (~10 fold) during the subsequent meiosis and sporulation (Suizu et al., 1995)."
CALM1 affects Dr, and Multiple Myeloma
|
4
CALM1 binds Multiple Myeloma and Dr. 4 / 4
|
4
sparser
"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
sparser
"The regions from 250–280 nm and 500–550 nm were excluded from the analysis because they only describe baseline modifications. xref presented the intensity of auto-peaks identified in the synchronous spectra. xref a,b indicates that three major auto-peaks can be clearly identified for the CaM during coagulation, while five auto-peaks are clearly visible for the other formulations containing CM (CM, CaM1:CM1, CaM1:CM3 and CaM3:CM1)."
sparser
"Recently, mutations in genes encoding the ubiquitous Ca 2+ sensing protein calmodulin (CaM), have been discovered as a novel genetic basis for
congenital arrhythmia susceptibility. xref – xref At least
12 mostly de novo mutations have been discovered in CALM1,
CALM2, and CALM3 associated with LQTS, CPVT or
idiopathic ventricular fibrillation."
CALM1 affects ATP
4
|
CALM1 catalyzes the conversion of ATP into 3',5'-cyclic AMP.
2
|
CALM1 catalyzes the conversion of ATP into 3',5'-cyclic AMP and diphosphoric acid.
2
|
CALM1 affects 3',5'-cyclic AMP
4
|
CALM1 catalyzes the conversion of ATP into 3',5'-cyclic AMP.
2
|
CALM1 catalyzes the conversion of ATP into 3',5'-cyclic AMP and diphosphoric acid.
2
|
Trifluoperazine affects CALM1
1
|
2
Nitrendipine affects CALM1
|
3
Hsa-miR-943 affects CALM1
3
|
Hsa-miR-891b affects CALM1
3
|
Hsa-miR-7851-3p affects CALM1
3
|
Hsa-miR-653-5p affects CALM1
3
|
Hsa-miR-634 affects CALM1
3
|
Hsa-miR-619-3p affects CALM1
3
|
Hsa-miR-586 affects CALM1
3
|
Hsa-miR-583 affects CALM1
3
|
Hsa-miR-5590-3p affects CALM1
3
|
Hsa-miR-5580-3p affects CALM1
3
|
Hsa-miR-548c-3p affects CALM1
3
|
Hsa-miR-4729 affects CALM1
3
|
Hsa-miR-4696 affects CALM1
3
|
Hsa-miR-4671-3p affects CALM1
3
|
Hsa-miR-454-3p affects CALM1
3
|
Hsa-miR-4530 affects CALM1
3
|
Hsa-miR-4439 affects CALM1
3
|
Hsa-miR-4311 affects CALM1
3
|
Hsa-miR-4295 affects CALM1
3
|
Hsa-miR-4280 affects CALM1
3
|
Hsa-miR-3666 affects CALM1
3
|
Hsa-miR-3613-3p affects CALM1
3
|
Hsa-miR-3163 affects CALM1
3
|
Hsa-miR-3136-5p affects CALM1
3
|
Hsa-miR-3123 affects CALM1
3
|
Hsa-miR-301b-3p affects CALM1
3
|
Hsa-miR-301a-3p affects CALM1
3
|
Hsa-miR-19b-2-5p affects CALM1
3
|
Hsa-miR-19b-1-5p affects CALM1
3
|
Hsa-miR-19a-5p affects CALM1
3
|
Hsa-miR-1911-5p affects CALM1
3
|
Hsa-miR-1827 affects CALM1
3
|
Hsa-miR-142-5p affects CALM1
3
|
Hsa-miR-130b-3p affects CALM1
3
|
Hsa-miR-130a-3p affects CALM1
3
|
Hsa-miR-129-5p affects CALM1
3
|
Hsa-miR-1279 affects CALM1
3
|
Capsid protein affects CALM1
|
3
Trimethyllysine affects CALM1
3
|
Subcutaneous Fat affects CALM1
|
3
Su affects CALM1
|
3
sparser
"By optimizing conditions to draw scatter plot maps, we further assessed the activity and food intake parameters using 2201 activity/rest scatter plots and 2160 food intake scatter plots at 1-hour intervals over 21 hours (ZT0: light on, ZT12: light off, plots deposited in the Cam-Su GRC database,) ( xref and xref Files)."
sparser
"The head position parameters include: the angles of both lines joining the center of acoustic meati (CAM) to the center of the bi-coxofemoral axis (BA) (CAM-BA) and the most superior point of dentiform apophyse of C2 odontoid (OD) to BA (OD-BA) with the vertical line; the distance between the vertical line passing CAM and the posterior upper edge of the S1 (CAM-SVA)."
