IndraLab

Statements


| 151

sparser
"We hypothesized that a decreased level of extracellular COL3A1 resulted in reduced drug binding, increased drug diffusion into cells, and reduced interaction between ECM and cell surface receptors, resulting in reduced CAM-DR strength."

sparser
"Thus it will be critical to move toward a personalized approach for targeting the CAM-DR phenotype associated with cell adhesion as well as for inhibitors of soluble factors that confer drug resistanc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Thus, integrin-mediated chemoresistance is perceived as a form of adhesion-mediated drug resistance (CAM-DR) ( xref )."

sparser
"In this study, we investigated the mechanism of CAM-DR induced by Fibronectin (Fn)."

sparser
"As Wnt signaling has been shown to be an aberrantly upregulated pathway in leukemia ( xref ) and is involved with chemoresistance, this warrants further exploration of celecoxib as a viable therapy to reverse CAM-DR in leukemia."

sparser
"Strengthening our comprehension of miRNA production and activity in the MM cell−BM relationship will help us to identify novel drug targets to overwhelm CAM-DR [ xref , xref ]."
| PMC

sparser
"Intracellular signaling initiated by binding to the ECM seems to be fundamental for cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC

sparser
"VTD-PACE is a good option for EMD considering CAM-DR and hypoxia, but might be intolerable for the majority of patients with a terminal phase of MM [ xref ]."

sparser
"One of the resistance phenomena involved in MM is the cell adhesion mediated drug resistance (CAM-DR) [ xref , xref ]."
| PMC

sparser
"Different ECM proteins, including laminin and fibronectin, are associated with CAM-DR in different cancer types [ xref ], including pancreatic cancer [ xref ]."

sparser
"Cell adhesion-mediated drug resistance (CAM-DR), a form of chemotherapy resistance, has been reported to confer resistance to various chemotherapeutic agents."

sparser
"Mounting evidence suggests that cell adhesion-mediated drug resistance (CAM-DR), caused by the interaction between the bone marrow microenvironment and tumour cells may play an important role in drug resistance to chemotherapy."

sparser
"The integrin VLA4 (a 4 b 1 ) is a key mediator of CAM-DR and its expression affects drug sensitivity of MMC."

sparser
"Treatment for Interaction with CAM-DR and SFM-DR."

sparser
"The phosphorylation-mediated enhancer of zeste homolog 2 (EZH2) inactivation and subsequent decreases in H3K27me3 levels are related to CAM-DR in MM cells [ xref ]."

sparser
"1S cells to fibronectin could increase miRNA-182 production and reduce programmed cell death 4 (PDCD4), which is essential for CAM-DR."
| PMC

sparser
"It was previously demonstrated that the adhesion molecule integrin α4, referred to hereafter as α4, mediates the cell adhesion-mediated drug resistance (CAM-DR) of B-cell ALL by binding to vascular cell adhesion molecule-1 (VCAM-1) on bone marrow stroma."

sparser
"Binding of VLA-4 to fibronectin of the ECM induces activation of nuclear factor κB (NFκB) leading to cell adhesion-mediated drug resistance (CAM-DR) and pro-survival signaling ( xref )."

sparser
"Apart from CXCR4, MM cells also express CXCR7, an alternative receptor of CXCL12, which may also be involved in CAM-DR in MM [ xref ] as well as in MM progression [ xref ]."
| PMC

sparser
"Thus, heparin, heparan sulphate, chondroitin sulphate, or other collagens hypothesized to be involved in CAM-DR could be incorporated into the 3D environment with the procedures discussed here."
| PMC

sparser
"CAM-DR is induced in fibroblasts derived from MM patients, but not in healthy individuals [ xref , xref ]."

sparser
"Cell adhesion mediated-drug resistance (CAM-DR) is one of main reasons for. the limitation to chemotherapy, but the underlying mechanism remains unclear in glioma."

sparser
"The focal adhesion pathway, along with CAM-DR has commonly been linked to drug resistance in MM patients xref , due partly to the increased abundance of Wnt3."
| PMC

sparser
"Overexpression of CCT8 could promote the proliferation, accelerate the G1/S transition and reverse cell adhesion-mediated drug resistance (CAM-DR) phenotype in B-cell non-Hodgkin’s lymphoma ( xref )."

