IndraLab

Statements

CALM1 binds Dr. 401 / 401
| 401
sparser
"There are some attractive features of anti CAM-DR strategy."
29882812
sparser
"We hypothesized that a decreased level of extracellular COL3A1 resulted in reduced drug binding, increased drug diffusion into cells, and reduced interaction between ECM and cell surface receptors, resulting in reduced CAM-DR strength."
33921897
sparser
"The bone marrow environment has been shown to promote cell adhesion-mediated drug resistance (CAM-DR) in leukemia cells, which may contribute to relapse."
30669372
sparser
"However, the underlying mechanisms of CAM-DR and the fact of whether and how it interferes with other types of resistance remain to be elucidated."
31779287
sparser
"Thus it will be critical to move toward a personalized approach for targeting the CAM-DR phenotype associated with cell adhesion as well as for inhibitors of soluble factors that confer drug resistanc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22959026
sparser
"They attribute this to cell adhesion-mediated drug resistance (CAM-DR) and suggest that the interaction of ECM components, including collagen, with the cancer cells results in chemoresistance."
35267582
sparser
"These data strongly support that translation of CAM-DR signaling pathway regulators to clinic in combination with standard therapy can be considered as a rational strategy to overcome resistance."
29882812
sparser
"Most mechanisms of CAM-DR are not fully understood, possibly due to multifactorial processes involving different molecular players such as cell adhesion molecules and ECM components."
29882812
sparser
"As Wnt signaling has been shown to be an aberrantly upregulated pathway in leukemia ( xref ) and is involved with chemoresistance, this warrants further exploration of celecoxib as a viable therapy to reverse CAM-DR in leukemia."
33425742
sparser
"It is obvious that SFM-DR and CAM-DR act closely with each other and cannot be separated completely."
30405034
sparser
"Nevertheless, CAM-DR has attracted relatively little attention during the last decade despite growing evidence concerning the relevance of CAM-DR for different tumor entities."
32668815
sparser
"VTD-PACE is a good option for EMD considering CAM-DR and hypoxia, but might be intolerable for the majority of patients with a terminal phase of MM [ xref ]."
33435539
sparser
"To further elucidate the effect of TRPV1 inhibition on stroma-mediated resistance to bortezomib, we evaluated the activation of pro-survival signaling pathways implicated in CAM-DR."
33239060
sparser
"Mounting evidence suggests that cell adhesion-mediated drug resistance (CAM-DR), caused by the interaction between the bone marrow microenvironment and tumour cells may play an important role in drug resistance to chemotherapy."
33214335
sparser
"To investigate whether the diverse dependency of CAM-DR in W1 and W1CR cells from ITGB1 is manifested in intracellular integrin signaling, we focused on integrin linked kinase (ILK)."
31779287
sparser
"Integrins the heterodimeric adhesion that molecules possess, depending on their subunit composition, the capability to bind ECM components further mediating CAM-DR ( xref )."
33041787
sparser
"Apart from CXCR4, MM cells also express CXCR7, an alternative receptor of CXCL12, which may also be involved in CAM-DR in MM [ xref ] as well as in MM progression [ xref ]."
| PMC
sparser
"Although CAM-DR is relevant in both cell lines in addition to the existing cisplatin resistance in W1CR cells, the β1-integrin signaling induces different signaling pathways in both cell lines."
31779287
sparser
"Again, the combination AUR/BTZ significantly decreased CAM-DR (−17.7% and −29.9% for viability, for the lowest concentration of AUR, comparing cells in suspension vs. on FBN-coated plates)."
33114738
sparser
"Studies have shown that MM cells can be protected from chemotherapy-induced apoptosis by the phenomenon called cell adhesion mediated drug resistance (CAM-DR) [ xref ]."
32354135
sparser
"In this study, we also construct the CAM-DR model with the co-culture of BMSCs and MM cells."
32526706
sparser
"Expression of VLA-4, a member of the integrin superfamily of adhesion receptors that is recognized as a main factor involved in CAM-DR [ xref ], is regulated by Btz treatment in MM cells."
29738534
sparser
"For example, the interaction between the tumoral cells and the extracellular matrix (ECM) through the binding with its components (collagen, fibronectin, and laminin) is responsible for the cell adhesion-mediated drug resistance (CAM-DR), that mediates the resistance to radiotherapy and antibody-based receptor tyrosine kinase (RTK) inhibition ( xref , xref )."
36341428
sparser
"The focal adhesion pathway, along with CAM-DR has commonly been linked to drug resistance in MM patients xref , due partly to the increased abundance of Wnt3."
| PMC
sparser
"Few studies analyze redundancy between integrins in CAM-DR, and how it might affect integrin targeting."
33425742
sparser
"Therefore, it can be stated the more stiffen collagen network the more efficient blocking of drug diffusion [ xref , xref ] and/or more efficient CAM-DR induction."
30583585
sparser
"The interaction between MM plasma cells and the BME can render myeloma cells resistant to current regimens of pharmacologic therapy, a mechanism coined, “cell adhesion-mediated drug resistance” (CAM-DR) (58)."
35399952
sparser
"On the contrary, the W1PR2 cell line revealed an increased level of extracellular COL3A1 after piperine treatment that may strengthen the CAM-DR mechanism and lower PAC sensitivity."
33921897
sparser
"Indeed, in the W1PR2 cell line, we observed a minimal synergistic effect of piperine on PAC resistance that may be explained by the protective effect of extracellular COL3A1 in the way of CAM-DR."
33921897
sparser
"Cell adhesion can mediate p27 kip1 elevation and it is associated with cell cycle arrest. xref , xref , xref Our study, for the first time, demonstrated that the negative correlation between VRK1 and p27 kip1 expression might be the reason for cell cycle arrest and CAM-DR in MM cells."
27319807
sparser
"The possible roles of collagens in drug resistance can be related to direct drug binding [ xref ], physical drug diffusion blocking [ xref , xref ], and induction of CAM-DR [ xref , xref ] and were discussed in more details previously [ xref , xref ]."
30583585
sparser
"Finally, next to the above described role of EZH2 in IMiD and PI resistance, it should be mentioned that Kikuchi et al. also described a correlation between phosphorylation-mediated inactivation of EZH2 and cell adhesion-mediated drug resistance (CAM-DR) against doxorubicin and the alkylating agent 4-OHCY in MM."
30619733
sparser
"This protects them from killing by cytotoxic drugs, so called cell adhesion-mediated drug resistance (CAM-DR), but also from killing by cytotoxic T−cells (CAM-immune resistance/CAM-IR) by upregulating several anti-apoptotic proteins after binding to stromal cells [ xref ]."
32331242
sparser
"Stromal cells utilize two mechanisms to induce drug resistance, including soluble factor-mediated drug resistance (SM-DR) and cell adhesion-mediated drug resistance (CAM-DR) [ xref ]."
| PMC
sparser
"Altogether, we can draw a preliminary conclusion that WCF combined with DDP reverses the CAM-DR, perhaps by inhibiting the expression of Integrin β1 and its ligand proteins."
33041787
sparser
"Surface molecule overexpression and CAM-DR have been addressed in many subtypes of leukemia, including B- and T-acute lymphoblastic leukemia (B- and T-ALL) and acute myeloid leukemia (AML)."
33425742
sparser
"Adhesion of leukemia cells to BM stromal cells may lead to cell adhesion-mediated drug resistance (CAM-DR) mediating intracellular signaling changes that support survival of leukemia cells."
36243854
sparser
"Given that the adhesion of MM cells to BMSC via VLA-4- VCAM-1 interaction confers CAM-DR in MM cells xref , xref , xref and osteoclastogenesis, xref these results suggested the therapeutic impact of TAK1 inhibition on CAM-DR as well as osteoclastogenesis induced by the MM-bone marrow interaction."
32273474
sparser
"This appears indicative for the ITGB1/COL1 axis triggering the CAM-DR process ( xref a)."
31779287
sparser
"WNT and Activation of Cell Adhesion-Mediated Drug Resistance (CAM-DR): CD44."
31921125
sparser
"CAM-DR is one mechanism through which leukemia cells obtain chemoresistance, and resistant clones will result in the recurrence of the disease."
33425742
sparser
"CAM-DR may be strong in minimal residual myeloma cells compared to newly diagnosed myeloma cells because of the rich presence of adhesion molecules on the minimal residual myeloma cells [ xref ]."
33435539
sparser
"Based on the ability of AMG9810 to suppress CXCR4 expression and activation on MM cells and given the role of CXCR4 in contact-dependent drug resistance (CAM-DR) of MM cells, we evaluated the effect of TRPV1 inhibition on stroma-mediated protection."
33239060
sparser
"Cell adhesion-mediated drug resistance (CAM-DR) is a process involved in chemoresistance and operates in B-ALL ( xref ) and in the response of MM cells to the proteasome inhibitor bortezomib (BTZ) ( xref – xref )."
30787933
sparser
"CAM-DR has attracted the primary attention in the treatment of multiple myeloma, but since then has also been accepted for its relevance in various solid tumors [ xref , xref ]."
30563275
sparser
"The gene set enrichments showed that sustained PI monotherapy was involved in inflammatory response pathways, which correspond to SFM-DR, whereas the gene sets involved in CAM-DR were enriched in both combination and intermittent therapy groups (Fig.  xref )."
33250513
sparser
"Therefore, therapeutic interference with CAM-DR appears promising to antagonize resistance as an early onset mechanism, relevant for different other types of resistance formation."
30563275
sparser
"By promoting a better survival of blasts, the stroma-induced SP functionality we identified in blasts could represent a new mechanism of CAM-DR."
31289201
sparser
"Concerning the mechanistic background of CAM-DR, although the binding to COL1 induces a comparable loss in sensitivity in both W1 and W1CR cells by doubling the EC 50 values, the underlying mechanisms appear to be diverse, following different routes in both cells."
31779287
sparser
"Hence, BTK bound directly with CXCR4 and prevented its ubiquitination-induced degradation, leading to CAM-DR maintenance."