S12h affects CALM1
|
3
sparser
"The recently developed S12h and M06−2X bring the deviation from CC−cf down to ca. 2 kcal·mol −1 , while excellent results (deviation <0.5 kcal·mol −1 ) are obtained with four functionals: B2PLYP (48.53 kcal·mol −1 ), M06−L (49.45 kcal·mol −1 ), B97−3 (48.46 kcal·mol −1 ) and CAM−S12h (48.41 kcal·mol −1 )."
RACE affects CALM1
|
3
sparser
"ABBREVIATIONS ABS : acrylonitrile butadiene styrene; ACGIH® TLV® : American Conference of Governmental Industrial Hygienists Threshold Limit Value; ACH : air change per hour; AM : additive manufacturing; ASA : acrylonitrile styrene acrylate; AVP : acetone vapor polishing; BJ : binder jetting; CAM-LEM : computer-aided manufacturing of laminated engineering materials; CNF : carbon nanofiber; CNT : carbon nanotube; CP : co-polyester; CNC : condensation nuclei counter; CVP : chloroform vapor polishing; DED : directed energy deposition; DLP : digital light processing; EBM : electron beam melting; EELS : electron energy loss spectrometry; EDB : electrical diffusion batteries; EDX : energy dispersive x-ray analyzer; ER : emission rate; FDM™ : fused deposition modeling; FFF : fused filament fabrication; IAQ : indoor air quality; LSP : laser scattering photometer; LCD : liquid crystal display; LDSA : lung deposited particle surface area; LOD : limit of detection; LOM : laminated object manufacturing; LOQ : limit of quantitation; MCE : mixed cellulose ester filter; ME : material extrusion; MJ : material jetting; OEL : occupational exposure limit; OPS : optical particle sizer; PBF : powder bed fusion; PBZ : personal breathing zone; PC : polycarbonate; PEEK : poly ether ether ketone; PET : polyethylene terephthalate; PETG : Polyethylene terephthalate glycol; PID : photoionization detector; PLA : polylactic acid; PM 1 : particulate matter with aerodynamic diameter less than 1 µm; PM 2.5 : particulate matter with aerodynamic diameter less than 2.5 µm; PM 10 : particulate matter with aerodynamic diameter less than 10 µm; PSL : plastic sheet lamination; PVA : polyvinyl alcohol; REL : recommended exposure limit; SDL : selective deposition lamination; SDS : safety data sheet; SEM : scanning electron microscopy; SL : sheet lamination; SLA : stereolithography; SLM : selective laser melting; SMPS : scanning mobility particle sizer; SVOC : semi-volatile organic compound; TEM : transmission electron microscopy; TGA : thermal gravimetric analysis; TPU : thermo polyurethane; UAM : ultrasonic additive manufacturing; UC : ultrasonic consolidation; TVOC : total volatile organic compounds; TWA : time-weighted average; VOC : volatile organic compound; VP : vat photopolymerization."
sparser
"The closest we have encountered are the computer-aided manufacturing of laminated engineering materials (CAM-LEM) method [ xref ] or a method used in composite manufacturing (e.g., the automotive industry) of the so-called laser-assisted tape placement (LATP) method [ xref , xref ]."
Infrared Rays affects CALM1
|
3
HIV1gp9 affects CALM1
3
|
Endothelial Cells affects CALM1
|
3
CALM1 binds Endothelial Cells. 3 / 3
|
3
sparser
"The majority of included studies examined “X” biomarkers, which were divided into the following subcategories: inflammation xref – xref , xref , xref – xref , xref – xref , xref ( N = 76), vascular xref – xref , xref ( N = 6), synucleinopathy xref , xref ( N = 2), frontotemporal dementia (FTD) ( N = 1), endothelial cell-cell adhesion molecule (EC-CAM) ( N = 1), neuronal function ( N = 22), and sleep ( N = 4). (Details about X biomarkers are listed in xref – xref .)"