sparser
"However, the expression of ECM components and CAM-DR seems not to be limited to cancer tissue."

sparser
"Few studies analyze redundancy between integrins in CAM-DR, and how it might affect integrin targeting."

sparser
"Moreover, another study reported that CAM-DR is associated with activation of canonical NF-κB (p65–p50) in MM cells."

sparser
"This study aimed to investigate the expression of HSPA12B and its role in cell adhesion mediated drug resistance (CAM-DR) of non-Hodgkin's lymphoma (NHL)."

sparser
"This phenomenon, called cell adhesion-mediated drug resistance (CAM-DR), has been demonstrated in many subsets of leukemia including B- and T-acute lymphoblastic leukemia (B- and T-ALL) and acute myeloid leukemia (AML)."

sparser
"On the contrary, the W1PR2 cell line revealed an increased level of extracellular COL3A1 after piperine treatment that may strengthen the CAM-DR mechanism and lower PAC sensitivity."

sparser
"The epigenetic mechanism is associated with CAM-DR as well."

sparser
"Interestingly, it has been observed in multiple studies that targeting NFκB signalling pathways when treating MM, reduces drug resistance to PIs xref , suggesting that the significantly increased abundance of Integrin β3 shown in this study may be leading to increased levels of NFκB signalling, causing CAM-DR to three of the five drugs."
| PMC

sparser
"Environmental mediated-drug resistance (EM-DR) contains cell adhesion-mediated drug resistance (CAM-DR) and soluble factor-mediated drug resistance (SM-DR) that contributes to de novo drug resistance."

sparser
"Indeed, in the W1PR2 cell line, we observed a minimal synergistic effect of piperine on PAC resistance that may be explained by the protective effect of extracellular COL3A1 in the way of CAM-DR."

sparser
"Suppression of integrin β7 decreases adhesion to fibronectin and E-cadherin and inhibits CAM-DR to bortezomib or melphalan in MM cells [ xref ]."

sparser
"This protects them from killing by cytotoxic drugs, so called cell adhesion-mediated drug resistance (CAM-DR), but also from killing by cytotoxic T−cells (CAM-immune resistance/CAM-IR) by upregulating several anti-apoptotic proteins after binding to stromal cells [ xref ]."

sparser
"Stromal cells utilize two mechanisms to induce drug resistance, including soluble factor-mediated drug resistance (SM-DR) and cell adhesion-mediated drug resistance (CAM-DR) [ xref ]."
| PMC

sparser
"Surface molecule overexpression and CAM-DR have been addressed in many subtypes of leukemia, including B- and T-acute lymphoblastic leukemia (B- and T-ALL) and acute myeloid leukemia (AML)."

sparser
"The attachment of tumor cells to the ECM may trigger cell adhesion-mediated drug resistance (CAM-DR)."

sparser
"Given that the adhesion of MM cells to BMSC via VLA-4- VCAM-1 interaction confers CAM-DR in MM cells xref , xref , xref and osteoclastogenesis, xref these results suggested the therapeutic impact of TAK1 inhibition on CAM-DR as well as osteoclastogenesis induced by the MM-bone marrow interaction."

sparser
"CAM-DR is one mechanism through which leukemia cells obtain chemoresistance, and resistant clones will result in the recurrence of the disease."

sparser
"CAM-DR may be strong in minimal residual myeloma cells compared to newly diagnosed myeloma cells because of the rich presence of adhesion molecules on the minimal residual myeloma cells [ xref ]."

sparser
"Elucidation of the mechanisms underlying cell adhesion-mediated drug resistance (CAM-DR) may prolong remission and ultimately improve the survival of MM patients."

sparser
"As discussed in this section, integrin blockades have been shown to increase chemosensitivity of leukemia cells and provide support for further studies of integrins as a viable target to abolish CAM-DR in leukemia."

sparser
"The gene set enrichments showed that sustained PI monotherapy was involved in inflammatory response pathways, which correspond to SFM-DR, whereas the gene sets involved in CAM-DR were enriched in both combination and intermittent therapy groups (Fig.  xref )."

sparser
"Hence, BTK bound directly with CXCR4 and prevented its ubiquitination-induced degradation, leading to CAM-DR maintenance."