33918655
sparser
"Furthermore, CAM-DR emerges as an independent process adding to the resistance phenomena already developed in ovarian cancer cells, which has not been shown before."
31779287
sparser
"It is accepted that CAM-DR contributes drug resistance to melphalan, vincristine, doxorubicin, mitoxantrone, and bortezomib [ xref , xref ]."
30405034
sparser
"This opens the view to other potential COL1 binding proteins contributing to CAM-DR."
32668815
sparser
"In addition, down-regulation of VRK1 expression resulted in induced CAM-DR phenotype, which was accomplished by enhancing the ability of cell adhesion."
27319807
sparser
"Cadherins, selectins, and integrins are known cell adhesion molecules that are involved in CAM-DR in leukemia ( xref )."
33425742
sparser
"The ITGB1 knockdown confirms that CAM-DR follows a COL1/ITGB1 signaling axis in W1 cells; thus, a blockade of ILK re-sensitized W1 cells on COL1 for cisplatin."
31779287
sparser
"CAM-DR plays an important role in drug resistance through the adhesion between Integrin β1 and ECM."
33041787
sparser
"Their aberrant expression and association in CAM-DR in different types of leukemia have been studied."
33425742
sparser
"These biological processes and pathways correspond to soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), xref respectively."
33250513
sparser
"In addition, bortezomib was found to overcome CAM-DR in BL cells by inhibiting NF-κB. Thus, bortezomib may have potential clinical applications in the treatment of CD49d- and CD49e-mediated CAM-DR in BL patients."
33214335
sparser
"The bone marrow environment has been shown to promote CAM-DR in ALL ( xref )."
34926269
sparser
"Thus, the limitation of TGFBI secretion by piperine can inhibit integrin signaling, which is the primary signaling in CAM-DR, and it eventually leads to higher TOP sensitivity [ xref ]. xref summarizes the main mechanisms of piperine action on drug-resistant cells in our model."
33921897
sparser
"USP14 reportedly contributes to CAM-DR by upregulating the anti-apoptotic protein Bcl-xl and Wnt 3 signaling pathways."
32354135
sparser
"Other integrin, including β7-integrin and VLA-5 (α5β1), also plays a role in CAM-DR of MM cells [ xref ]."
30405034
sparser
"SFM-DR is primarily mediated by the induction of gene transcription, whereas CAM-DR is mediated largely, but not entirely, by non-transcriptional mechanisms including the degradation of activators of apoptosis [ xref ], subcellular redistribution [ xref ], and increased stability of suppressors of apoptosis and cell cycle regulators [ xref ]."
34067236
sparser
"The binding of MM cells to fibronectin upregulates p27 and induces nuclear factor κB (NFκB) activation in MM cells [ xref ], which confer cell adhesion-mediated drug resistance (CAM-DR) to conventional chemotherapy [ xref ]."
32256871
sparser
"CDC5L interference inhibited the CAM-DR in MM cells to alleviate the promotion effects of ANXA7 overexpression on CAM-DR to make MM cells become more susceptible to bortezomib."
32526706
sparser
"Our data suggest that HSPA12B may play a functional role in CAM-DR and is thus a potential novel target for NHL treatment."
34734014
sparser
"Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stroma cells triggers intracellular signals regulating cell-adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
30669372
sparser
"Binding to ECM components, also referred to as cell adhesion-mediated drug resistance (CAM-DR), appears as a functional onset to escape cytotoxic stress rapidly at a non-genetic basis and, thus, as a premise for subsequent genetic adaptations."
31779287
sparser
"However, the molecular mechanism underlying CAM-DR in BL has not been identified yet."
33214335
sparser
"BTK plays a role in CAM-DR through the regulation of CXCR4 degradation in MM cells and suggests that targeting therapy for the BTK/CXCR4 interaction may be effective for reversing CAM-DR."
33918655
sparser
"ANXA7 overexpression increases the cell adhesion-mediated drug resistance (CAM-DR), which was inhibited by ANXA7 interference."
32526706
sparser
"It strongly indicates that CAM-DR is associated with post-transcriptional mechanisms while the acquired drug resistance is associated with specific transcriptomes’ change [ xref ]."
30405034
sparser
"Cell-adhesion mediated drug resistance (CAM-DR) to melphalan is induced in MM cell lines and in patient primary cells through adhesion to fibronectin or bone marrow stromal cells (BMSCs), which is mediated by very late antigen-4 (VLA4) integrin (α4β1) and VLA-5 (α5β1) [ xref ]."
33922721
sparser
"Thus, induction of β1-integrin, which causes VLA-4-mediated CAM-DR in MM, is characterized by G1 cell cycle arrest accompanied by an increase of expression in CDK inhibitors, p21 Cip1 /Waf1 and p27 Kip1 [ xref ], and a decrease in Bim (an apoptotic BCL-2 family) [ xref ] and Cyclin A and Cyclin E activity [ xref ]."
30405034
sparser
"Furthermore, CAM-DR can also augment signaling pathways that cause increased expression of soluble factors in conferring tumor cell drug resistance."
32898723
sparser
"Numerous studies have demonstrated that cell-adhesion mediated drug resistance (CAM-DR) is based on a number of mechanisms."
29882812
sparser
"Multiple myeloma (MM) is a hematological neoplasia in which the BMN’s role in disease progression via elevated proliferation, migration and CAM-DR has been extensively reported [ xref ]."
32796596
sparser
"In vitro studies show that contact between leukemia and stromal cells promotes cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ], which prevents apoptosis of ALL cells [ xref , xref , xref ]."
30669372
sparser
"In contrast, CAM-DR adds to cisplatin resistance in W1CR cells independent of ITGB1."
31779287
sparser
"Introduction of miR-202 mimics into BMSCs inhibits the NF-κB signaling pathway and reverses CAM-DR [ xref ]."
30405034
sparser
"Several articles have been published supporting a role for CD44 in CAM-DR."
31921125
sparser
"On the other hand, the ECM model establishes the role of ECM-producing cells as responsible for development of drug resistance and its induction in surrounding cells via CAM-DR mechanism [ xref , xref ]."
30583585
sparser
"In such structure another mechanism of drug resistance like limited drug diffusion or cell adhesion mediated drug resistance (CAM-DR) can be important [ xref ]."
29649113
sparser
"Cell adhesion mediated-drug resistance (CAM-DR) is an established mechanism used by MMC to survive chemotherapy and its markers are upregulated in residual disease."
33355244
sparser
"Here we elucidate whether CAM-DR occurs in ovarian cancer cells and contributes to still-existing cisplatin resistance."
31779287
sparser
"This highly dynamic adaptation of malignant tumor signaling argues for a multitarget-inhibition approach, which is shown here to successfully interrupt CAM-DR."
32668815
sparser
"However, the specific role of VLA-3 in CAM-DR in leukemia is still unclear."
33425742
sparser
"During treatment, leukemia cells interact with the bone marrow (BM) microenvironment and obtain a survival benefit, known as cell adhesion-mediated drug resistance (CAM-DR) ( xref )."
34926269
sparser
"In particular, adhesion between MM cells and bone marrow stromal cells mediated by adhesion molecules induces cell adhesion-mediated drug resistance (CAM-DR)."
36354732
sparser
"As a receptor of hyaluronic acid (HA), CD44 confers resistance to lenalidomide in myeloma cells as the factor that CD44/HA adhered to BMSCs more strongly in lenalidomide-resistant MM cells, suggesting CD44 and BMSC-mediated CAM-DR [ xref ]."
30405034
sparser
"Integrin β1 signaling plays an important role in CAM-DR and has been proposed as a potential target for NSCLC."
33041787
sparser
"This adhesion mediated drug resistance referred to as CAM-DR was not caused by reduced drug accumulation or upregulation of anti-apoptotic Bcl-2 family members [ xref , xref ]."
32898723
sparser
"These initial results of preclinical studies suggest inhibitors of Notch signaling as potential anti CAM-DR drugs and further studies are warranted."
29882812
sparser
"The lack of CAM-DR effect against BRZ, induced by the interaction with hyaluronic acid and collagen, has been confirmed."
| PMC
sparser
"Altogether, our results demonstrate that the stroma-induced SP functionality is a new mechanism of CAM-DR for AML blasts."
31289201
sparser
"Previous studies indicated that adhesion of hematologic malignancies cells to FN leads to a reversible cell cycle arrest, which in turn promotes CAM-DR. xref , xref Hence, it is necessary for us to elucidate the correlation between cell adhesion and the expression of VRK1."
27319807
sparser
"Interaction between VLA-4 and vascular cell adhesion molecule-1 (VCAM-1) binds between MM cells and BMSC, contributing to the survival of MM cells via activation of phosphoinositide 3-kinase (PI3K)/(protein kinase B) AKT pathway and CAM-DR [ xref ]."
33435539
sparser
"EM-DR is rapidly induced by signaling events that are initiated by factors present in the tumor microenvironment and can be subdivided into two categories: soluble factor-mediated drug resistance (SFM-DR), which is induced by cytokines, chemokines, and growth factors secreted by MSCs such as IL-6, IGF-1, IL-1, IL-17 and TNF-α; and cell adhesion-mediated drug resistance (CAM-DR), which is mediated by the adhesion of tumor cell integrins to MSCs or stromal fibroblasts or components of the ECM, such as fibronectin, laminin, hyaluronan and collagen IV [ xref , xref , xref , xref ]."
34067236
sparser
"The significant increase in W1CR resistance induced by COL1 points to the fact that CAM-DR is obviously an independent process contributing to the already existing cisplatin resistance of W1CR, but is not the basis for the “intrinsic” resistance."
31779287
sparser
"Recent studies have verified that the BM microenvironment which provides a niche that promotes MM cells survival must be considered when evaluating drug response. xref Specially, MM cells adhered to FN or stromal cells conferred a multidrug resistant phenotype, known as CAM-DR, owing to the cell cycle arrest. xref Therefore, a hypothesis was proposed that abnormal expression of cell cycle regulators might be conduced to CAM-DR, then we focused on identifying them as targets to overcome CAM-DR."
