IndraLab

Statements


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"The migration of alloreactive donor T cells to the GI tract is mediated by the binding of the α4β7 integrin on T cells to its ligand, mucosal addressing cellular adhesion molecule (Mad-CAM1), on gut-associated endothelium[ xref ]."

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"Vedolizumab is a monoclonal antibody specific for α4β7 that blocks its binding to MAd-CAM1."