IndraLab

Statements


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sparser
"Selectin (32) or LEC-CAM (33) include lymphocyte homing receptor (MEL-14), endothelial leucocyte adhesion molecule 1(ELAM- l), and granule membrane protein (GMP- 140)."

sparser
"l The LEC-CAM Family At least three other adhesion molecules (ELAM-1, GMP-140, and LAM-l) that influence neutrophils have been characterized."

sparser
"This is illus- trated in the elucidation of the LEC-CAM ligands de- scribed below."

sparser
"Granule membrane protein 140 (GMP- 140) and endothelial leukocyte adhesion molecule 1 (ELAM-1) are members of the LEC-CAM family."

sparser
"Since adhesion and homing involve multiple, structurally distinct receptodligand molecules, it is possible that LEC-CAM 1 does not cover a central role in the ALL blast localization in lymphoid organs, but requires the contribution of additional cytoadhesion structures."

sparser
"Final confirmation that the oligosaccharides described here are indeed LEC-CAM ligands must await de novo synthesis and confirmation of their binding activity."

sparser
"Recent evidence from cloning the Hermes-l/CD44 and MEL-14 genes indicates the MEL-14 belongs to a structurally different family of molecules (termed Lectin, EGF, Complement-cellular adhesion molecule [LEC-CAM])'o'*'0"'07."

sparser
"The expression of some adhesion molecules on BM mononuclear cells was assessed by a panel of MoAbs directed against: CD1 la, CDI lb, CDI lc, CD44, CD49d(VLA4), CD49e(VLA-5), LEC-CAM I. P-170 expression P-170 expression was evaluated by the MoAb C219 (Cis International, Centocor Diagnostics), which is an IgG2b antibody that recognizes a cytoplasmic antigen."

sparser
"Here we will briefly describe these ap- proaches and the considerable amount of information ob- tained about the LEC-CAM carbohydrate ligands."