27319807
sparser
"So far, there is one study that has reported its relationship with head and neck cancer, indicating that ENO1 promotes transformation partly via chemokine CCL20 induction and can be regarded as a potential prognostic marker. xref Moreover, ENO1 participates in the process of lymphoma cell adhesion mediated drug resistance (CAM-DR), besides promoting tumor proliferation. xref ENO1 overexpression was also observed in pancreatic cancer, xref and ENO1 silencing could sensitize hypoxia-induced chemoresistance. xref Some Italian scholars used a genetic model of pancreatic carcinoma and observed the effects that vaccination with ENO1 DNA elicits."
32884340
sparser
"Overexpression of miR-21 suppresses its targets, such as phosphatase and tensin homolog (PTEN), PUMA, and RhoB, which promote MM viability and contribute to CAM-DR [ xref , xref ]."
30405034
sparser
"Cell adhesion-mediated drug resistance (CAM-DR), a form of chemotherapy resistance, has been reported to confer resistance to various chemotherapeutic agents."
33041787
sparser
"Kikuchi et al. demonstrated that pharmacological and genetic inhibition of the IGF1R-PI3K-AKT pathway reverses CAM-DR by promoting enhancer of zeste homolog 2 (EZH2) dephosphorylation and H3K27 hypermethylation both in vitro and in refractory murine MM models, suggesting an epigenetic mechanism underlying CAM-DR [ xref ]."
33435632
sparser
"In addition to increases in transporter genes, Fibronectin-1 was also massively augmented, which lead the authors to propose a cell adhesion mediated drug resistant (CAM-DR) phenotype, in which anchorage to the ECM appears essential for cell survival in the presence of antineoplasic drugs."
30618566
sparser
"In search of novel targets to sensitize breast cancer cells against the guideline-based drugs MX and CDDP, we focused on CAM-DR."
30563275
sparser
"At the same time, leukemia cells can aberrantly express CAM to facilitate surface molecule-mediated interaction with BM microenvironment, thereby inducing cell-adhesion mediated drug resistance (CAM-DR)."
33425742
sparser
"BMSC-derived CXCL12γ and HSPGs mediate CAM-DR."
| PMC
sparser
"MGr1-Ag can prompt CAM-DR through interaction with laminin while MGr1-Ag/37LRP, as a receptor for ECM components, may interact with phosphorylated FAK to activate downstream signaling pathways PI3K/AKT and MAPK/ERK."
34071794
sparser
"In contrast, a clear CAM-DR was observed for H929 cells treated with AUR alone or BTZ alone (+ 20.6% and +12.0% of viability, respectively)."
33114738
sparser
"Although the combination of ERK1/2 and EGFR blockade in breast cancer has been demonstrated before using MEK1/2-inhibitors [ xref , xref ], combination in the context of CAM-DR or COL1 dependency have not been described so far."
32668815
sparser
"Data of this study provide evidence for the role of CAM-DR in breast cancer cells to attenuate the sensitivity to the guideline based cytotoxic drugs MX and CDDP."
30563275
sparser
"Our study revealed that the therapeutic basis for SFM-DR as well as for CAM-DR is the dysregulation of epigenetic regulators in MM patients during treatment."
33250513
sparser
"To further evaluate the effects of prior drug exposure in the context of CAM-DR, patient stroma–MMC co-cultures were exposed to dexamethasone for 24h, washed to remove the free drug and non-adherent cells, then treated with V-ND or V-CP."
33355244
sparser
"KO cells also overexpressed N-cadherin, expressed by osteogenic precursors, and ICAM1, also implicated in adhesion and CAM-DR."
34996933
sparser
"For example, protecting cells from drug-induced cytotoxic damage in cancer cells with CAM-DR was achieved by enhancing the repair of DNA damage due to overexpression of histone methyltransferase multiple myeloma SET domain (MMSET) in multiple myeloma [ xref , xref ], or elevated expression of FANCF and RAD51C which are important DNA repair proteins [ xref , xref , xref , xref , xref , xref ]."
29882812
sparser
"Integrins, a family of heterodimeric adhesion molecules with ubiquitous cellular expression, represent the most important group of candidates to be involved in CAM-DR."
30563275
sparser
"Therefore, identifying the underlying mechanism of this survival promoting CAM-DR is critical to overcoming chemotherapeutic drug resistance."
30669372
sparser
"The changes in EC 50 values are not as high as in genetically resistant cell lines, based on the epigenetic nature of CAM-DR."
30563275
sparser
"Anti CD38 MoAbs have several anti-myeloma and microenvironment activities, such as complement-dependent cytotoxicity (CDC), ADCC, direct myeloma killing, enhancement of the immune system, inhibition of CAM-DR, and enhancement of bone remodeling as above."
33435539
sparser
"MM adhesion to hyaluronan also confers CAM-DR to MM cells [ xref ], and OPN has been shown to mediate multidrug resistance in other cancers by enhancing hyaluronate binding and may act similarly in MM [ xref ]."
34067236
sparser
"De novo resistance includes environment-mediated drug resistance, which is categorized as either cell adhesion-mediated drug resistance (CAM-DR) or soluble factor-mediated drug resistance (SFM-DR)."
33435539
sparser
"A recent study has also shown that CXCL12 is a relevant target to attenuate CAM-DR in MM [ xref ]."
33435632
sparser
"Consequently, ITGB1 activity has been shown to be dominant to confer CAM-DR to tumor cells of different origin upon binding to COL1 [ xref , xref ]."
32668815
sparser
"Interference with this pathway has been shown to alleviate CAM-DR phenomena in hematopoietic cells [ xref ]."
30563275
sparser
"Cadherins, Selectins, and Integrins in CAM-DR in Leukemia."
33425742
sparser
"Second, the TME might aid cancer cell survival and induce epithelial–mesenchymal transition (EMT) through the enhanced adhesion of cancer cells to the ECM, leading to therapeutic resistance, often described as cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref , xref ]."
33673405
sparser
"Therefore, clarification of the molecular systems inherent in CAM-DR may facilitate identification of new therapeutic tactics to overcome this problem."
| PMC
sparser
"Since integrin binding activity does not only regulate a physical cell embedding into an ECM, but also activates specific signaling pathways, integrins appear as relevant candidates for mediating CAM-DR."
31779287
sparser
"Taken together, our data suggest a scenario in which CXCL12γ functions as a ‘niche chemokine’ that, in conjunction with HSPGs, plays a key role in controlling adhesion, BM retention, and CAM-DR of MM cells (Fig.  xref c)."
| PMC
sparser
"Both ectopic expression of miR-548m and knockdown of HDAC6 were able to disrupt the stroma-lymphoma adhesion and consequently induce cell apoptosis, suppress colony formation, sensitize B-lymphoma cells to the cytotoxic drug mitoxantrone, and abolishing the cell adhesion–mediated drug resistance acquisition (CAM-DR) [ xref ]."
32403283
sparser
"The resistance is believed to be selected during a treatment course, which contributes to acquired drug resistance by CAM-DR [ xref ]."
30405034
sparser
"Since expression of the majority of adhesion molecules including VLA-4 is regulated by NF-κB, inhibition of NF-κB may represent a novel strategy to overcome CAM-DR."
33435632
sparser
"Considering the extensive collagenous areas of e.g., collagen type 1 (COL1) surrounding the lobules forming the connective tissue in the mammary gland, breast cancer appears highly probable to undergo CAM-DR and to make use of this mechanism."
30563275
sparser
"Fn could decrease the apoptosis-inducing effect of TMZ and led to the CAM-DR in glioma cells."
32918978
sparser
"The integrin VLA4 (α 4 β 1 ) is a key mediator of CAM-DR and its expression affects drug sensitivity of MMC."
33355244
sparser
"Our previous studies have shown that cell adhesion-mediated drug resistance (CAM-DR) plays a crucial role in relapsed and refractory B-ALL ( xref , xref )."
34926269
sparser
"This type of drug resistance, named “cell adhesion-mediated drug resistance” (CAM-DR), is regarded as the most important mechanism able to cause the escape of MM cells from therapeutic effects [ xref , xref ]."
| PMC
sparser
"In this way, the implication of two biomolecules, hyaluronic acid and collagen, have been proven on mPCs proliferation and CAM-DR effect towards DEX and BRZ."
| PMC
sparser
"The PI3K/AKT pathway is a central hub in drug resistance of leukemia, particularly in CAM-DR, involving several downstream signaling pathways that support survival and proliferation of leukemia cells."
36243854
sparser
"Notably, in the MCF-7-β1-integrin knockdown cells, inhibition of MEK, and even more ERK and CREB is efficient to overcome COL1 induced CAM-DR and foster cell sensitization."
30563275
sparser
"Thus, EZH2 is a target of treatment for the apoptosis of myeloma cells and release of CAM-DR [ xref , xref ]."
33435539
sparser
"All in all, these findings illustrate the potential of a therapeutic interference with intracellular signaling pathways, differing in the various tumor entities, to disrupt the processes of CAM-DR and therefore deprive the cells of the suitable conditions to generate genetically based resistance mechanisms at an early onset point."
30563275
sparser
"Tumor cell binding to microenvironment components such as collagen type 1 (COL1) attenuates the sensitivity to cytotoxic drugs like cisplatin (CDDP) or mitoxantrone (MX), referred to as cell adhesion mediated drug resistance (CAM-DR)."
30563275
sparser
"MM cell adhesion to BMSC through the interaction between VLA-4 and its corresponding ligand, VCAM-1, is among the predominant mechanisms for cell adhesionmediated drug resistance (CAM-DR) in MM, xref , xref while enhancing the production of IL-6 30 and RANKL, an critical osteoclastogenic factor in MM. xref In addition to TAK1 activation in MM cells, TAK1 was found to be phosphorylated along with PIM2 upregulation in BMSC, when cocultured with MM cells ( xref )."
32273474
sparser
"CD44 is an adhesion molecule found on the MM cell surface that mediates binding to BMSCs, which induces IL-6 secretion and cell adhesion mediated-drug resistance (CAM-DR) [ xref ]."