Deacetoxyvinzolidine affects CALM1
3
|
CALM1 affects transcription, DNA-templated
|
2
1
CALM1 affects signal transduction
|
3
CALM1 affects nitrendipine
|
3
CALM1 affects glucocerebrosidase
|
3
CALM1 affects function
|
3
CALM1 affects capsid protein
|
3
CALM1 affects activation
|
3
CALM1 affects Subcutaneous Fat
|
3
CALM1 affects Su
|
3
sparser
"By optimizing conditions to draw scatter plot maps, we further assessed the activity and food intake parameters using 2201 activity/rest scatter plots and 2160 food intake scatter plots at 1-hour intervals over 21 hours (ZT0: light on, ZT12: light off, plots deposited in the Cam-Su GRC database,) ( xref and xref Files)."
sparser
"The head position parameters include: the angles of both lines joining the center of acoustic meati (CAM) to the center of the bi-coxofemoral axis (BA) (CAM-BA) and the most superior point of dentiform apophyse of C2 odontoid (OD) to BA (OD-BA) with the vertical line; the distance between the vertical line passing CAM and the posterior upper edge of the S1 (CAM-SVA)."
CALM1 affects S12h
|
3
sparser
"The recently developed S12h and M06−2X bring the deviation from CC−cf down to ca. 2 kcal·mol −1 , while excellent results (deviation <0.5 kcal·mol −1 ) are obtained with four functionals: B2PLYP (48.53 kcal·mol −1 ), M06−L (49.45 kcal·mol −1 ), B97−3 (48.46 kcal·mol −1 ) and CAM−S12h (48.41 kcal·mol −1 )."
CALM1 affects RACE
|
3
sparser
"ABBREVIATIONS ABS : acrylonitrile butadiene styrene; ACGIH® TLV® : American Conference of Governmental Industrial Hygienists Threshold Limit Value; ACH : air change per hour; AM : additive manufacturing; ASA : acrylonitrile styrene acrylate; AVP : acetone vapor polishing; BJ : binder jetting; CAM-LEM : computer-aided manufacturing of laminated engineering materials; CNF : carbon nanofiber; CNT : carbon nanotube; CP : co-polyester; CNC : condensation nuclei counter; CVP : chloroform vapor polishing; DED : directed energy deposition; DLP : digital light processing; EBM : electron beam melting; EELS : electron energy loss spectrometry; EDB : electrical diffusion batteries; EDX : energy dispersive x-ray analyzer; ER : emission rate; FDM™ : fused deposition modeling; FFF : fused filament fabrication; IAQ : indoor air quality; LSP : laser scattering photometer; LCD : liquid crystal display; LDSA : lung deposited particle surface area; LOD : limit of detection; LOM : laminated object manufacturing; LOQ : limit of quantitation; MCE : mixed cellulose ester filter; ME : material extrusion; MJ : material jetting; OEL : occupational exposure limit; OPS : optical particle sizer; PBF : powder bed fusion; PBZ : personal breathing zone; PC : polycarbonate; PEEK : poly ether ether ketone; PET : polyethylene terephthalate; PETG : Polyethylene terephthalate glycol; PID : photoionization detector; PLA : polylactic acid; PM 1 : particulate matter with aerodynamic diameter less than 1 µm; PM 2.5 : particulate matter with aerodynamic diameter less than 2.5 µm; PM 10 : particulate matter with aerodynamic diameter less than 10 µm; PSL : plastic sheet lamination; PVA : polyvinyl alcohol; REL : recommended exposure limit; SDL : selective deposition lamination; SDS : safety data sheet; SEM : scanning electron microscopy; SL : sheet lamination; SLA : stereolithography; SLM : selective laser melting; SMPS : scanning mobility particle sizer; SVOC : semi-volatile organic compound; TEM : transmission electron microscopy; TGA : thermal gravimetric analysis; TPU : thermo polyurethane; UAM : ultrasonic additive manufacturing; UC : ultrasonic consolidation; TVOC : total volatile organic compounds; TWA : time-weighted average; VOC : volatile organic compound; VP : vat photopolymerization."
sparser
"The closest we have encountered are the computer-aided manufacturing of laminated engineering materials (CAM-LEM) method [ xref ] or a method used in composite manufacturing (e.g., the automotive industry) of the so-called laser-assisted tape placement (LATP) method [ xref , xref ]."
