IndraLab

Statements

CALM1 binds MXD1. 9 / 9
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"This is an important difference compared to the homing into GALT, where the adhesion is driven by the binding of α4β7 integrins to Mad-CAM1 ( xref )."
36936934
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"The migration of alloreactive donor T cells to the GI tract is mediated by the binding of the α4β7 integrin on T cells to its ligand, mucosal addressing cellular adhesion molecule (Mad-CAM1), on gut-associated endothelium[ xref ]."
34669521
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"Vedolizumab is a monoclonal antibody specific for α4β7 that blocks its binding to MAd-CAM1."
34669521
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"These ligands include PSGL-1, the hemopoietic stem cell marker CD34, glycosylation-dependent cell adhesion molecule 1 (GlyCAM1) and mucosal addressin cell adhesion molecule 1 (MAd-CAM1), all of which contain a sulphated form of the sLe x tetrasaccharide. xref - xref However, there are other selectin ligands that occur naturally in humans which do not contain sLe x , the similar tetrasaccharide sLe a , nor structurally related carbohydrate moieties."
38957672
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"α4β1 binds to fibronectin splice variants at the CS-1 domain, and to vascular cell adhesion protein 1 (VCAM-1) which is expressed on activated endothelia near sites of inflammation, whereas α4β7 binds[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22633092
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"The gene NCAN , a CNS-specific extracellular matrix protein whose expression has been linked to malignant behavior of neuroblastoma, xref and additional genes encoding cell surface proteins relevant for adhesion of neurons and leukocytes ( DSCAML1 , MAD-CAM1 ) also correlated significantly with OMAS neuroimmune symptoms."
37537844
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"Its mechanism of action comprises blocking the interaction between the α4-β7 integrin in lymphocytes and the MAD-CAM1 adressin at the endothelial wall."
37859629
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"Throughout foetal development in mice, chemokines such as CXCL12 and -13, CCL19, -20 and -21, and adhesion molecules including vascular cell adhesion molecule 1 (VCAM-1), mucosal vascular addressing cell adhesion molecule 1 (MAD-CAM1) and intercellular adhesion molecule 1 (ICAM-1), altogether signal to promote the circulation of LTi cells and the migration of T- and B-lymphocytes into primordia resembling Peyer’s patches (Kunkel et al. xref ; Patel et al. xref )."
36309872
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"Moreover, hypersialylation promotes tumor dissemination and metastasis by modulating the function of different integrins. xref For example, inhibiting sialylation in MM impairs interactions between tumor cells, VCAM1 and mucosal vascular addressin cell adhesion molecule 1 (MAD-CAM1) by altering the maturation of CD49d. xref Sialylation also participates in the generation of selectin ligands."
36779594