IndraLab
Statements
sparser
"To test our claim, we evaluate the degree of neural coordination using phase synchrony measures xref at different regimes of alpha frequency band in resting-state MEG recordings collected from participants aged 18–88 at the Cambridge Center for Ageing and Neuroscience (Cam-CAN) xref ."
sparser
"The spatial distribution of the CRON in the HCP and Cam-CAN samples is shown in xref A, B and C. As in the PRONIA study (Supplementary Fig. 2), the neurosignature comprised lower gray matter volume in cingulate, orbitofrontal, insular, temporal, parietal, and occipital brain regions, and higher cerebellar and prefrontal volumes."
sparser
"The distribution of decision scores in the Cam-CAN and HCP samples is shown in xref E. Even at uncorrected P-values, there was no association between decision scores and whole-brain gray matter volume in the young (r = 0.02, P = 0.82) and older Cam-CAN sub-sets (Pearson's r = 0.06, P = 0.28) and in the HCP sample (Pearson's r = −0.03, P = 0.27)."
sparser
"To test this hypothesis, the CHR-outcome-neurosignature derived from the PRONIA study, was used to build a binary classifier which was applied to sMRI data of participants from the Human Connectome Project (HCP) ( xref ) and the Cambridge Centre for Ageing and Neuroscience project (Cam-CAN) ( xref )."
sparser
"We predicted that if the neuroanatomical correlates of social dysfunction in CHR-P individuals were on a continuum with the general population, then HCP and Cam-CAN participants whose neuroanatomical profiles were aligned with the PRONIA CHR-outcome-neurosignature would also present with social difficulties."
sparser
"It is unlikely that these findings are attributable to misidentification of future psychosis cases in the HCP and Cam-CAN as no more than 15 individuals in both samples combined could ever present with schizophrenia assuming an approximate lifetime prevalence of 8/1000 persons ( xref )."
sparser
"The PSMD values in Cam-CAN were similar to those in comparable population-based cohorts, xref , xref and showed a similar profile of continuous increase with age, accelerating after 60 years of age. xref , xref Here, the spread of PSMD values also increased substantially with age."
sparser
"However, it should be kept in mind that inferences drawn from our current findings could be limited by the cross-sectional design of currently available Cam-CAN data, in which age effects are confounded by the effects of generational changes across people born in different years."
sparser
"The authors thank the Cam-CAN (The Cambridge Center for Aging and Neuroscience) respondents and their primary care teams in Cambridge for their participation in this study, and colleagues at the MRC Cognition and Brain Sciences Unit Magnetoencephalogrphy (MEG) and Magnetic Resonance Imaging (MRI) facilities for their assistance."
sparser
"A total of 51,467 participants aged 9y – 70y with 53,199 neuroimaging scans across four cohorts (ABCD, IMAGEN, HCP and UKB) were included in the discovery set, and a total of 2,127 participants aged 12y – 89y from the cross-sectional NKI-RS, Cam-CAN and BRAINMINT studies were included for validation."
sparser
"The dependent variable was the difference in fMRI activation for blocks of hard vs. easy odd-one-out problems ( xref ), as measured in 223 adults between 19 and 87 years of age, from Stage 3 of the Cambridge Centre for Ageing & Neuroscience (Cam-CAN) project ( xref ); performance was measured as the proportion of all problems correct."
sparser
"In fact, the results from the spread analysis showed that as age increased, this frontal area processed less, rather than more, multivariate information about the cognitive outcome ( xref ) as previously observed in two (memory) tasks for a comparable ROI within the same Cam-CAN cohort ( xref )."
sparser
"In fact, the results from the spread analysis showed that as age increased, this frontal area processed less, rather than more, multivariate information about the cognitive outcome (Figure 3C) as previously observed in two (memory) tasks for a comparable ROI within the same Cam-CAN cohort (Morcom & Henson, 2018).”"
sparser
"For assessing reliability and validity, behavioural performance (total number of puzzles correct) was also collected from the same participants during a full version of the Cattell task (Scale 2 Form A) administered outside the scanner at Stage 2 of the Cam-CAN study (Shafto et al., 2014)."
sparser
"In order to prove this claim, once, we use our biggest dataset (BSGP) as training set and test the model on CamCAN dataset, and also, we separated the Cam-CAN dataset from the training data and trained the model on ADNI, ABIDE, and BSGP datasets, and then we tested it on the Cam-CAN dataset."
sparser
"Here, we characterized inter-subject functional correlation (ISFC) between the thalamus and several cortical brain networks in 500 healthy participants aged 18–87 years old from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) cohort using movie-watching state fMRI data."
sparser
"Specifically, we used the currently largest MEG resting-state dataset in adults aged 18 to 88 y from the Cambridge Centre for Aging and Neuroscience (Cam-CAN) and performed extensive extraction of signal characteristics using highly comparative time-series analyses (hctsa) ( xref , xref )."
sparser
"We examine the stability of spectral features derived from varying lengths of source-imaged MEG resting-state data collected from two different models of MEG instrument and available from two different shared repositories: the Open MEG Archive (OMEGA; CTF instrument; N = 107; xref ) and the Cambridge Centre for Ageing and Neuroscience dataset (Cam-CAN; MEGIN/Elekta instrument; N = 50; xref )."
