IndraLab

Statements

CALM1 binds NUP214. 218 / 218
| 218
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"We found that stability estimates from the Cam-CAN data were unaffected by the length of raw recordings used for pre-processing and source imaging, as data lengths from 60 s to 150 s (tested in increments of 30 s) indicated no meaningful difference in stability from the full length (480 s) version in all frequencies except high-gamma ( xref )."
34923132
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."
33323116
sparser
"Age-Related Trends in Neuromagnetic Transient Beta Burst Characteristics During a Sensorimotor Task and Rest in the Cam-CAN Open-Access Dataset - Supplementary Information."
32818620
sparser
"The Cam-CAN is a unique resource of multimodal neuroimaging data with sufficient data points to enable machine learning approaches."
32423528
sparser
"Both Cohort 1 and Cam-CAN data showed that SC-ISV negatively correlates with the R1 map."
36151363
sparser
"As was reported to be the case with the Dahl mask ( xref ), it was observed that the Cam-CAN LC mask did not extend as far caudally as did the Keren and Betts masks, explaining the relatively lower overlap with these masks (see xref )."
30447418
sparser
"In this work, we have adapted this reasoning to the more general problem of predicting age while exploiting the advanced source-modeling options supported by the Cam-CAN dataset based on MEG and the individual MRIs."
32423528
sparser
"The Cam-CAN LC mask showed good overlap relative to the previously published Dahl mask volume (94%) and the rostral/middle portions of the Keren and Betts masks."
30447418
sparser
"Similarly, when identifying markers or developing interventions to support cognition, results from the Cam-CAN cohort highlight the need for a lifespan, targeted approach that builds on strengths as well as seeking to ameliorate decline."
31592706
sparser
"In this work, we utilized a dataset ( N = 638, age-range 20–88) comprising rsfMRI images from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) repository of a healthy population."
36172055
sparser
"We examine the stability of spectral features derived from varying lengths of source-imaged MEG resting-state data collected from two different models of MEG instrument and available from two different shared repositories: the Open MEG Archive (OMEGA; CTF instrument; N = 107; xref ) and the Cambridge Centre for Ageing and Neuroscience dataset (Cam-CAN; MEGIN/Elekta instrument; N = 50; xref )."
34923132
sparser
"Here, we analyze the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) resting-state magnetoencephalography (MEG) dataset-the largest aging cohort available-in light of the quasicriticality framework, a novel organizing principle for brain functionality which relates information processing and scaling properties of brain activity to brain connectivity and stimulus."
36532868
sparser
"Cam-CAN study was conducted in compliance with the Helsinki Declaration, and was approved by the local ethics committee, Cambridgeshire 2 Research Ethics Committee (reference: 10/H0308/50)."
36118967
sparser
"The original version of this Article contained an error in the order of author names, which were incorrectly listed as ‘Noham Wolpe, Jiaxiang Zhang, Cristina Nombela, James N. Ingram, Daniel M. Wolpert, James B. Rowe & Cam-CAN’."
30467360
sparser
"The limitations of current work are following: first, the aim of this work was to detect the information between health young group and old group (aging), and the current age division was based on the published paper of Cam-CAN open dataset ( xref )."
32009894
sparser
"Investigation of cognitively healthy older adults is also a fruitful avenue to provide information about the neural resilience mechanisms able to curb the onset or the progression of cognitive deficits as shown by the works of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) group ( xref ; xref )."
36185469
sparser
"We administered a film-based emotion reactivity and regulation task ( xref ) in the magnetic resonance imaging (MRI) scanner to a subsample ( n  = 104, age range: 23–88 years) of a neuropsychiatrically healthy population-representative Cam-CAN ( xref ) cohort."
31119296
sparser
"Whereas the estimation of the spectral offset was stable for OMEGA data durations of about two minutes, its estimation from Cam-CAN data required longer durations and offset estimates in several frontal and medial regions did not reach excellent stability."
34923132
sparser
"At the same time, the fact that the Cam-CAN has been unique so far, hinders generalization testing to equivalent multimodal datasets from other sites based on alternative scanning methodologies, protocols and devices ( xref )."
32423528
sparser
"Data 130 Models were trained using the Cambridge Centre for Ageing and Neu-131 roscience (Cam-CAN) data [28, 29]."
| DOI
sparser
"We used data from the population‐based, lifespan Cam‐CAN cohort."
33210312
sparser
"Hierarchical clustering of the individual predicted brain-ages in the Cam-CAN sample showed that elastic-net regression, Lasso and ridge regression together formed one cluster, SVR and RVR formed another cluster while OLS regression showed the lowest similarity with all the other algorithms ( xref )."
33714090
sparser
"We found that estimates of the aperiodic slope were robust when derived from at least two minutes of OMEGA and Cam-CAN data."
34923132
sparser
"We tested out our model in Cam-CAN study processing the T1w MRI images using the same pipeline as the other samples."
32305781
sparser
"A support vector regression model was trained on two independent datasets of healthy adults across the adult life-span (n=765, Cam-CAN = 588; UiO = 177) to predict participant age from DTI metrics, and applied to the HIV dataset."
| DOI
sparser
"First, given the inclusion criteria for Cam-CAN imaging (see xref ), our sample are likely more healthy than the average population."
30415127
sparser
"T.D. and Cam-CAN helped with the funding acquisition."
31119296
sparser
"The Cam-CAN data set provides an important resource that supports the growing vision of cognitive aging as a lifelong developmental process with complex relationships across life stages and cognitive domains."