34414281
sparser
"The CAM-mediated interaction of leukemia cells with the surrounding microenvironment contributes to drug resistance, which is called cell adhesion-mediated drug resistance (CAM-DR)."
33425742
sparser
"In case of De Novo drug resistance transiently acquired by signaling cascade in tumor microenvironment by cell-adhesion mediated drug resistance (CAM-DR) or soluble factor-mediated drug resistance (SFM-DR) ( xref )."
35028802
sparser
"On the other hand, CAM-DR suppresses drug-induced apoptosis through other well-characterized mediators of drug resistance such as P-glycoprotein, fibronectin, laminin, and collagen IV [ xref ]."
34067236
sparser
"These data clearly confirm that the CAM-DR follows other pathways in the W1CR cells than the ITGB1 route relevant for W1 wild type cells."
31779287
sparser
"PTPRK can influence CAM-DR by dephosphorization of the AKT and MAPK pathways [ xref ]."
33921897
sparser
"Concluding, we provide evidence for importance of CAM-DR in breast cancer cells and identify intracellular signaling pathways as targets to sensitize cells for cytotoxicity treatment regimes."
30563275
sparser
"CAM-DR, a form of chemoresistance, is mediated by the adhesion of tumor cells to the extracellular matrix (ECM) which enhances tumorigenicity and suppresses chemotherapy‐induced apoptosis to confer resistance to chemotherapeutic agents ( xref )."
33041787
sparser
"Conversely, the amount and the structure of “finger-like” collagen, which can also result in cell adhesion mediated drug resistance (CAM-DR), was destroyed after GLPM/Tel treatment."
31660067
sparser
"Furthermore, Wang et al. recently demonstrated that BTK induces CAM-DR through CXCR4 regulation degradation in MM [ xref ], promoting BTK expression induced MM cell adherence to the extracellular matrix and stromal cells in vitro and in vivo and increased drug resistance to bortezomib and doxorubicin in MM cells."
33918655
sparser
"DARA releases CAM-DR by inhibiting adhesion to BMSCs by internalizing CD38 in myeloma cells [ xref ]."
33435539
sparser
"CAM-DR has initially been described as a rapid, nongenetic adaptation of leukemia cells to cytostatics for an increased survival of treatment, associated with the phenomenon of minimal residual disease [ xref , xref ]."
32668815
sparser
"One of the prominent features of cell adhesion-mediated signaling in MM pathogenesis is cell-adhesion mediated drug resistance (CAM-DR)."
33435632
sparser
"EMDR can be separated in two groups: EMDR due to soluble factors which is called Soluble Factor-Mediated Drug Resistance (SFM-DR), and EMDR due to adhesion process between the tumor cell receptors and extracellular matrix (ECM) proteins which is called Cell Adhesion-Mediated Drug Resistance (CAM-DR)."
33014812
sparser
"These findings support the post-transcriptional mechanisms of CAM-DR, all of which is accomplished by the modulation of ubiquitin-dependent degradation mechanisms."
30405034
sparser
"ITGB7 is necessary for myeloma cell survival and CAM-DR, and has been shown to be constitutively active in myeloma cells ( xref , xref )."
33634031
sparser
"In vitro studies show that contact between leukemia and stromal cells and other non-cellular components of the BM promotes cell adhesion-mediated drug resistance (CAM-DR) ( xref ; xref ), which prevents apoptosis of ALL cells ( xref ; xref ; xref )."
36243854
sparser
"The transcriptional regulation of Ephrin receptors, whose expression is frequently augmented in tumors, might provide a further mechanism of CAM-DR promotion through Teneurins."
30618566
sparser
"However, CD49a, CD49b, CD11a, CD29, CD18, and CD61 were not found to be associated with CAM-DR in BL cells."
33214335
sparser
"Therefore, even though specific ligands are preferentially used in different cells, this does not mean that other molecules are less crucial in conferring CAM-DR."
33425742
sparser
"In addition, CAM-DR also elicits resistance through blocking a specific element of the caspase-mediated apoptotic pathway."
30405034
sparser
"The ECM model of drug resistance development postulates that small populations of tumor cells express ECM molecules at high levels and only these cells survive chemotherapy because of CAM-DR [ xref , xref , xref , xref , xref , xref , xref , xref ]."
30583585
sparser
"In these clinical trials, GMI-1271 will be administered in combination with existing chemotherapies, which highlights how targeting both the microenvironment and leukemia cells may be necessary in order to ameliorate CAM-DR."
33425742
sparser
"However, due to the complexity of the bone marrow microenvironment and the diversity of the niche delineating diagnostic biomarkers of response signatures for targets associated with SM-DR, CAM-DR and EM-DR will be required to guide combination strategies with standard of care agents to improve individualized patient outcomes."
32898723
sparser
"The mechanisms of resistance in cancers due to bone marrow microenvironment effects are best explained majorly by two forms of environment factors, which are soluble factor-mediated drug resistance (SFM-DR) and cell-adhesion-mediated drug resistance (CAM-DR) [ xref , xref ] and in the MM situation."
30405034
sparser
"At present, several integrins have been proposed as likely contributors to CAM-DR in ALL and different routes of dissemination from BM to the CNS have been suggested ( xref , xref )."
32528884
sparser
"Furthermore, VRK1 could reverse cell adhesion mediated drug resistance (CAM-DR) by down-regulating the ability of cell adhesion."
27319807
sparser
"Moreover, suppression of the miR-30a-5p or upregulation of the BCL2L11 promoted apoptosis of the myeloma cells independent of the BMSCs, thus suggesting clinical significance of miR-30a-5p inhibitor and PLBCL2L11 plasmid in CAM-DR."
35339472
sparser
"ANXA7 was also demonstrated to be combined with CDC5L. Therefore, ANXA7 interference could promote cell cycle arrest in G2/M phase through CDC5L to inhibit proliferation of MM cells and reduce CAM-DR."
32526706
sparser
"This type of acquired resistance can be divided into two categories: soluble factor-mediated drug resistance (SFM-DR) and cell adhesion mediated drug resistance (CAM-DR) ( xref f)."
32050631
sparser
"Toward this goal, we identified trimethylation of histone H3 at lysine-27 (H3K27me3) as a critical histone modification associated with CAM-DR."
32759572
sparser
"Taken together, our results confirm that the combination of WCF with DDP could reverse the lung cancer CAM-DR through the Integrin β1 signaling pathway."
33041787
sparser
"This study aims to investigate the effect and mechanism of WCF combined with DDP in reversing CAM-DR."
33041787
sparser
"BOR enhances the activity of IMiDs by releasing CAM-DR and elevating IKZF1 expression."
33435539
sparser
"CAM-DR and SFM-DR are therapeutic targets to overcome drug resistance and to suppress the proliferation and survival of MM cells via the inhibition of signaling pathways."
33435539
sparser
"MSCs also contribute to drug resistance through cell-adhesion-mediated drug resistance (CAM-DR) [ xref , xref ], in which the Wnt signaling pathway is involved [ xref ]."
32872365
sparser
"This biological process is associated with a multidrug resistant phenotype, “cell adhesion-mediated drug resistance,” or CAM-DR [ xref ]."
30991985
sparser
"However, in the meantime, CAM-DR has been accepted as a phenomenon of de novo resistance with relevance for different solid tumor cells [ xref ], displaying a prerequisite for the acquisition of genetic drug resistance mechanisms."
32668815
sparser
"CDC5L interference inhibits the CAM-DR promotion effect of ANXA7."
32526706
sparser
"Inhibition of EZH is known to inactivate CAM-DR in vitro [ xref ]."
33435539
sparser
"Although on basis of these and similar findings in other tumor entities [ xref ], DDR1 emerges as a promising novel target to interfere with tumorigenicity, an explicit involvement of DDR1 in the process of CAM-DR is experimentally still lacking."
32668815
sparser
"As shown by the structure, the protein has an ability to interact with ECM, which can be important from a CAM-DR point of view."
31412536
sparser
"Background: Tumor cell binding to the microenvironment is regarded as the onset of therapeutic resistance, referred to as cell adhesion mediated drug resistance (CAM-DR)."
31779287
sparser
"Herein, we develop an ECM deprivation system (EDS) based on FN targeting self-assembly peptide for constructing nanofibers in the ECM of renal cell carcinoma (RCC), which contributes to (i) targeting and recognizing FN to form nanofibers for long-term retention in ECM, (ii) reversing anoikis resistance via arresting the FN signaling pathway, and (iii) serving as a drug-loading platform for sensitizing chemotherapy by ameliorating CAM-DR."
36004775
sparser
"Thus, CXCL12γ and HSPG on the cell surface of BMSCs promote MM cell adhesion to these BMSCs and thereby play an important role in CAM-DR."
| PMC
sparser
"While we found alterations in other metabolism-associated genes (e.g. PKM2, CS, IDH1, ACO2, FH, MDH2, or HK1)), we focused on examining the functional significance of ENO1 in the present study since: (1) a significant induction of ENO1 was noted during pDC-MM interactions versus other molecules; (2) ENO1 is essential for maintaining tumor cell metabolism and represents a potential therapeutic target in cancer [ xref – xref ]; (3) ENO1 promotes tumor cell proliferation and cell adhesion-mediated drug-resistance (CAM-DR) [ xref ] characteristic of MM; and (4) ENO1 functions as an immunoregulatory molecule both in T-regulatory cell differentiation and dendritic cell function [ xref , xref ]."
32024967
sparser
"The apoptosis-protective adhesion to stromal cells, termed cell adhesion-mediated drug resistance (CAM-DR), is another underlying mechanism of R-CHOP resistance in DLBCL.[ xref ]CAM-DR was revealed to correlate with rituximab resistance through ADAM metalloproteinase domain 12 ( ADAM-12 ) upregulation and phosphatidylinositol 3-kinase ( PI3K ) -Akt signaling modulation.[ xref ]However, as per findings reported by Lenz et al ,[ xref ]genetically identified non-malignant signatures of stromal-1 (fibrosis and myeloid infiltration) and stromal-2 (vessel formation) in pretreatment biopsies were found to be prognostically favorable and unfavorable for patients with DLBCL who received R-CHOP, respectively."
