IndraLab

Statements

CALM1 binds PPP3CA. 11 / 11
1 | 8 2
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
33193633
reach
"Moreover, KIF1Bbeta induced co-precipitation of DRP1, in contrast to non transduced cells where DRP1 failed to co-precipitate with the CALM2 and CNA complex."
26812016
reach
"Meanwhile, another CALM2 dependent enzyme, calmodulin dependent protein kinase II (CaMKII) co-precipitated together with CALM2 independent of KIF1Bbeta expression, indicating that KIF1Bbeta specifical[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"We considered the possibility that KIF1Bbeta might enhance CNA-CALM2 binding by affecting the intracellular Ca 2+ concentration, since CNA binds CALM2 with higher affinity in Ca 2+ -saturated conditio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
signor
"Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain."
11796223
reach
"We conclude that KIF1Bbeta acts as a direct scaffold for CALM2 and CNA, facilitating the formation and stabilization of the CALM2 and CNA complex, relieving CNA autoinhibition, and thus enabling full [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"In contrast, addition of wild-type Flag-KIF1Bbeta or Flag-KIF1Bbeta600-1400 drastically enhanced S 35 CNA binding to DRP1 peptide and enabled co-precipitation of CALM2 and Flag-KIF1Bbeta, indicating t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"We found that endogenous CNA-CALM2 interaction requires KIF1Bbeta, which acts as a scaffold to potentiate and stabilize the CNA and CALM2 complex."
26812016
reach
"We conclude that KIF1Bbeta is required for CNA-CALM2 association and enables DRP1 substrate recognition.We considered the possibility that KIF1Bbeta might potentiate CNA-CALM2 binding by affecting int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"We infer that KIF1Bbeta might stabilize the CNA and CALM2 complex and is potentially required for CNA substrate recognition."
26812016
sparser
"The p values for CALM1-PPP3CA and CASP12-CASP3 are 0.010 and 0.045, respectively for PMINR, but 0.485 and 0.854, respectively for DGCA."
33193633