31592706
sparser
"The SC-ISV maps derived from our data and the Cam-CAN dataset were consistent across cortical ROIs ( R  = 0.76, 95% CI = [0.72, 0.79], p  = 0.0002 SA-corrected, p  = 2.51×10 −124 uncorrected, Spearman’s correlation, see also Supplementary Fig.  xref for the correction of spatial autocorrelation), suggesting that the ISV of structural connectivity is robust and generalizable between cohorts."
36151363
sparser
"A final limitation of the current study is that, although the Cam-CAN data set uses an unusually diverse range of cognitive experiments, the factors that emerge from a PCA or related approach will depend on the variables included, and no single data set can be all-inclusive."
31592706
sparser
"The forceps minor has been shown to predict processing speed and fluid intelligence in the Cam-CAN cohort ( xref )."
30415127
sparser
"All Cam-CAN data is freely available on request through the access portal ()."
31119296
sparser
"To allow comparison between the Cam-CAN LC mask and previously published LC masks ( xref , xref , xref ), the MT-weighted template was coregistered to the MNI152 space (using the “antsRegistrationSyNQuick.sh” routine in ANTS v2.1, with “rigid + deformable syn” as transformation type) and the obtained transformation matrices were applied to warp the mask to MNI space."
30447418
sparser
"The article reports on analysis of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data."
30091631
sparser
"The dataset used in the present study is curated by the Cam-CAN ( xref ; xref ) and was specifically designed for studying the neural correlates of aging continuously across the life-span."
32423528
sparser
"The Cam-CAN DWI images were collected on a Siemens TIM Trio 3T scanner (Siemens, Germany) at the Medical Research Counsel (UK) Cognition and Brain Sciences Unit (MRC-CBSU)."
| DOI
sparser
"The minimal recording durations required to derive robust, stable estimates of MEG spectral features using LCMV beamforming are illustrated for OMEGA ( n = 107) and Cam-CAN ( n = 50) in xref and xref and summarized in xref and xref ."
34923132
sparser
"Our first aim is to examine the range of relationships between age and cognitive performance in the Cam-CAN data set, including 24 cognitive measures from 21 tasks across seven cognitive domains."
31592706
sparser
"We compare the results using nonuniform dataset with the MAE performance in Cam-CAN dataset."
32305781
sparser
"Cam-CAN and Leipzig resting-state datasets show that increased age, in turn, was associated with destabilization of brain networks (Leipzig <50 y [ n = 214] vs. ≥50 y [ n = 78], Mann–Whitney U test = 0.28, P = 1.4 × 10 −8 ; Cam-CAN <50 y [ n = 281] vs. ≥50 y [ n = 355], Mann–Whitney U test = 0.27, P = 1.6 × 10 −22 ; xref , Left )."
32127481
sparser
"Theta frequency derivatives from the right superior temporal sulcus, for example, appear to reach excellent stability before 120 s in the Cam-CAN sample, but did not reach an equivalent level of stability in the 120 s of the OMEGA data."
34923132
sparser
"The studies involving human participants were reviewed and approved by the Publicly available database (Cam-CAN)."
36118967
sparser
"We test this possibility here using resting state fMRI data from over 500 individuals across the lifespan from the Cambridge Center for Aging and Neuroscience (Cam‐CAN) population‐based cohort."
34713955
sparser
"Due to memory requirements, MP could not be used on the large Cam-CAN dataset as it exceeded our technical capability during the Covid-19 pandemic."
| DOI
sparser
"Future research is needed to explore the sources of this disagreement between the OMEGA and Cam-CAN samples."
34923132
sparser
"The training set used for the age prediction model comprised 765 healthy community dwelling individuals aged 20-78 years sampled from two different cohorts, including the ongoing STROKEMRI study at the University of Oslo (UiO; n=177, M age = 57.59; SD = 15.05, 60 % female, PI: L.W.) and the Cambridge Centre for Ageing and Neuroscience 13 (Cam-CAN) (n=588, M age = 52.31; SD = 17.38, 50 % female) from the Cambridge Center for Ageing and Neuroscience 14 (CamCAN)."
| DOI
sparser
"Existing large-scale projects to produce large normative databases have focused on small numbers of modalities collected in large numbers of people (e.g., UK Biobank ( xref ), Human Connectome Project ( xref ) and the Cam-CAN dataset presented here)."
31667357
sparser
"The Cam-CAN data set includes measures of general cognitive health and also includes a range of cognitive experiments which are sensitive to normal as opposed to pathological age-related changes."
31592706
sparser
"We applied dynamic causal modeling (DCM) to task fMRI data from 635 participants aged 18-88 from the Cam-CAN dataset, who performed a cued button pressing task with their right hand."
34573152
sparser
"While some tasks used in Cam-CAN are standardized (e.g., Cattell test of fluid intelligence), others (e."
32249849
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"These include the relatively low resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic), which may have contributed to some of the inter-individual variability of LC CR values, and the fact that the structural imaging protocol used a Repetition Time (TR) of either 30 ms or 50 ms, depending on the participant’s SAR estimation."
32249849
sparser
"Second, the Cam-CAN cohort is cross-sectional, with the attendant limitations on our ability to draw causal conclusions about the relationships between age, cognition, and lifestyle measures."
31592706
sparser
"The Cam-CAN dataset is currently the largest public resource on multimodal imaging with high-resolution electrophysiology in the form of MEG alongside MRI data and rich neuropsychological data for more than 650 healthy subjects between 17 and 90 years."
32423528
sparser
"Participants were recruited from a large population-derived cohort, aged 18-89 years, at the Cambridge Centre for Ageing and Neuroscience (Cam-CAN; xref )."
