IndraLab

Statements

CALM1 activates PDE. 11 / 11
| 10 1
reach
"Cal- modulin when complexed with the drug is unable to activate phosphodiesterase or several other calmodulin dependent systems such as erythrocyte calcium activated ATPase [7]."
6280730
reach
"A CAM assay based on the ability of CAM to stimulate PDE was used [21]."
11024266
reach
"This conclusion is based on the fact that interference with CAM expression via an antisense approach resulted in (i) negligible steady state levels of cam RNA expression; (ii) highly reduced CAM prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11024266
sparser
"In this study, the EC 50 of scoparone for PDE activation by CaM1 was 4.92 μM, suggesting that scoparone could indirectly activate the CaM1 protein in vitro ( xref a-c)."
35572395
reach
"After cultivation for 3 d at 27 °C, CaM1-expressing Sf9 cells were collected and further resuspended to measure the specific activation of PDE by CaM1."
35572395
reach
"Effect of various concentrations of CaCk on the ability of cetiedil to inhibit calmodulin stimulated phospho- diesterase activity Calmodulin- stimulated phosphodiesterase activity Cetiedil CaCli [nmol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6231031
reach
"As mentioned above, calmo- dulin activates a cytosolic phosphodiesterase which displays a low-A " ", value (micromolar) for cyclic GMP."
6268109
reach
"In this study, the EC of scoparone for PDE activation by CaM1 was 4.92 μM, suggesting that scoparone could indirectly activate the CaM1 protein in vitro (Fig. 4a-c)."
35572395
reach
"Additionally, the CaM1 assay showed that compared with the control treatment, treatment with the LC , LC , and LC doses of scoparone for 48 h markedly increased the specific activation of PDE by extracted CaM in vivo (by 3.67-, 2.79-, and 1.87-fold, respectively), further demonstrating that scoparone is an agonist of CaM1 (Fig. 4d)."
35572395
reach
"CaM- modulated PDE, however, did not appear to be the target for the effects of CaM inhibitors on GVBD, since concentrations of W7 that inhibited maturation did not inhibit cAMP hydrolysis in the oocy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6207062
reach
"Moreover, no inhibition of activity by trifluo- perazine (0.2-5, M), the specific inhibitor [4,121 of Ca2 / calmodulin- activated phosphodiesterase, was observed either in basal or in VIP- treated ceU[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
6262879