CALM1 affects Infrared Rays
|
3
CALM1 affects HIV1gp9
3
|
CALM1 affects Endothelial Cells
|
3
CALM1 binds Endothelial Cells. 3 / 3
|
3
sparser
"The majority of included studies examined “X” biomarkers, which were divided into the following subcategories: inflammation xref – xref , xref , xref – xref , xref – xref , xref ( N = 76), vascular xref – xref , xref ( N = 6), synucleinopathy xref , xref ( N = 2), frontotemporal dementia (FTD) ( N = 1), endothelial cell-cell adhesion molecule (EC-CAM) ( N = 1), neuronal function ( N = 22), and sleep ( N = 4). (Details about X biomarkers are listed in xref – xref .)"
sparser
"The primary endpoint was the incidence of POD, and the secondary endpoints were the levels of inflammatory factors (tumor necrosis factor- α [TNF-α], interleukin [IL]-1β, IL-6, and IL-10), nerve injury-related factors (brain-derived neurotrophic factor [BDNF], S-100β protein, neuron-specific enolase [NSE], and neurofilament light chain [NfL]), and antioxidant factors (heme oxygenase-1 [HO-1]), as well as the Visual Analogue Scale (VAS) and Confusion Assessment Method-Chinese Reversion (CAM-CR) scores."
sparser
"The primary endpoint was the incidence of POD, and the secondary endpoints were the levels of inflammatory factors (tumor necrosis factor- α [TNF-α], interleukin [IL]-1β, IL-6, and IL-10), nerve injury-related factors (brain-derived neurotrophic factor [BDNF], S-100β protein, neuron-specific enolase [NSE], and neurofilament light chain [NfL]), and antioxidant factors (heme oxygenase-1 [HO-1]), as well as the Visual Analogue Scale (VAS) and Confusion Assessment Method-Chinese Reversion (CAM-CR) scores."
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects CALM1
|
1
2
Β3 affects NFASC
|
2
Tetrachloromethane affects CALM1
2
|
Tert-butanol affects CALM1
2
|
Pirinixic acid affects CALM1
2
|
Melittin affects mastoparan
|
2
Laminin affects CALM1
|
2
Hsa-miR-7856-5p affects CALM1
2
|
Hsa-miR-6862-5p affects CALM1
2
|
Hsa-miR-6765-5p affects CALM1
2
|
Hsa-miR-6743-5p affects CALM1
2
|
Hsa-miR-6738-5p affects CALM1
2
|
Hsa-miR-6734-5p affects CALM1
2
|
Hsa-miR-655-3p affects CALM1
2
|
Hsa-miR-6088 affects CALM1
2
|
Hsa-miR-550b-2-5p affects CALM1
2
|
Hsa-miR-548x-5p affects CALM1
2
|
Hsa-miR-548g-5p affects CALM1
2
|
Hsa-miR-548f-5p affects CALM1
2
|
Hsa-miR-548aj-5p affects CALM1
2
|
Hsa-miR-5192 affects CALM1
2
|
Hsa-miR-510-5p affects CALM1
2
|
Hsa-miR-495-5p affects CALM1
2
|
Hsa-miR-4770 affects CALM1
2
|
Hsa-miR-4659b-3p affects CALM1
2
|
Hsa-miR-4659a-3p affects CALM1
2
|
Hsa-miR-4644 affects CALM1
2
|
Hsa-miR-4306 affects CALM1
2
|
Hsa-miR-4260 affects CALM1
2
|
Hsa-miR-4253 affects CALM1
2
|
Hsa-miR-423-5p affects CALM1
2
|
Hsa-miR-382-5p affects CALM1
2
|
Hsa-miR-374c-5p affects CALM1
2
|
Hsa-miR-369-3p affects CALM1
2
|
Hsa-miR-3622b-5p affects CALM1
2
|
Hsa-miR-3184-5p affects CALM1
2
|
Hsa-miR-3148 affects CALM1
2
|
Hsa-miR-302c-5p affects CALM1
2
|
Hsa-miR-196b-5p affects CALM1
2
|
Hsa-miR-196a-5p affects CALM1
2
|
Hsa-miR-1914-3p affects CALM1
2
|
Hsa-miR-185-5p affects CALM1
2
|
Hsa-miR-143-3p affects CALM1
2
|
Hsa-miR-1305 affects CALM1
2
|
Hsa-miR-1304-5p affects CALM1
2
|
Hsa-miR-1261 affects CALM1
2
|
Hsa-miR-1250-3p affects CALM1
2
|
Hsa-miR-1227-3p affects CALM1
2
|
Hsa-let-7g-3p affects CALM1
2
|
Hsa-let-7a-2-3p affects CALM1
2
|
Cytochrome P450 affects CALM1
|
2
CALM1 binds cytochrome P450. 2 / 2
|
2
sparser
"PubMed, EMBASE® and the Cochrane Central Register of Controlled Trials (CCTR) were systematically reviewed for research articles pertaining to known CYP mediated CAM-drug interactions; case reports describing adverse events in patients, and clinical trials which examined the effects of herbs and supplements used during cancer treatment."
