IndraLab

Statements


| 107

sparser
"We used a large (N = 708) age-heterogeneous population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), employing age-residualized measures of cognition, data-driven exploratory structural equation modelling and confirmatory factor analysis."

sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."

sparser
"Age-Related Trends in Neuromagnetic Transient Beta Burst Characteristics During a Sensorimotor Task and Rest in the Cam-CAN Open-Access Dataset - Supplementary Information."

sparser
"For completeness, we also related motor adaptation to several other cognitive variables collected in Cam-CAN ( xref ), as shown in the xref ."

sparser
"The acquisition times of the Cam-CAN MT-weighted sequences were under 5 minutes, which would be more acceptable for translation to clinical populations such as AD and PD compared with the other studies that acquired MT-weighted images in over 12 minutes."

sparser
"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project that aims to identify the neural mechanisms underlying successful aging in a population-based sample spanning the adult life span ( xref )."

sparser
"As was reported to be the case with the Dahl mask ( xref ), it was observed that the Cam-CAN LC mask did not extend as far caudally as did the Keren and Betts masks, explaining the relatively lower overlap with these masks (see xref )."

sparser
"These scans were obtained from an open-access database (Cam-CAN) that did not specifically use imaging parameters to investigate the LC and provide insights on how neuromelanin contrast and scanning parameters can be optimized for future studies."

sparser
"The Cam-CAN LC mask showed good overlap relative to the previously published Dahl mask volume (94%) and the rostral/middle portions of the Keren and Betts masks."

sparser
"Similarly, when identifying markers or developing interventions to support cognition, results from the Cam-CAN cohort highlight the need for a lifespan, targeted approach that builds on strengths as well as seeking to ameliorate decline."

sparser
"Using resting-state fMRI data from the Cam-CAN project, a study on healthy ageing, we demonstrate how our method can be used to characterise and compare the brain's functional connectivity structure across a group of young individuals and a group of old individuals."

sparser
"We show in a series of experiments, performed on ISLES, BraTS and Cam-CAN datasets, that our method is better than several baselines and methods from the literature."

sparser
"We tested out our model in Cam-CAN study processing the T1w MRI images using the same pipeline as the other samples."

sparser
"First, we explain how data were simulated to follow a specific correlation structure, approximating the general structure of empirical data such as that in the Cam-CAN study (see xref section)."

sparser
"In contradistinction, a positive association of the Fmn with the FI (CamCAN) has been reported by Kievit et al. (2016)."

sparser
"A support vector regression model was trained on two independent datasets of healthy adults across the adult life-span (n=765, Cam-CAN = 588; UiO = 177) to predict participant age from DTI metrics, and applied to the HIV dataset."
| DOI

sparser
"This provides evidence that cognitive diversity is maintained across the lifespan, despite the decline in many of the cognitive measures (see also xref , for similar results from the Cam-CAN cohort)."

sparser
"In this study, we examined the relationship between age, self-reported physical activity, WM microstructure, and processing speed within a large, population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) ( xref )."

sparser
"Compared with the published images from these studies, the LC signal from the MT-weighted Cam-CAN group template appears to have higher signal contrast and lower spatial resolution, leading to better visualization but potentially lower precision for manual segmentation."

sparser
"Cam-CAN is a community derived lifespan sample (ages 18–88) of healthy individuals."

sparser
"Noise reduction (using temporal signal space separation, tSSS,Taulu et al, 2005), reconstruction of missing or corrupted MEG channels, continuous head motion correction, and a transformation to a common head position were performed by the Cam-CAN group with MaxFilter(Taulu and Simola, 2006)."
| DOI

sparser
"The relationship between the estimated age and chronological age in Cam-CAN is shown in xref ."

sparser
"The Cam-CAN data set provides an important resource that supports the growing vision of cognitive aging as a lifelong developmental process with complex relationships across life stages and cognitive domains."

sparser
"Accordingly, in a second study we analyzed an open-access dataset acquired at the Cambridge Centre for Ageing and Neuroscience (Cam-CAN; Shafto et al, 2014; Taylor et al, 2017) ."
| DOI

sparser
"A final limitation of the current study is that, although the Cam-CAN data set uses an unusually diverse range of cognitive experiments, the factors that emerge from a PCA or related approach will depend on the variables included, and no single data set can be all-inclusive."

