IndraLab

Statements

CALM1 binds IQ. 6 / 6
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sparser
"Thus, we hypothesized that yeast Cam1 may interact with the HsMyo1e IQ domain."
31542284
reach
"Cam1 binding to the IQ motif(s) stabilizes the α-helix and results in a drop in FRET signal in the absence of calcium (Figure 2E–G)."
31566560
sparser
"Cam1 binding to the IQ motif(s) stabilizes the α-helix and results in a drop in FRET signal in the absence of calcium ( xref )."
31566560
sparser
"To characterize Cam1 binding to the IQ neck region of Myo1, recombinant FRET constructs were produced in which CyPet and YPet were separated by one of the two Myo1 IQ motifs or by both of these motifs (Myo1 IQ1 -FRET, Myo1 IQ2 -FRET or Myo1 IQ12 -FRET) ( xref and xref )."
31566560
sparser
"Importantly, mutation of the IQ motif significantly weakened CaM1 binding and eliminated the CaM1-mediated enhancement of scoparone-induced L-VGCC activation, indicating that the effect of scoparone was dependent on the CaM1-IQ interaction."
35572395
sparser
"This recruitment was specific for the IQ motif-Cam1 interaction as cells overexpressing mGFP-HsMyo1e tail produced no such effect ( xref )."
31542284