32184030
sparser
"The Cam-CAN LC mask percentage spatial overlap was 94%, 48%, and 19% relative to the Dahl, Keren (1SD), and Betts mask volumes, respectively."
30447418
sparser
"We therefore characterize aging effects on MEG phase synchrony in healthy young and older adults from the Cam-CAN database."
35914474
sparser
"A total of 135 participants between the age of 18-35 years were selected from the healthy population-derived Cam-CAN cohort 79 ."
| DOI
sparser
"Ten-fold cross-validation on the training sample (Cam-CAN) revealed high correlations between chronological and predicted age for the DTI based white matter microstructure ( r  = 0.87) and FreeSurfer based morphometric ( r  = 0.88) models."
30533290
sparser
"Spatially, the similarity of clustering results to those observed in the discovery sample was substantiated by Dice coefficients far higher than expected by chance (Cam-CAN = 0.54; BASE-II = 0.56; BETULA = 0.50; DLBS = 0.41; true expected Dice at random = 0.1, all p perm  < 0.001)."
33526780
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"To illustrate this, after dividing the Keren mask into three equally sized (upper, middle, and lower) sections, the resulting Cam-CAN LC mask percentage spatial overlap values relative to these areas were 67%, 89%, and 7%, respectively."
30447418
sparser
"It is also worth noting that the proposed model was built solely based on the dataset from the Cam‐CAN study."
33277955
sparser
"In recent years, several studies ( xref – xref ) have made use of Cam-CAN database to study the brain functional activity pattern of individual aging process from different perspectives, which provide an opportunity for our research."
36226096
sparser
"Training data including MRI data from UiO and Cam-CAN."
| DOI
sparser
"Data from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort was examined across a range of cognitive domains."
31592706
sparser
"This is not surprising since FI (Cam‐CAN) in the words of the authors they are all subtests of a single cognitive domain (Cattell, xref )."
32026600
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"In recent years, the field has witnessed the emergence of numerous and widely used data sharing initiatives for multimodal MRI data, such as the Human Connectome Project xref , UK BioBank xref , NSPN xref , Cam-CAN xref , ABIDE xref , xref , and many others."
36109562
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"By using a large movie fMRI dataset from the Cam-CAN project ( xref ) that shows reliable stimulus-driven activity (i.e., significant inter-subject correlations) over nearly all cortical brain regions ( xref ; xref ), we were able to study neural state segmentation across the entire cortex for the first time."
36111671
sparser
"Examples include the Human Connectome Project (HCP) ( xref ; xref ), UK Biobank ( xref ; xref ), Cambridge Centre for Aging and Neuroscience (Cam-CAN) ( xref ; xref ), and Nathan Kline Institute’s Rock-land Sample (NKI-RS) ( xref )."
33995924
sparser
"It is also the first study to use existing MT-weighted scans from an open-access database (Cam-CAN) that had used scanning parameters not specifically selected to investigate and visualize the LC."
30447418
sparser
"In the current work, we apply a data-driven convolutional dictionary learning (CDL) approach to detect neuromagnetic transient bursts in a large group of healthy participants from the Cam-CAN dataset."
36584759
sparser
"We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset."
32249849
sparser
"The current study presents data from the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN;), a study of healthy neurocognitive development across the adult lifespan."
31592706
sparser
"As most previous studies relied exclusively on magnetic resonance imaging (MRI) data, we hereby investigate whether combining structural MRI with functional magnetoencephalography (MEG) information improves age prediction using a large cohort of healthy subjects (N=613, age 18-88 yrs) from the Cam-CAN repository."
33549751
sparser
"After being trained with a large dataset from the Cam-CAN repository, the model has learned to represent and generate patterns of spontaneous cortical activity using latent nonlinear components, which reflects principal cortical patterns with specific spectral modes."
37120044
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"Multimodal fusion using linked ICA in an independent Cam-CAN subset."
35855641
sparser
"In keeping with the more targeted experiments included in the Cam-CAN project, age effects differed within domain as well; for example, in the Language domain, Picture Naming is lowest for older adults but Sentence Comprehension did not differ across the age groups."
31592706
sparser
"To address our hypothesis, we will leverage three well-established cohorts of aging, including two longitudinal cohorts [Baltimore Longitudinal Study of Aging (BLSA) ( xref ), Vanderbilt Memory & Aging Project (VMAP) ( xref )] and one cross-sectional cohort [Cambridge Centre for Ageing and Neuroscience (Cam-CAN) ( xref )]."
35604444
sparser
"In addition, it is important to note that the Cam-CAN sample represents the population in the United Kingdom, and thus these results may not generalize to a non-Caucasian population."
30285083
sparser
"With the high spatial resolution of fMRI and high temporal resolution of EEG, applying causal analysis on the Cam-CAN dataset should be a promising prospect."
34867282
sparser
"To extend previous work, we used a large cohort (N = 547) of participants from the Cam-CAN database (18-88 years old) to examine whether resting-state functional connectivity between EC and DMN can reliably predict participant age."
| PMC
sparser
"Evaluation of the six algorithms in two sizable samples of healthy individuals from the HCP and Cam-CAN yielded reproducible results with regards to the similarity between Lasso regression and elastic-net regression, and between the SVR and RVR that consistently clustered together."
33714090
sparser
"Thus, the UKB results were in agreement with the lack of meaningful cross-sectional sleep-hippocampal volume relationships in Lifebrain, and aligns with previous findings within a Lifebrain cohort (Cam-CAN) which found no cross-sectional associations between PSQI subcomponents and white matter microstructure (indexed by Fractional anisotropy) across 10 tracts [ xref ]."