33323828
sparser
"Type I collagen plays an important role in tissues scaffolding but is also important in CAM-DR ( xref )."
33014812
sparser
"The adhesion molecules, such as very late angine-4 (VLA-4) plays an important role for CAM-DR [ xref ]."
33435539
sparser
"CAM-DR, on the other hand, is caused by direct cell-cell interactions ( xref ) [ xref ]."
| PMC
sparser
"In “Cell Adhesion Drug Resistance” (CAM-DR), signaling through adhesion molecules, engaged with the bone matrix and stromal cells ( xref ), protects MMC from chemotherapy ( xref , xref )."
33355244
sparser
"To figure out whether CAM-DR is an additional independent process or an integrative part of an already existing cisplatin resistance, we also apply a cisplatin-resistant subtype of W1 cells (W1CR)."
31779287
sparser
"Integrin families, such as Very Late Antigen-4 (VLA-4), Syndecan-1 (CD138, SDC1), CD44, Vascular Cell Adhesion Molecule-1 (VCAM-1), Lymphocyte Function-Associated Antigen-1 (LFA-1), Mucin-1 antigen (MUC-1), and Intercellular Adhesion Molecule-1 (ICAM-1), have been shown to associate with CAM-DR [ xref , xref ]."
30405034
sparser
"This sort of drug resistance, called “cell adhesion-mediated drug resistance” (CAM-DR), is considered one of the most relevant systems able to provoke the escape of MM cells from therapeutic actions [ xref , xref ]."
| PMC
sparser
"Although a recent study reported on an inverse relation of DDR1 expression and cisplatin sensitivity in ovarian cancer [ xref ], a potential role of DDR1 in CAM-DR of W1CR cells remains a matter of further investigations."
31779287
sparser
"In this regimen, THAL enhances the sensitivity of BOR and cytotoxic agents by improving hypoxia, and BOR, in turn, increases the sensitivity of doxorubicin and etoposide, whose activities are dependent on the cell cycle, through the release of CAM-DR."
33435539
sparser
"Thus, the re-expression of PTPRK after piperine treatment can result in decreased CAM-DR."
33921897
sparser
"Here we provide evidence for a direct link between ITGB1-mediated matrix binding properties and CAM-DR in W1 and W1CR cells, resulting in significantly attenuated cisplatin sensitivity."
31779287
sparser
"Here, we describe the discovery of these drug resistance mechanisms and the identification of promising therapeutic agents primarily targeting CAM-DR, mitochondrial transfer, and TNTs."
36354732
sparser
"Adhesion of MM cells to BMSC and fibronectin upregulates heat shock protein-70 (HSP-70), which confers CAM-DR; blocking HSP-70 results in an increase of melphalan-induced apoptosis and reverses the CAM-DR [ xref ]."
30405034
sparser
"Thus, integrin-mediated chemoresistance is perceived as a form of adhesion-mediated drug resistance (CAM-DR) ( xref )."
32528884
sparser
"Overexpression of this protein was observed in lenalidomide-resistant human multiple myeloma cell lines (HMCLs), and in correlation with that, increased adhesion to bone marrow (BM) stromal cells was detected, indicative of CAM-DR."
31921125
sparser
"In this study, we investigated the mechanism of CAM-DR induced by Fibronectin (Fn)."
32918978
sparser
"Strengthening our comprehension of miRNA production and activity in the MM cell−BM relationship will help us to identify novel drug targets to overwhelm CAM-DR [ xref , xref ]."
| PMC
sparser
"Intracellular signaling initiated by binding to the ECM seems to be fundamental for cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC
sparser
"One of the resistance phenomena involved in MM is the cell adhesion mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC
sparser
"Most research targeting CAM-DR has focused largely on integrins [ xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref , xref ] (see xref )."
29882812
sparser
"Different ECM proteins, including laminin and fibronectin, are associated with CAM-DR in different cancer types [ xref ], including pancreatic cancer [ xref ]."
33673405
sparser
"Consequently, FAK and PI3K appear as promising targets in MCF-7 cells to interfere with CAM-DR and suggest a proof of concept experiment by a β1-integrin knockdown."
30563275
sparser
"The integrin VLA4 (a 4 b 1 ) is a key mediator of CAM-DR and its expression affects drug sensitivity of MMC."
33355244
sparser
"It has been previously reported that adhesion of myeloma cells to fibronectin (FN) via beta1 integrin is associated with CAM-DR, which may induce perturbation in cell cycle progression and protect cells from apoptosis via increasing p27 kip1 protein expression. xref Similar phenomenon also appears in lymphomas cells. xref In conclusion, these researches suggest that p27 kip1 can induce a cell cycle arrest through BM ECM and plays an important role in cell adhesion mediated regulation of cell cycle progression."
27319807
sparser
"Treatment for Interaction with CAM-DR and SFM-DR."
33435539
sparser
"Integrin β1 is almost ubiquitously expressed in cancer cells, which closely related to CAM-DR."
33041787
sparser
"The phosphorylation-mediated enhancer of zeste homolog 2 (EZH2) inactivation and subsequent decreases in H3K27me3 levels are related to CAM-DR in MM cells [ xref ]."
33435539
sparser
"Environmental mediated-drug resistance (EM-DR) contains cell adhesion mediated drug resistance (CAM-DR) and soluble factor mediated drug resistance (SM-DR) that contributes to de-novo drug resistance."
32898723
sparser
"1S cells to fibronectin could increase miRNA-182 production and reduce programmed cell death 4 (PDCD4), which is essential for CAM-DR."
| PMC
sparser
"Aptamer NOX-A12 had anti-myeloma CAM-DR activity ( xref )."
34095130
sparser
"Future studies will define the dependency of TRPC1 for survival in the bone-marrow microenvironment and whether this signaling pathway is required for growth, cell adhesion-mediated drug resistance (CAM-DR), or soluble mediate drug resistance (SM-DR)."
34199280
sparser
"It was previously demonstrated that the adhesion molecule integrin α4, referred to hereafter as α4, mediates the cell adhesion-mediated drug resistance (CAM-DR) of B-cell ALL by binding to vascular cell adhesion molecule-1 (VCAM-1) on bone marrow stroma."
34934426
sparser
"Although several studies illustrate a link between integrins and increased malignancy or resistance of ovarian cancer cells, a generalization of CAM-DR mediated mechanisms remain open."
31779287
sparser
"Binding of VLA-4 to fibronectin of the ECM induces activation of nuclear factor κB (NFκB) leading to cell adhesion-mediated drug resistance (CAM-DR) and pro-survival signaling ( xref )."
33634031
sparser
"Thus, heparin, heparan sulphate, chondroitin sulphate, or other collagens hypothesized to be involved in CAM-DR could be incorporated into the 3D environment with the procedures discussed here."
| PMC
sparser
"CAM-DR is induced in fibroblasts derived from MM patients, but not in healthy individuals [ xref , xref ]."
33435539
sparser
"Cell adhesion mediated-drug resistance (CAM-DR) is one of main reasons for. the limitation to chemotherapy, but the underlying mechanism remains unclear in glioma."
32918978
sparser
"Despite original responses to chemotherapy, MM patients finally develop drug resistance and become unresponsive to a wide spectrum of antineoplastic agents, a phenomenon called multidrug resistance (MDR). xref Accumulating evidence reveals that the bone marrow (BM) microenvironment which consists of hematopoietic cells, stromal cells, and extracellular matrix (ECM) confers resistance to chemotherapy. xref xref – xref Previous researches indicated that the direct adhesive interactions of myeloma cells with BM stromal cells and ECM components could transduce into the anti-apoptotic and cell cycle arrest signals and ultimately lead to MDR. xref – xref This protection phenomenon is termed as ‘cell adhesion mediated drug resistance’ (CAM-DR)."
27319807
sparser
"IGF-1R and PI3K/Akt inhibitors reversed this CAM-DR by blocking the IGF-1 mediated EZH2 phosphorylation ( xref )."
30619733
sparser
"As another more complex TME model, we tested the response of H929 and L363 BTZ-sensitive cells cultured on a layer of HS-5 bone marrow mesenchymal cells, mimicking the bone marrow environment and also allowing CAM-DR [ xref ]."
33114738
sparser
"Applying proteome profiler arrays, mapping the status of human kinases in both cell lines treated with MX and COL1, we investigated different β1-integrin related signaling molecules to explain underlying mechanisms of CAM-DR."
30563275
sparser
"Overexpression of CCT8 could promote the proliferation, accelerate the G1/S transition and reverse cell adhesion-mediated drug resistance (CAM-DR) phenotype in B-cell non-Hodgkin’s lymphoma ( xref )."
33815471
sparser
"However, the expression of ECM components and CAM-DR seems not to be limited to cancer tissue."
33921897
sparser
"Moreover, another study reported that CAM-DR is associated with activation of canonical NF-κB (p65–p50) in MM cells."
33435632
sparser
"Despite significant progress in the treatment of myeloma, multiple myeloma (MM) remains an incurable hematological malignancy due to cell adhesion-mediated drug resistance (CAM-DR) phenotype."
35339472
sparser
"VRK1 is regulated in cell cycle and its impact is mediated by the contribution to the coordination of several processes required for cell division. xref However, the role of VRK1 in MM, especially in CAM-DR, has never been reported."
27319807
sparser
"This study aimed to investigate the expression of HSPA12B and its role in cell adhesion mediated drug resistance (CAM-DR) of non-Hodgkin's lymphoma (NHL)."
34734014
sparser
"Studies have shown that USP14 is significantly overexpressed in CAM-DR models and downregulated in apoptotic models of MM."
32354135
sparser
"This phenomenon, called cell adhesion-mediated drug resistance (CAM-DR), has been demonstrated in many subsets of leukemia including B- and T-acute lymphoblastic leukemia (B- and T-ALL) and acute myeloid leukemia (AML)."