sparser
"Finally, we leverage the balanced demographic distribution and detailed cognitive testing of the Cam-CAN dataset to investigate potential linear effects of key demographics (i.e., age, sex, and handedness) and cognitive function (as measured by the Addenbrooke’s Cognitive Examination – Revised; ACE-R; xref ) on the intra-session stability of MEG resting-state spectral features, derived from multiple tested data durations."
sparser
"In the alpha (8–12 Hz) and beta (15–29 Hz) bands, activity in every region showed “excellent” stability (ICC > 0.90) when derived from data durations of 2 min or less (i.e., within the range of the OMEGA data set), while activity in the delta (2–4 Hz), theta (5–7 Hz) and low-gamma (30–59 Hz) bands reached excellent stability in every region with less than 3.5 min of data (i.e., within the range of the Cam-CAN data set)."
sparser
"We found that stability estimates from the Cam-CAN data were unaffected by the length of raw recordings used for pre-processing and source imaging, as data lengths from 60 s to 150 s (tested in increments of 30 s) indicated no meaningful difference in stability from the full length (480 s) version in all frequencies except high-gamma ( xref )."
sparser
"We next tested whether the clustering of asymmetry trajectories was reliable across four independent longitudinal adult lifespan cohorts (Cambridge Center for Aging and Neuroscience (Cam-CAN), Berlin Study of Aging-II (BASE-II), BETULA, and Dallas Lifespan Brain Study (DLBS): described in Supplementary Table xref and Fig. xref )."
sparser
"Spatially, the similarity of clustering results to those observed in the discovery sample was substantiated by Dice coefficients far higher than expected by chance (Cam-CAN = 0.54; BASE-II = 0.56; BETULA = 0.50; DLBS = 0.41; true expected Dice at random = 0.1, all p perm < 0.001)."
sparser
"Another significant resource is the Cam-CAN (N = 16) database, a large-scale collaborative research project by the University of Cambridge, which aims to use epidemiological, cognitive, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age."
sparser
"In this study, we investigated whether the intrinsic functional connectivity of the DMN-C subnetwork is related to individual differences in memory ability, examining this relationship across 243 individuals (ages 18–50 years) from the openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset."
sparser
"The logical memory subtest of the Wechsler Memory Scale was chosen because it was available for the largest number of subjects in the Cam-CAN dataset, compared to other included memory measures, and this measure has been previously shown to correlate with individual differences in brain activity in response to event boundaries during the Cam-CAN movie watching scan ( xref )."
sparser
"To address this, we analysed dMRI data from 651 adults approximately uniformly aged from 18 to 88 years in the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort, using six dMRI metrics: Fractional Anisotropy (FA) from standard DTI; Mean Signal Diffusion (MSD) and Mean Signal Kurtosis (MSK) from Diffusional Kurtosis Imaging (DKI) applied to directional averaged diffusion-weighted signals; and Neurite Density Index (NDI), Orientation Dispersion Index (ODI), and isotropic Free water volume fraction (F iso ) estimated from Neurite Orientation Dispersion and Density Imaging (NODDI)."
sparser
"In summary, we compared the sensitivity to age of the main metrics from phenomenological and microstructural models of dMRI, using a large and homogeneous sample across the adult lifespan, namely from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort ( xref ; xref )."
sparser
"Here, we characterize time-resolved, resting-state magnetoencephalography activity of the hippocampus and subcortical brain regions in a large cohort of healthy young (20-30 years) and older (70-80 years) volunteers from the Cam-CAN (Cambridge Centre for Ageing and Neuroscience) open repository."
sparser
"Based on the Cam-CAN cohort with uniform sampling of adult ages, MSK and NDI values peak at later ages than FA in all WM regions ( xref and xref ), suggesting that previous DTI-based studies examining WM difference across the adult lifespan may have underestimated the ages at which tracts stop maturing and start degenerating."
sparser
"We computed thefrom parcellated BOLD time series of resting state, naturalistic movie watching task where the participants watched and listened to an excerpt from Alfred Hitchcock’s “Bang! You’re Dead,” and a SMT where participants responded by a button press to either a visual or an auditory stimulus from the Cam-CAN dataset (details in Methods). xref represents dFC obtained using BOLD phase coherence connectivity in resting state."
sparser
"Next, we have included 3 age cohorts, young, middle, and old adults from the Cam-CAN dataset and carried out unsupervised characterization of dFC using participant’s resting state, movie watching, and SMT data to identify age associated alterations in temporal stability of dominantsubspaces."
sparser
"Here, we examined this relationship by applying graph theory to analyze the topological properties of the semantic memory network, using diffusion magnetic resonance imaging (dMRI) data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository ( N = 576; age: 18-87)."
sparser
"In this study, we systematically investigate the impact of varying gradient counts in Procrustes alignment on the principal FC gradient, using data from four high-quality fMRI datasets, including the Human Connectome Project (HCP-YA), Amsterdam Open MRI Collection (AOMIC) PIOP1 and PIOP2, and Cambridge Centre for Ageing and Neuroscience (Cam-CAN)."