31738420
sparser
"AGE PREDICTION AND BRAIN AGE GAP: UiO and Cam-CAN data were used to train a support vector regression model (SVR) to predict participant age using FA, L1, RD and MD from atlas-derived ROIs (the exact same regions described above 29, 30, 31 ) as features."
| DOI
sparser
"The Cam-CAN data set also contains MEG responses ( k = 120 trials) to the same visual stimuli as described in the section on event-related fMRI, recorded using a VectorView system (Elekta Neuromag, Helsinki, Finland)."
32673043
sparser
"Having established a robust within-sample prediction for task-FC derived models, we next aimed to investigate whether those models derived in HCP-Aging cohort would generalize to predict individual response time variability in two independent samples of n = 100 (Cam-CAN data) and n = 47 (SCAN data) healthy older adults."
35007719
sparser
"Although the Cam-CAN data set has limitations due to being cross-sectional, it serves as a complement to longitudinal data sets by providing features that are difficult to achieve longitudinally."
31592706
sparser
"Here we use functional connectivity matrices from five participants in the Cam-CAN study measured during an eyes-closed resting-state block."
33688604
sparser
"Here, we have focused on the example of age-prediction by multimodal modeling on 674 subjects from the Cam-CAN dataset, the currently largest publicly available collection of MEG, fMRI and MRI data."
32423528
sparser
"Participants completed other tasks as part of the Cam-CAN assessment ( xref )."
31119296
sparser
"By using the Cam-CAN database, we were able to use a much larger sample size than previous studies to investigate the relationship between LC signal intensity and age."
30447418
sparser
"The Cam-CAN dataset includes MEG data recorded during wakeful rest and also during a simple cued-button pressing task in 631 subjects (age range 18-88, uniformly distributed and gender balanced)."
| DOI
sparser
"DWI scans from UCLA, UiO and Cam-CAN were processed simultaneously through the same pipeline to harmonize imaging methods across sites."
| DOI
sparser
"This study analyzes these Cam-CAN participants’ cognitive and behavioral outcomes to clarify the functional significance of age-related differences in LC CR."
32249849
sparser
"The greater caudal extension of the Keren/Betts LC masks compared with our mask could be because the relatively lower resolution of the Cam-CAN scanning sequence could not sufficiently identify this portion, which has previously been reported to show a less reliably observable signal ( xref )."
30447418
sparser
"While the dataset used in this study is longitudinal and targeting at the normal elderly (aged 70–90), the Cam-CAN dataset is cross-sectional adult-lifespan (aged 18–87) population-based ( xref )."
34867282
sparser
"First, although Cam-CAN recruitment was population-based, it was not population-representative, and participants who completed full cognitive assessments were qualified to undergo cognitive neuroscience experiments including neuroimaging (see xref , for a description of participant selection for testing stages)."
31592706
sparser
"Large-scale network connectivity as a predictor of age: Evidence across the adult lifespan from the Cam-CAN data set."
35604697
sparser
"Across the life span measured by Cam-CAN, cognitive acuity declined with age, as measured by the standard clinical instrument used to assess dementia, the Mini-Mental State Examination (MMSE) ( xref ) ( r = –0.30, P = 3.63 × 10 −15 )."
32127481
sparser
"We report here on a wide range of cognitive measures extracted from the Cam-CAN data set and examine how diverse cognitive assessment in a cohort study improves our understanding of normal cognitive aging."
31592706
sparser
"This is likely a consequence of reporting the best fitting exploratory model, which, in a large lifespan observational sample such as Cam-CAN, is likely to group together variables with only moderately strong relations to each other."
32437448
sparser
"First, there is an ongoing debate about the mechanisms underlying measures of functional connectivity (Laumann et al., xref ; Lehmann, White, Henson, Cam-CAN, & Geerligs, xref ; Mateo, Knutsen, Tsai, Shih, & Kleinfeld, xref ; Winder, Echagarruga, Zhang, & Drew, xref )."
30221246
sparser
"Cognitive/behavioral factors (measured by variables in the Cam-CAN database) previously demonstrated in vivo to be related to LC–NA system integrity are chosen as NA-dependent variables (emotional memory, emotional reactivity, and response inhibition +/− executive function, sleep quality, and three measures—years of education, verbal intelligence, and occupational complexity—representing cognitive reserve), and those not previously proposed or shown to rely on the LC–NA system are included in the NA-independent factor (general intelligence, face recognition, and sentence comprehension)."
32249849
sparser
"The Cam-CAN MEG data were recorded using 306- We used FieldTrip (v 20191127) and MATLAB (R2019b) to apply a high-pass (0.5 Hz) and notch (49-51 Hz) filter to the MEG sensor signals, similarly to the EEG analysis in the first study."
| DOI
sparser
"In the current work, we used data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository to evaluate differences in resting-state network segregation as a product of sex and reproductive stage."
36541480
sparser
"We next tested whether the clustering of asymmetry trajectories was reliable across four independent longitudinal adult lifespan cohorts (Cambridge Center for Aging and Neuroscience (Cam-CAN), Berlin Study of Aging-II (BASE-II), BETULA, and Dallas Lifespan Brain Study (DLBS): described in Supplementary Table  xref and Fig.  xref )."
33526780
sparser
"In a second study, we analyzed a large open MEG dataset for age-related obtained from the Cam-CAN repository (Shafto et al, 2014; Taylor et al, 2017) , aiming to replicate the results from our EEG dataset and to determine whether any non-linear age changes in sensorimotor beta activity were paralleled by a similar age-related non-linear modulation of sensorimotor task performance -as available in this dataset."
| DOI
sparser
"Finally, because Cam-CAN represents a sample of healthy adults, the generalizability of our findings to other populations remains to be investigated by future research."