33425742
sparser
"Integrin β1 appears as a relevant candidate for mediating CAM-DR ( xref ; xref )."
33041787
sparser
"Together, these findings indicated that NRF2 could inhibit both the secretion of IL-6 and the expression of adhesion molecules in BMSCs; thus, reducing SFM-DR and CAM-DR ( xref )."
30405034
sparser
"The epigenetic mechanism is associated with CAM-DR as well."
33435539
sparser
"Interestingly, it has been observed in multiple studies that targeting NFκB signalling pathways when treating MM, reduces drug resistance to PIs xref , suggesting that the significantly increased abundance of Integrin β3 shown in this study may be leading to increased levels of NFκB signalling, causing CAM-DR to three of the five drugs."
| PMC
sparser
"Suppression of integrin β7 decreases adhesion to fibronectin and E-cadherin and inhibits CAM-DR to bortezomib or melphalan in MM cells [ xref ]."
33922721
sparser
"The attachment of tumor cells to the ECM may trigger cell adhesion-mediated drug resistance (CAM-DR)."
32796596
sparser
"Cell adhesion molecules that mediate the adhesion of MM cells to stroma cells play a critical role in cell adhesion-mediated drug resistance (CAM-DR) [ xref ]."
29738534
sparser
"Conclusions: CAM-DR appears relevant for ovarian cancer cells, adding to existing genetic resistance and thus emerges as a target for sensitization strategies."
31779287
sparser
"These data demonstrated the close cross-talk between SFM-DR and CAM-DR in the complex bone marrow microenvironment to the resistance of MM."
30405034
sparser
"Elucidation of the mechanisms underlying cell adhesion-mediated drug resistance (CAM-DR) may prolong remission and ultimately improve the survival of MM patients."
32759572
sparser
"However, daratumumab may also internalize CD38 in MM cells to inhibit adhesion to BMSCs and overcome CAM drug resistance (CAM-DR)[ xref ]."
36176763
sparser
"As discussed in this section, integrin blockades have been shown to increase chemosensitivity of leukemia cells and provide support for further studies of integrins as a viable target to abolish CAM-DR in leukemia."
33425742
sparser
"MiR-138 promoted CAM-DR phenotype through cell adhesion-mediated SGTA down-regulation and cell cycle arrest."
30180469
sparser
"There is increasing evidence that selectins play an important role in the progression of different types of cancer, in particular the interaction of tumor cells with the endothelium that is needed for extravasation and the formation of new metastatic lesions [ xref , xref ] Selectins are molecules expressed on the cell surface of endothelial cells that have been shown to promote the first interaction between an extravasating cell and the blood-vessel wall [ xref ], and have been implicated in CAM-DR [ xref , xref , xref , xref ]."
29882812
sparser
"This study gives a link to CAM-DR in the clinical setting of ovarian cancer."
31779287
sparser
"Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stroma cells triggers intracellular signals regulating cell-adhesion-mediated drug resistance (CAM-DR)."
30669372
sparser
"Simvastatin as an inhibitor of CAM-DR in patients with refractory multiple myeloma was tested in Phase II clinical trials by Ludwig-Maximilian University of Munich."
29882812
sparser
"We hypothesized that the reversal of drug resistance is related to the decline of ECM proteins or participators of CAM-DR."
33041787
sparser
"Nevertheless, the molecular mechanisms of CAM-DR remain elusive."
31779287
sparser
"The interaction of cancer cells with ECM activates the intracellular signaling leading to cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
30583585
sparser
"CAM-DR induces a multidrug resistant phenotype as cell adhesion can protect tumors cells from multiple structurally and mechanistically diverse chemotoxic agents in MM [ xref , xref – xref ] and leukemia model systems [ xref – xref ]."
32898723
sparser
"Our observation of chemoresistance for SK-OV-3 ( xref and xref ) in RGD- and collagen I (GFOGER)-conjugated PeptiGels could also be due to the CAM-DR phenomenon, although further studies are needed to validate this."
35267582
sparser
"Several new drugs are developed to overcome de novo drug resistance, such as proteasome inhibitors and EZH2 inhibitors to overcome CAM-DR, and anti-IL-6 monoclonal antibodies and IGF-1R inhibitors to overcome SFM-DR, in a preclinical study, although several of those have not shown efficacy in clinical trials and thus are not available in clinical practice."
33435539
sparser
"Such a protective microenvironment has been reported to be implicated in the stemness and chemoresistance of leukemia blasts at the origin of the process of Environment Mediated-Drug Resistance (EM-DR), and specifically of Cell Adhesion Mediated-Drug Resistance (CAM-DR). xref , xref Quiescence, as well as protection against environmental and drug aggressions, are major characteristics of stem cells also characterized by the Side Population (SP) phenotype. xref We have previously shown that, whereas circulating HSPC from heathy donors (HD) do not exhibit a SP phenotype, this functionality can be induced after co-culture with MSC in a VLA4- and CD44-dependent manner. xref Interestingly, this MSC-induced SP population is enriched in HSC, as shown by its engraftment in immunodeficient mice. xref "
31289201
sparser
"Our previous studies have identified the integrin α4 and α6 as an adhesion molecule that plays a critical role in B-ALL through CAM-DR ( xref , xref )."
34926269
sparser
"Also, the Ephrin receptor-A4 (EPHA4) was required for CAM-DR in multiple myeloma (Ding et al., xref ), and Teneurins are known regulators of Ephrin receptor expression in structures of the visual system (Young et al., xref ; Glendining et al., xref )."
30618566
sparser
"Drug resistance mediated by the MM BM microenvironment can be caused either by soluble factors or by direct physical cell–cell interactions mediated by cell adhesion molecules, termed soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), respectively [ xref , xref , xref ]."
| PMC
sparser
"Furthermore, ANXA7 overexpression promoted the CAM-DR in MM cells to make MM cells become more insusceptible to bortezomib while inhibited by ANXA7 interference."
32526706
sparser
"These data emphasize the upregulation of α4β1 expression and function as a key event during resistance to BTZ in MM, which might indirectly contribute to stabilize this resistance, as stronger MM cell attachment to BM stroma will regain CAM-DR and MM cell growth and survival."
32501543
sparser
"The PI3K-AKT pathway has been identified as one of the most significant pro-survival pathways in CAM-DR and leukemia cell-BM stromal cell contact has been shown to upregulate phosphorylated AKT in B-ALL ( xref )."
34926269
sparser
"Overexpression of USP14 in MM cells significantly enhances cell adhesion-mediated drug resistance (CAM-DR) through the upregulation of the Wnt signaling."
35069211
sparser
"Moreover, matrix remodeling by CAFs can form the chemoprotective niche and hence blocks the effective delivery of chemotherapeutic drugs to the cancer cells via cell adhesion-mediated drug resistance (CAM-DR), contributing its role in evading cancer cells to treatment (Meads et al. xref )."
30680600
sparser
"Considering the key role of CAM-DR as an early form of resistance formation, an insight into the underlying molecular pathways could provide novel targets for early pharmacological interference with resistance formation."
31779287
sparser
"Together, our data demonstrated the role of P65-miR-30a-5p-BCL2L11 loop in CAM-DR myeloma cells."
35339472
sparser
"Although CAM-DR has initially been described in multiple myeloma and other malignancies of hematopoietic origin [ xref ], which has been related to the minimal residual disease phenomenon [ xref ], some recent reports refer to CAM-DR in solid tumors, too."
30563275
sparser
"Similarly to VLA4, VLA5 (α 5 β 1 ) can bind fibronectin, and LFA-1 (α L β 2 ) is a known mediator of CAM-DR."
34996933
sparser
"Several studies described above have suggested that a TGF-beta signaling activation-related ECM of tumor cells can play a role in cell adhesion-mediated drug resistance (CAM-DR), such as resistance to platinum drugs ( xref )."
34888242
sparser
"However, the underlying mechanisms of CAM-DR are still not fully understood."
30563275
sparser
"In this study, we investigated the molecular mechanism responsible for CAM-DR in BL cells."
33214335
sparser
"A growing body of evidence indicates that cell-cell and cell-extracellular matrix (ECM) contacts can modulate drug resistance and the phenomenon is referred to as cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
29882812
sparser
"Thus, cell adhesion mediated drug resistance (CAM-DR) appears as functional onset to escape cytotoxic stress for different tumor cell entities."
30563275
sparser
"The most important was to study the expression changes of HSPA12B in the adhesion model and the effect of overexpression of HSPA12B on CAM-DR."
34734014
sparser
"Therefore, identifying the underlying mechanism of survival and promotion of CAM-DR may be critical to target chemotherapeutic drug resistance in leukemia ( xref )."
36243854
sparser
"However, CDC5L interference increased cell apoptosis which reversed the CAM-DR promotion effect of ANXA7 on U266 cells ( xref )."
32526706
sparser
"Elucidating the mechanism of CAM-DR and developing the corresponding drugs are urgently required to improve outcomes."
33918655
sparser
"This paper will review the role of cadherins, selectins, and integrins in CAM-DR and the results of clinical trials targeting these molecules."
33425742
sparser
"Hence, VRK1 appeared to have specific effects on CAM-DR which was similar to apoptotic proteins."
27319807
sparser
"Extracellular matrix (ECM) is crucial in various biological functions during tumor progression, including induction of anoikis resistance and cell adhesion-mediated drug resistance (CAM-DR)."
36004775
sparser
"Our data provide evidence for the relevance of CAM-DR in cisplatin treatment of W1 ovarian cancer cells, both for therapeutically naïve ones or, as a novelty, for those cells that have already developed a genetic resistance mechanism against this antineoplastic drug."
31779287
sparser
"Additionally, an enhanced level of VLA4 on MM cells indicates a drug-resistant phenotype xref and is implicated in CAM-DR xref ."
34996933
sparser
"Bortezomib (BOR) overcomes CAM-DR by inhibiting VLA-4 [ xref ], and shows a synergistic effect with various drugs in co-culturing human myeloma cell lines with BMSC [ xref ]."
