IndraLab

Statements


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sparser
"Direct CAM-FGFR interaction has been suggested (Doherty and Walsh xref ) between the FN3 domains I–V of the similarly organized L1-CAM and FGFR1 (Kulahin et al. xref )."

sparser
"133, 657-{)66 (1996). [11] Doherty, P., F. S. Walsh: CAM-FGF receptor interactions: A model for axonal growth."

sparser
"The evolutionary conservation of putative binding motifs between the above CAMs and the FGFR suggests that activation of the FGFR-PLCgamma cascade by the CAMs might involve a direct CAM-FGFR interaction."

sparser
"Moreover, there is now increasing evidence that CAM interactions with the FGFR are not only important for neuronal function but also for contact dependent survival of some cell types [ xref , xref ] and for the development and progression of some cancers [ xref , xref , xref ]."

sparser
"These results indicate that activation of FGFR in neurons by the NCAM F3 module 2 and the FG loop peptide induces neuritogenesis, and that this effect (as predicted) can be inhibited by ATP; they thus corroborate Discussion We here describe the structure of the NCAM F3 module 2, present the first direct evidence of an interaction between a CAM molecule and FGFR, and demonstrate a regulatory role of ATP in the NCAM-FGFR interaction."

sparser
"The evolutionary conservation of putative binding motifs between the above CAMs and the FGFR suggests that activation of the FGFR-PLCgamma cascade by the CAMs might involve a direct CAM-FGFR interaction."