32437448
sparser
"We used a large (N = 708) age-heterogeneous population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), employing age-residualized measures of cognition, data-driven exploratory structural equation modelling and confirmatory factor analysis."
32437448
sparser
"The full Cam-CAN dataset provides an ideal opportunity for such analyses, as it contains rich imaging data across a large age span xref ."
36151363
sparser
"For completeness, we also related motor adaptation to several other cognitive variables collected in Cam-CAN ( xref ), as shown in the xref ."
32184030
sparser
"The acquisition times of the Cam-CAN MT-weighted sequences were under 5 minutes, which would be more acceptable for translation to clinical populations such as AD and PD compared with the other studies that acquired MT-weighted images in over 12 minutes."
30447418
sparser
"In line with suggested strategies to maximize statistical diagnosticity in these cases xref , we transparently reported in our pre-registered analysis plan that we already had access to the pre-existing data in Cam-CAN, but had not performed any analyses of the cognitive/behavioral measures."
32249849
sparser
"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project that aims to identify the neural mechanisms underlying successful aging in a population-based sample spanning the adult life span ( xref )."
30447418
sparser
"To do this, we leveraged three well-established cohorts of aging, including two longitudinal cohorts [Baltimore Longitudinal Study of Aging (BLSA) [ xref ], Vanderbilt Memory & Aging Project (VMAP) [ xref ]], and one cross-sectional cohort [Cambridge Centre for Ageing and Neuroscience (Cam-CAN) [ xref ]]."
36817413
sparser
"Cam-CAN was responsible for the investigation."
31119296
sparser
"In particular, we used the Cam-CAN dataset for a population aged 18–88 years and constructed hemispheric functional connectivity networks for rs-fMRI data of each individual."
36226096
sparser
"These scans were obtained from an open-access database (Cam-CAN) that did not specifically use imaging parameters to investigate the LC and provide insights on how neuromelanin contrast and scanning parameters can be optimized for future studies."
30447418
sparser
"It should be noted that some of our recommendations are predicated on the premise of equivalent stability between the OMEGA and Cam-CAN samples, as the OMEGA recordings (~4 min) were substantially shorter in duration than those collected for Cam-CAN (~8 min)."
34923132
sparser
"In an empirical study based on the population-based lifespan Cam-CAN cohort, xref demonstrate that no residual age variability or correlations with brain atrophy remain after adjusting RSFA for a combination of cardiovascular and cerebrovascular measures."
34021598
sparser
"At this point, unfortunately, there is no public dataset equivalent of the Cam-CAN including EEG or, both, EEG and MEG."
32423528
sparser
"Finally, we leverage the balanced demographic distribution and detailed cognitive testing of the Cam-CAN dataset to investigate potential linear effects of key demographics (i.e., age, sex, and handedness) and cognitive function (as measured by the Addenbrooke’s Cognitive Examination – Revised; ACE-R; xref ) on the intra-session stability of MEG resting-state spectral features, derived from multiple tested data durations."
34923132
sparser
"We tested a mechanistic account of the 'neural noise' hypothesis in a large adult lifespan cohort (Cam-CAN) with over 2500 adults (ages 18-102; 1508 female; 1173 male; 2681 behavioral sessions; 708 MRI scans) using WM fractional anisotropy (FA) to predict mean levels and variability in reaction time performance on a simple behavioral task using a dynamic structural equation model (DSEM)."
37028933
sparser
"We show in a series of experiments, performed on ISLES, BraTS and Cam-CAN datasets, that our method is better than several baselines and methods from the literature."
32540700
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"First, we explain how data were simulated to follow a specific correlation structure, approximating the general structure of empirical data such as that in the Cam-CAN study (see xref section)."
33688604
sparser
"In contradistinction, a positive association of the Fmn with the FI (Cam‐CAN) has been reported by Kievit et al. (2016)."
32026600
sparser
"On the other hand, it is important to consider that the Cam-CAN sample consists of healthy individuals only."
32423528
sparser
"This provides evidence that cognitive diversity is maintained across the lifespan, despite the decline in many of the cognitive measures (see also xref , for similar results from the Cam-CAN cohort)."
31592706
sparser
"In this study, we examined the relationship between age, self-reported physical activity, WM microstructure, and processing speed within a large, population-based sample from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) ( xref )."
30285083
sparser
"The correct Cam-CAN LC mask can be found here:."
32312580
sparser
"Compared with the published images from these studies, the LC signal from the MT-weighted Cam-CAN group template appears to have higher signal contrast and lower spatial resolution, leading to better visualization but potentially lower precision for manual segmentation."
30447418
sparser
"Recently, for instance, the UK “Cambridge Centre for Ageing and Neuroscience” (Cam-CAN) cohort study in East Anglia/England collected self-reported health and lifestyle questions and objective measures from 2406 healthy adults, aged 18 to 98 years."
30669659
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"Cam-CAN is a community derived lifespan sample (ages 18–88) of healthy individuals."
33688604
sparser
"The LC Cam-CAN mask spatial overlap relative to the Betts mask should be 51%, not 19% as reported, due to a data analysis coding error."
32312580
sparser
"Two samples comprised healthy individuals participating either in the Human Connectome Project (HCP) [ xref ] or the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN) [ xref ]."