Cobalt dichloride affects CALM1
2
|
sparser
"Zhang et al. [73] used 3D densely connected convolutional neural network (CAM-CNN) to extract brain MRI multilevel features for classification of Alzheimer's disease and mild cognitive impairment, densely connected difference at different unit levels; 3D dense unit introduces attention mechanism to generate attention maps and sum transformed MRI hierarchical data into more compact high-level; model has high classification prediction accuracy, and classification performance is at the highest level."
Calcium atom affects CALM1
1
|
1
Arachidonic acid affects CALM1
|
2
Albumin affects CALM1
|
2
Trifluoperazine affects CALM1
2
|
Shprintzen-Goldberg Syndrome affects CCI
|
2
CALM1 binds CCI and Shprintzen-Goldberg Syndrome. 2 / 2
|
2
SP affects CALM1
|
2
sparser
"Next, correlation analysis was undertaken to delineate putative relationships between the aforementioned soluble markers and cellular subsets described above We also noted a heretofore unreported positive correlation of sMAd-CAM levels with CD8+ effector memory T cell counts (Supplementary Figure S4A )."
sparser
"The correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery were explored with the Beck Anxiety Inventory (BAI) scale, 10-point Visual Analogue Scale (VAS), and Confusion Assessment Method Chinese Reversion (CAM-CR) scale."
NFASC affects β3
|
2
NET affects CALM1
|
2
sparser
"Specifically, CAM-Net learns to generate pixel-wise weights to suppress noisy regions with incorrect pseudo-labels while highlighting clean ones by exploiting hybrid strengthened features from image content, providing straightforward and reliable guidance for optimizing the segmentation model."
Myo1 affects CAMK2B
|
2
Mel affects CALM1
|
2
sparser
"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."
sparser
"Mt-CamH purified from E. coli cultured with supplemental iron (Fe-Mt-CamH) was also a trimer containing 0.15 iron per monomer and only a trace amount of zinc and had an effective k(cat) (k(cat)(eff)) value normalized for iron that was 6-fold less than that for the iron form of Mt-Cam, whereas the k(cat)/K(m)(eff) was similar to that for Fe-Mt-Cam."
sparser
"These parameters included the offset between the centre of the acoustic meatus and the gravity line (CAM-GL), saggital vertical axis (SVA), T1 pelvic angle (TPA), McGregor slope, C2-7 lordosis, thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), PI-LL, sacral slope (SS), pelvic tilt (PT), and knee flexion."
sparser
"These receptors include the immunoglobulin super family (ICAM-1 and -2, LFA-3, VCAM-1, ENDOCAM-1, and NCAM-1); the integrins (LFA-1 or C D l l a / 1 8 , MAC-1, LPAM-1, 0 1 , β2, β3 families); the LEC-CAM family for lectins ; Cadherins (Ρ, Ν, E-Cadherins), and the Hermes group of antigens (CD-44) (Harlan, 1985; Dustin and Springer, 1988; Lassmann et al, 1991 , Staunton et al, 1990 Yednock, 1985) ."