sparser
"Cadherins, selectins, and integrins are known cell adhesion molecules that are involved in CAM-DR in leukemia ( xref )."

sparser
"Their aberrant expression and association in CAM-DR in different types of leukemia have been studied."

sparser
"These biological processes and pathways correspond to soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), xref respectively."

sparser
"In addition, bortezomib was found to overcome CAM-DR in BL cells by inhibiting NF-κB. Thus, bortezomib may have potential clinical applications in the treatment of CD49d- and CD49e-mediated CAM-DR in BL patients."

sparser
"Several new drugs are developed to overcome de novo drug resistance, such as proteasome inhibitors and EZH2 inhibitors to overcome CAM-DR, and anti-IL-6 monoclonal antibodies and IGF-1R inhibitors to overcome SFM-DR, in a preclinical study, although several of those have not shown efficacy in clinical trials and thus are not available in clinical practice."

sparser
"Thus, the limitation of TGFBI secretion by piperine can inhibit integrin signaling, which is the primary signaling in CAM-DR, and it eventually leads to higher TOP sensitivity [ xref ]. xref summarizes the main mechanisms of piperine action on drug-resistant cells in our model."

sparser
"Drug resistance mediated by the MM BM microenvironment can be caused either by soluble factors or by direct physical cell–cell interactions mediated by cell adhesion molecules, termed soluble factor-mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAM-DR), respectively [ xref , xref , xref ]."
| PMC

sparser
"These data emphasize the upregulation of α4β1 expression and function as a key event during resistance to BTZ in MM, which might indirectly contribute to stabilize this resistance, as stronger MM cell attachment to BM stroma will regain CAM-DR and MM cell growth and survival."

sparser
"Our data suggest that HSPA12B may play a functional role in CAM-DR and is thus a potential novel target for NHL treatment."

sparser
"However, the molecular mechanism underlying CAM-DR in BL has not been identified yet."

sparser
"BTK plays a role in CAM-DR through the regulation of CXCR4 degradation in MM cells and suggests that targeting therapy for the BTK/CXCR4 interaction may be effective for reversing CAM-DR."

sparser
"Cell-adhesion mediated drug resistance (CAM-DR) to melphalan is induced in MM cell lines and in patient primary cells through adhesion to fibronectin or bone marrow stromal cells (BMSCs), which is mediated by very late antigen-4 (VLA4) integrin (α4β1) and VLA-5 (α5β1) [ xref ]."

sparser
"Multiple myeloma (MM) is a hematological neoplasia in which the BMN’s role in disease progression via elevated proliferation, migration and CAM-DR has been extensively reported [ xref ]."

sparser
"This study aimed to investigate whether annexin A7 (ANXA7) could promote the cell cycle, proliferation and cell adhesion-mediated drug resistance (CAM-DR) of multiple myeloma (MM) cells by up-regulating cell division cycle 5-like (CDC5L)."

sparser
"In this study, we investigated the molecular mechanism responsible for CAM-DR in BL cells."

sparser
"This study aims to investigate the effect and mechanism of WCF combined with DDP in reversing CAM-DR."

sparser
"The most important was to study the expression changes of HSPA12B in the adhesion model and the effect of overexpression of HSPA12B on CAM-DR."

sparser
"Elucidating the mechanism of CAM-DR and developing the corresponding drugs are urgently required to improve outcomes."

sparser
"This paper will review the role of cadherins, selectins, and integrins in CAM-DR and the results of clinical trials targeting these molecules."

sparser
"However, the specific role of VLA-3 in CAM-DR in leukemia is still unclear."

sparser
"Bortezomib (BOR) overcomes CAM-DR by inhibiting VLA-4 [ xref ], and shows a synergistic effect with various drugs in co-culturing human myeloma cell lines with BMSC [ xref ]."

sparser
"The lack of CAM-DR effect against BRZ, induced by the interaction with hyaluronic acid and collagen, has been confirmed."
| PMC

sparser
"Such an environment can be used to further study the individual or synergic effects of bone marrow extracellular matrix components on CAM-DR against different known or new drugs, or even to develop drugs capable of inhibiting the interaction of mPCs with specific biomolecules."
| PMC

sparser
"The binding of cancer cells to ECM activates the intracellular signals transduction and is designated as a cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref ]."