sparser
"Quantitatively, the clustering trajectories in Cam-CAN, BASE-II, and BETULA were comparable to the clustering trajectories in LCBC (Supplementary Fig.  xref )."

sparser
"To allow comparison between the Cam-CAN LC mask and previously published LC masks ( xref , xref , xref ), the MT-weighted template was coregistered to the MNI152 space (using the “antsRegistrationSyNQuick.sh” routine in ANTS v2.1, with “rigid + deformable syn” as transformation type) and the obtained transformation matrices were applied to warp the mask to MNI space."

sparser
"The present results are limited in their ability to achieve these goals, both by the reported analyses (which use a fairly exploratory approach) and by limitations of the Cam-CAN data set itself."

sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [76], Collation of Connectivity Data for the Macaque (CoCoMac) database [77] and Human Connectome Project (HCP) [78], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [79], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [80], the National Alzheimer’s Coordinating Center (NACC) [81], UK Biobank [82] and the Dementias Platform UK (DPUK) [83]."

sparser
"Clustering solutions in Cam-CAN, BASE-II, and BETULA exhibited highly similar mean intercept and slope effects to those described in the discovery sample, and mapped onto near-identical regions (Fig.  xref )."

sparser
"Cam-CAN consortium provided all data, approved the design and manuscript"

sparser
"In fact, one of the limitations of previous work was the limited measures of FI employed (four subtests of fluid reasoning) collected on the CamCAN project (Shafto et al., xref )."

sparser
"Third, we illustrate EFAST in a large neuroimaging cohort (Cam-CAN; Shafto et al., xref )."

sparser
"This MIMIC/watershed model was fit to a cross‐sectional sample of 555 subjects aged from 18 to 87 years of age (CamCAN; Shafto et al., xref )."

sparser
"Limitations and Benefits of the Cam-CAN Data Set for Diverse Cognitive Assessment."

sparser
"The Cam-CAN DWI images were collected on a Siemens TIM Trio 3T scanner (Siemens, Germany) at the Medical Research Counsel (UK) Cognition and Brain Sciences Unit (MRC-CBSU)."
| DOI

sparser
"We obtained normalized, mean LC signal intensities from previously acquired MT-weighted images from the Cam-CAN database (obtained from the Cam-CAN repository available at) to investigate the relationship between LC signal intensity and age in cognitively normal healthy adults."

sparser
"Because the Betts and Keren LC masks were observed to extend more caudally than the Cam-CAN LC mask ( xref ), the latter is likely to be capturing the rostral and middle portion of the LC."

sparser
"Our first aim is to examine the range of relationships between age and cognitive performance in the Cam-CAN data set, including 24 cognitive measures from 21 tasks across seven cognitive domains."

sparser
"We compare the results using nonuniform dataset with the MAE performance in Cam-CAN dataset."

sparser
"Experiments on the Cam-CAN dataset show improvements in spatial specificity in population imaging compared to individual models such as dSPM as well as a state-of-the-art Bayesian group level model."

sparser
"Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy."

sparser
"Examples of such large electrophysiological datasets include the Human Connectome Project (HCP) ( xref ; xref ), the Physiobank ( xref ), the OMEGA archive ( xref ) and Cam-CAN ( xref )."

sparser
"The resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic) was relatively low compared with previous MT-weighted studies (typically 0.39 × 0.39 × 3 mm to 0.7 × 0.7 × 0.7 mm) ( xref , xref , xref ), which limited the precision of segmentation and may have contributed to some of the variability of LC signal intensity values."

sparser
"A consensus scanning protocol to investigate the LC has not yet been achieved, thus the Cam-CAN scanning parameters reported in this study may inform how visualization of the LC signal can be optimized for future studies."

sparser
"Due to memory requirements, MP could not be used on the large Cam-CAN dataset as it exceeded our technical capability during the Covid-19 pandemic."
| DOI

sparser
"Notably, the raw data from the Cam-CAN cohort is freely available through our data portal."