sparser
"Some projects focus on systematic data collection from population samples, with regular tracking and follow-up, aiming at building integrated data covering the lifespan of individuals, including the Human Brain Projects (HBP) [ xref ], Open Access Series of Imaging Studies (OASIS) [ xref ], Cambridge Centre for Ageing and Neuroscience (Cam-CAN) [ xref , xref ], Brain Genomics Superstruct Project (GSP) [ xref ] and the Chinese Imaging Genetics (CHIMGEN) [ xref ], etc."
sparser
"Data could also be shared on institutional and funder archives such as the National Institute of Mental Health Data Archive (NDA); on dedicated repositories, such as the the Cambridge Centre for Ageing and Neuroscience, Cam-CAN ( xref ; xref ) or The Open MEG Archive, OMEGA ( xref ); or on generic archives that are not neuroscience or neuroimaging specific, such as figshare, GitHub, the Open Science Framework, and Zenodo."
sparser
"By utilizing large-scale datasets such as the Human Connectome Project (HCP-Aging, N=621, 349 females) and Cambridge Centre for Ageing and Neuroscience (Cam-CAN, N=333, 155 females), we were able to investigate how emotion regulation networks’ functional topography differs across the entire adult lifespan."
sparser
"First, we replicate the finding of frontoparietal mediation of age differences in fluid intelligence ( xref ), using an independent, nonoverlapping sample of participants from the population-based, healthy, adult lifespan cohort (Cambridge Center for Ageing and Neuroscience [Cam-CAN]) ( xref ) used by xref ."
sparser
"Although much work has been done to assess the impact of age and sex on MRI, MEG and scalp EEG, to our knowledge intracranial EEG (icEEG) has not yet been investigated in this context, most likely because its invasive nature precludes data collection from healthy controls (Gomez et al. xref ; Hinault et al. xref ; Cam-CAN et al. xref ; Coffey et al. xref )."
sparser
"Using support vector machine and regression, brain topology features, derived from PLs + CCs, differentiated the high DFS subgroup from low and mix DFS subgroups with accuracies of 65.82% and 84.78% in Cam-CAN and CF samples, respectively, which predicted cross-task DFS score in CF samples at 58.06% and 70.53% for cognitive and physical stability, respectively."
sparser
"This will always be difficult due to the risk of surgical operations on the elderly (Grivas et al. xref ), which limits the ability to directly compare our results to the many other modalities which extend to much older ages (Gómez et al. xref ; Cam-CAN et al. xref ; Hashemi et al. xref ; Duffy et al. xref )."
sparser
"The age range in the UK Biobank sample (40–69 years) is very different to the age range in the Cam-CAN dataset (18–88 years); therefore, in order to rule that out as a possible explanation for the discrepancy observed, we repeated our TBSS analyses for a subset of the Cam-CAN data matching the same age range as the UK Biobank (295 participants included)."
sparser
"To allow comparison between the Cam-CAN LC mask and previously published LC masks ( xref , xref , xref ), the MT-weighted template was coregistered to the MNI152 space (using the “antsRegistrationSyNQuick.sh” routine in ANTS v2.1, with “rigid + deformable syn” as transformation type) and the obtained transformation matrices were applied to warp the mask to MNI space."
sparser
"The greater caudal extension of the Keren/Betts LC masks compared with our mask could be because the relatively lower resolution of the Cam-CAN scanning sequence could not sufficiently identify this portion, which has previously been reported to show a less reliably observable signal ( xref )."
sparser
"The resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic) was relatively low compared with previous MT-weighted studies (typically 0.39 × 0.39 × 3 mm to 0.7 × 0.7 × 0.7 mm) ( xref , xref , xref ), which limited the precision of segmentation and may have contributed to some of the variability of LC signal intensity values."
sparser
"Noise reduction (using temporal signal space separation, tSSS,Taulu et al, 2005), reconstruction of missing or corrupted MEG channels, continuous head motion correction, and a transformation to a common head position were performed by the Cam-CAN group with MaxFilter(Taulu and Simola, 2006)."
| DOI
sparser
"Results for the in silico MFM over the multimodal imaging and connectome analysis–microstructure-informed connectomics (MICA-MICs) dataset is presented in the xref section, and results from the alternate Cambridge Centre for Ageing and Neuroscience (Cam-CAN) dataset and LSM is shown in the xref figures."
sparser
"We investigated these questions in the cross-sectional Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data (N = 708, age 18–88), using data-driven exploratory structural equation modelling, confirmatory factor analyses, and age-residualized measures of cognitive differences across the lifespan."
sparser
"For example, in the same Cam-CAN sample, Fuhrmann et al. observed strong associations such that low diastolic blood pressure (usually associated with lower overall blood pressure) was associated with worse neural health–but only when the model also included systolic blood pressure [ xref ]."
sparser
"In addition, the button-press data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository ( xref )—which to our knowledge represents the largest such dataset that is publicly available—includes trials with ISIs as low as 2 s (in fact, approximately 50% of button-press cues in this dataset occur within 3 s of the preceding cue; see xref )."
sparser
"In a second study, we analyzed a large open MEG dataset for age-related obtained from the Cam-CAN repository (Shafto et al, 2014; Taylor et al, 2017) , aiming to replicate the results from our EEG dataset and to determine whether any non-linear age changes in sensorimotor beta activity were paralleled by a similar age-related non-linear modulation of sensorimotor task performance -as available in this dataset."