sparser
"By demonstrating that GBM cells can alternate from one form of CAM-DR (cell-substrate tethering) to another (homocellular cell-cell adhesion) and that inhibition of both forms is necessary for apoptosis sensitization, our findings not only have important implications for novel approaches to restore defective apoptosis programs, but also reveal a novel role of gap junctions in GBM."

sparser
"Interaction between VLA-4 and vascular cell adhesion molecule-1 (VCAM-1) binds between MM cells and BMSC, contributing to the survival of MM cells via activation of phosphoinositide 3-kinase (PI3K)/(protein kinase B) AKT pathway and CAM-DR [ xref ]."

sparser
"Interestingly, the interactions between MSCs and LSCs rely on cell-adhesion molecules, such as cadherins and integrins, and are involved in the process of Wnt signaling activation; therefore, CAM-DR plays a critical role in Wnt signaling."

sparser
"So far, there is one study that has reported its relationship with head and neck cancer, indicating that ENO1 promotes transformation partly via chemokine CCL20 induction and can be regarded as a potential prognostic marker. xref Moreover, ENO1 participates in the process of lymphoma cell adhesion mediated drug resistance (CAM-DR), besides promoting tumor proliferation. xref ENO1 overexpression was also observed in pancreatic cancer, xref and ENO1 silencing could sensitize hypoxia-induced chemoresistance. xref Some Italian scholars used a genetic model of pancreatic carcinoma and observed the effects that vaccination with ENO1 DNA elicits."

sparser
"Kikuchi et al. demonstrated that pharmacological and genetic inhibition of the IGF1R-PI3K-AKT pathway reverses CAM-DR by promoting enhancer of zeste homolog 2 (EZH2) dephosphorylation and H3K27 hypermethylation both in vitro and in refractory murine MM models, suggesting an epigenetic mechanism underlying CAM-DR [ xref ]."

sparser
"At the same time, leukemia cells can aberrantly express CAM to facilitate surface molecule-mediated interaction with BM microenvironment, thereby inducing cell-adhesion mediated drug resistance (CAM-DR)."

sparser
"BMSC-derived CXCL12γ and HSPGs mediate CAM-DR."
| PMC

sparser
"Our study revealed that the therapeutic basis for SFM-DR as well as for CAM-DR is the dysregulation of epigenetic regulators in MM patients during treatment."

sparser
"Waldschmidt et al. also evaluated CAM-DR restoration using different antimyeloma agents and the CXCR4 inhibitor plerixafor [ xref ]."

sparser
"Anti CD38 MoAbs have several anti-myeloma and microenvironment activities, such as complement-dependent cytotoxicity (CDC), ADCC, direct myeloma killing, enhancement of the immune system, inhibition of CAM-DR, and enhancement of bone remodeling as above."

sparser
"De novo resistance includes environment-mediated drug resistance, which is categorized as either cell adhesion-mediated drug resistance (CAM-DR) or soluble factor-mediated drug resistance (SFM-DR)."

sparser
"A recent study has also shown that CXCL12 is a relevant target to attenuate CAM-DR in MM [ xref ]."

sparser
"VLA4-nanoparticles hijack cell adhesion mediated drug resistance (CAM-DR) to target refractory myeloma cells and prolong survival."

sparser
"Cadherins, Selectins, and Integrins in CAM-DR in Leukemia."

sparser
"Second, the TME might aid cancer cell survival and induce epithelial–mesenchymal transition (EMT) through the enhanced adhesion of cancer cells to the ECM, leading to therapeutic resistance, often described as cell adhesion-mediated drug resistance (CAM-DR) [ xref , xref , xref ]."

sparser
"Therefore, clarification of the molecular systems inherent in CAM-DR may facilitate identification of new therapeutic tactics to overcome this problem."
| PMC

sparser
"The drug resistance that results from direct cell contact with the ECM or other cells has been called “cell-adhesion-mediated drug resistance” or CAM-DR [ xref ]."
| PMC

sparser
"Collectively, SOX11 could inhibit tumor proliferation and promote CAM-DR in a CD43 dependent manner."