sparser
"The training set used for the age prediction model comprised 765 healthy community dwelling individuals aged 20-78 years sampled from two different cohorts, including the ongoing STROKEMRI study at the University of Oslo (UiO; n=177, M age = 57.59; SD = 15.05, 60 % female, PI: L.W.) and the Cambridge Centre for Ageing and Neuroscience 13 (Cam-CAN) (n=588, M age = 52.31; SD = 17.38, 50 % female) from the Cambridge Center for Ageing and Neuroscience 14 (CamCAN)."
| DOI

sparser
"Existing large-scale projects to produce large normative databases have focused on small numbers of modalities collected in large numbers of people (e.g., UK Biobank ( xref ), Human Connectome Project ( xref ) and the Cam-CAN dataset presented here)."

sparser
"The Cam-CAN data set includes measures of general cognitive health and also includes a range of cognitive experiments which are sensitive to normal as opposed to pathological age-related changes."

sparser
"We applied dynamic causal modeling (DCM) to task fMRI data from 635 participants aged 18-88 from the Cam-CAN dataset, who performed a cued button pressing task with their right hand."

sparser
"Second, the Cam-CAN cohort is cross-sectional, with the attendant limitations on our ability to draw causal conclusions about the relationships between age, cognition, and lifestyle measures."

sparser
"Participants were recruited from a large population-derived cohort, aged 18-89 years, at the Cambridge Centre for Ageing and Neuroscience (Cam-CAN; xref )."

sparser
"The Cam-CAN LC mask percentage spatial overlap was 94%, 48%, and 19% relative to the Dahl, Keren (1SD), and Betts mask volumes, respectively."

sparser
"A total of 135 participants between the age of 18-35 years were selected from the healthy population-derived Cam-CAN cohort 79 ."
| DOI

sparser
"We focus on age prediction as a surrogate biomarker in 674 subjects from the Cam-CAN dataset."

sparser
"Spatially, the similarity of clustering results to those observed in the discovery sample was substantiated by Dice coefficients far higher than expected by chance (Cam-CAN = 0.54; BASE-II = 0.56; BETULA = 0.50; DLBS = 0.41; true expected Dice at random = 0.1, all p perm  < 0.001)."

sparser
"To illustrate this, after dividing the Keren mask into three equally sized (upper, middle, and lower) sections, the resulting Cam-CAN LC mask percentage spatial overlap values relative to these areas were 67%, 89%, and 7%, respectively."

sparser
"In that study, when the Cam-CAN data were pre-processed with the optimal parameters selected from the independent training sample, their proposed model achieved an MAE of 6.08 years and correlation coefficient r = 0.929."

sparser
"It is also worth noting that the proposed model was built solely based on the dataset from the CamCAN study."

sparser
"Training data including MRI data from UiO and Cam-CAN."
| DOI

sparser
"We investigated these questions in the cross-sectional Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data (N = 708, age 18–88), using data-driven exploratory structural equation modelling, confirmatory factor analyses, and age-residualized measures of cognitive differences across the lifespan."

sparser
"We test this possibility here using resting state fMRI data from over 500 individuals across the lifespan from the Cambridge Center for Aging and Neuroscience (Cam-CAN) population-based cohort."

sparser
"Data from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort was examined across a range of cognitive domains."

sparser
"This is not surprising since FI (CamCAN) in the words of the authors they are all subtests of a single cognitive domain (Cattell, xref )."

sparser
"Examples include the Human Connectome Project (HCP) ( xref ; xref ), UK Biobank ( xref ; xref ), Cambridge Centre for Aging and Neuroscience (Cam-CAN) ( xref ; xref ), and Nathan Kline Institute’s Rock-land Sample (NKI-RS) ( xref )."

sparser
"The overlap of the rostral Cam-CAN mask relative to the upper third of Keren's mask was 67%, and the overlap of the caudal Cam-CAN mask relative to the middle third of Keren's mask was 64%."

sparser
"It is also the first study to use existing MT-weighted scans from an open-access database (Cam-CAN) that had used scanning parameters not specifically selected to investigate and visualize the LC."

sparser
"The current study presents data from the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN;), a study of healthy neurocognitive development across the adult lifespan."

