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CALM1 inhibits autophagy. 5 / 5
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"Thus, the underlying molecular mechanism for autophagy initiation is dissociated from EGFR kinase inactivation and even from EGFR expression.In contrast to GEF treatment, autophagy flux analysis revea[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We initially confirmed that AZM and CAM inhibit autophagy in HNSCC cell lines as previously described in myeloma and breast cancer cell lines by flux analysis [ xref , xref , xref ]."
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"As the CAM induced effects on LC3 are similar to those of CQ, this provides evidence that CAM may also act as a late stage inhibitor of autophagy.However, to further validate that CAM was inhibiting autophagy and not inducing autophagy, we examined the morphology of K562 cells."
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"Results presented here suggest that CAM inhibits autophagy in a similar way to the late stage autophagy inhibitor CQ [Figure 1 (E)]."
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"These differential findings with late and early stage autophagy inhibitors led us to hypothesize that CAM may block a later stage of autophagy, similar to the action proposed for CQ [14]."
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