33714090
sparser
"Noise reduction (using temporal signal space separation, tSSS,Taulu et al, 2005), reconstruction of missing or corrupted MEG channels, continuous head motion correction, and a transformation to a common head position were performed by the Cam-CAN group with MaxFilter(Taulu and Simola, 2006)."
| DOI
sparser
"g, the emotional memory task) were developed specifically for Cam-CAN xref , in order to test specific hypotheses about ageing, and so do not have independent measures of reliability."
32249849
sparser
"The relationship between the estimated age and chronological age in Cam-CAN is shown in xref ."
32305781
sparser
"Here, we used the data from a large cohort ( N = 547) of participants from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database (18-88 years old) to investigate first whether resting-state ECN-DMN functional connectivity predicts age."
35604697
sparser
"We also found that the estimation of high-gamma spectral power was not stable over the recording durations available from OMEGA and Cam-CAN."
34923132
sparser
"Accordingly, in a second study we analyzed an open-access dataset acquired at the Cambridge Centre for Ageing and Neuroscience (Cam-CAN; Shafto et al, 2014; Taylor et al, 2017) ."
| DOI
sparser
"Five hundred healthy participants aged 18–87 years with movie-watching state fMRI data were selected from the Cam-CAN dataset."
36213738
sparser
"Quantitatively, the clustering trajectories in Cam-CAN, BASE-II, and BETULA were comparable to the clustering trajectories in LCBC (Supplementary Fig.  xref )."
33526780
sparser
"However, the estimation of the aperiodic offset was noticeably less robust in Cam-CAN participants, particularly in frontal cortices ( xref )."
34923132
sparser
"We further replicated this result in an independent dataset (Cam-CAN), and a similar pattern has been reported elsewhere using different acquisition parameters, atlases and pre-processing methods xref , xref , xref ."
36151363
sparser
"The present results are limited in their ability to achieve these goals, both by the reported analyses (which use a fairly exploratory approach) and by limitations of the Cam-CAN data set itself."
31592706
sparser
"Comparative Performance of the algorithms in the HCP and Cam-CAN samples."
33714090
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [76], Collation of Connectivity Data for the Macaque (CoCoMac) database [77] and Human Connectome Project (HCP) [78], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [79], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [80], the National Alzheimer’s Coordinating Center (NACC) [81], UK Biobank [82] and the Dementias Platform UK (DPUK) [83]."
33323116
sparser
"Clustering solutions in Cam-CAN, BASE-II, and BETULA exhibited highly similar mean intercept and slope effects to those described in the discovery sample, and mapped onto near-identical regions (Fig.  xref )."
33526780
sparser
"We partitioned the CAM-CAN data set (N = 550) into the young, middle, and old age-groups, then used the young and old age-groups to construct prediction models for 11 behavioral outcomes using multimodal neuroimaging features (i.e., structural and resting-state functional connectivity, and gray matter volume/cortical thickness)."
35906870
sparser
"Cam-CAN consortium provided all data, approved the design and manuscript"
32828920
sparser
"In fact, one of the limitations of previous work was the limited measures of FI employed (four subtests of fluid reasoning) collected on the Cam‐CAN project (Shafto et al., xref )."
32026600
sparser
"Third, we illustrate EFAST in a large neuroimaging cohort (Cam-CAN; Shafto et al., xref )."
33688604
sparser
"Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort ( N  = 667, aged 18–88)."
30415127
sparser
"We focus on age prediction as a surrogate biomarker in 674 subjects from the Cam-CAN dataset."
32423528
sparser
"This MIMIC/watershed model was fit to a cross‐sectional sample of 555 subjects aged from 18 to 87 years of age (Cam‐CAN; Shafto et al., xref )."
32026600
sparser
"Limitations and Benefits of the Cam-CAN Data Set for Diverse Cognitive Assessment."
31592706
sparser
"Thus, the first goal of the current study was to examine the whole‐brain connectivity pattern of the brainstem nuclei of the ARAS and age differences therein using resting state fMRI data from the Cambridge Center for Aging and Neuroscience's (Cam‐CAN) population‐based cohort."
34713955
sparser
"The article reports on analysis of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data."
36848967
sparser
"Data could also be shared on institutional and funder archives such as the National Institute of Mental Health Data Archive (NDA); on dedicated repositories, such as the the Cambridge Centre for Ageing and Neuroscience, Cam-CAN ( xref ; xref ) or The Open MEG Archive, OMEGA ( xref ); or on generic archives that are not neuroscience or neuroimaging specific, such as figshare, GitHub, the Open Science Framework, and Zenodo."
36100172
sparser
"We obtained normalized, mean LC signal intensities from previously acquired MT-weighted images from the Cam-CAN database (obtained from the Cam-CAN repository available at) to investigate the relationship between LC signal intensity and age in cognitively normal healthy adults."
30447418
sparser
"Because the Betts and Keren LC masks were observed to extend more caudally than the Cam-CAN LC mask ( xref ), the latter is likely to be capturing the rostral and middle portion of the LC."
30447418
sparser
"Here, the authors tested a pre-registered hypothesis on a large number of subjects as part of the Cam-CAN consortium."
32249849
sparser
"Experiments on the Cam-CAN dataset show improvements in spatial specificity in population imaging compared to individual models such as dSPM as well as a state-of-the-art Bayesian group level model."
32438046
sparser
"Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy."
30285083
sparser
"Examples of such large electrophysiological datasets include the Human Connectome Project (HCP) ( xref ; xref ), the Physiobank ( xref ), the OMEGA archive ( xref ) and Cam-CAN ( xref )."