sparser
"As most previous studies relied exclusively on magnetic resonance imaging (MRI) data, we hereby investigate whether combining structural MRI with functional magnetoencephalography (MEG) information improves age prediction using a large cohort of healthy subjects (N=613, age 18-88 yrs) from the Cam-CAN repository."

sparser
"In this section, we compare the model fit and factor solutions of EFA and EFAST for the Cam-CAN data, and we show how EFAST decomposes the correlation matrix in xref into factor, structure, and residual variance components."

sparser
"In keeping with the more targeted experiments included in the Cam-CAN project, age effects differed within domain as well; for example, in the Language domain, Picture Naming is lowest for older adults but Sentence Comprehension did not differ across the age groups."

sparser
"One explanation for this could be that Cam-CAN represents a wealthier and more educated sample than the general population, and that in the absence of the “full” range, the effects of income diminish."

sparser
"In addition, it is important to note that the Cam-CAN sample represents the population in the United Kingdom, and thus these results may not generalize to a non-Caucasian population."

sparser
"With the high spatial resolution of fMRI and high temporal resolution of EEG, applying causal analysis on the Cam-CAN dataset should be a promising prospect."
| PMC

sparser
"To extend previous work, we used a large cohort (N = 547) of participants from the Cam-CAN database (18-88 years old) to examine whether resting-state functional connectivity between EC and DMN can reliably predict participant age."
| PMC

sparser
"Thus, the UKB results were in agreement with the lack of meaningful cross-sectional sleep-hippocampal volume relationships in Lifebrain, and aligns with previous findings within a Lifebrain cohort (Cam-CAN) which found no cross-sectional associations between PSQI subcomponents and white matter microstructure (indexed by Fractional anisotropy) across 10 tracts [ xref ]."

sparser
"AGE PREDICTION AND BRAIN AGE GAP: UiO and Cam-CAN data were used to train a support vector regression model (SVR) to predict participant age using FA, L1, RD and MD from atlas-derived ROIs (the exact same regions described above 29, 30, 31 ) as features."
| DOI

sparser
"Although the Cam-CAN data set has limitations due to being cross-sectional, it serves as a complement to longitudinal data sets by providing features that are difficult to achieve longitudinally."

sparser
"To complement our structural imaging analyses, we performed post hoc behavioural analyses looking at the relationship between motor adaptation and Cam-CAN’s behavioural measures of explicit memory collected on the same cohort, namely visual short-term memory (STM) and declarative long-term memory (LTM)."

sparser
"This is an important line for future work, initiated by the RANN ( xref ) and the Cambridge Centre for Aging and Neuroscience (Cam-CAN, xref ) studies."

sparser
"Second, the range of measures available in the Cam-CAN data set would be difficult to acquire longitudinally."

sparser
"Cross-sectional patient data were first contrasted to pooled normative data set of healthy controls (‘HC’, n  = 776, 383 males, age: 55.08 ± 17.63) from Trinity College Dublin ( n =  125) and subjects from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database ( n =  651) xref ."
| PMC

sparser
"Here we use functional connectivity matrices from five participants in the Cam-CAN study measured during an eyes-closed resting-state block."

sparser
"We used data from the population-based, lifespan Cam-CAN cohort."

sparser
"By using the Cam-CAN database, we were able to use a much larger sample size than previous studies to investigate the relationship between LC signal intensity and age."

sparser
"The Cam-CAN dataset includes MEG data recorded during wakeful rest and also during a simple cued-button pressing task in 631 subjects (age range 18-88, uniformly distributed and gender balanced)."
| DOI

sparser
"DWI scans from UCLA, UiO and Cam-CAN were processed simultaneously through the same pipeline to harmonize imaging methods across sites."
| DOI

sparser
"Here, we focus on predicting continuous outcomes from M/EEG signal defined at the subject-level, and analyze about 600 MEG recordings from Cam-CAN dataset and about 1000 EEG recordings from TUH dataset."

sparser
"The greater caudal extension of the Keren/Betts LC masks compared with our mask could be because the relatively lower resolution of the Cam-CAN scanning sequence could not sufficiently identify this portion, which has previously been reported to show a less reliably observable signal ( xref )."

