IndraLab

"In contrast, CAM still inhibited mitochondrial protein translation, showing the specificity of c-Myc in regulation of HsPDF and its function."

"These results suggest that, whereas the parent antibiotic CAM inhibits bacterial translation, neither compound 1 nor 4 does so efficiently."

"CAM was discovered through its isolation from Streptomyces venezuelae and Streptomyces phleochromogenes var. chloromyceticus in 1947. xref Notably, CAM is one of the few natural products discovered to date that contains both a nitrophenyl ring and a halogen functional group. xref CAM inhibits translation by binding at the peptidyltransferase center of the 50S subunit of the bacterial ribosome in a position that overlaps with the aminoacyl moiety of the A-site tRNA. xref , xref An X-ray crystal structure of CAM bound to the 50S subunit of the bacterial ribosome revealed that its primary and secondary alcohols as well as the carbonyl of its dichloroacetamide functionality form hydrogen bonds with nucleotides of the 23S rRNA ( xref ). xref , xref "