IndraLab

Statements

CALM1 binds PPP3CA. 13 / 13
1 2 | 8 2
reach
"We found that endogenous CNA-CALM2 interaction requires KIF1Bbeta, which acts as a scaffold to potentiate and stabilize the CNA and CALM2 complex."
26812016
reach
"We conclude that KIF1Bbeta acts as a direct scaffold for CALM2 and CNA, facilitating the formation and stabilization of the CALM2 and CNA complex, relieving CNA autoinhibition, and thus enabling full [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"Moreover, KIF1Bbeta induced co-precipitation of DRP1, in contrast to non transduced cells where DRP1 failed to co-precipitate with the CALM2 and CNA complex."
26812016
reach
"We infer that KIF1Bbeta might stabilize the CNA and CALM2 complex and is potentially required for CNA substrate recognition."
26812016
biogrid
No evidence text available
35271311
reach
"We conclude that KIF1Bbeta is required for CNA-CALM2 association and enables DRP1 substrate recognition.We considered the possibility that KIF1Bbeta might potentiate CNA-CALM2 binding by affecting int[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
sparser
"Both CALM1 and PPP3CA play essential roles in the transduction of intracellular Ca(2+)-mediated signals, in that CALM1 encodes calcium binding protein which is a subunits of phosphorylase kinase and can bind PPP3CA regulatory domain and causes a conformational change in removing PPP3CA autoinhibitory domain from its catalytic site, i.e., activating PPP3CA ( xref )."
33193633
reach
"In contrast, addition of wild-type Flag-KIF1Bbeta or Flag-KIF1Bbeta600-1400 drastically enhanced S 35 CNA binding to DRP1 peptide and enabled co-precipitation of CALM2 and Flag-KIF1Bbeta, indicating t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
signor
"Calcium-bound calmodulin associates with calcineurin (cn), releasing the phosphatase from the repressive effects on an autoinhibitory domain."
11796223
reach
"We considered the possibility that KIF1Bbeta might enhance CNA-CALM2 binding by affecting the intracellular Ca 2+ concentration, since CNA binds CALM2 with higher affinity in Ca 2+ -saturated conditio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
reach
"Meanwhile, another CALM2 dependent enzyme, calmodulin dependent protein kinase II (CaMKII) co-precipitated together with CALM2 independent of KIF1Bbeta expression, indicating that KIF1Bbeta specifical[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26812016
biogrid
No evidence text available
33961781
sparser
"The p values for CALM1-PPP3CA and CASP12-CASP3 are 0.010 and 0.045, respectively for PMINR, but 0.485 and 0.854, respectively for DGCA."
33193633