33435539
sparser
"In turn, a cell adhesion-mediated drug resistance (CAM-DR) phenomenon occurs."
33114738
sparser
"In ALL and chronic lymphocytic leukemia (CLL), adhesion-mediated activation of the PI3K/AKT signaling pathway has been shown to be critical in CAM-DR."
36243854
sparser
"Interestingly, W1CR cells also respond to COL1 in the way of CAM-DR, additionally to the intrinsic cisplatin resistance."
31779287
sparser
"However, data on the molecular mechanisms underlying the CAM-DR remains scanty."
35339472
sparser
"An extracellularly secreted OSF-2 protein could be involved in CAM-DR."
31412536
sparser
"This mechanism is designated as a cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref , xref , xref ]."
35008952
sparser
"Such an environment can be used to further study the individual or synergic effects of bone marrow extracellular matrix components on CAM-DR against different known or new drugs, or even to develop drugs capable of inhibiting the interaction of mPCs with specific biomolecules."
| PMC
sparser
"The binding of cancer cells to ECM activates the intracellular signals transduction and is designated as a cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
33921897
sparser
"By demonstrating that GBM cells can alternate from one form of CAM-DR (cell-substrate tethering) to another (homocellular cell-cell adhesion) and that inhibition of both forms is necessary for apoptosis sensitization, our findings not only have important implications for novel approaches to restore defective apoptosis programs, but also reveal a novel role of gap junctions in GBM."
18469856
sparser
"Interestingly, the interactions between MSCs and LSCs rely on cell-adhesion molecules, such as cadherins and integrins, and are involved in the process of Wnt signaling activation; therefore, CAM-DR plays a critical role in Wnt signaling."
32872365
sparser
"One well-established concept of chemotherapy-resistance in leukemia is cell adhesion-mediated drug resistance (CAM-DR)."
36056084
sparser
"In conclusion, ANXA7 could promote the cell cycle, proliferation and CAM-DR of MM cells by up-regulating CDC5L."
32526706
sparser
"Conclusion and discussion : Our data supports a role for VRK1 in MM cell proliferation, adhesion, and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in MM."
27319807
sparser
"It was also reported that CAM-DR induced by the adhesion of MM cells to stromal cells were dominantly mediated by VLA-4 [ xref ]."
32256871
sparser
"Schmidmaier and co-authors showed that simvastatin at very low concentrations overcomes CAM-DR in multiple myeloma by geranylgeranylation of Rho proteins and activation of Rho kinase [ xref ]."
29882812
sparser
"However, although these findings emphasize CAM-DR in its relevance, our present data have to be discussed and interpreted cautiously, for other ovarian cancer cells, also with respect to other types of ECM matrices, other environmental components, or antineoplastic drugs."
31779287
sparser
"Silencing of integrin β7 in MM cells reduces adhesion to fibronectin or E-cadherin, and inhibit CAM-DR of MM cell to bortezomib or melphalan."
32256871
sparser
"Another mechanisms of CAM-DR is increasing resistance to detachment-induced cell death (anoikis resistance), and inhibition of FAS-mediated apoptosis [ xref , xref , xref , xref ]."
29882812
sparser
"Waldschmidt et al. also evaluated CAM-DR restoration using different antimyeloma agents and the CXCR4 inhibitor plerixafor [ xref ]."
33918655
sparser
"However, the molecular mechanisms of CAM-DR and underlying signaling pathways appear elusive."
30563275
sparser
"Although these data do not claim a generalization with respect to the in vitro background and the treatment with only one cytotoxic drug, they provide arguments for the process and relevance of CAM-DR in ovarian cancer cells."
31779287
sparser
"Fibronectin (FN), a vital ECM component with direct regulatory effects on ECM-mediated anoikis resistance and CAM-DR, making it an attractive and innovative therapeutic target for depriving ECM in tumor tissue."
36004775
sparser
"VLA4-nanoparticles hijack cell adhesion mediated drug resistance (CAM-DR) to target refractory myeloma cells and prolong survival."
33355244
sparser
"It has been established by multiple studies that cancer cell adhesion to various matrixes is sufficient to confer de novo drug resistance a phenomenon which has been referred to as CAM-DR [ xref – xref ]."
32898723
sparser
"Consequently, these findings motivated us to examine the function of VRK1 protein in CAM-DR of MM cells."
27319807
sparser
"CAM-DR is crucial to induction of CAM-IR with the subsequent response being a dampening of the immune response through reduced adhesion molecule expression."
35399952
sparser
"At present numerous studies have pointed out that Integrin β1 has been reported to be one of the most significant adhesion molecules that has been suggested to be involved in CAM-DR ( xref )."
33041787
sparser
"However, in comparison with the significant advances in other strategies for overcoming chemoresistance, progress made with respect to anti CAM-DR therapy has been relatively slow."
29882812
sparser
"It becomes clear that both cell lines respond to COL1 binding by an evident increase in EC 50 values, confirming the relevance of ECM substrates for CAM-DR formation in this scenario ( xref a)."
31779287
sparser
"The drug resistance that results from direct cell contact with the ECM or other cells has been called “cell-adhesion-mediated drug resistance” or CAM-DR [ xref ]."
| PMC
sparser
"However, these drugs may lose their efficacy because of CAM-DR in refractory MM (RRMM) [ xref – xref ]."
32526706
sparser
"Collectively, SOX11 could inhibit tumor proliferation and promote CAM-DR in a CD43 dependent manner."
32449421
sparser
"Cell adhesion-mediated drug resistance (CAM-DR) is mainly due to the attachment of tumor cells to the stroma, which may trigger several signal transduction pathways, resulting in reduced sensitivity to anticancer therapies [ xref ]."
34071794
sparser
"In this report, we demonstrated for the first time the role of VRK1 in the proliferation and CAM-DR of MM cells."
27319807
sparser
"This is comparable to recent studies in other tumor entities showing an interference with integrin signaling as promising targets for sensitization against CAM-DR [ xref ]."
31779287
sparser
"Further insights based on these findings are needed to decipher the peculiarities of the underlying molecular mechanisms of CAM-DR in both cell types to generalize the importance of CAM-DR for ovarian cancer cells and for the treatment with other cytotoxic drugs as well."
31779287
sparser
"Our previous studies showed that Oroxylin A combined with Paclitaxel reverses cell adhesion mediated-drug resistance (CAM-DR) in HepG2 cells by inhibiting integrinβ1 and PI3K/Akt signaling ( xref )."
31024831
sparser
"This kind of resistance, known as cell-adhesion-mediated drug resistance (CAM-DR) is observed both in vivo [ xref ] and in vitro [ xref ], as it was observed in drug-resistant cancer cell lines of breast [ xref ] and ovarian origin [ xref , xref , xref , xref ]."
31412536
sparser
"In this study we aimed to elucidate the role of VRK1 in CAM-DR by meddling in its expression using VRK1 shRNA and HA-VRK1 in RPMI 8226 and U266 cell lines."
27319807
sparser
"To evaluate CAM-DR as target for sensitization strategies, we analyzed signaling pathways in human estrogen-positive MCF-7 and triple-negative MDA-MB-231 breast cancer cells by western blot, proteome profiler array and TOP-flash assay in presence of COL1."
30563275
sparser
"In a recent study, Zhu et al. investigated clinical specimens of ovarian cancer and correlated the expression of CAM-DR related markers, such as CD44, CD147, α5, or β1-integrin subunits with higher resistance and a worse prognosis [ xref ]."
31779287
sparser
"This experiment was carried out in a conventional 2D culture at 72 h, varying the dosage from 1 to 1000 µM. The results shown in xref A support the use of a 1000 µM concentration in CAM-DR trials, which produce mortality of around 70%."
| PMC
sparser
"To further study the mechanism by which the combination of WCF and DDP reverses CAM-DR through the Integrin β1 pathway tested the colocalization of Integrin β1 and its ligand proteins by immunofluorescence."
33041787
sparser
"These data suggest that MM cells share common regulatory pathways for drug resistance in different models, including SFM-DR and CAM-DR."
33250513
sparser
"Considering the key role of CAM-DR for enabling a genetic resistance formation, an insight into the molecular basis of CAM-DR could offer attractive novel targets for an early interference with resistance formation by pharmacological sensitization strategies."
30563275
sparser
"Recently, we [ xref , xref , xref , xref ] and others [ xref ] observed the expression of different ECM components in drug-resistant cancer cell lines suggesting their active role in CAM-DR [ xref , xref ]."
33921897
sparser
"Cell adhesion mediated drug resistance (CAM-DR) has been strongly linked with the increased abundance of Integrin β3."
| PMC
sparser
"It was an important reason for VRK1 to affect the CAM-DR in MM."
27319807
sparser
"Adhesion of ALL cells to BM stromal cells triggers intracellular signals regulating cell adhesion-mediated drug resistance (CAM-DR) ( xref ; xref )."
36243854
sparser
"Bortezomib decreased the protein levels of CHD1L, but cell adhesion increased the expression levels of CHD1L, overexpression of CHD1L contributes to cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma cells [ xref ]."
33663617
sparser
"The binding of CXCL12 to its receptor CXC receptor 4 (CXCR4; CD184) will affect cell chemotaxis, cell survival, proliferation, and gene transcription ( xref ). xref found that in multiple myeloma (MM), inhibition of cell adhesion-mediated drug resistance (CAM-DR) caused by bone marrow (BM) is the key to anti-myeloma treatment."
34095130
sparser
"Johannes M et al found that interference of CXCL12 and CXCR4 could functionally interfered with MM chemotaxis to the bone marrow (BM), which led to the resensitization of MM cells to drugs by reversing the CAM-DR in MM [ xref ]."
32526706
sparser
"The susceptibility of tumor cells adhering to the ECM to a variety of chemotherapeutic drugs is significantly reduced and the drug resistance called cell adhesion-mediated drug resistance (CAM-DR)."