| PMC
Flunarizine affects CALM1
2
|
ESP32 affects CALM1
|
2
|
2
CCI affects Shprintzen-Goldberg Syndrome
|
2
CALM1 binds CCI and Shprintzen-Goldberg Syndrome. 2 / 2
|
2
CB affects CALM1
|
2
CAMK2B affects Myo1
|
2
CALM1 affects ATP, and 3',5'-cyclic AMP
2
|
CALM1 affects ATP, 3',5'-cyclic AMP, and diphosphoric acid
2
|
CALM1 affects β3
|
2
CALM1 affects upregulation
|
2
CALM1 affects shedding ectodomain
|
2
CALM1 affects shedding ectodomain virus receptor ACE2
|
2
eidos
"Genes from the constructed protein-interaction network provide a first snapshot of a comprehensive image : IFI16 controls the interferon response to the virus 31 , LIMA1 mediating the interaction between Cadherins ( CDH1 , CDH13 ) and Actin in the context of adherens junctions potentially playing a role in virus infection , CALM1 inhibits shedding of the ectodomain of the virus receptor ACE2 36 ."
eidos
"Genes from the constructed protein interaction network provide a first snapshot of a comprehensive image : IFI16 controls the interferon response to the virus 20 , LIMA1 mediating the interaction between Cadherins ( CDH1 , CDH13 ) and Actin in the context of adherens junctions potentially playing a role in virus infection , CALM1 inhibits shedding of the ectodomain of the virus receptor ACE2 25 ."
| DOI
CALM1 affects release
|
2
CALM1 affects phosphorylation
|
2
CALM1 affects mastoparan, and melittin
|
2
CALM1 affects laminin
|
2
CALM1 affects innate immune response
|
2
CALM1 affects inflammatory response
|
2
CALM1 activates inflammatory response. 2 / 2
|
2
CALM1 affects expression
|
2
CALM1 affects elongation
|
2
CALM1 affects diphosphoric acid
2
|
CALM1 affects development
|
2
CALM1 affects cytokine production
|
2
CALM1 affects cytochrome P450
|
2
CALM1 binds cytochrome P450. 2 / 2
|
2
sparser
"PubMed, EMBASE® and the Cochrane Central Register of Controlled Trials (CCTR) were systematically reviewed for research articles pertaining to known CYP mediated CAM-drug interactions; case reports describing adverse events in patients, and clinical trials which examined the effects of herbs and supplements used during cancer treatment."
CALM1 affects control enzymes ion channels aquaporins proteins
|
2
sparser
"Zhang et al. [73] used 3D densely connected convolutional neural network (CAM-CNN) to extract brain MRI multilevel features for classification of Alzheimer's disease and mild cognitive impairment, densely connected difference at different unit levels; 3D dense unit introduces attention mechanism to generate attention maps and sum transformed MRI hierarchical data into more compact high-level; model has high classification prediction accuracy, and classification performance is at the highest level."
CALM1 affects cell population proliferation
|
2
CALM1 inhibits cell population proliferation. 2 / 2
|
2
CALM1 affects cell growth
|
2
CALM1 affects biosynthetic process
|
1
1
CALM1 affects Shprintzen-Goldberg Syndrome
|
2
CALM1 binds CCI and Shprintzen-Goldberg Syndrome. 2 / 2
|
2
CALM1 affects SP
|
2
sparser
"Next, correlation analysis was undertaken to delineate putative relationships between the aforementioned soluble markers and cellular subsets described above We also noted a heretofore unreported positive correlation of sMAd-CAM levels with CD8+ effector memory T cell counts (Supplementary Figure S4A )."
sparser
"A possible solution to this problem is deep learning -a branch of AI that utilises neural networks as uni-with an anomaly localisation component, which combines the U-Net's CAM activation with lung regions extracted with 3D connected component (3DCC) method to form localisation results [6] ."
sparser
"The correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery were explored with the Beck Anxiety Inventory (BAI) scale, 10-point Visual Analogue Scale (VAS), and Confusion Assessment Method Chinese Reversion (CAM-CR) scale."
CALM1 affects PI3K-Akt
|
2
CALM1 affects Net
|
2
sparser
"A possible solution to this problem is deep learning -a branch of AI that utilises neural networks as uni-with an anomaly localisation component, which combines the U-Net's CAM activation with lung regions extracted with 3D connected component (3DCC) method to form localisation results [6] ."
