IndraLab

Statements



eidos
"CaM inhibitors ( CaMi ) and several kinases facilitate Ser-181 phosphorylation , thus promoting apoptosis ."

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"Identification of cells undergoing apoptosis in human PBMNC treated with CAM."

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"PtdEtn formation through PtdSer decarboxylation showed little change in apoptotic cells induced by UV irradiation or TNF-alpha and CHX similar to the CAM induced apoptosis, but [3 H] serine derived Pt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Our data also showed that caspase-1 was cleaved to its active 20 kDa form during CAM mediated apoptosis in U937 cells.To assess PtdSer biosynthesis in U937 cells during CAM induced apoptosis, cells we[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The mechanisms by which CAM induces apoptosis and exerts its well known anti-cancer effects in tumour cells are not fully elucidated."

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"After induction of apoptosis by CAM also sequential time dependent increase of the 2E12 reactivity in all cell lines was detected."

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"For most experiments, camptothecin (CAM; Calbiochem) was administered at various concentrations to induce apoptosis with or without co-incubation or pre-incubation for 60 min with caspase inhibitor, c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"On the basis of this, it might be hypothesised that 1alpha,25 (OH) 2 D 3 suppresses CAM induced apoptosis by inhibiting cell proliferation, which then reduces the number of the dividing cells and thus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Treatment with CAM for 5 h resulted in an 8-fold increase of newly radiolabelled PtdSer in the medium.We also examined the synthesis of other phospholipids during CAM induced apoptosis."

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"Furthermore, knockdown of CNA and CALM2 impairs apoptosis of primary sympathetic neurons following neurotrophin deprivation to the same extent as loss of DRP1 expression."

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"Thus, our data indicated that during CAM induced apoptosis in U937 cells, PtdSer synthesis was stimulated and newly synthesized PtdSer was transferred preferentially to CFMV.Caspases are key ' executi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Thus, we could show that T cells are relatively resistant to CAM induced apoptosis compared to other peripheral blood mononuclear cells and that both double negative and single positive thymocytes are[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"As shown, pro-caspase-3, an inactive 32 kDa protein, was cleaved to active 17 kDa and 12 kDa fragments during CAM induced apoptosis; PARP, a direct substrate of caspase-3, was cleaved to its active 85[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We compared percentages of 2E12 and APO2.7 positive cells in both cell lines KG-1, HL-60 after induction of apoptosis by CAM."

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"Thus, approximately 28% of CAM induced cells demonstrated apoptosis at 6 h in FCM as compared to 10% in the non induced cells."