IndraLab

Statements


| 7

sparser
"In addition to this, expression of androgen-dependent genes ( Drd4, Rhox 5, Aqp8 , and Eppin) were tested in the Fshr-CAM / Lhr −/− males."

sparser
"The crossbreeding of Fshr-CAM male mice [ xref ] with heterozygous LuRKO female mice [ xref ] brought about the generation of a double-mutant Fshr-CAM/LuRKO mouse [ xref ], with strong FSHR stimulation and marginal T production."
| PMC

sparser
"Unexpectedly, the mutant Fshr-CAM reversed the azoospermia and infertility of the LuRKO mice to a near-normal phenotype ( xref C,D), with normal development of the testes and accessory reproductive organs, and completion of spermatogenesis, despite delayed puberty and small litter sizes."
| PMC

sparser
"Interestingly, the Fshr-CAM / Lhr −/− males had only reduced seminal vesicle size after anti-androgen treatment, with no change in testicular size, and normal spermatogenesis ( xref )."

sparser
"Anti-androgen treated WT males showed reduced expression profiles of these genes, whereas mutant Fshr-CAM / Lhr −/− showed no reduction ( xref )."

sparser
"In WT control mice that had no Fshr-CAM , reduction in the size of testes and seminal vesicles was observed as well as arrested spermatogenesis."

sparser
"However, testosterone production persisted in the initial Fshr-CAM / Lhr −/− male mice, as serum levels recovered to about 40% of wild-type concentrations."