CALM1 affects Neoplasm Metastasis
|
1
1
sparser
"Specifically, increased CAM expression by pro-inflammatory stimuli has been observed in a number of cardiovascular pathologies, which include atherosclerosis, hypoxia-induced pulmonary hypertension, and acute lung injury. xref – xref The nuclear factor NF-κB has emerged as a central coordinator key to the transactivation of CAM genes in response to inflammatory cues. xref The co-factors involved in this process that fine-tune NF-κB dependent CAM activation and their pathophysiological relevance in CVD, however, are not well understood."
CALM1 affects NET
|
2
sparser
"Specifically, CAM-Net learns to generate pixel-wise weights to suppress noisy regions with incorrect pseudo-labels while highlighting clean ones by exploiting hybrid strengthened features from image content, providing straightforward and reliable guidance for optimizing the segmentation model."
CALM1 affects Mel
|
2
sparser
"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."
sparser
"Mt-CamH purified from E. coli cultured with supplemental iron (Fe-Mt-CamH) was also a trimer containing 0.15 iron per monomer and only a trace amount of zinc and had an effective k(cat) (k(cat)(eff)) value normalized for iron that was 6-fold less than that for the iron form of Mt-Cam, whereas the k(cat)/K(m)(eff) was similar to that for Fe-Mt-Cam."
sparser
"These parameters included the offset between the centre of the acoustic meatus and the gravity line (CAM-GL), saggital vertical axis (SVA), T1 pelvic angle (TPA), McGregor slope, C2-7 lordosis, thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), PI-LL, sacral slope (SS), pelvic tilt (PT), and knee flexion."
sparser
"These receptors include the immunoglobulin super family (ICAM-1 and -2, LFA-3, VCAM-1, ENDOCAM-1, and NCAM-1); the integrins (LFA-1 or C D l l a / 1 8 , MAC-1, LPAM-1, 0 1 , β2, β3 families); the LEC-CAM family for lectins ; Cadherins (Ρ, Ν, E-Cadherins), and the Hermes group of antigens (CD-44) (Harlan, 1985; Dustin and Springer, 1988; Lassmann et al, 1991 , Staunton et al, 1990 Yednock, 1985) ."
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CALM1 affects Interferon
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2
CALM1 inhibits Interferon. 2 / 2
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2
CALM1 affects ESP32
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2
CALM1 affects Calcium
2
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"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
"Protein interaction studies demonstrated physical association of HDAC4 with SRF in living cells. The SRF/HDAC4 co-association was disrupted by treatment of cells with hypertrophic agonists such as angiotensin-II and a Ca2+ ionophore, ionomycin. Furthermore, activation of Ca2+/calmodulin-dependent protein kinase (CaMK)-IV prevented SRF/HDAC4 interaction and derepressed SRF-dependent transcription activity."
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2
CALM1 affects CCI, and Shprintzen-Goldberg Syndrome
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2
CALM1 binds CCI and Shprintzen-Goldberg Syndrome. 2 / 2
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2
CALM1 affects CB
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2
"OMIM summary: Human: Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. Pubmed titles from omim summary: (summary is not available from this source) Entrez Gene GeneRifs summary: Human: Calmodulin is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 149 amino acids and has 4 calcium-binding domains. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[supplied by OMIM] Pubmed titles from gene summary: (summary is not available from this source) Jubilant PathArt summary: (summary is not available from this source) Ariadne Resnet summary: (summary is not available from this source) calcium/calmodulin activates calcium/calmodulin-dependent protein kinase I (CAMK1 Entrez gene list of calmodulin dependent proteins"
"Calcium is a well established regulator of transcription. Modulation of responses to this ubiquitous second messenger can occur by superposition of coincident Ca2+-independent signals, but there is also growing evidence that the strength, frequency, source, and location of the Ca2+ signal are determinants for specific transcriptional results. These complex variations must be translated into changes in protein function that preserve and process the information conveyed by the original signal. The Ca2+ receptor calmodulin (CaM)1 is involved in many of these changes through its effects on a variety of CaM-binding proteins (1). Among these, the multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are notable for their effects on components of transcription complexes, directly connecting Ca2+ with changes in gene expression. The highly homologous CaMKI and CaMKIV are distinct from the multimeric CaMKII, although all have broad and overlapping substrate preferences, because their activation is greatly enhanced following phosphorylation catalyzed by \"upstream\" kinases in a manner analogous to the mitogen-activated protein kinase cascade. Based on an evolving understanding of CaMKI/IV regulation and cloning of the CaMKI/IV kinases (CaMKKs), a Ca2+/CaM-dependent protein kinase I/IV cascade (CaMK cascade) has been proposed (2, 3). This review will discuss the biochemical and physiologic basis for the existence of this cascade and its potential for mediating Ca2+ regulation of transcription. Identification and Biochemical Characterization of a CaMK Cascade TOP INTRODUCTION Identification and Biochemical... Does the Cascade Function... Is the Cascade Physiologic? Other Transcriptional Targets... Evidence for a CaMK... REFERENCES CaMKI and CaMKIV are closely related protein kinases with many similarities in mode of activation and substrate preferences in vitro but with different tissue distributions. The kinases are regulated by Ca2+/CaM binding, which relieves intramolecular steric inhibition of the active site by a C-terminal autoinhibitory domain (Fig. 1)."