| DOI
sparser
"That being said, previous analyses of the Cam-CAN dataset have revealed movement-related beta modulation that is consistent with the wider experimental literature (e.g., xref ; xref ; xref ); therefore, it seems unlikely that the bimodal stimuli substantively affected beta suppression or rebound."
sparser
"Although we indeed find that the average correlation of the 25% longest connections is slightly more strongly anticorrelated with age compared with the average correlation of the 25% shortest connections for Cam-CAN ( xref , left), we find the opposite trend for HCP ( xref , right)."
sparser
"To address our hypothesis, we will leverage three well-established cohorts of aging, including two longitudinal cohorts [Baltimore Longitudinal Study of Aging (BLSA) ( xref ), Vanderbilt Memory & Aging Project (VMAP) ( xref )] and one cross-sectional cohort [Cambridge Centre for Ageing and Neuroscience (Cam-CAN) ( xref )]."
sparser
"In this study, we investigated age-related changes in ER accuracy and its association with magnetic resonance imaging (MRI) measures (both structural and functional), on data collected for the ‘The Cambridge Centre for Ageing and Neuroscience (Cam-CAN)’ project ( xref ; xref ), with two specific aims."
sparser
"This data organisation mirrors that of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository xref , the rationale being that data grouped by scan type means that users can avoid having to download all of the MRI data if they are only interested in one specific type of scan."
sparser
"Previously, ketamine-induced ‘delta-to-gamma’ shift has been observed in animal studies, indicating the underlying N-methyl-D-aspartic acid (NMDA) mechanism. xref Previous researchers claimed that EEG delta-band phase and gamma-band amplitudes predict some complementary aspects of the time course of spikes of visual cortical neurons. xref Another possible explanation by Cam-CAN studies claimed that higher-order visual system may be more involved than lower-order visual system with healthy aging. xref , xref These researches provide possible explanations for the delta and gamma intra-subject variability in our findings."
sparser
"Here, we analyze the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) resting-state magnetoencephalography (MEG) dataset—the largest aging cohort available—in light of the quasicriticality framework, a novel organizing principle for brain functionality which relates information processing and scaling properties of brain activity to brain connectivity and stimulus."
sparser
"The SC-ISV maps derived from our data and the Cam-CAN dataset were consistent across cortical ROIs ( R = 0.76, 95% CI = [0.72, 0.79], p = 0.0002 SA-corrected, p = 2.51×10 −124 uncorrected, Spearman’s correlation, see also Supplementary Fig. xref for the correction of spatial autocorrelation), suggesting that the ISV of structural connectivity is robust and generalizable between cohorts."
sparser
"We pre-registered a cross-sectional study to investigate the relationship between measures of emotion regulation, HRV and LC structural MRI integrity in a lifespan sample of cognitively normal healthy adults ( n = 678, aged 18–88 years, 51% female), recruited between 2010 and 2012 as part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort."
sparser
"In particular, the size of the Cam-CAN cohort allowed us to take a multivariate approach, namely to use canonical correlation analysis (CCA) to relate the temporal properties of the data-driven HMM states to profiles of cognitive performance, and to test whether these relations differ with age."
sparser
"We investigated the cross-sectional relationship between measures of emotion regulation, HRV and LC MRI integrity in a lifespan sample of cognitively normal healthy adults using the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) dataset, a large population-based cohort aged between 18 and 88 years ( n = 678)."
sparser
"The nature and degree of missing data may also have limited the reliability of the findings on the relationship between HRV and reappraisal outcomes, as Cam-CAN participants were invited to attend either the session that included the ERRT or a different session that did not include the ERRT, leading to only n = 314 completing the ERRT, thus only n = 130 older adults’ and n = 160 younger adults’ reappraisal task scores were available."
sparser
"While there are large single-site MEG studies, such as Cam-CAN (over 600 participants; xref ), and several multi-site studies such as MEG-UK (over 400 participants), BioFIND (324 participants; xref ), and Dev-CoG (over 200 subjects; xref ), none approach the numbers available in large multi-site MRI studies."
sparser
"The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (BB/H008217/1); R.T is supported by a British Academy Postdoctoral Fellowship (PF170046: SUAI/028 RG94188); K.A.T is supported by British Academy (PF160048) and the Guarantors of Brain (G101149); R.H is supported by a UK Medical Research Council grant (SUAG/010 RG91365)."
sparser
"Thanks to large-scale collaborations and recent data sharing initiatives, however, large-scale multi-modal datasets, such as the Human Connectome Project (HCP) xref , Adolescent Brain Cognitive Development (ABCD) study xref , Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository xref , developing Chinese Color Nest Project xref , the I See Your Brains (ISYB) dataset xref , The Latin American Brain Health Institute (BrainLat) project xref , UK Biobank, Chinese Human Connectome Project, and Multimodal Imaging and Connectome Analysis dataset for Microstructure-Informed Connectomics (MICA-MICs) xref are now publicly available."
sparser
"Cross-sectional patient data were first contrasted to pooled normative data set of healthy controls (‘HC’, n = 776, 383 males, age: 55.08 ± 17.63) from Trinity College Dublin ( n = 125) and subjects from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database ( n = 651) xref ."
