IndraLab

"CD146, also known as melanoma cell adhesion molecule (MCAM), melanoma‐cell adhesion molecule (Mel‐CAM), and mucin 18 (MUC18), belongs to the immunoglobulin superfamily and is a cell adhesion molecule (CAM), that found abundantly in malignant tumors [ xref ]."

"The diagnosis was made based on the increased serum levels of β‐HCG and confirmed by the pathological report after D&C. Therefore, measurement of the serum values of β‐HCG can be beneficial in the diagnosis of both the primary and gestational presentations and secondary/metastatic conditions; β‐HCG can help determine the possibility of a germ cell or GTD origin of the tumor or rule out the differentiation of an epithelial tumor. xref Furthermore, immunohistochemical analysis has revealed the presence of antibodies, such as Mel‐CAM, HLA‐G, MUC‐4, and β‐catenin in the specimens, which suggests the possible mechanisms of the development of choriocarcinoma. xref Consistent with this notion, in our patient, an immunohistochemistry study revealed positive CK, Sall 4, high ki‐67 (>90%), and negative p63."

"Tumor cells diffusely express human placental lactogen (hPL), MUC‐4, HSD3B1, HLA‐G, and Mel‐CAM (CD146)."

"Cluster differentiation 146 (CD146), also known as Melanoma Cell Adhesion Molecule (Mel‐CAM, MCAM), is a membrane glycoprotein that functions as a receptor for lamin alpha 4 to mediate cell adhesion."

"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."