sparser
"Taken together, our data suggest a scenario in which CXCL12γ functions as a ‘niche chemokine’ that, in conjunction with HSPGs, plays a key role in controlling adhesion, BM retention, and CAM-DR of MM cells (Fig.  xref c)."
| PMC

sparser
"Both ectopic expression of miR-548m and knockdown of HDAC6 were able to disrupt the stroma-lymphoma adhesion and consequently induce cell apoptosis, suppress colony formation, sensitize B-lymphoma cells to the cytotoxic drug mitoxantrone, and abolishing the cell adhesion–mediated drug resistance acquisition (CAM-DR) [ xref ]."

sparser
"Since expression of the majority of adhesion molecules including VLA-4 is regulated by NF-κB, inhibition of NF-κB may represent a novel strategy to overcome CAM-DR."

sparser
"Our previous studies showed that Oroxylin A combined with Paclitaxel reverses cell adhesion mediated-drug resistance (CAM-DR) in HepG2 cells by inhibiting integrinβ1 and PI3K/Akt signaling ( xref )."

sparser
"Fn could decrease the apoptosis-inducing effect of TMZ and led to the CAM-DR in glioma cells."

sparser
"This type of drug resistance, named “cell adhesion-mediated drug resistance” (CAM-DR), is regarded as the most important mechanism able to cause the escape of MM cells from therapeutic effects [ xref , xref ]."
| PMC

sparser
"In this way, the implication of two biomolecules, hyaluronic acid and collagen, have been proven on mPCs proliferation and CAM-DR effect towards DEX and BRZ."
| PMC

sparser
"This experiment was carried out in a conventional 2D culture at 72 h, varying the dosage from 1 to 1000 µM. The results shown in xref A support the use of a 1000 µM concentration in CAM-DR trials, which produce mortality of around 70%."
| PMC

sparser
"Thus, EZH2 is a target of treatment for the apoptosis of myeloma cells and release of CAM-DR [ xref , xref ]."

sparser
"These data suggest that MM cells share common regulatory pathways for drug resistance in different models, including SFM-DR and CAM-DR."

sparser
"MM cell adhesion to BMSC through the interaction between VLA-4 and its corresponding ligand, VCAM-1, is among the predominant mechanisms for cell adhesionmediated drug resistance (CAM-DR) in MM, xref , xref while enhancing the production of IL-6 30 and RANKL, an critical osteoclastogenic factor in MM. xref In addition to TAK1 activation in MM cells, TAK1 was found to be phosphorylated along with PIM2 upregulation in BMSC, when cocultured with MM cells ( xref )."

sparser
"Recently, we [ xref , xref , xref , xref ] and others [ xref ] observed the expression of different ECM components in drug-resistant cancer cell lines suggesting their active role in CAM-DR [ xref , xref ]."

sparser
"Cell adhesion mediated drug resistance (CAM-DR) has been strongly linked with the increased abundance of Integrin β3."
| PMC

sparser
"The CAM-mediated interaction of leukemia cells with the surrounding microenvironment contributes to drug resistance, which is called cell adhesion-mediated drug resistance (CAM-DR)."

sparser
"Bortezomib decreased the protein levels of CHD1L, but cell adhesion increased the expression levels of CHD1L, overexpression of CHD1L contributes to cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma cells [ xref ]."

sparser
"PTPRK can influence CAM-DR by dephosphorization of the AKT and MAPK pathways [ xref ]."

sparser
"As we observed, reduced protein phosphorylation resulting probably in reduced signal transduction, reduced number of CSCs, decreased expression of drug transporters, and decreased expression of ECM molecules, resulting likely in reduced CAM-DR."

sparser
"Furthermore, Wang et al. recently demonstrated that BTK induces CAM-DR through CXCR4 regulation degradation in MM [ xref ], promoting BTK expression induced MM cell adherence to the extracellular matrix and stromal cells in vitro and in vivo and increased drug resistance to bortezomib and doxorubicin in MM cells."

sparser
"DARA releases CAM-DR by inhibiting adhesion to BMSCs by internalizing CD38 in myeloma cells [ xref ]."

sparser
"Taken together, our results confirm that the combination of WCF with DDP could reverse the lung cancer CAM-DR through the Integrin β1 signaling pathway."

sparser
"One of the prominent features of cell adhesion-mediated signaling in MM pathogenesis is cell-adhesion mediated drug resistance (CAM-DR)."