sparser
"Using the high‐resolution T1‐weighted structural MRI scans from the Cambridge Centre for Ageing and Neuroscience project (Cam‐CAN) project ( N = 611;; Taylor et al., xref ), our team has recently investigated the performance metrics in individuals with different age ranges, including pre‐adulthood (aged from 18 to 22), young adulthood (aged from 23 to 40), middle adulthood (aged from 41 to 60), and late adulthood (aged from 60 to 90) using Support Vector Regression."
sparser
"Studies based on already existing databases of neural and cognitive data can also be helpful [such as the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) repository ( xref )] provided future datasets like these have information on language experiences and bilingual language use patterns."
sparser
"Notable datasets, such as the Human Connectome Project (HCP) xref – xref , the Cambridge Centre for Aging and Neuroscience (Cam-CAN) xref , the UK Biobank xref , xref , the Adolescent Brain Cognitive Development (ABCD) Study xref , the Amsterdam Ultra-high Field Adult Lifespan Database (AHEAD) xref , xref , and the Amsterdam Open MRI Collection (AOMIC) xref , have provided critical resources for analyzing healthy and diseased human brain anatomical and connectional patterns in large scale."
sparser
"Cam-CAN and Leipzig resting-state datasets show that increased age, in turn, was associated with destabilization of brain networks (Leipzig <50 y [ n = 214] vs. ≥50 y [ n = 78], Mann–Whitney U test = 0.28, P = 1.4 × 10 −8 ; Cam-CAN <50 y [ n = 281] vs. ≥50 y [ n = 355], Mann–Whitney U test = 0.27, P = 1.6 × 10 −22 ; xref , Left )."
sparser
"Using the MEG RSNs from the Cam‐CAN dataset as a benchmark for evaluating brain networks of fast oscillatory activity, we investigated EEG‐derived RSNs to ascertain if both modalities can yield meaningful network descriptions and establish how comparable they are to one another."
sparser
"We pre-registered a study to investigate the cross-sectional relationship between measures of emotion regulation, HRV and LC MRI integrity in a lifespan sample of cognitively normal healthy adults using the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) dataset, a large population-based cohort aged between 18-88 years (N=678)."
| PMC
sparser
"We now turn our attention to a real data example: networks derived from resting-state fMRI scans of human brains from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research project Shafto et al. ( xref ), a study on the effect of healthy ageing on cognitive and brain function."
sparser
"To address this, we undertook the first large-scale evaluation of BRO responses in healthy aging using the Cambridge Centre for Aging and Neuroscience (Cam-CAN) repository, which contains magnetoencephalography (MEG) data from a large sample ( N = 457) of healthy adults across a broad age range (18–88) during the performance of a simple target detection task."
sparser
"Our approach relied on a two-layer multiplex network, with a structural layer based on DWI data and another layer based on resting-state MEG data, to identify changes between younger and older healthy individuals from the Cam-CAN repository and to further understand maintenance xref and compensation xref phenomena observed in ageing."
sparser
"Notable open big data initiatives include those for fundamental brain sciences such as the Allen Brain Map [ xref ], Collation of Connectivity Data for the Macaque (CoCoMac) database [ xref ] and Human Connectome Project (HCP) [ xref ], and for clinical and translational sciences, including the Cambridge Centre for Ageing Neuroscience (Cam-CAN) dataset inventory [ xref ], Alzheimer’s Disease Neuroimaging Initiative (ADNI) [ xref ], the National Alzheimer’s Coordinating Center (NACC) [ xref ], UK Biobank [ xref ] and the Dementias Platform UK (DPUK) [ xref ]."
sparser
"Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy."
sparser
"Therefore, we expect our results to generalise to other datasets with similar specifications, such as the publicly available and intensely studied Cam-CAN xref , Philadelphia Neurodevelopmental Cohort xref , CENTER-TBI xref , Harvard Aging Brain Study xref , Autism Brain Imaging Data Exchange (ABIDE) xref , and UCLA Neurophenomics xref datasets among others, enabling the functional connectomics community to make the most of these valuable resources to study development, aging, and disease."
sparser
"To this end, we used data from over 300 healthy individuals uniformly spread across the adult lifespan from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and tested the multivariate relationship between grey matter volumes and item/associative memory scores using canonical correlation analysis."
sparser
"Through empirical benchmarks on the
Cam-CAN MEG dataset (= 646) and two EEG datasets (TUAB-normal,= 1385;
LEMON,= 213),
we evaluate the practical impact of these alignment techniques for boosting the generalization
capacity of regression models across acquisition protocols (resting state vs. audiovisual
& motor tasks) and cohorts (clinical EEG vs. research & laboratory-grade EEG)."
sparser
"Thus, the UKB results were in agreement with the lack of meaningful cross-sectional sleep-hippocampal volume relationships in Lifebrain, and aligns with previous findings within a Lifebrain cohort (Cam-CAN) which found no cross-sectional associations between PSQI subcomponents and white matter microstructure (indexed by Fractional anisotropy) across 10 tracts [ xref ]."
sparser
"Using a large population-based cross-sectional data set of cognitively normal healthy adults ( N = 605, age range 18–88 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) xref , xref , we previously reported the presence of a quadratic relationship between mean normalized LC MRI signal intensity (LC contrast ratio, or LC CR) and age, the peak occurring around 60 years xref ."