CALM1 affects B3LYP/6-31G
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2
sparser
"Density functional calculations were executed, and the geometries of losartan anion ( 1 ) were optimized at the DFT [ xref ] level of theory (Becke three-term correlation functional; the Lee, Yang and Parr exchange functional B3LYP, or long range corrected version of the B3LYP functional, or the Perdew, Burke and Ernzerhof functional PBE1PBE) or applying the Mőller–Plesset second order perturbation theory MP2 using the Gaussian 09 D.01 program [ xref ], namely the (1) B3LYP/6-31G(d,p) [ xref ], (2) CAM-B3LYP/6-31G(d,p) [ xref ], (3) B3LYP/6-311+G(d,p) [ xref , xref ], (4) PBE1PBE/6-31G(d,p) [ xref , xref ] and (5) MP2/6-31G(d,p) [ xref ] approach in the gaseous phase and applying the conductor-like polarizable continuum model (CPCM, water as a solvent) [ xref , xref , xref ]."
sparser
"NMR shielding for proton (H ref ) was calculated for TMS (tetramethylsilane) at the (1) B3LYP/6-31G(d,p), (2) CAM-B3LYP/6-31G(d,p), (3) B3LYP/6-311+G(d,p), (4) PBE1PBE/6-31G(d,p) and (5) MP2/6-31G(d,p) level of theory (gaseous phase and CPCM solvation model and water as solvent) at 293 K. It is noteworthy that the difference between dielectric constant values of water and DMSO are not significant (ε = 78.3 and 46.8, respectively [ xref ])."
CALM1 affects B.S1
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2
B3LYP/6-31G affects CALM1
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2
sparser
"Density functional calculations were executed, and the geometries of losartan anion ( 1 ) were optimized at the DFT [ xref ] level of theory (Becke three-term correlation functional; the Lee, Yang and Parr exchange functional B3LYP, or long range corrected version of the B3LYP functional, or the Perdew, Burke and Ernzerhof functional PBE1PBE) or applying the Mőller–Plesset second order perturbation theory MP2 using the Gaussian 09 D.01 program [ xref ], namely the (1) B3LYP/6-31G(d,p) [ xref ], (2) CAM-B3LYP/6-31G(d,p) [ xref ], (3) B3LYP/6-311+G(d,p) [ xref , xref ], (4) PBE1PBE/6-31G(d,p) [ xref , xref ] and (5) MP2/6-31G(d,p) [ xref ] approach in the gaseous phase and applying the conductor-like polarizable continuum model (CPCM, water as a solvent) [ xref , xref , xref ]."
sparser
"NMR shielding for proton (H ref ) was calculated for TMS (tetramethylsilane) at the (1) B3LYP/6-31G(d,p), (2) CAM-B3LYP/6-31G(d,p), (3) B3LYP/6-311+G(d,p), (4) PBE1PBE/6-31G(d,p) and (5) MP2/6-31G(d,p) level of theory (gaseous phase and CPCM solvation model and water as solvent) at 293 K. It is noteworthy that the difference between dielectric constant values of water and DMSO are not significant (ε = 78.3 and 46.8, respectively [ xref ])."
B.S1 affects CALM1
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2