IndraLab

"Cluster differentiation 146 (CD146), also known as Melanoma Cell Adhesion Molecule (Mel‐CAM, MCAM), is a membrane glycoprotein that functions as a receptor for lamin alpha 4 to mediate cell adhesion."

"Mesenchymal progenitor cells that reside within vessel walls are multipotent, xref , xref , xref , xref , xref , xref are native progenitors of mesenchymal stem cells (MSCs), and contribute to endogenous bone repair. xref , xref When purified according to the expression of CD146 (Mel‐CAM) and CD34, human perivascular stem cells (PSCs) from adipose tissue or other tissue compartments hasten bone repair. xref , xref , xref , xref , xref , xref Despite direct differentiation of human PSCs toward chondroblasts, osteoblasts, and osteocytes, xref PSCs induce bone healing primarily via paracrine stimulation of resident host cells within the bone tissue. xref , xref Osteoinductive paracrine effects are either via elaboration of nonvesicular proteins, such as bone morphogenetic proteins, xref , xref , xref or via secretion of bioactive extracellular vesicles (EVs). xref In contrast, various and contradictory effects of mesenchymal progenitor cells on osteoclasts have been reported. xref , xref , xref , xref However, the role of purified PSCs in regulating osteoclastic formation or function has not been investigated."