sparser
"EMDR can be separated in two groups: EMDR due to soluble factors which is called Soluble Factor-Mediated Drug Resistance (SFM-DR), and EMDR due to adhesion process between the tumor cell receptors and extracellular matrix (ECM) proteins which is called Cell Adhesion-Mediated Drug Resistance (CAM-DR)."

sparser
"ITGB7 is necessary for myeloma cell survival and CAM-DR, and has been shown to be constitutively active in myeloma cells ( xref , xref )."

sparser
"However, CD49a, CD49b, CD11a, CD29, CD18, and CD61 were not found to be associated with CAM-DR in BL cells."

sparser
"Therefore, even though specific ligands are preferentially used in different cells, this does not mean that other molecules are less crucial in conferring CAM-DR."

sparser
"MM is considered to be uncurable because MM cells are protected by the BM microenvironment, including CAM-DR, SFM-DR, vascular and endosteal niches, and clonal evolution leads to refractoriness for chemotherapy."

sparser
"In CAM-DR model, both SOX11 and CD43 in MCL cells were elevated when co-cultured with M2-10B4 bone marrow fibroblasts or fibronectin."

sparser
"Indeed, an earlier study has shown that VLA-4 plays a critical role in CAM-DR of MM cells, and that combination of bortezomib with conventional anti-MM drugs may be effective in overcoming CAM-DR [ xref ]."

sparser
"Cell adhesion-mediated drug resistance (CAM-DR) is induced by the adhesion of tumor cell integrins to stromal fibroblasts or to components of the extracellular matrix, such as fibronectin, laminin, and collagen [ xref ]."

sparser
"In these clinical trials, GMI-1271 will be administered in combination with existing chemotherapies, which highlights how targeting both the microenvironment and leukemia cells may be necessary in order to ameliorate CAM-DR."

sparser
"IGF-1, which are secreted from BMSC and autocrined by MM cells, binds with IGF-1R, contributing to the proliferation of myeloma cells and CAM-DR [ xref , xref ]."

sparser
"Finally, the microenvironment, such as CAM-DR, hypoxia, and the endosteal niche, contributes to the survival of MRD and MM stem cells."

sparser
"Cell adhesion mediated-drug resistance (CAM-DR) is an established mechanism used by MMC to survive chemotherapy and its markers are upregulated in residual disease."

sparser
"At present, several integrins have been proposed as likely contributors to CAM-DR in ALL and different routes of dissemination from BM to the CNS have been suggested ( xref , xref )."

sparser
"These molecular interactions suggest that the heterodimer α2β1 contributes to CAM-DR."
| PMC

sparser
"This type of acquired resistance can be divided into two categories: soluble factor-mediated drug resistance (SFM-DR) and cell adhesion mediated drug resistance (CAM-DR) ( xref f)."

sparser
"Toward this goal, we identified trimethylation of histone H3 at lysine-27 (H3K27me3) as a critical histone modification associated with CAM-DR."

sparser
"Furthermore, we clarified that CD49d- and CD49e-mediated CAM-DR could be attributed to an increase in the expression of B cell leukemia-xL (Bcl-xL) and survivin proteins, and a decrease in the expression of Bcl-2 associated X (Bax), Bcl-2 interacting mediator (Bim) and p53 upregulated modulator of apoptosis (PUMA) proteins via nuclear factor kappaB (NF-κB) activation."

sparser
"Finally, it was revealed that HSPA12B overexpression enhances CAM-DR."

sparser
"Additionally, ECM proteins can induce cell adhesion mediated drug resistance (CAM-DR), leading to increased resistance to apoptosis [ xref ]."

sparser
"BOR enhances the activity of IMiDs by releasing CAM-DR and elevating IKZF1 expression."

sparser
"CAM-DR and SFM-DR are therapeutic targets to overcome drug resistance and to suppress the proliferation and survival of MM cells via the inhibition of signaling pathways."

sparser
"MSCs also contribute to drug resistance through cell-adhesion-mediated drug resistance (CAM-DR) [ xref , xref ], in which the Wnt signaling pathway is involved [ xref ]."

sparser
"The PI3K-Akt signaling pathway is involved in rituximab action, chronic activation of BCR signaling, and CAM-DR."