sparser
"Data collection and sharing for this project was provided by the Quebec Parkinson Network (QPN), the Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer’s Disease (PREVENT-AD; release 6.0) program, the Cambridge Centre for Aging Neuroscience (Cam-CAN), and the Open MEG Archives (OMEGA)."
sparser
"Cognitive/behavioral factors (measured by variables in the Cam-CAN database) previously demonstrated in vivo to be related to LC–NA system integrity are chosen as NA-dependent variables (emotional memory, emotional reactivity, and response inhibition +/− executive function, sleep quality, and three measures—years of education, verbal intelligence, and occupational complexity—representing cognitive reserve), and those not previously proposed or shown to rely on the LC–NA system are included in the NA-independent factor (general intelligence, face recognition, and sentence comprehension)."
sparser
"Each of these pre-registered functions correspond to a task or questionnaire in the Cam-CAN database, apart from emotional regulation and emotional memory, which had multiple outcome measures xref , xref , and we justify the choice of the final variables in our analyses in the Methods section."
sparser
"Therefore, the primary goal of this study was to further examine microstructural white matter changes in the medial temporal lobe using DTI, including associations with age and memory function, in SCD and unaffected control participants from Cambridge Center for Ageing and Neuroscience (Cam-CAN) ( xref , xref )."
sparser
"For example, a recent study using Cam-CAN data showed age-related differences in the relationship between response inhibition performance and brain connectivity but not activity in a distributed inhibition network xref , which raises the possibility of compensatory changes in response to age-related reductions in LC structural integrity."
sparser
"Although we made pre-registered predictions on the relationship between LC CR and cognitive/behavioral processes, which were based on the wider literature underpinning our hypotheses, we did not pre-register the precise Cam-CAN outcome variables for all processes (i.e., SSRT for response inhibition, Hotel task for executive function, PSQI total score for sleep quality, three measures for negatively valenced emotional memory, and two for emotional reactivity/regulation) that were included in our final analyses."
sparser
"However, we have benefited greatly from the quality of the Cam-CAN dataset and the ability to observe the lifespan changes in how SC relates to age and cognitive ability over such a large range of ages, from the beginning of adulthood (age 18) to late in the aging process (age 88)."
sparser
"In line with suggested strategies to maximize statistical diagnosticity in these cases xref , we transparently reported in our pre-registered analysis plan that we already had access to the pre-existing data in Cam-CAN, but had not performed any analyses of the cognitive/behavioral measures."
sparser
"These include the relatively low resolution of the Cam-CAN MT-weighted images (original voxel size 1.5 mm isotropic), which may have contributed to some of the inter-individual variability of LC CR values, and the fact that the structural imaging protocol used a Repetition Time (TR) of either 30 ms or 50 ms, depending on the participant’s SAR estimation."
sparser
"This study revisited this issue by examining the relationship between the microstructural integrity of the phonological processing brain network and TOT, utilizing graph-theoretical analyses of neuroimaging data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), which included diffusion tensor imaging (DTI) data from 576 participants aged 18–87."
sparser
"Materials and Methods In a retrospective study (October 2010 to September 2013), rsfMRI data from healthy participants in the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) data repository were used to generate CAPs by applying single-volume temporal clustering analysis."
sparser
"Together with new tools for data management [ xref ], this makes it easier for users of our ecosystem to use a large range of methods matched to their datasets and questions and to deploy them in a reproducible and scalable manner on large openly available datasets, such as the Human Connectome Project (HCP), the Healthy Brain Network (HBN), Cam-CAN [ xref , xref , xref ]."
sparser
"For example, Engemann et al reported a benchmark of brain age prediction from MEG resting-state data, where a couple of methods, such as deep learning based, handcrafted features based, and covariance-based filterbank approaches, were used and shown the MAE scores of the Cam-CAN dataset with 8 to 10 years ( xref )."
sparser
"In this study, we aimed to utilize single‐subject morphological brain network methods to systemically investigate age‐related changes in multiple morphological features for 650 participants (aged from 18 to 88 years old) from a publicly available dataset of the Cambridge Centre for Aging and Neuroscience (Cam‐CAN)."
sparser
"The data analyzed in this study are subject to the following licenses/restrictions: prospective users who wish to use the Cam-CAN dataset in their research must confirm first the data use agreement, then submit a research proposal detailing which data modalities/measures are requested and why."
sparser
"First, although Cam-CAN recruitment was population-based, it was not population-representative, and participants who completed full cognitive assessments were qualified to undergo cognitive neuroscience experiments including neuroimaging (see xref , for a description of participant selection for testing stages)."
sparser
"Importantly, cohorts with diverse cognitive assessment such as in the Cam-CAN data set are also able to contribute to the understanding of domain-general function and cognitive factors that may be related to pathology in later life, as is evident from the domain-general Fluid Abilities and Typically Declining factors."
sparser
"In the Cam-CAN data, there were strong correlations between emotional and neutral memory measures; positive and negative object memory scores were highly correlated, r (301) = 0.90, p < 0.011; and neutral object memory performance was also highly correlated with both positive, r (301) = 0.89, p < 0.001, and negative memory performance, r (301) = 0.88, p < 0.001."
