IndraLab

Statements

CALM1 activates calcium(2+). 8 / 8
| 8
reach
"In contrast, the EC value of scoparone in oocytes expressing L-VGCC and pretreated with CaM1 (at a K of 0.61 μM) was reduced ~ 10-fold to 0.46 μM (Fig. 4m-n; Table S11), indicating that CaM1 enhanced the Ca channel-activating effect of scoparone."
35572395
reach
"The facilitating effect of CaM1 was significantly enhanced (the K value was reduced from 0.61 to 0.28), but the inhibitory effect was significantly decreased (the K value was increased from 8 to 12) (Fig. 4q; Table S12), indicating that activation of CaM1 and L-VGCC by scoparone likely induced excessive activation of Ca signalling pathways by promoting CDF or blocking CDI of L-VGCC."
35572395
reach
"Cahalan and Hall [21] have elegantly demonstrated the regulation of MIP water permeability by Ca 2+, which is modulated by CAM."
11335105
reach
"Regulation of calcium transport in the CAM is not clearly understood; physical interaction of the CAM with the eggshell and/or shell membranes is needed to stimulate development of a functional calciu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8153083
reach
"Moreover, a Ca ^-ATPase stimulated by PICA and PKG and CAM dependent protein kinases has been described in a microsomal fraction from canine trachea!"
8622566
reach
"Thus, the novel Ca signalling pathways mediated by CaM1 and L-VGCC are critical for the acaricidal mechanism of scoparone.It can be hypothesized that the activation of Ca signalling by scoparone is mediated by targeting and interaction with CaM1 and L-VGCC."
35572395
reach
"Meanwhile, calmo- dulin was reported to activate calcium uptake by cardiac SR vesicles [14]."
7013831
reach
"To examine if CAM mediates the regulatory effects of calcium on phototransduction, we analyzed light responses of wild-type and cam cells in various extracellular calcium concentrations."
9363946