28645840
sparser
"The resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic) was relatively low compared with previous MT-weighted studies (typically 0.39 × 0.39 × 3 mm to 0.7 × 0.7 × 0.7 mm) ( xref , xref , xref ), which limited the precision of segmentation and may have contributed to some of the variability of LC signal intensity values."
30447418
sparser
"Using resting-state fMRI data from the Cam-CAN project, a study on healthy ageing, we demonstrate how our method can be used to characterise and compare the brain’s functional connectivity structure across a group of young individuals and a group of old individuals."
33099009
sparser
"A consensus scanning protocol to investigate the LC has not yet been achieved, thus the Cam-CAN scanning parameters reported in this study may inform how visualization of the LC signal can be optimized for future studies."
30447418
sparser
"Notably, the raw data from the Cam-CAN cohort is freely available through our data portal."
33688604
sparser
"Yet, from the point of view of machine learning, the Cam-CAN dataset is a small dataset."
32423528
sparser
"For example, a recent study using Cam-CAN data showed age-related differences in the relationship between response inhibition performance and brain connectivity but not activity in a distributed inhibition network xref , which raises the possibility of compensatory changes in response to age-related reductions in LC structural integrity."
32249849
sparser
"The MAE and R values for each algorithm in the HCP and Cam-CAN samples are shown in xref and xref ."
33714090
sparser
"In the Cam-CAN sample, MAE values for all algorithms ranged between 7.2-7.7 and correlations in individual predicted brain-ages between-algorithms ranged from 0.76-0.99 ( xref )."
33714090
sparser
"Using a large population-based cross-sectional data set of cognitively normal healthy adults ( N  = 605, age range 18–88 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) xref , xref , we previously reported the presence of a quadratic relationship between mean normalized LC MRI signal intensity (LC contrast ratio, or LC CR) and age, the peak occurring around 60 years xref ."
32249849
sparser
"We further analyzed the SC-ISV of an independent dataset from the Cam-CAN repository xref (Fig.  xref )."
36151363
sparser
"These findings were shown to be reproducible in the Cam-CAN dataset, which had a similar healthy aging sample and a slightly different imaging protocol (see xref )."
36368498
sparser
"Note that dependable numerical p-values are hard to obtain for paired model comparisons based on cross-validation on the same dataset: Many datasets equivalent to the Cam-CAN would be required."
32423528
sparser
"In contrast, the stability of the aperiodic offset differed between the OMEGA and Cam-CAN samples."
34923132
sparser
"Here, we characterize time-resolved, resting-state magnetoencephalography activity of the hippocampus and subcortical brain regions in a large cohort of healthy young (20-30 years) and older (70-80 years) volunteers from the Cam-CAN (Cambridge Centre for Ageing and Neuroscience) open repository."
35989316
sparser
"In this study, the Cam-CAN datasets with a large age span were used and the index named “hemispheric similarity of functional connectivity (HSFC)” was proposed."
36226096
sparser
"In that study, when the Cam-CAN data were pre-processed with the optimal parameters selected from the independent training sample, their proposed model achieved an MAE of 6.08 years and correlation coefficient r = 0.929."
32305781
sparser
"We investigated these questions in the cross-sectional Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data (N = 708, age 18–88), using data-driven exploratory structural equation modelling, confirmatory factor analyses, and age-residualized measures of cognitive differences across the lifespan."
32437448
sparser
"Here, we characterized inter-subject functional correlation (ISFC) between the thalamus and several cortical brain networks in 500 healthy participants aged 18–87 years old from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort using movie-watching state fMRI data."
36213738
sparser
"The overlap of the rostral Cam-CAN mask relative to the upper third of Keren's mask was 67%, and the overlap of the caudal Cam-CAN mask relative to the middle third of Keren's mask was 64%."
30447418
sparser
"This paper reports on analysis of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data, a large, population-based cohort of healthy males and females across the adult lifespan."
36639907
sparser
"For the sake of brevity, in all following sections, we report the results for the NKI dataset (DS1), then provide an abbreviated report of the Cam-CAN dataset (DS2) leaving only the statistics while excluding the text (see the xref for the complete report of DS2)."
34390875
sparser
"In this section, we compare the model fit and factor solutions of EFA and EFAST for the Cam-CAN data, and we show how EFAST decomposes the correlation matrix in xref into factor, structure, and residual variance components."
33688604
sparser
"We are unable to empirically determine the origin of this discrepancy in this study, as many experimental parameters (e.g., MEG instrument, resting-state paradigm, and noise-cancellation approach) were different between the OMEGA and Cam-CAN samples."
34923132
sparser
"One explanation for this could be that Cam-CAN represents a wealthier and more educated sample than the general population, and that in the absence of the “full” range, the effects of income diminish."
32437448
sparser
"We demonstrate our method on functional connectivity networks derived from resting-state fMRI scans of participants from the Cam-CAN project, a study on healthy ageing ( xref )."
33099009
sparser
"Materials and Methods In a retrospective study (October 2010 to September 2013), rsfMRI data from healthy participants in the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository were used to generate CAPs by applying single-volume temporal clustering analysis."
35503014
sparser
"If the Cam-CAN included many more data points, for example beyond 10–100 k subjects, the proposed stacking model might possibly be of limited advantage compared to purely non-linear models, for example random forests, gradient boosting or deep learning methods ( xref )."
32423528
sparser
"To complement our structural imaging analyses, we performed post hoc behavioural analyses looking at the relationship between motor adaptation and Cam-CAN’s behavioural measures of explicit memory collected on the same cohort, namely visual short-term memory (STM) and declarative long-term memory (LTM)."
