IndraLab

Statements


CALM1 activates PDE. 7 / 7
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"Cal- modulin when complexed with the drug is unable to activate phosphodiesterase or several other calmodulin dependent systems such as erythrocyte calcium activated ATPase [7]."

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"Effect of various concentrations of CaCk on the ability of cetiedil to inhibit calmodulin stimulated phospho- diesterase activity Calmodulin- stimulated phosphodiesterase activity Cetiedil CaCli [nmol[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"A CAM assay based on the ability of CAM to stimulate PDE was used [21]."

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"Moreover, no inhibition of activity by trifluo- perazine (0.2-5, M), the specific inhibitor [4,121 of Ca2 / calmodulin- activated phosphodiesterase, was observed either in basal or in VIP- treated ceU[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"This conclusion is based on the fact that interference with CAM expression via an antisense approach resulted in (i) negligible steady state levels of cam RNA expression; (ii) highly reduced CAM prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"CaM- modulated PDE, however, did not appear to be the target for the effects of CaM inhibitors on GVBD, since concentrations of W7 that inhibited maturation did not inhibit cAMP hydrolysis in the oocy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"As mentioned above, calmo- dulin activates a cytosolic phosphodiesterase which displays a low-A " ", value (micromolar) for cyclic GMP."