IndraLab

Statements

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"In summary, Numbl plays a significant role in the formation of CAM-DR in MM cells."
31888545
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"Observations in one study indicated that CAM-DR in MM cells was associated with increase in solubility and redistribution of c-FLIP L allowing its binding to and inhibiting death-inducing signaling complex (DISC) (which forms following CD95 ligation) and thus blocking apoptosis [ xref ]."
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"For example, anticancer drug-induced H3K27 hypermethylation is associated with CAM-DR in MM cells [ xref ]."
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"Finally, we showed that the interaction of Numbl with integrin β1 promotes the formation of CAM-DR in MM cells."
31888545