sparser
"We investigated whether resting-state FC predicts emotional memory using a large database—the Cambridge Centre for Ageing and Neuroscience (Cam-CAN)—that includes emotional memory scores, structural and functional MRI (fMRI) scans of 303 individuals of ages 18–87 years xref , xref ."
sparser
"Nevertheless, it is important to note that in the Cam-CAN project, the two measures of the emotional background images were not independent from the object memory measure; participants were given a chance to answer the valence and the content of a background image associated with each neutral object only when they recognized the neutral object as studied (see “ xref ”)."
sparser
"Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort ( N = 667, aged 18–88)."
sparser
"We partitioned the CAM‐CAN data set ( N = 550) into the young, middle, and old age‐groups, then used the young and old age‐groups to construct prediction models for 11 behavioral outcomes using multimodal neuroimaging features (i.e., structural and resting‐state functional connectivity, and gray matter volume/cortical thickness)."
sparser
"Investigation of cognitively healthy older adults is also a fruitful avenue to provide information about the neural resilience mechanisms able to curb the onset or the progression of cognitive deficits as shown by the works of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) group ( xref ; xref )."
sparser
"For instance, CAM‐CAN consortium et al. ( xref ) demonstrated that cognitively high performing older adults tend to possess more youth‐like functional characteristics, which is likely to optimize brain function to support a healthy aging process and maintain, as far as possible, one's cognitive functions at a level similar to those observed in the young."
sparser
"To support the needs of a mature neuroimaging field, several data collection efforts have been started; relevant examples are the Human Connectome Project (HCP) xref , Cambridge Centre for Ageing and Neuroscience study (Cam-CAN) xref , Adolescent Brain Cognitive Development (ABCD) study xref , the UK-Biobank xref , Healthy Brain Network (HBN) xref , Pediatric Imaging Neurocognition and Genetics (PING) study xref and the Natural Scene Dataset xref ."
sparser
"Using four large-scale neuroimaging datasets (HCP-A, UK Biobank [UKB], Mayo Clinic Study of Aging, and Cam-CAN), we first reproduced our previously measured nonlinear trends in brain network instability (), focusing on the three subnetworks that were identified as most sensitive to aging: auditory, visual, and cingulo-opercular () ( xref )."
sparser
"Here, we take advantage of a broad set of MRI-derived WM measures in a large life-span cohort (650 adults aged 18–89 from the Cam-CAN cohort) to address two questions: (1) how these measures cluster into latent factors reflecting distinct aspects of WM health, and (2) how these factors relate to cardiovascular risk and cognitive abilities."
sparser
"To complement our structural imaging analyses, we performed post hoc behavioural analyses looking at the relationship between motor adaptation and Cam-CAN’s behavioural measures of explicit memory collected on the same cohort, namely visual short-term memory (STM) and declarative long-term memory (LTM)."
sparser
"As most previous studies relied exclusively on magnetic resonance imaging (MRI) data, we hereby investigate whether combining structural MRI with functional magnetoencephalography (MEG) information improves age prediction using a large cohort of healthy subjects (N=613, age 18-88 yrs) from the Cam-CAN repository."
sparser
"Pooled across cohorts, physical activity levels did not significantly vary with age or sex (Appendix C), even though there was a large negative age effect in CAM-CAN, which included the widest age range, and a large positive sex effect (wherein men reported more METs than women) in Whitehall, which had the smallest proportion of females across the five studies."
sparser
"To address this objective, we leveraged a population‐based resting‐state fMRI dataset from the CamCAN cohort (Cam‐CAN et al., xref ) and applied graph theory analyses to evaluate the reorganization of the language connectome in terms of integration and segregation properties at multiple topological scales of analysis."
sparser
"We tested a mechanistic account of the 'neural noise' hypothesis in a large adult lifespan cohort (Cam-CAN) with over 2500 adults (ages 18-102; 1508 female; 1173 male; 2681 behavioral sessions; 708 MRI scans) using WM fractional anisotropy (FA) to predict mean levels and variability in reaction time performance on a simple behavioral task using a dynamic structural equation model (DSEM)."
sparser
"Data used in the present study came from the Cambridge Centre for Ageing and Neuroscience (Cam‐CAN), which is a large‐scale, population‐based adult lifespan dataset aiming at uncovering neural underpinnings of cognitive aging. [ xref ] Participants included in this project were all cognitively healthy adults."
sparser
"Hierarchical clustering of the individual predicted brain-ages in the Cam-CAN sample showed that elastic-net regression, Lasso and ridge regression together formed one cluster, SVR and RVR formed another cluster while OLS regression showed the lowest similarity with all the other algorithms ( xref )."
sparser
"To do this, we leveraged three well-established cohorts of aging, including two longitudinal cohorts [Baltimore Longitudinal Study of Aging (BLSA) xref , Vanderbilt Memory & Aging Project (VMAP) xref ], and one cross-sectional cohort [Cambridge Centre for Ageing and Neuroscience (Cam-CAN) xref ]."
sparser
"Evaluation of the six algorithms in two sizable samples of healthy individuals from the HCP and Cam-CAN yielded reproducible results with regards to the similarity between Lasso regression and elastic-net regression, and between the SVR and RVR that consistently clustered together."
