IndraLab

Statements

Rbr binds CALM1. 14 / 14
| 14
sparser
"Further studies are necessary to dissect the mechanisms used by tumour cells and non-tumour cells to overcome CAM-RR and CAM-DR in order to design targeted therapies directed to specific signalling mo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17084981
sparser
"As mentioned already, tumor cells grown in a 3D environment have increased resistance to stressors, such as IR, compared to 2D cultures; this phenomenon is known as cell-adhesion mediated radioresistance (CAM-RR)."
34900673
sparser
"Searching for specific integrins in CAM-RR or -DR, Kremer et al. [46] found a dependence of radiation-induced G2 cell cycle arrest in human prostate epithelial but not prostate epithelial cancer cells[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16448744
sparser
"Cell adhesion-mediated radiation (CAM-RR) and drug (CAM-DR) resistance hold clinical relevance and are inevitably linked to aggravated tumor control or treatment failure."
16448744
sparser
"This resistance to radiation has been contributed to a phenomenon called cell adhesion-mediated radioresistance (CAM-RR) [ xref , xref ]."
| PMC
sparser
"Integrins and adhesion of cells to ECM confer higher resistance to ionizing radiation and cytotoxic drug; a phenomenon known as CAM-RR and CAM-DR [173–184] ."
17084981
sparser
"However, some questions related to both CAM-RR and CAM-DR remain largely untouched."
25117005
sparser
"This is thought to enable the cell to optimize the repair of the DNA [186,187] and seems at least partly to be responsible for CAM-DR and CAM-RR."
17084981
sparser
"This reduced sensitivity has been attributed to CAM-RR which in turn has been shown to be a consequence of strong integrin clustering at the site of cellular adhesion to the matrix, aiding in better cell survival when compared to 2D cells [ xref ]."
| PMC
sparser
"CAM-RR is analogous term of CAM-DR referring to cell adhesion-mediated resistance to radiotherapy [27] ."
24177012
sparser
"Cell adhesion-mediated radioresistance (CAM-RR) mechanisms are complex, diverse, and tumor type-specific ( xref )."
39149513
sparser
"Here, the CAM-RR was studied by using age-matched, paired androgen-independent DU145 parental (DU145 P) and radioresistant (DU145 RR) sublines, which were generated by multiple fractionated irradiation of DU145 cells ( xref ; xref )."
39149513
sparser
"CAM-RR has been described for different tumor types, but the mechanisms operating in PC are not understood."
39149513
sparser
"Among the radioresistance mechanisms, CAM-RR is another mediator that cells can rely on upon exposure to irradiation."
39149513