32184030
sparser
"This is an important line for future work, initiated by the RANN ( xref ) and the Cambridge Centre for Aging and Neuroscience (Cam-CAN, xref ) studies."
31457069
sparser
"Considering the TR of rs-fMRI in Cam-CAN dataset was 1.97 s, the window length of 50 time points was used in this work (i.e., 100/1.97≈50)."
32009894
sparser
"Second, the range of measures available in the Cam-CAN data set would be difficult to acquire longitudinally."
31592706
sparser
"Cross-sectional patient data were first contrasted to pooled normative data set of healthy controls (‘HC’, n  = 776, 383 males, age: 55.08 ± 17.63) from Trinity College Dublin ( n =  125) and subjects from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database ( n =  651) xref ."
34901337
sparser
"Nevertheless, most of our analyses are between imaging modalities or between independent cohorts (e.g., between Cohort 1 and Cam-CAN)."
36151363
sparser
"The negative association between SC-ISV and R1 value is replicated in Cam-CAN dataset ( R  = −0.45, 95% CI = [−0.52, −0.38], p  = 0.0002 SA-corrected, p  = 7.49 × 10 −32 uncorrected) (Fig.  xref and Supplementary Fig.  xref )."
36151363
sparser
"This suggests that brain age Δ might be used as a screening tool for a wide array of clinical settings for which the Cam-CAN dataset could serve as a normative sample."
32423528
sparser
"Here, we focus on predicting continuous outcomes from M/EEG signal defined at the subject-level, and analyze about 600 MEG recordings from Cam-CAN dataset and about 1000 EEG recordings from TUH dataset."
32439535
sparser
"Although we made pre-registered predictions on the relationship between LC CR and cognitive/behavioral processes, which were based on the wider literature underpinning our hypotheses, we did not pre-register the precise Cam-CAN outcome variables for all processes (i.e., SSRT for response inhibition, Hotel task for executive function, PSQI total score for sleep quality, three measures for negatively valenced emotional memory, and two for emotional reactivity/regulation) that were included in our final analyses."
32249849
sparser
"We obtained data from the Cam-CAN repository (available at) for an event-related fMRI experiment detailed by xref and xref ."
32673043
sparser
"Each of these pre-registered functions correspond to a task or questionnaire in the Cam-CAN database, apart from emotional regulation and emotional memory, which had multiple outcome measures xref , xref , and we justify the choice of the final variables in our analyses in the Methods section."
32249849
sparser
"Comparison of Cam-CAN participants within these age ranges (mean age in older adults, 66 years; in younger adults, 28 years) also showed that the older group had a significantly higher mean LC signal intensity than the younger group (t = 8.06, p < 0.001)."
30447418
sparser
"It will be valuable to obtain follow-up investigations of emergent diagnoses of dementia from the Cam-CAN sample, as well as deploy similar models in other large healthy samples such as UK Biobank, using peer-reviewed pre-registration."
32249849
sparser
"In the alpha (8–12 Hz) and beta (15–29 Hz) bands, activity in every region showed “excellent” stability (ICC > 0.90) when derived from data durations of 2 min or less (i.e., within the range of the OMEGA data set), while activity in the delta (2–4 Hz), theta (5–7 Hz) and low-gamma (30–59 Hz) bands reached excellent stability in every region with less than 3.5 min of data (i.e., within the range of the Cam-CAN data set)."
34923132
sparser
"Some posit that increased variability in older age is due to a lifetime of accumulating risk and protective factors like increased brain pathology (Rabbitt, xref ), but others find an increased variability is not inevitable across one’s cognitive development (Salthouse, xref ) or may be due to ceiling effects in young adulthood (Green, Shafto, Matthews, Cam-CAN, & White, xref )."
29868167
sparser
"In this study, we used the resting-state functional magnetic resonance imaging (rs-fMRI) data from Cambridge Center for Aging and Neuroscience (Cam-CAN) database with large sample and long lifespan, and computed the functional connectivity (FC) values for each individual."
36226096
sparser
"Importantly, cohorts with diverse cognitive assessment such as in the Cam-CAN data set are also able to contribute to the understanding of domain-general function and cognitive factors that may be related to pathology in later life, as is evident from the domain-general Fluid Abilities and Typically Declining factors."
31592706
sparser
"We employ the Cam-CAN data set, which combines general measures of cognitive health with domain-specific experiments that tap into normal rather than pathological variability (see xref , for a full description of the project protocol)."
31592706
sparser
"In the Cam-CAN dataset, the penumbra had higher SC-ISV than non-MD regions ( p  = 0.003)."
36151363
sparser
"For example, in the same Cam-CAN sample, Fuhrmann et al. observed strong associations such that low diastolic blood pressure (usually associated with lower overall blood pressure) was associated with worse neural health–but only when the model also included systolic blood pressure [ xref ]."
32437448
sparser
"The paradigm used in the CAM–CAN data set provides limited insight into the precise factors that triggered activation at event boundaries."
32769969
sparser
"The Cam-CAN LC mask, warped to 0.5 mm 3 MNI space, is available to download from the online Supplementary materials."
30447418
sparser
"The recent study by West et al . [ xref ] addressed these problems by using a large, population-derived cohort called Cam-CAN, in which a simple sensorimotor task was optimized for detection of HRF shape [ xref ]."
33190597
sparser
"In both the OMEGA and Cam-CAN samples, the estimation of the aperiodic slope achieved excellent stability when derived from less than 2 min of data."
34923132
sparser
"As effect sizes can be expected to be small in the curated and healthy population of the Cam-CAN dataset, we considered classical hypothesis testing for characterizing associations."
32423528