sparser
"Some aspects of the differences that were observed between these matched datasets could thus have been driven by participant variability (for instance, ISC can vary over large age ranges; Geerligs, Cam‐CAN, & Campbell, xref ; Petroni et al., xref ) rather than scanner differences."
sparser
"In this preregistered cross-sectional study, we used a 3D MT-weighted MRI sequence to assess the relationship between locus coeruleus integrity in vivo and test its relationship with inhibitory control in cognitively normal healthy adults from the Cambridge Centre for Ageing and Neuroscience cohort (Cam-CAN; xref ) using the Stop-Signal Task (SST)."
sparser
"Our preregistered analysis was designed to specifically probe the association of locus coeruleus integrity with response inhibition and differs in many respects from an earlier analysis of the Cam-CAN cohort looking for associations of coeruleus integrity with a cognitive component expressing mainly general abilities ( xref )."
sparser
"The integration of a hybrid CNN-Transformer architecture allows our model to capture both local and global contextual features, leading to more precise disease classification and nodule detection. xref further illustrates the effectiveness of our approach on Cam-CAN Dataset and HCP Dataset."
sparser
"Research on the reproducibility of scientific findings indicates that limited sample sizes might have hindered the validity of early, foundational results in hypothesis-driven cognitive neuroscience research, xref – xref but reproducibility issues can be found in biological science, xref , xref psychology, 12 data science, and computational methods, xref , xref cancer biology, xref , and artificial intelligence. xref , xref , xref This is largely because small sample sizes increase the probability of reporting spurious effects as statistically significant. xref , xref Recent findings also make the case for increasing sample sizes into the thousands when research focuses on discovery science. xref Notable examples of large-scale data sharing within neuroscience and neuroimaging include the Human Connectome Project (HCP), xref the Cambridge Centre for Ageing and Neuroscience study (Cam-CAN), xref , xref the Adolescent Brain Cognitive Development (ABCD) study, xref , xref the UK-Biobank, xref the Healthy Brain Network (HBN), xref the Pediatric Imaging Neurocognition and Genetics (PING) study, xref the Natural Scene Dataset xref and the thousands of individual brain datasets deposited on. xref These data-sharing projects not only serve the needs of the neuroscience community with demonstrated impact xref , but also the incoming generation of AI research. xref – xref However, larger datasets generally entail greater complexity as well."
sparser
"The experiments focused on the four axes of scientific transparency: data processing external validity (DPEV), reliability, reproducibility, and replicability. xref , xref Four data modalities (sMRI, fMRI, dMRI, MEG) were evaluated using, among others, the test-retest HCP TR, xref the Cam-CAN, xref the HBN, xref and the ABCD xref datasets."
sparser
"Some posit that increased variability in older age is due to a lifetime of accumulating risk and protective factors like increased brain pathology (Rabbitt, xref ), but others find an increased variability is not inevitable across one’s cognitive development (Salthouse, xref ) or may be due to ceiling effects in young adulthood (Green, Shafto, Matthews, Cam-CAN, & White, xref )."
sparser
"For example, some big datasets that include fMRI data are the Autism Brain Imaging Data Exchange (ABIDE), the Alzheimer's Disease Neuroimaging Initiative (ADNI), the UKBioBank, SchizConnect, and the Cambridge Centre for Ageing and Neuroscience (Cam‐CAN) (see Table xref for more information)."
sparser
"In this study, we investigated whether the intrinsic functional connectivity of the DMN-C subnetwork is related to individual differences in memory ability, examining this relationship across 243 individuals (ages 18-50 years) from the openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset."
sparser
"The logical memory subtest of the Wechsler Memory Scale was chosen because it was available for the largest number of subjects in the Cam-CAN dataset, compared with other included memory measures, and this measure has been previously shown to correlate with individual differences in brain activity in response to event boundaries during the Cam-CAN movie-watching scan ( xref )."
sparser
"By using a large movie fMRI dataset from the Cam-CAN project ( xref ) that shows reliable stimulus-driven activity (i.e., significant inter-subject correlations) over nearly all cortical brain regions ( xref ; xref ), we were able to study neural state segmentation across the entire cortex for the first time."
sparser
"Having established a robust within-sample prediction for task-FC derived models, we next aimed to investigate whether those models derived in HCP-Aging cohort would generalize to predict individual response time variability in two independent samples of n = 100 (Cam-CAN data) and n = 47 (SCAN data) healthy older adults."
sparser
"The training set used for the age prediction model comprised 765 healthy community dwelling individuals aged 20-78 years sampled from two different cohorts, including the ongoing STROKEMRI study at the University of Oslo (UiO; n=177, M age = 57.59; SD = 15.05, 60 % female, PI: L.W.) and the Cambridge Centre for Ageing and Neuroscience 13 (Cam-CAN) (n=588, M age = 52.31; SD = 17.38, 50 % female) from the Cambridge Center for Ageing and Neuroscience 14 (CamCAN)."
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sparser
"A total of 51,467 participants aged 9y – 70y with 53,199 neuroimaging scans across four cohorts (ABCD, IMAGEN, HCP and UKB) were included in the discovery set, and a total of 2,127 participants aged 12y – 89y from the cross-sectional NKI-RS, Cam-CAN and BRAINMINT studies were included for validation."