32526706
sparser
"To analyze the effects of miR-138 on the expression of small glutamine-rich TPR-containing protein A (SGTA) and cell adhesion-mediated drug resistance (CAM-DR) phenotype in non-Hodgkin's lymphoma (NHL)."
30180469
sparser
"Our findings provide evidence for the importance of different CAM-DR mechanisms depending on the respective breast cancer cells and reveal potential targets originating from the integrin signaling routes."
30563275
sparser
"While multiple factors play a role in myeloma carcinogenesis, the Very Late Antigen 4 (VLA4, CD49d/CD29, integrin α 4 β 1 ) is a front-runner implicated in myeloma cell homing, survival and acquisition of cell-adhesion mediated drug resistance (CAM-DR)."
34996933
sparser
"At a functional level, the link between ECM binding and loss of chemosensitivity of BC refers to the phenomenon of cell-adhesion-mediated drug resistance (CAM-DR)."
32668815
sparser
"Cell adhesion-mediated drug resistance (CAM-DR)."
32898723
sparser
"As we observed, reduced protein phosphorylation resulting probably in reduced signal transduction, reduced number of CSCs, decreased expression of drug transporters, and decreased expression of ECM molecules, resulting likely in reduced CAM-DR."
33921897
sparser
"Targeting CAM-DR and Mitochondrial Transfer for the Treatment of Multiple Myeloma."
36354732
sparser
"CAM-DR, which has initially been described in multiple myeloma and other malignancies of hematopoietic origin [ xref ], also appears relevant for different solid tumor entities [ xref , xref , xref ]."
31779287
sparser
"The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR)."
35464064
sparser
"Given the known concept of CAM-DR we assessed whether factors with implications in intercellular contact or signaling were dysregulated."
36056084
sparser
"These data indicate that ITGB1-driven CAM-DR is a clear factor for cisplatin resistance in W1 cells when they are in contact with COL1."
31779287
sparser
"Thus, targeting the ECM, Integrins and the interaction between them in CAM-DR might be an effective method to control cancer chemoresistance."
33041787
sparser
"CD44 upregulates the expression of cell cycle proteins inhibitors, anti-apoptotic proteins, and ABC transporters, and others, thus inducing a form of drug resistance known as cell adhesion-mediated drug resistance (CAM-DR)."
31921125
sparser
"One study explained the role of CAM-DR on modulation of cancer cell adhesion on ECM in multiple myeloma showing that the adhesion resulted in increased p27kip1 levels that associated with cell cycle arrest and resistance to melphalan (Hazlehurst and Dalton xref )."
30680600
sparser
"In terms of the environmentally-mediated communication of tumor cells, CAM-DR is meanwhile considered as an important initial trigger mechanism to escape apoptosis by a rapid, non-genetically based adaptation [ xref ]."
31779287
sparser
"MM is considered to be uncurable because MM cells are protected by the BM microenvironment, including CAM-DR, SFM-DR, vascular and endosteal niches, and clonal evolution leads to refractoriness for chemotherapy."
33435539
sparser
"CD44 upregulates the expression of ABC transporters, thereby inducing a form of drug resistance known as cell adhesion-mediated drug resistance (CAM-DR) ( xref )."
33968932
sparser
"In CAM-DR model, both SOX11 and CD43 in MCL cells were elevated when co-cultured with M2-10B4 bone marrow fibroblasts or fibronectin."
32449421
sparser
"Indeed, an earlier study has shown that VLA-4 plays a critical role in CAM-DR of MM cells, and that combination of bortezomib with conventional anti-MM drugs may be effective in overcoming CAM-DR [ xref ]."
33435632
sparser
"Cell adhesion-mediated drug resistance (CAM-DR) is induced by the adhesion of tumor cell integrins to stromal fibroblasts or to components of the extracellular matrix, such as fibronectin, laminin, and collagen [ xref ]."
33435539
sparser
"IGF-1, which are secreted from BMSC and autocrined by MM cells, binds with IGF-1R, contributing to the proliferation of myeloma cells and CAM-DR [ xref , xref ]."
33435539
sparser
"Finally, the microenvironment, such as CAM-DR, hypoxia, and the endosteal niche, contributes to the survival of MRD and MM stem cells."
33435539
sparser
"This study aimed to investigate whether annexin A7 (ANXA7) could promote the cell cycle, proliferation and cell adhesion-mediated drug resistance (CAM-DR) of multiple myeloma (MM) cells by up-regulating cell division cycle 5-like (CDC5L)."
32526706
sparser
"These molecular interactions suggest that the heterodimer α2β1 contributes to CAM-DR."
| PMC
sparser
"VRK1 acts as a negative factor of CAM-DR in MM."
27319807
sparser
"These findings point towards a novel PTK2B-LPXN axis in CAM-DR by altered niche interactions in the context of LSC properties in FLT3-ITD AML."
36056084
sparser
"Bortezomib decreases α4β1 expression and results in inhibition of CAM-DR in MM a finding that may contribute to the clinical success of bortezomib [ xref ]."
32898723
sparser
"CAM-DR is considered as the onset for resistance mutations, but underlying mechanisms remain elusive."
30563275
sparser
"Furthermore, we clarified that CD49d- and CD49e-mediated CAM-DR could be attributed to an increase in the expression of B cell leukemia-xL (Bcl-xL) and survivin proteins, and a decrease in the expression of Bcl-2 associated X (Bax), Bcl-2 interacting mediator (Bim) and p53 upregulated modulator of apoptosis (PUMA) proteins via nuclear factor kappaB (NF-κB) activation."
33214335
sparser
"Finally, it was revealed that HSPA12B overexpression enhances CAM-DR."
34734014
sparser
"Additionally, ECM proteins can induce cell adhesion mediated drug resistance (CAM-DR), leading to increased resistance to apoptosis [ xref ]."
32283808
sparser
"Shain et al.showed that drug resistance of myeloma cell lines correlates with increased adherence potential (i.e., CAM-DR), via either increased VLA4 expression or shift from low- to high- affinity state xref , xref , xref ."
34996933
sparser
"The string database predicts that ANXA7 can combine with CDC5L. Therefore, we further hypothesized that ANXA7 interference could promote cell cycle arrest in G2/M phase through CDC5L to inhibit proliferation of MM cells and reduce cell adhesion-mediated drug resistance (CAM-DR)."
32526706
sparser
"Heterodimeric complexes, such as integrin α4/β1 dimer, have been linked to cell adhesion-mediated drug resistance (CAM-DR) to EGFR inhibitors (cetuximab) [ xref ]."
35159370
sparser
"Although the acquired resistance is only moderate, CAM-DR is considered as essential prerequisite to confer a prolonged survival of tumor cells towards antineoplastic agents and thus favors the acquisition of genetic drug resistance mechanisms [ xref ]."
30563275
sparser
"Although those protumorigenic effects of integrins in breast cancer have not been considered in terms of CAM-DR, a link between integrins and malignancy of breast cancers could be elucidated."
30563275
sparser
"The PI3K-Akt signaling pathway is involved in rituximab action, chronic activation of BCR signaling, and CAM-DR."
33323828
sparser
"To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers."
35464064
sparser
"Notably, the COL1 induced CAM-DR adds as an independent process to the pre-existing cisplatin resistance in W1CR cells, which is a novel and unexpected finding improving our understanding."
31779287
sparser
"The molecular interaction between tumor cells and microenvironment is considered to be the onset of chemotherapy resistance, namely cell adhesion mediated drug resistance (CAM-DR)."
33041787
sparser
"However, the role of VLA-1 in CAM-DR in leukemia is still unknown."
33425742
sparser
"However, these differences are not significant enough to attribute to hyaluronic acid and collagen a CAM-DR effect against BRZ, as occurs with DEX."
| PMC
sparser
"The α4β1 integrin is a main adhesion receptor mediating MM cell-stroma interactions and MM cell survival, and its expression and function are downregulated by BTZ, leading to inhibition of cell adhesion-mediated drug resistance (CAM-DR) and MM cell apoptosis."
32501543
sparser
"Furthermore, they can induce drug resistance in surrounding cells by CAM-DR [ xref ]."
30583585
sparser
"Consistent with this prediction, CAM-DR involves signaling through MEK/ERK and FAK pathways (Dickreuter and Cordes, xref ) and in breast cancer, upregulation of Teneurin-related Tenascin-C was implicated (Jansen et al., xref )."
30618566
sparser
"Furthermore, several other signaling pathways including MAP/ERK [ xref , xref ], Wnt3/RhoA/ROCK [ xref ], and HMG-CoA/Rho/Rho-kinase [ xref ] are involved in CAM-DR of MM."
33918655
sparser
"Aiming to elucidate the relevance and underlying mechanisms of CAM-DR in ovarian cancer cells, the present study investigates the role of collagen binding of W1 ovarian cancer cells with respect to cisplatin sensitivity."
31779287
sparser
"We were able to simulate CAM-DR by showing a decrease in sensitivity of human MCF-7 and MDA-MB-231 breast cancer cells to MX or CDDP cytotoxicity when cells were cultivated in presence of COL1."
30563275
sparser
"Whether this contributes to cell adhesion‐mediated drug resistance (CAM‐DR) has to be further elucidated. xref "
31957290
sparser
"We also examined the therapeutic targets of CAM-DR in BL cells and found CD49d and CD49e to be the important adhesion molecules involved."
33214335
sparser
"Cellular adhesion-mediated drug resistance (CAM-DR) is one of the underlying mechanisms of disease relapse and refractoriness to antimyeloma therapy [ xref ]."
33918655
sparser
"Pazopanib may find use as a CAM-DR inhibitor as it inhibits VEGF-induced up-regulation of adhesion molecules on tumor cells [ xref ]."
29882812
sparser
"In the W1PR2 cell line, the strength of CAM-DR can result from dephosphorization signaling molecules by PTPRK and stimulation of CAM-DR by extracellular COL3A1."
33921897
sparser
"In tumor tissue, other mechanisms of drug resistance such as cell adhesion mediated drug resistance (CAM-DR) can be developed [ xref ]."
29027969