sparser
"Inhibition of EZH is known to inactivate CAM-DR in vitro [ xref ]."

sparser
"However, the role of VLA-1 in CAM-DR in leukemia is still unknown."

sparser
"However, these differences are not significant enough to attribute to hyaluronic acid and collagen a CAM-DR effect against BRZ, as occurs with DEX."
| PMC

sparser
"The α4β1 integrin is a main adhesion receptor mediating MM cell-stroma interactions and MM cell survival, and its expression and function are downregulated by BTZ, leading to inhibition of cell adhesion-mediated drug resistance (CAM-DR) and MM cell apoptosis."

sparser
"Furthermore, several other signaling pathways including MAP/ERK [ xref , xref ], Wnt3/RhoA/ROCK [ xref ], and HMG-CoA/Rho/Rho-kinase [ xref ] are involved in CAM-DR of MM."

sparser
"Thus, CXCL12γ and HSPG on the cell surface of BMSCs promote MM cell adhesion to these BMSCs and thereby play an important role in CAM-DR."
| PMC

sparser
"While we found alterations in other metabolism-associated genes (e.g. PKM2, CS, IDH1, ACO2, FH, MDH2, or HK1)), we focused on examining the functional significance of ENO1 in the present study since: (1) a significant induction of ENO1 was noted during pDC-MM interactions versus other molecules; (2) ENO1 is essential for maintaining tumor cell metabolism and represents a potential therapeutic target in cancer [ xref – xref ]; (3) ENO1 promotes tumor cell proliferation and cell adhesion-mediated drug-resistance (CAM-DR) [ xref ] characteristic of MM; and (4) ENO1 functions as an immunoregulatory molecule both in T-regulatory cell differentiation and dendritic cell function [ xref , xref ]."

sparser
"The apoptosis-protective adhesion to stromal cells, termed cell adhesion-mediated drug resistance (CAM-DR), is another underlying mechanism of R-CHOP resistance in DLBCL.[ xref ]CAM-DR was revealed to correlate with rituximab resistance through ADAM metalloproteinase domain 12 ( ADAM-12 ) upregulation and phosphatidylinositol 3-kinase ( PI3K ) -Akt signaling modulation.[ xref ]However, as per findings reported by Lenz et al ,[ xref ]genetically identified non-malignant signatures of stromal-1 (fibrosis and myeloid infiltration) and stromal-2 (vessel formation) in pretreatment biopsies were found to be prognostically favorable and unfavorable for patients with DLBCL who received R-CHOP, respectively."

sparser
"Type I collagen plays an important role in tissues scaffolding but is also important in CAM-DR ( xref )."

sparser
"The adhesion molecules, such as very late angine-4 (VLA-4) plays an important role for CAM-DR [ xref ]."

sparser
"CAM-DR, on the other hand, is caused by direct cell-cell interactions ( xref ) [ xref ]."
| PMC

sparser
"This sort of drug resistance, called “cell adhesion-mediated drug resistance” (CAM-DR), is considered one of the most relevant systems able to provoke the escape of MM cells from therapeutic actions [ xref , xref ]."
| PMC

sparser
"We also examined the therapeutic targets of CAM-DR in BL cells and found CD49d and CD49e to be the important adhesion molecules involved."

sparser
"In this regimen, THAL enhances the sensitivity of BOR and cytotoxic agents by improving hypoxia, and BOR, in turn, increases the sensitivity of doxorubicin and etoposide, whose activities are dependent on the cell cycle, through the release of CAM-DR."

sparser
"Integrin β1 signaling plays an important role in CAM-DR and has been proposed as a potential target for NSCLC."

sparser
"Thus, the re-expression of PTPRK after piperine treatment can result in decreased CAM-DR."

sparser
"Cellular adhesion-mediated drug resistance (CAM-DR) is one of the underlying mechanisms of disease relapse and refractoriness to antimyeloma therapy [ xref ]."

sparser
"In conclusion, ANXA7 could promote the cell cycle, proliferation and CAM-DR of MM cells by up-regulating CDC5L."

sparser
"In the W1PR2 cell line, the strength of CAM-DR can result from dephosphorization signaling molecules by PTPRK and stimulation of CAM-DR by extracellular COL3A1."