sparser
"Comparison of Cam-CAN participants within these age ranges (mean age in older adults, 66 years; in younger adults, 28 years) also showed that the older group had a significantly higher mean LC signal intensity than the younger group (t = 8.06, p < 0.001)."

sparser
"While the dataset used in this study is longitudinal and targeting at the normal elderly (aged 70–90), the Cam-CAN dataset is cross-sectional adult-lifespan (aged 18–87) population-based ( xref )."
| PMC

sparser
"First, although Cam-CAN recruitment was population-based, it was not population-representative, and participants who completed full cognitive assessments were qualified to undergo cognitive neuroscience experiments including neuroimaging (see xref , for a description of participant selection for testing stages)."

sparser
"Some posit that increased variability in older age is due to a lifetime of accumulating risk and protective factors like increased brain pathology (Rabbitt, xref ), but others find an increased variability is not inevitable across one’s cognitive development (Salthouse, xref ) or may be due to ceiling effects in young adulthood (Green, Shafto, Matthews, Cam-CAN, & White, xref )."

sparser
"We report here on a wide range of cognitive measures extracted from the Cam-CAN data set and examine how diverse cognitive assessment in a cohort study improves our understanding of normal cognitive aging."

sparser
"Importantly, cohorts with diverse cognitive assessment such as in the Cam-CAN data set are also able to contribute to the understanding of domain-general function and cognitive factors that may be related to pathology in later life, as is evident from the domain-general Fluid Abilities and Typically Declining factors."

sparser
"This is likely a consequence of reporting the best fitting exploratory model, which, in a large lifespan observational sample such as Cam-CAN, is likely to group together variables with only moderately strong relations to each other."

sparser
"We employ the Cam-CAN data set, which combines general measures of cognitive health with domain-specific experiments that tap into normal rather than pathological variability (see xref , for a full description of the project protocol)."

sparser
"First, there is an ongoing debate about the mechanisms underlying measures of functional connectivity (Laumann et al., xref ; Lehmann, White, Henson, Cam-CAN, & Geerligs, xref ; Mateo, Knutsen, Tsai, Shih, & Kleinfeld, xref ; Winder, Echagarruga, Zhang, & Drew, xref )."

sparser
"For example, in the same Cam-CAN sample, Fuhrmann et al. observed strong associations such that low diastolic blood pressure (usually associated with lower overall blood pressure) was associated with worse neural health–but only when the model also included systolic blood pressure [ xref ]."

sparser
"The paradigm used in the CAMCAN data set provides limited insight into the precise factors that triggered activation at event boundaries."

sparser
"The Cam-CAN LC mask, warped to 0.5 mm 3 MNI space, is available to download from the online Supplementary materials."

sparser
"The Cam-CAN MEG data were recorded using 306- We used FieldTrip (v 20191127) and MATLAB (R2019b) to apply a high-pass (0.5 Hz) and notch (49-51 Hz) filter to the MEG sensor signals, similarly to the EEG analysis in the first study."
| DOI

sparser
"The recent study by West et al . [ xref ] addressed these problems by using a large, population-derived cohort called Cam-CAN, in which a simple sensorimotor task was optimized for detection of HRF shape [ xref ]."

sparser
"We next tested whether the clustering of asymmetry trajectories was reliable across four independent longitudinal adult lifespan cohorts (Cambridge Center for Aging and Neuroscience (Cam-CAN), Berlin Study of Aging-II (BASE-II), BETULA, and Dallas Lifespan Brain Study (DLBS): described in Supplementary Table  xref and Fig.  xref )."

sparser
"In a second study, we analyzed a large open MEG dataset for age-related obtained from the Cam-CAN repository (Shafto et al, 2014; Taylor et al, 2017) , aiming to replicate the results from our EEG dataset and to determine whether any non-linear age changes in sensorimotor beta activity were paralleled by a similar age-related non-linear modulation of sensorimotor task performance -as available in this dataset."
| DOI

sparser
"Finally, because Cam-CAN represents a sample of healthy adults, the generalizability of our findings to other populations remains to be investigated by future research."