
IndraLab
Statements
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."
sparser
"Noise reduction (using temporal signal space separation, tSSS,Taulu et al, 2005), reconstruction of missing or corrupted MEG channels, continuous head motion correction, and a transformation to a common head position were performed by the Cam-CAN group with MaxFilter(Taulu and Simola, 2006)."
| DOI
sparser
"To allow comparison between the Cam-CAN LC mask and previously published LC masks ( xref , xref , xref ), the MT-weighted template was coregistered to the MNI152 space (using the “antsRegistrationSyNQuick.sh” routine in ANTS v2.1, with “rigid + deformable syn” as transformation type) and the obtained transformation matrices were applied to warp the mask to MNI space."
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [76], Collation of Connectivity Data for the Macaque (CoCoMac) database [77] and Human Connectome Project (HCP) [78], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [79], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [80], the National Alzheimer’s Coordinating Center (NACC) [81], UK Biobank [82] and the Dementias Platform UK (DPUK) [83]."
sparser
"Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy."
sparser
"The resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic) was relatively low compared with previous MT-weighted studies (typically 0.39 × 0.39 × 3 mm to 0.7 × 0.7 × 0.7 mm) ( xref , xref , xref ), which limited the precision of segmentation and may have contributed to some of the variability of LC signal intensity values."
sparser
"The training set used for the age prediction model comprised 765 healthy community dwelling individuals aged 20-78 years sampled from two different cohorts, including the ongoing STROKEMRI study at the University of Oslo (UiO; n=177, M age = 57.59; SD = 15.05, 60 % female, PI: L.W.) and the Cambridge Centre for Ageing and Neuroscience 13 (Cam-CAN) (n=588, M age = 52.31; SD = 17.38, 50 % female) from the Cambridge Center for Ageing and Neuroscience 14 (CamCAN)."
| DOI
sparser
"Spatially, the similarity of clustering results to those observed in the discovery sample was substantiated by Dice coefficients far higher than expected by chance (Cam-CAN = 0.54; BASE-II = 0.56; BETULA = 0.50; DLBS = 0.41; true expected Dice at random = 0.1, all p perm < 0.001)."
sparser
"We investigated these questions in the cross-sectional Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data (N = 708, age 18–88), using data-driven exploratory structural equation modelling, confirmatory factor analyses, and age-residualized measures of cognitive differences across the lifespan."
sparser
"As most previous studies relied exclusively on magnetic resonance imaging (MRI) data, we hereby investigate whether combining structural MRI with functional magnetoencephalography (MEG) information improves age prediction using a large cohort of healthy subjects (N=613, age 18-88 yrs) from the Cam-CAN repository."
sparser
"Thus, the UKB results were in agreement with the lack of meaningful cross-sectional sleep-hippocampal volume relationships in Lifebrain, and aligns with previous findings within a Lifebrain cohort (Cam-CAN) which found no cross-sectional associations between PSQI subcomponents and white matter microstructure (indexed by Fractional anisotropy) across 10 tracts [ xref ]."
sparser
"To complement our structural imaging analyses, we performed post hoc behavioural analyses looking at the relationship between motor adaptation and Cam-CAN’s behavioural measures of explicit memory collected on the same cohort, namely visual short-term memory (STM) and declarative long-term memory (LTM)."
sparser
"Cross-sectional patient data were first contrasted to pooled normative data set of healthy controls (‘HC’, n = 776, 383 males, age: 55.08 ± 17.63) from Trinity College Dublin ( n = 125) and subjects from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database ( n = 651) xref ."
| PMC
sparser
"The greater caudal extension of the Keren/Betts LC masks compared with our mask could be because the relatively lower resolution of the Cam-CAN scanning sequence could not sufficiently identify this portion, which has previously been reported to show a less reliably observable signal ( xref )."
sparser
"First, although Cam-CAN recruitment was population-based, it was not population-representative, and participants who completed full cognitive assessments were qualified to undergo cognitive neuroscience experiments including neuroimaging (see xref , for a description of participant selection for testing stages)."
sparser
"Some posit that increased variability in older age is due to a lifetime of accumulating risk and protective factors like increased brain pathology (Rabbitt, xref ), but others find an increased variability is not inevitable across one’s cognitive development (Salthouse, xref ) or may be due to ceiling effects in young adulthood (Green, Shafto, Matthews, Cam-CAN, & White, xref )."
sparser
"Importantly, cohorts with diverse cognitive assessment such as in the Cam-CAN data set are also able to contribute to the understanding of domain-general function and cognitive factors that may be related to pathology in later life, as is evident from the domain-general Fluid Abilities and Typically Declining factors."
sparser
"For example, in the same Cam-CAN sample, Fuhrmann et al. observed strong associations such that low diastolic blood pressure (usually associated with lower overall blood pressure) was associated with worse neural health–but only when the model also included systolic blood pressure [ xref ]."
sparser
"We next tested whether the clustering of asymmetry trajectories was reliable across four independent longitudinal adult lifespan cohorts (Cambridge Center for Aging and Neuroscience (Cam-CAN), Berlin Study of Aging-II (BASE-II), BETULA, and Dallas Lifespan Brain Study (DLBS): described in Supplementary Table xref and Fig. xref )."
sparser
"In a second study, we analyzed a large open MEG dataset for age-related obtained from the Cam-CAN repository (Shafto et al, 2014; Taylor et al, 2017) , aiming to replicate the results from our EEG dataset and to determine whether any non-linear age changes in sensorimotor beta activity were paralleled by a similar age-related non-linear modulation of sensorimotor task performance -as available in this dataset."
| DOI